{"transactions":[{"id":1496316,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option","published_at":"2024-05-31T08:54:13.000Z","date":"2024-05-29","kind":"grant","planned":false,"acquired":true,"shares":6336,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock option shall vest in full on the earlier to occur of (i) May 29, 2025 and (ii) the date of the next annual meeting following the grant date, subject to continued service through the applicable vesting date."}],"balance_after":6336,"derivative":{"exercise_price":29.33,"expiration_date":"2034-05-29","underlying":"Common Stock","underlying_shares":6336},"source":{"system":"sec-edgar","filing":"0001415889-24-014966","document":"form4-05312024_120509.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000141588924014966/form4-05312024_120509.xml","form_type":"4"}},{"id":1612461,"issuer":{"id":7352,"kind":"organization","name":"Aligos Therapeutics, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true}}],"security":"Stock Option (Right to Buy)","published_at":"2024-02-28T22:30:38.000Z","date":"2024-02-28","kind":"grant","planned":false,"acquired":true,"shares":4411,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"On February 27, 2024, the issuer canceled, pursuant to the issuer's option exchange program, an option for 15,000 of the issuer's shares granted to the reporting person on June 17, 2021. In exchange, on February 28, 2024, the reporting person received a replacement option, for 4,411 shares, having an exercise price of $0.96 per share."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The shares subject to the option will vest and become exercisable on the one year anniversary of the date of grant, subject to the reporting person's continued service with the issuer through such one year anniversary."}],"balance_after":4411,"derivative":{"exercise_price":0.96,"expiration_date":"2031-06-17","underlying":"Common Stock","underlying_shares":4411},"source":{"system":"sec-edgar","filing":"0001610717-24-000096","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1799448/000161071724000096/form4.xml","form_type":"4"}},{"id":1612460,"issuer":{"id":7352,"kind":"organization","name":"Aligos Therapeutics, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true}}],"security":"Stock Option (Right to Buy)","published_at":"2024-02-28T22:30:38.000Z","date":"2024-02-27","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":15000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"On February 27, 2024, the issuer canceled, pursuant to the issuer's option exchange program, an option for 15,000 of the issuer's shares granted to the reporting person on June 17, 2021. In exchange, on February 28, 2024, the reporting person received a replacement option, for 4,411 shares, having an exercise price of $0.96 per share."}],"balance_after":0,"derivative":{"exercise_price":26.58,"exercise_date":"2022-06-17","expiration_date":"2031-06-17","underlying":"Common Stock","underlying_shares":15000},"source":{"system":"sec-edgar","filing":"0001610717-24-000096","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1799448/000161071724000096/form4.xml","form_type":"4"}},{"id":1681346,"issuer":{"id":7177,"kind":"organization","name":"Instil Bio, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to 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day of the month, or if earlier, the day immediately before the day of the next annual meeting of stockholders."}],"balance_after":20200,"derivative":{"exercise_price":8.14,"expiration_date":"2033-06-19","underlying":"Common Stock","underlying_shares":20200},"source":{"system":"sec-edgar","filing":"0001209191-23-039109","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1810182/000120919123039109/doc4.xml","form_type":"4"}},{"id":1857410,"issuer":{"id":8764,"kind":"organization","name":"IO Biotech, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true}}],"security":"Stock Option (Right to 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were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $59.88 to $60.00, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (2) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2571024,"source":{"system":"sec-edgar","filing":"0001415889-22-012646","document":"form4-12172022_121244.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000141588922012646/form4-12172022_121244.xml","form_type":"4"}},{"id":2090784,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-12-09T20:34:07.000Z","date":"2022-12-09","kind":"sale","acquired":false,"shares":9847,"price":59.89,"value":589736.83,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $59.88 to $60.03, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2573858,"source":{"system":"sec-edgar","filing":"0001415889-22-012358","document":"form4-12102022_011258.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000141588922012358/form4-12102022_011258.xml","form_type":"4"}},{"id":2090783,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-12-09T20:34:07.000Z","date":"2022-12-08","kind":"sale","acquired":false,"shares":36878,"price":59.9,"value":2208992.2,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $59.88 to $60.11, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2583705,"source":{"system":"sec-edgar","filing":"0001415889-22-012358","document":"form4-12102022_011258.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000141588922012358/form4-12102022_011258.xml","form_type":"4"}},{"id":2090782,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-12-09T20:34:07.000Z","date":"2022-12-07","kind":"sale","acquired":false,"shares":64026,"price":60.35,"value":3863969.1,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $59.93 to $60.54, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (2) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2620583,"source":{"system":"sec-edgar","filing":"0001415889-22-012358","document":"form4-12102022_011258.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000141588922012358/form4-12102022_011258.xml","form_type":"4"}},{"id":2099744,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-12-01T19:52:46.000Z","date":"2022-12-01","kind":"sale","acquired":false,"shares":65652,"price":60,"value":3939120.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $59.88 to $60.38, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2684609,"source":{"system":"sec-edgar","filing":"0001415889-22-011913","document":"form4-12022022_121234.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000141588922011913/form4-12022022_121234.xml","form_type":"4"}},{"id":2099743,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-12-01T19:52:46.000Z","date":"2022-11-30","kind":"sale","acquired":false,"shares":42667,"price":58.93,"value":2514366.31,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $57.5 to $59.84, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2750261,"source":{"system":"sec-edgar","filing":"0001415889-22-011913","document":"form4-12022022_121234.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000141588922011913/form4-12022022_121234.xml","form_type":"4"}},{"id":2099742,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-12-01T19:52:46.000Z","date":"2022-11-29","kind":"sale","acquired":false,"shares":21333,"price":57.82,"value":1233474.06,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $57.21 to $58.38, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (2) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2792928,"source":{"system":"sec-edgar","filing":"0001415889-22-011913","document":"form4-12022022_121234.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000141588922011913/form4-12022022_121234.xml","form_type":"4"}},{"id":2106346,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-11-22T20:57:39.000Z","date":"2022-11-22","kind":"sale","acquired":false,"shares":31902,"price":57.6,"value":1837555.2,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022"},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $56.21 to $58.14, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2814261,"source":{"system":"sec-edgar","filing":"0001104659-22-121399","document":"tm2230208-4_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922121399/tm2230208-4_4seq1.xml","form_type":"4"}},{"id":2106345,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-11-22T20:57:39.000Z","date":"2022-11-21","kind":"sale","acquired":false,"shares":24898,"price":57.08,"value":1421177.84,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022"},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $55.89 to $57.61, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2846163,"source":{"system":"sec-edgar","filing":"0001104659-22-121399","document":"tm2230208-4_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922121399/tm2230208-4_4seq1.xml","form_type":"4"}},{"id":2106344,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-11-22T20:57:39.000Z","date":"2022-11-18","kind":"sale","acquired":false,"shares":20800,"price":57,"value":1185600.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022"},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $56.4 to $57.5, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2871061,"source":{"system":"sec-edgar","filing":"0001104659-22-121399","document":"tm2230208-4_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922121399/tm2230208-4_4seq1.xml","form_type":"4"}},{"id":2115798,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-11-15T18:26:38.000Z","date":"2022-11-15","kind":"sale","acquired":false,"shares":62933,"price":56.8,"value":3574594.4,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $55.91 to $61.22, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2891861,"source":{"system":"sec-edgar","filing":"0001104659-22-119223","document":"tm2230208-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922119223/tm2230208-2_4seq1.xml","form_type":"4"}},{"id":2115797,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-11-15T18:26:38.000Z","date":"2022-11-14","kind":"sale","acquired":false,"shares":58667,"price":58.7,"value":3443752.9,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $56.82 to $59.25, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":2954794,"source":{"system":"sec-edgar","filing":"0001104659-22-119223","document":"tm2230208-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922119223/tm2230208-2_4seq1.xml","form_type":"4"}},{"id":2115796,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-11-15T18:26:38.000Z","date":"2022-11-11","kind":"sale","acquired":false,"shares":36800,"price":57.14,"value":2102752.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price.  These shares were sold on the open market in multiple transactions at prices ranging from $55.89 to $58.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3013461,"source":{"system":"sec-edgar","filing":"0001104659-22-119223","document":"tm2230208-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922119223/tm2230208-2_4seq1.xml","form_type":"4"}},{"id":2191694,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-08-08T20:18:10.000Z","date":"2022-08-08","kind":"sale","acquired":false,"shares":75000,"price":53.56,"value":4017000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $52.40 to $54.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3050261,"source":{"system":"sec-edgar","filing":"0001104659-22-087481","document":"tm2222520-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922087481/tm2222520-2_4seq1.xml","form_type":"4"}},{"id":2191693,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-08-08T20:18:10.000Z","date":"2022-08-05","kind":"sale","acquired":false,"shares":115000,"price":52.42,"value":6028300.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $51.50 to $53.07, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3125261,"source":{"system":"sec-edgar","filing":"0001104659-22-087481","document":"tm2222520-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922087481/tm2222520-2_4seq1.xml","form_type":"4"}},{"id":2191692,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-08-08T20:18:10.000Z","date":"2022-08-04","kind":"sale","acquired":false,"shares":60000,"price":52.3,"value":3138000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $51.70 to $52.72, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (2) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3240261,"source":{"system":"sec-edgar","filing":"0001104659-22-087481","document":"tm2222520-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922087481/tm2222520-2_4seq1.xml","form_type":"4"}},{"id":2195220,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-08-03T16:16:00.000Z","date":"2022-08-02","kind":"sale","acquired":false,"shares":75117,"price":55.22,"value":4147960.74,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $55.00 to $55.80, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3300261,"source":{"system":"sec-edgar","filing":"0001104659-22-085635","document":"tm2222520-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922085635/tm2222520-1_4seq1.xml","form_type":"4"}},{"id":2204422,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-07-20T18:26:14.000Z","date":"2022-07-18","kind":"sale","acquired":false,"shares":40087,"price":55.19,"value":2212401.53,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $55.00 to $55.75, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3375378,"source":{"system":"sec-edgar","filing":"0001104659-22-081249","document":"tm2220923-3_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922081249/tm2220923-3_4seq1.xml","form_type":"4"}},{"id":2206787,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-07-15T21:18:05.000Z","date":"2022-07-13","kind":"sale","acquired":false,"shares":5773,"price":55.04,"value":317745.92,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $55.00 to $55.08, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3415465,"source":{"system":"sec-edgar","filing":"0001104659-22-080294","document":"tm2220923-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922080294/tm2220923-2_4seq1.xml","form_type":"4"}},{"id":2208446,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-07-12T18:37:05.000Z","date":"2022-07-11","kind":"sale","acquired":false,"shares":3058,"price":55.01,"value":168220.58,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $55.00 to $55.25, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3421238,"source":{"system":"sec-edgar","filing":"0001104659-22-079272","document":"tm2220923-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922079272/tm2220923-1_4seq1.xml","form_type":"4"}},{"id":2208445,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-07-12T18:37:05.000Z","date":"2022-07-08","kind":"sale","acquired":false,"shares":7710,"price":55.07,"value":424589.7,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $55.00 to $55.12, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3424296,"source":{"system":"sec-edgar","filing":"0001104659-22-079272","document":"tm2220923-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922079272/tm2220923-1_4seq1.xml","form_type":"4"}},{"id":2210524,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-07-07T18:22:08.000Z","date":"2022-07-07","kind":"sale","acquired":false,"shares":180838,"price":56.01,"value":10128736.38,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $55.00 to $56.69, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3432006,"source":{"system":"sec-edgar","filing":"0001104659-22-078112","document":"tm2220313-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922078112/tm2220313-2_4seq1.xml","form_type":"4"}},{"id":2210523,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-07-07T18:22:08.000Z","date":"2022-07-06","kind":"sale","acquired":false,"shares":87417,"price":55.26,"value":4830663.42,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $55.00 to $55.52, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3612844,"source":{"system":"sec-edgar","filing":"0001104659-22-078112","document":"tm2220313-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922078112/tm2220313-2_4seq1.xml","form_type":"4"}},{"id":2210522,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-07-07T18:22:08.000Z","date":"2022-07-05","kind":"sale","acquired":false,"shares":32486,"price":52.27,"value":1698043.22,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $52.68, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3700261,"source":{"system":"sec-edgar","filing":"0001104659-22-078112","document":"tm2220313-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922078112/tm2220313-2_4seq1.xml","form_type":"4"}},{"id":2216729,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-07-01T18:50:44.000Z","date":"2022-07-01","kind":"sale","acquired":false,"shares":11038,"price":52.04,"value":574417.52,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $52.11, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3732747,"source":{"system":"sec-edgar","filing":"0001104659-22-076951","document":"tm2220313-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922076951/tm2220313-1_4seq1.xml","form_type":"4"}},{"id":2216728,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-07-01T18:50:44.000Z","date":"2022-06-29","kind":"sale","acquired":false,"shares":3533,"price":52.2,"value":184422.6,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $52.45, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3743785,"source":{"system":"sec-edgar","filing":"0001104659-22-076951","document":"tm2220313-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922076951/tm2220313-1_4seq1.xml","form_type":"4"}},{"id":2219966,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-06-28T18:34:12.000Z","date":"2022-06-28","kind":"sale","acquired":false,"shares":2726,"price":52.1,"value":142024.6,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $52.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3747318,"source":{"system":"sec-edgar","filing":"0001104659-22-075352","document":"tm2219926-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922075352/tm2219926-1_4seq1.xml","form_type":"4"}},{"id":2219965,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-06-28T18:34:12.000Z","date":"2022-06-27","kind":"sale","acquired":false,"shares":86209,"price":52.37,"value":4514765.33,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $52.65, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3750044,"source":{"system":"sec-edgar","filing":"0001104659-22-075352","document":"tm2219926-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922075352/tm2219926-1_4seq1.xml","form_type":"4"}},{"id":2219964,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-06-28T18:34:12.000Z","date":"2022-06-24","kind":"sale","acquired":false,"shares":11528,"price":52.06,"value":600147.68,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $52.32, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3836253,"source":{"system":"sec-edgar","filing":"0001104659-22-075352","document":"tm2219926-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922075352/tm2219926-1_4seq1.xml","form_type":"4"}},{"id":2221261,"issuer":{"id":7352,"kind":"organization","name":"Aligos Therapeutics, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2022-06-27T20:13:10.000Z","date":"2022-06-23","kind":"grant","acquired":true,"shares":15000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or immediately prior to the annual meeting in 2023 of the Issuer's stockholders, subject to continuous service to the Issuer through such vesting date."}],"balance_after":15000,"derivative":{"exercise_price":1.34,"expiration_date":"2032-06-23","underlying":"Common Stock","underlying_shares":15000},"source":{"system":"sec-edgar","filing":"0001567619-22-013389","document":"doc1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1799448/000156761922013389/doc1.xml","form_type":"4"}},{"id":2230120,"issuer":{"id":6040,"kind":"organization","name":"ALX ONCOLOGY HOLDINGS INC"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2022-06-17T01:25:33.000Z","date":"2022-06-15","kind":"grant","acquired":true,"shares":12004,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Shares subject to the option vest in 12 equal monthly installments on the same day of the month as the grant date, or if earlier, the day immediately before the day of the next annual meeting of stockholders."}],"balance_after":12004,"derivative":{"exercise_price":6.67,"expiration_date":"2032-06-14","underlying":"Common Stock","underlying_shares":12004},"source":{"system":"sec-edgar","filing":"0001209191-22-037677","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1810182/000120919122037677/doc4.xml","form_type":"4"}},{"id":2251616,"issuer":{"id":8764,"kind":"organization","name":"IO Biotech, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2022-05-31T23:34:23.000Z","date":"2022-05-26","kind":"grant","acquired":true,"shares":23885,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"These options vest on May 26, 2023, subject to the reporting person's continued service through the applicable vesting date, and subject to 100% acceleration upon a change of control."}],"balance_after":23885,"derivative":{"exercise_price":4.85,"expiration_date":"2032-05-26","underlying":"Common Stock","underlying_shares":23885},"source":{"system":"sec-edgar","filing":"0001567619-22-011959","document":"doc1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1865494/000156761922011959/doc1.xml","form_type":"4"}},{"id":2256430,"issuer":{"id":7177,"kind":"organization","name":"Instil Bio, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Employee Stock Option (right to buy)","published_at":"2022-05-25T18:02:45.000Z","date":"2022-05-20","kind":"grant","acquired":true,"shares":30000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The option will vest in 12 equal monthly installments commencing on June 20, 2022, subject to the Report Person's continued service as a director through the vesting date."}],"balance_after":30000,"derivative":{"exercise_price":7.27,"expiration_date":"2032-05-19","underlying":"Common Stock","underlying_shares":30000},"source":{"system":"sec-edgar","filing":"0001789769-22-000051","document":"wf-form4_165351614718058.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000178976922000051/wf-form4_165351614718058.xml","form_type":"4"}},{"id":2257762,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option","published_at":"2022-05-24T16:16:50.000Z","date":"2022-05-20","kind":"grant","acquired":true,"shares":4742,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock option shall vest in full on the earlier to occur of (i) May 20, 2023 and (ii) the date of the next annual meeting following the grant date, subject to continued service through the applicable vesting date."}],"balance_after":4742,"derivative":{"exercise_price":41.33,"expiration_date":"2032-05-20","underlying":"Common Stock","underlying_shares":4742},"source":{"system":"sec-edgar","filing":"0001104659-22-064247","document":"tm2216688-3_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922064247/tm2216688-3_4seq1.xml","form_type":"4"}},{"id":2290968,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-25T19:51:18.000Z","date":"2022-04-21","kind":"sale","acquired":false,"shares":6554,"price":52.19,"value":342053.26,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $52.75, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3847781,"source":{"system":"sec-edgar","filing":"0001104659-22-049788","document":"tm2211710-6_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922049788/tm2211710-6_4seq1.xml","form_type":"4"}},{"id":2293474,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-20T19:58:40.000Z","date":"2022-04-20","kind":"sale","acquired":false,"shares":30177,"price":52.14,"value":1573428.78,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $53.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3854335,"source":{"system":"sec-edgar","filing":"0001104659-22-047993","document":"tm2211710-5_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922047993/tm2211710-5_4seq1.xml","form_type":"4"}},{"id":2293473,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-20T19:58:40.000Z","date":"2022-04-19","kind":"sale","acquired":false,"shares":97886,"price":52.35,"value":5124332.1,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $53.35, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3884512,"source":{"system":"sec-edgar","filing":"0001104659-22-047993","document":"tm2211710-5_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922047993/tm2211710-5_4seq1.xml","form_type":"4"}},{"id":2293472,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-20T19:58:40.000Z","date":"2022-04-18","kind":"sale","acquired":false,"shares":4195,"price":52.14,"value":218727.3,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $52.56, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3982398,"source":{"system":"sec-edgar","filing":"0001104659-22-047993","document":"tm2211710-5_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922047993/tm2211710-5_4seq1.xml","form_type":"4"}},{"id":2296778,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-14T19:26:15.000Z","date":"2022-04-14","kind":"sale","acquired":false,"shares":13668,"price":52.08,"value":711829.44,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $52.00 to $52.35, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":3986593,"source":{"system":"sec-edgar","filing":"0001104659-22-046146","document":"tm2211710-4_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922046146/tm2211710-4_4seq1.xml","form_type":"4"}},{"id":2296777,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-14T19:26:15.000Z","date":"2022-04-13","kind":"sale","acquired":false,"shares":75465,"price":51.15,"value":3860034.75,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $52.18, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4000261,"source":{"system":"sec-edgar","filing":"0001104659-22-046146","document":"tm2211710-4_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922046146/tm2211710-4_4seq1.xml","form_type":"4"}},{"id":2296776,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-14T19:26:15.000Z","date":"2022-04-13","kind":"sale","acquired":false,"shares":10741,"price":51.15,"value":549402.15,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $52.18, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001104659-22-046146","document":"tm2211710-4_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922046146/tm2211710-4_4seq1.xml","form_type":"4"}},{"id":2296775,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-14T19:26:15.000Z","date":"2022-04-12","kind":"sale","acquired":false,"shares":17469,"price":50.05,"value":874323.45,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.15, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4075726,"source":{"system":"sec-edgar","filing":"0001104659-22-046146","document":"tm2211710-4_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922046146/tm2211710-4_4seq1.xml","form_type":"4"}},{"id":2296774,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-14T19:26:15.000Z","date":"2022-04-12","kind":"sale","acquired":false,"shares":2486,"price":50.05,"value":124424.3,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.15, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":10741,"source":{"system":"sec-edgar","filing":"0001104659-22-046146","document":"tm2211710-4_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922046146/tm2211710-4_4seq1.xml","form_type":"4"}},{"id":2299279,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-11T19:25:44.000Z","date":"2022-04-08","kind":"sale","acquired":false,"shares":5164,"price":50.09,"value":258664.76,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4093195,"source":{"system":"sec-edgar","filing":"0001104659-22-044759","document":"tm2211710-3_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922044759/tm2211710-3_4seq1.xml","form_type":"4"}},{"id":2299278,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-11T19:25:44.000Z","date":"2022-04-08","kind":"sale","acquired":false,"shares":735,"price":50.09,"value":36816.15,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":13227,"source":{"system":"sec-edgar","filing":"0001104659-22-044759","document":"tm2211710-3_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922044759/tm2211710-3_4seq1.xml","form_type":"4"}},{"id":2299277,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-11T19:25:44.000Z","date":"2022-04-07","kind":"sale","acquired":false,"shares":4610,"price":50.25,"value":231652.5,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.35, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4098359,"source":{"system":"sec-edgar","filing":"0001104659-22-044759","document":"tm2211710-3_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922044759/tm2211710-3_4seq1.xml","form_type":"4"}},{"id":2299276,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-11T19:25:44.000Z","date":"2022-04-07","kind":"sale","acquired":false,"shares":656,"price":50.25,"value":32964.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.35, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":13962,"source":{"system":"sec-edgar","filing":"0001104659-22-044759","document":"tm2211710-3_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922044759/tm2211710-3_4seq1.xml","form_type":"4"}},{"id":2302195,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-06T18:20:25.000Z","date":"2022-04-05","kind":"sale","acquired":false,"shares":17829,"price":50.25,"value":895907.25,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $51.17, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4102969,"source":{"system":"sec-edgar","filing":"0001104659-22-043316","document":"tm2211710-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922043316/tm2211710-2_4seq1.xml","form_type":"4"}},{"id":2302194,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-06T18:20:25.000Z","date":"2022-04-05","kind":"sale","acquired":false,"shares":2538,"price":50.25,"value":127534.5,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $51.17, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":14618,"source":{"system":"sec-edgar","filing":"0001104659-22-043316","document":"tm2211710-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922043316/tm2211710-2_4seq1.xml","form_type":"4"}},{"id":2302193,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-06T18:20:25.000Z","date":"2022-04-04","kind":"sale","acquired":false,"shares":899,"price":50,"value":44950.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4120798,"source":{"system":"sec-edgar","filing":"0001104659-22-043316","document":"tm2211710-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922043316/tm2211710-2_4seq1.xml","form_type":"4"}},{"id":2302192,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-06T18:20:25.000Z","date":"2022-04-04","kind":"sale","acquired":false,"shares":128,"price":50,"value":6400.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":17156,"source":{"system":"sec-edgar","filing":"0001104659-22-043316","document":"tm2211710-2_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922043316/tm2211710-2_4seq1.xml","form_type":"4"}},{"id":2310754,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-01T18:37:06.000Z","date":"2022-04-01","kind":"sale","acquired":false,"shares":2079,"price":50,"value":103950.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.02, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4121697,"source":{"system":"sec-edgar","filing":"0001104659-22-041861","document":"tm2211416-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922041861/tm2211416-1_4seq1.xml","form_type":"4"}},{"id":2310753,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-01T18:37:06.000Z","date":"2022-04-01","kind":"sale","acquired":false,"shares":296,"price":50,"value":14800.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.02, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":17284,"source":{"system":"sec-edgar","filing":"0001104659-22-041861","document":"tm2211416-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922041861/tm2211416-1_4seq1.xml","form_type":"4"}},{"id":2310752,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-01T18:37:06.000Z","date":"2022-03-31","kind":"sale","acquired":false,"shares":6272,"price":50.15,"value":314540.8,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.63, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4123776,"source":{"system":"sec-edgar","filing":"0001104659-22-041861","document":"tm2211416-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922041861/tm2211416-1_4seq1.xml","form_type":"4"}},{"id":2310751,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-01T18:37:06.000Z","date":"2022-03-31","kind":"sale","acquired":false,"shares":893,"price":50.15,"value":44783.95,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.63, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":17580,"source":{"system":"sec-edgar","filing":"0001104659-22-041861","document":"tm2211416-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922041861/tm2211416-1_4seq1.xml","form_type":"4"}},{"id":2310750,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-01T18:37:06.000Z","date":"2022-03-30","kind":"sale","acquired":false,"shares":24381,"price":50.24,"value":1224901.44,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.60, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4130048,"source":{"system":"sec-edgar","filing":"0001104659-22-041861","document":"tm2211416-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922041861/tm2211416-1_4seq1.xml","form_type":"4"}},{"id":2310749,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-04-01T18:37:06.000Z","date":"2022-03-30","kind":"sale","acquired":false,"shares":3470,"price":50.24,"value":174332.8,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.60, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":18473,"source":{"system":"sec-edgar","filing":"0001104659-22-041861","document":"tm2211416-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922041861/tm2211416-1_4seq1.xml","form_type":"4"}},{"id":2314921,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-29T20:40:48.000Z","date":"2022-03-29","kind":"sale","acquired":false,"shares":30996,"price":50.89,"value":1577386.44,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.03 to $52.25, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4154429,"source":{"system":"sec-edgar","filing":"0001104659-22-039635","document":"tm228148-9_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922039635/tm228148-9_4seq1.xml","form_type":"4"}},{"id":2314920,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-29T20:40:48.000Z","date":"2022-03-29","kind":"sale","acquired":false,"shares":4412,"price":50.89,"value":224526.68,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.03 to $52.25, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":21943,"source":{"system":"sec-edgar","filing":"0001104659-22-039635","document":"tm228148-9_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922039635/tm228148-9_4seq1.xml","form_type":"4"}},{"id":2314919,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-29T20:40:48.000Z","date":"2022-03-28","kind":"sale","acquired":false,"shares":37195,"price":50.82,"value":1890249.9,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $51.80, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4185425,"source":{"system":"sec-edgar","filing":"0001104659-22-039635","document":"tm228148-9_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922039635/tm228148-9_4seq1.xml","form_type":"4"}},{"id":2314918,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-29T20:40:48.000Z","date":"2022-03-28","kind":"sale","acquired":false,"shares":5294,"price":50.82,"value":269041.08,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $51.80, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":26355,"source":{"system":"sec-edgar","filing":"0001104659-22-039635","document":"tm228148-9_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922039635/tm228148-9_4seq1.xml","form_type":"4"}},{"id":2314917,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-29T20:40:48.000Z","date":"2022-03-25","kind":"sale","acquired":false,"shares":31710,"price":50.24,"value":1593110.4,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.48 to $51.83, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4222620,"source":{"system":"sec-edgar","filing":"0001104659-22-039635","document":"tm228148-9_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922039635/tm228148-9_4seq1.xml","form_type":"4"}},{"id":2314916,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-29T20:40:48.000Z","date":"2022-03-25","kind":"sale","acquired":false,"shares":4514,"price":50.24,"value":226783.36,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.48 to $51.83, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":31649,"source":{"system":"sec-edgar","filing":"0001104659-22-039635","document":"tm228148-9_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922039635/tm228148-9_4seq1.xml","form_type":"4"}},{"id":2318603,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-24T20:07:37.000Z","date":"2022-03-24","kind":"sale","acquired":false,"shares":16576,"price":50.12,"value":830789.12,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.38, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4254330,"source":{"system":"sec-edgar","filing":"0001104659-22-037649","document":"tm228148-7_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922037649/tm228148-7_4seq1.xml","form_type":"4"}},{"id":2318602,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-24T20:07:37.000Z","date":"2022-03-24","kind":"sale","acquired":false,"shares":2359,"price":50.12,"value":118233.08,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.38, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":36163,"source":{"system":"sec-edgar","filing":"0001104659-22-037649","document":"tm228148-7_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922037649/tm228148-7_4seq1.xml","form_type":"4"}},{"id":2318601,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-24T20:07:37.000Z","date":"2022-03-23","kind":"sale","acquired":false,"shares":9439,"price":50.25,"value":474309.75,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $51.05, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4270906,"source":{"system":"sec-edgar","filing":"0001104659-22-037649","document":"tm228148-7_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922037649/tm228148-7_4seq1.xml","form_type":"4"}},{"id":2318600,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-24T20:07:37.000Z","date":"2022-03-23","kind":"sale","acquired":false,"shares":1344,"price":50.25,"value":67536.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $51.05, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":38522,"source":{"system":"sec-edgar","filing":"0001104659-22-037649","document":"tm228148-7_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922037649/tm228148-7_4seq1.xml","form_type":"4"}},{"id":2318599,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-24T20:07:37.000Z","date":"2022-03-22","kind":"sale","acquired":false,"shares":5757,"price":50.13,"value":288598.41,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.36, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4280345,"source":{"system":"sec-edgar","filing":"0001104659-22-037649","document":"tm228148-7_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922037649/tm228148-7_4seq1.xml","form_type":"4"}},{"id":2318598,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-24T20:07:37.000Z","date":"2022-03-22","kind":"sale","acquired":false,"shares":819,"price":50.13,"value":41056.47,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.36, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":39866,"source":{"system":"sec-edgar","filing":"0001104659-22-037649","document":"tm228148-7_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922037649/tm228148-7_4seq1.xml","form_type":"4"}},{"id":2322786,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-21T20:31:50.000Z","date":"2022-03-18","kind":"sale","acquired":false,"shares":9003,"price":50.1,"value":451050.3,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.31, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4286097,"source":{"system":"sec-edgar","filing":"0001104659-22-036243","document":"tm228148-6_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922036243/tm228148-6_4seq1.xml","form_type":"4"}},{"id":2322785,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-21T20:31:50.000Z","date":"2022-03-18","kind":"sale","acquired":false,"shares":1282,"price":50.1,"value":64228.2,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.31, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":40685,"source":{"system":"sec-edgar","filing":"0001104659-22-036243","document":"tm228148-6_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922036243/tm228148-6_4seq1.xml","form_type":"4"}},{"id":2322784,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-21T20:31:50.000Z","date":"2022-03-17","kind":"sale","acquired":false,"shares":5161,"price":50.05,"value":258308.05,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.13, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The shares are held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. As a managing member of Vivo Capital VIII, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":4295100,"source":{"system":"sec-edgar","filing":"0001104659-22-036243","document":"tm228148-6_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922036243/tm228148-6_4seq1.xml","form_type":"4"}},{"id":2322783,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2022-03-21T20:31:50.000Z","date":"2022-03-17","kind":"sale","acquired":false,"shares":735,"price":50.05,"value":36786.75,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2021."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price. These shares were acquired on the open market in multiple transactions at prices ranging from $50.00 to $50.13, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":41967,"source":{"system":"sec-edgar","filing":"0001104659-22-036243","document":"tm228148-6_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000110465922036243/tm228148-6_4seq1.xml","form_type":"4"}},{"id":2515537,"issuer":{"id":8764,"kind":"organization","name":"IO Biotech, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true}}],"security":"Series C Preferred Stock","published_at":"2021-11-12T21:15:36.000Z","date":"2021-11-09","kind":"exercise","acquired":false,"shares":188168,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Upon the closing of the Issuer's initial public offering, each share of Series C Preferred Stock beneficially owned by the reporting person automatically converted, for no additional consideration, into the number of shares of Common Stock reported in Column 7 of Table II. These shares of Series C Preferred Stock had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Upon the closing of the Issuer's initial public offering, each share of Series C Preferred Stock beneficially owned by the reporting person automatically converted, for no additional consideration, into the number of shares of Common Stock reported in Column 7 of Table II. These shares of Series C Preferred Stock had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Upon the closing of the Issuer's initial public offering, each share of Series C Preferred Stock beneficially owned by the reporting person automatically converted, for no additional consideration, into the number of shares of Common Stock reported in Column 7 of Table II. These shares of Series C Preferred Stock had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Vivo Capital Fund IX, L.P. (\"Fund IX\"). Vivo Capital IX, LLC (\"Capital IX\") is the general partner of Fund IX. The reporting person is a managing member of Capital IX and may be deemed to share voting and investment power with respect to the shares beneficially owned by Fund IX and disclaims Section 16 beneficial ownership of such securities held by Fund IX, except to the extent of his pecuniary interest therein, if any."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":2365545},"source":{"system":"sec-edgar","filing":"0001140361-21-037652","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1865494/000114036121037652/form4.xml","form_type":"4"}},{"id":2515536,"issuer":{"id":8764,"kind":"organization","name":"IO Biotech, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true}}],"security":"Common Stock","published_at":"2021-11-12T21:15:36.000Z","date":"2021-11-09","kind":"purchase","acquired":true,"shares":650000,"price":14,"value":9100000.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Vivo Capital Fund IX, L.P. (\"Fund IX\"). Vivo Capital IX, LLC (\"Capital IX\") is the general partner of Fund IX. The reporting person is a managing member of Capital IX and may be deemed to share voting and investment power with respect to the shares beneficially owned by Fund IX and disclaims Section 16 beneficial ownership of such securities held by Fund IX, except to the extent of his pecuniary interest therein, if any."}],"balance_after":3015545,"source":{"system":"sec-edgar","filing":"0001140361-21-037652","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1865494/000114036121037652/form4.xml","form_type":"4"}},{"id":2515535,"issuer":{"id":8764,"kind":"organization","name":"IO Biotech, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true}}],"security":"Common Stock","published_at":"2021-11-12T21:15:36.000Z","date":"2021-11-09","kind":"exercise","acquired":true,"shares":2365545,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Upon the closing of the Issuer's initial public offering, each share of Series C Preferred Stock beneficially owned by the reporting person automatically converted, for no additional consideration, into the number of shares of Common Stock reported in Column 7 of Table II. These shares of Series C Preferred Stock had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Vivo Capital Fund IX, L.P. (\"Fund IX\"). Vivo Capital IX, LLC (\"Capital IX\") is the general partner of Fund IX. The reporting person is a managing member of Capital IX and may be deemed to share voting and investment power with respect to the shares beneficially owned by Fund IX and disclaims Section 16 beneficial ownership of such securities held by Fund IX, except to the extent of his pecuniary interest therein, if any."}],"balance_after":2365545,"source":{"system":"sec-edgar","filing":"0001140361-21-037652","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1865494/000114036121037652/form4.xml","form_type":"4"}},{"id":2664039,"issuer":{"id":7352,"kind":"organization","name":"Aligos Therapeutics, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2021-06-17T22:46:59.000Z","date":"2021-06-17","kind":"grant","acquired":true,"shares":15000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day prior to the annual meeting in 2022 of the Issuer's stockholders, assuming continuous service as a director until such vesting date."}],"balance_after":15000,"derivative":{"exercise_price":26.58,"expiration_date":"2031-06-17","underlying":"Common Stock","underlying_shares":15000},"source":{"system":"sec-edgar","filing":"0001567619-21-012370","document":"doc1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1799448/000156761921012370/doc1.xml","form_type":"4"}},{"id":2668643,"issuer":{"id":6040,"kind":"organization","name":"ALX ONCOLOGY HOLDINGS INC"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2021-06-15T22:59:11.000Z","date":"2021-06-11","kind":"grant","acquired":true,"shares":12004,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Shares subject to the option vest in 12 equal monthly installments on the same day of the month as the grant date, or if earlier, the day immediately before the day of the next annual meeting of stockholders."}],"balance_after":12004,"derivative":{"exercise_price":59.66,"expiration_date":"2031-06-10","underlying":"Common Stock","underlying_shares":12004},"source":{"system":"sec-edgar","filing":"0001209191-21-040732","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1810182/000120919121040732/doc4.xml","form_type":"4"}},{"id":2669660,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option","published_at":"2021-06-14T16:30:19.000Z","date":"2021-05-20","kind":"grant","acquired":true,"shares":7246,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock option shall vest in full on the earlier to occur of (i) May 20, 2022 and (ii) the date of the next annual meeting following the grant date, subject to continued service through the applicable vesting date."}],"balance_after":7246,"derivative":{"exercise_price":32.5,"expiration_date":"2031-05-20","underlying":"Common Stock","underlying_shares":7246},"source":{"system":"sec-edgar","filing":"0000899243-21-023566","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000089924321023566/doc4.xml","form_type":"4"}},{"id":2669793,"issuer":{"id":12293,"kind":"organization","name":"REATA PHARMACEUTICALS INC","symbol":"RETA"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2021-06-14T11:26:03.000Z","date":"2021-06-10","kind":"grant","acquired":true,"shares":1201,"price":83.24,"value":99971.24,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"This option was issued to the reporting person pursuant to the Reata Non-Employee Director Compensation Policy in lieu of future director fees of $100,000."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The options vest in the following installments: 300 shares on September 10, 2021, December 10, 2021 and March 10, 2022, respectively, and 301 shares June 10, 2022, subject to continued service through each vesting date."}],"balance_after":1201,"derivative":{"exercise_price":146.01,"expiration_date":"2031-06-10","underlying":"Class A common stock","underlying_shares":1201},"source":{"system":"sec-edgar","filing":"0001209191-21-040136","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1358762/000120919121040136/doc4.xml","form_type":"4"}},{"id":2669792,"issuer":{"id":12293,"kind":"organization","name":"REATA PHARMACEUTICALS INC","symbol":"RETA"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2021-06-14T11:26:03.000Z","date":"2021-06-10","kind":"grant","acquired":true,"shares":5000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The options vest in 4 equal installments on September 10, 2021, December 10, 2021, March 10, 2022, and June 10, 2022, subject to continued service through each vesting date."}],"balance_after":5000,"derivative":{"exercise_price":146.01,"expiration_date":"2031-06-10","underlying":"Class A common stock","underlying_shares":5000},"source":{"system":"sec-edgar","filing":"0001209191-21-040136","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1358762/000120919121040136/doc4.xml","form_type":"4"}},{"id":2771646,"issuer":{"id":7177,"kind":"organization","name":"Instil Bio, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Series C Preferred Stock","published_at":"2021-03-25T17:30:17.000Z","date":"2021-03-23","kind":"exercise","acquired":false,"shares":397576,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series B Preferred Stock and Series C Preferred Stock automatically converted into shares of Common Stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1.2 for one basis, and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series B Preferred Stock and Series C Preferred Stock automatically converted into shares of Common Stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1.2 for one basis, and had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series B Preferred Stock and Series C Preferred Stock automatically converted into shares of Common Stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1.2 for one basis, and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Vivo Capital Fund IX, L.P. (\"Fund IX\"). Vivo Capital IX, LLC (\"Capital IX\") is the general partner of Fund IX. The\nReporting Person is a managing member of Capital IX and may be deemed to share voting and investment power with respect to the shares\nbeneficially owned by Fund IX and disclaims Section 16 beneficial ownership of such securities held by Fund IX, except to the extent of his\npecuniary interest therein, if any."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":477091},"source":{"system":"sec-edgar","filing":"0001209191-21-023064","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000120919121023064/doc4.xml","form_type":"4"}},{"id":2771645,"issuer":{"id":7177,"kind":"organization","name":"Instil Bio, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Series B Preferred Stock","published_at":"2021-03-25T17:30:17.000Z","date":"2021-03-23","kind":"exercise","acquired":false,"shares":9758080,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series B Preferred Stock and Series C Preferred Stock automatically converted into shares of Common Stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1.2 for one basis, and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series B Preferred Stock and Series C Preferred Stock automatically converted into shares of Common Stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1.2 for one basis, and had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series B Preferred Stock and Series C Preferred Stock automatically converted into shares of Common Stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1.2 for one basis, and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Vivo Capital Fund IX, L.P. (\"Fund IX\"). Vivo Capital IX, LLC (\"Capital IX\") is the general partner of Fund IX. The\nReporting Person is a managing member of Capital IX and may be deemed to share voting and investment power with respect to the shares\nbeneficially owned by Fund IX and disclaims Section 16 beneficial ownership of such securities held by Fund IX, except to the extent of his\npecuniary interest therein, if any."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":11709696},"source":{"system":"sec-edgar","filing":"0001209191-21-023064","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000120919121023064/doc4.xml","form_type":"4"}},{"id":2771644,"issuer":{"id":7177,"kind":"organization","name":"Instil Bio, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2021-03-25T17:30:17.000Z","date":"2021-03-23","kind":"purchase","acquired":true,"shares":300000,"price":20,"value":6000000.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Vivo Capital Fund IX, L.P. (\"Fund IX\"). Vivo Capital IX, LLC (\"Capital IX\") is the general partner of Fund IX. The\nReporting Person is a managing member of Capital IX and may be deemed to share voting and investment power with respect to the shares\nbeneficially owned by Fund IX and disclaims Section 16 beneficial ownership of such securities held by Fund IX, except to the extent of his\npecuniary interest therein, if any."}],"balance_after":12486787,"source":{"system":"sec-edgar","filing":"0001209191-21-023064","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000120919121023064/doc4.xml","form_type":"4"}},{"id":2771643,"issuer":{"id":7177,"kind":"organization","name":"Instil Bio, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2021-03-25T17:30:17.000Z","date":"2021-03-23","kind":"exercise","acquired":true,"shares":477091,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series B Preferred Stock and Series C Preferred Stock automatically converted into shares of Common Stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1.2 for one basis, and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Vivo Capital Fund IX, L.P. (\"Fund IX\"). Vivo Capital IX, LLC (\"Capital IX\") is the general partner of Fund IX. The\nReporting Person is a managing member of Capital IX and may be deemed to share voting and investment power with respect to the shares\nbeneficially owned by Fund IX and disclaims Section 16 beneficial ownership of such securities held by Fund IX, except to the extent of his\npecuniary interest therein, if any."}],"balance_after":12186787,"source":{"system":"sec-edgar","filing":"0001209191-21-023064","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000120919121023064/doc4.xml","form_type":"4"}},{"id":2771642,"issuer":{"id":7177,"kind":"organization","name":"Instil Bio, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2021-03-25T17:30:17.000Z","date":"2021-03-23","kind":"exercise","acquired":true,"shares":11709696,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series B Preferred Stock and Series C Preferred Stock automatically converted into shares of Common Stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1.2 for one basis, and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Vivo Capital Fund IX, L.P. (\"Fund IX\"). Vivo Capital IX, LLC (\"Capital IX\") is the general partner of Fund IX. The\nReporting Person is a managing member of Capital IX and may be deemed to share voting and investment power with respect to the shares\nbeneficially owned by Fund IX and disclaims Section 16 beneficial ownership of such securities held by Fund IX, except to the extent of his\npecuniary interest therein, if any."}],"balance_after":11709696,"source":{"system":"sec-edgar","filing":"0001209191-21-023064","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000120919121023064/doc4.xml","form_type":"4"}},{"id":2775960,"issuer":{"id":7177,"kind":"organization","name":"Instil Bio, Inc."},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2021-03-22T20:56:32.000Z","date":"2021-03-18","kind":"grant","acquired":true,"shares":52000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The option will vest in 36 equal monthly installments commencing on April 18, 2021, subject to the Report Person's continued service as a director through the vesting date."}],"balance_after":52000,"derivative":{"exercise_price":20,"expiration_date":"2031-03-18","underlying":"Common Stock","underlying_shares":52000},"source":{"system":"sec-edgar","filing":"0001209191-21-022477","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000120919121022477/doc4.xml","form_type":"4"}},{"id":3045263,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2020-08-27T19:26:40.000Z","date":"2020-08-26","kind":"purchase","acquired":true,"shares":3922,"price":34.3,"value":134524.6,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $33.9 to $35.0, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":42702,"source":{"system":"sec-edgar","filing":"0000899243-20-023547","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000089924320023547/doc4.xml","form_type":"4"}},{"id":3045262,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2020-08-27T19:26:40.000Z","date":"2020-08-25","kind":"purchase","acquired":true,"shares":823,"price":34.2,"value":28146.6,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $33.3 to $34.8, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (2) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":38780,"source":{"system":"sec-edgar","filing":"0000899243-20-023547","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000089924320023547/doc4.xml","form_type":"4"}},{"id":3048380,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2020-08-24T21:09:56.000Z","date":"2020-08-24","kind":"purchase","acquired":true,"shares":3057,"price":34.3,"value":104855.1,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $35.0 to $33.8, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":37957,"source":{"system":"sec-edgar","filing":"0000899243-20-023341","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000089924320023341/doc4.xml","form_type":"4"}},{"id":3048379,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2020-08-24T21:09:56.000Z","date":"2020-08-21","kind":"purchase","acquired":true,"shares":7352,"price":34.1,"value":250703.2,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported herein is a weighted average price.  These shares were acquired on the open market in multiple transactions at prices ranging from $33.3 to $35.0, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (3) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":34900,"source":{"system":"sec-edgar","filing":"0000899243-20-023341","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000089924320023341/doc4.xml","form_type":"4"}},{"id":3048378,"issuer":{"id":4381,"kind":"organization","name":"Harmony Biosciences Holdings, Inc.","symbol":"HRMY"},"owners":[{"id":90378,"kind":"person","name":"Nielsen Jack","position":1,"cik":"0001602402","reported_name":"Nielsen Jack","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2020-08-24T21:09:56.000Z","date":"2020-08-21","kind":"purchase","acquired":true,"shares":24812,"price":24,"value":595488.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported herein is the public offering price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The shares are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the General Partner of Vivo Capital Fund IX, L.P. As a managing member of Vivo Capital IX, LLC, Jack Nielsen shares voting and dispositive power with respect to the shares held of record by Vivo Capital Fund IX, L.P with other managing members, but disclaims beneficial ownership of such shares except to the extent of his individual pecuniary interest therein."}],"balance_after":27548,"source":{"system":"sec-edgar","filing":"0000899243-20-023341","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1602402/000089924320023341/doc4.xml","form_type":"4"}}],"next_cursor":"2020-08-24T21:09:56.000000Z,3048378"}