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(\"Cayman IV\"). Management 4 is the ultimate general partner of Cayman IV. As a result Management 4 may be deemed to share voting and dispositive power with respect to the shares held by Cayman IV. Management 4 disclaims beneficial ownership of such shares, except to the extent of its pecuniary interest therein, and the inclusion of the shares in this report shall not be deemed to be an admission of beneficial ownership of the reported shares for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise."}],"balance_after":1015256,"source":{"system":"sec-edgar","filing":"0001209191-20-024231","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1726334/000120919120024231/doc4.xml","form_type":"4"}},{"id":3178014,"issuer":{"id":6242,"kind":"organization","name":"Keros Therapeutics, Inc."},"owners":[{"id":74162,"kind":"organization","name":"Pontifax Management 4 G.P. 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(\"Israel IV\"). Pontifax Management 4 G.P. (2015) Ltd. (\"Management 4\") is the ultimate general partner of Israel IV. As a result Management 4 may be deemed to share voting and dispositive power with respect to the shares held by Israel IV. Management 4 disclaims beneficial ownership of such shares, except to the extent of its pecuniary interest therein, and the inclusion of the shares in this report shall not be deemed to be an admission of beneficial ownership of the reported shares for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise."}],"balance_after":2067314,"source":{"system":"sec-edgar","filing":"0001209191-20-024231","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1726334/000120919120024231/doc4.xml","form_type":"4"}},{"id":3178013,"issuer":{"id":6242,"kind":"organization","name":"Keros Therapeutics, Inc."},"owners":[{"id":74162,"kind":"organization","name":"Pontifax Management 4 G.P. (2015) Ltd.","position":1,"cik":"0001726334","reported_name":"Pontifax Management 4 G.P. 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(\"Late Stage\"). Pontifax Late Stage GP Ltd. (\"Late Stage GP\") is the general partner of Late Stage and the sole shareholder of Late Stage GP is Mr. Shlomo Karako. Pursuant to Strategic Alliance Agreement, dated August 9, 2018, between Late Stage, Israel IV, Cayman IV and China IV (collectively the, \"Pontifax IV Funds\"), Late Stage invests side-by-side with the Pontifax IV Funds. By virtue of the strategic relationship, Management 4 may be deemed to share voting and dispositive power with respect to the shares held by Late Stage in a manner similar to the voting and investment power with respect to the shares held by each of the Pontifax IV Funds."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Each of Management 4 and Late Stage GP disclaims beneficial ownership of such shares, except to the extent of its pecuniary interest therein, and the inclusion of the shares in this report shall not be deemed to be an admission of beneficial ownership of the reported shares for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise."}],"balance_after":68654,"source":{"system":"sec-edgar","filing":"0001209191-20-024231","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1726334/000120919120024231/doc4.xml","form_type":"4"}},{"id":3178012,"issuer":{"id":6242,"kind":"organization","name":"Keros Therapeutics, Inc."},"owners":[{"id":74162,"kind":"organization","name":"Pontifax Management 4 G.P. 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(\"Israel IV\"). Pontifax Management 4 G.P. (2015) Ltd. (\"Management 4\") is the ultimate general partner of Israel IV. As a result Management 4 may be deemed to share voting and dispositive power with respect to the shares held by Israel IV. Management 4 disclaims beneficial ownership of such shares, except to the extent of its pecuniary interest therein, and the inclusion of the shares in this report shall not be deemed to be an admission of beneficial ownership of the reported shares for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise."}],"balance_after":1734395,"source":{"system":"sec-edgar","filing":"0001209191-20-024231","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1726334/000120919120024231/doc4.xml","form_type":"4"}},{"id":3373051,"issuer":{"id":73682,"kind":"organization","name":"89bio, Inc.","symbol":"ETNB"},"owners":[{"id":74168,"kind":"person","name":"Kariv Tomer","position":1,"cik":"0001568077","reported_name":"Kariv Tomer","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153848,"kind":"organization","name":"Pontifax (Israel) V, L.P.","position":2,"cik":"0001792890","reported_name":"Pontifax (Israel) V, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153849,"kind":"organization","name":"Pontifax (Cayman) V, L.P.","position":3,"cik":"0001792893","reported_name":"Pontifax (Cayman) V, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153850,"kind":"organization","name":"Pontifax (China) V, L.P.","position":4,"cik":"0001792891","reported_name":"Pontifax (China) V, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153851,"kind":"organization","name":"Pontifax 5 G.P. L.P.","position":5,"cik":"0001792892","reported_name":"Pontifax 5 G.P. L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":74162,"kind":"organization","name":"Pontifax Management 4 G.P. (2015) Ltd.","position":6,"cik":"0001726334","reported_name":"Pontifax Management 4 G.P. (2015) Ltd.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":74167,"kind":"organization","name":"Pontifax Late Stage GP Ltd.","position":7,"cik":"0001793770","reported_name":"Pontifax Late Stage GP Ltd.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":74166,"kind":"organization","name":"Pontifax Late Stage Fund L.P.","position":8,"cik":"0001793769","reported_name":"Pontifax Late Stage Fund L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series A Preferred Stock","published_at":"2019-11-14T00:10:44.000Z","date":"2019-11-13","kind":"exercise","acquired":false,"shares":5500001,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"The Series A Preferred Stock automatically converted into shares of the Issuer's common stock on a one-for-6.217 basis immediately prior the closing of the Issuer's initial public offering on November 13, 2019 and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The Series A Preferred Stock automatically converted into shares of the Issuer's common stock on a one-for-6.217 basis immediately prior the closing of the Issuer's initial public offering on November 13, 2019 and had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Series A Preferred Stock automatically converted into shares of the Issuer's common stock on a one-for-6.217 basis immediately prior the closing of the Issuer's initial public offering on November 13, 2019 and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Includes (a) 534,342 shares held by Pontifax (Israel) V, L.P., (b) 142,726 shares held by Pontifax (Cayman) V, L.P. and (c) 207,603 shares held by Pontifax (China) V, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Pontifax 5 G.P. L.P. (\"Pontifax 5 GP\") is the general partner of each of the Pontifax Entities, and Pontifax Management 4 G.P. (2015) Ltd. (\"Pontifax Management\") is the general partner of Pontifax 5 GP. Mr. Tomer Kariv is one of two Managing Partners of Pontifax Management and, as a result, may be deemed to share voting and investment power with respect to the shares held by each of the Pontifax Entities. Mr. Kariv disclaims beneficial ownership of those shares held by the Pontifax Entities, except to the extent of his pecuniary interest therein. Late Stage L.P. invests side by side with Pontifax 5 GP pursuant to a Strategic Alliance Agreement with Pontifax 5 GP. Pontifax Late Stage GP Ltd. (\"Late Stage GP\") is the general partner of Late Stage L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"(Continued from footnote 6) and the sole shareholder of Late Stage GP is Mr. Shlomo Karako. By virtue of the strategic relationship, each of Pontifax 5 GP, Pontifax Management, Ran Nussbaum, and Tomer Kariv may be deemed to share voting and dispositive power with respect to the shares held by Late Stage L.P. in a manner similar to the voting and investment power with respect to the shares held by each of the Pontifax Entities. In that context, Mr. Kariv disclaims beneficial ownership of such shares, and the inclusion of the shares in this report shall not be deemed to be an admission of beneficial ownership of the reported shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":884671},"source":{"system":"sec-edgar","filing":"0000899243-19-027228","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1726334/000089924319027228/doc4.xml","form_type":"4"}},{"id":3373050,"issuer":{"id":73682,"kind":"organization","name":"89bio, Inc.","symbol":"ETNB"},"owners":[{"id":74168,"kind":"person","name":"Kariv Tomer","position":1,"cik":"0001568077","reported_name":"Kariv Tomer","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153848,"kind":"organization","name":"Pontifax (Israel) V, L.P.","position":2,"cik":"0001792890","reported_name":"Pontifax (Israel) V, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153849,"kind":"organization","name":"Pontifax (Cayman) V, L.P.","position":3,"cik":"0001792893","reported_name":"Pontifax (Cayman) V, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153850,"kind":"organization","name":"Pontifax (China) V, L.P.","position":4,"cik":"0001792891","reported_name":"Pontifax (China) V, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153851,"kind":"organization","name":"Pontifax 5 G.P. L.P.","position":5,"cik":"0001792892","reported_name":"Pontifax 5 G.P. L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":74162,"kind":"organization","name":"Pontifax Management 4 G.P. (2015) Ltd.","position":6,"cik":"0001726334","reported_name":"Pontifax Management 4 G.P. (2015) Ltd.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":74167,"kind":"organization","name":"Pontifax Late Stage GP Ltd.","position":7,"cik":"0001793770","reported_name":"Pontifax Late Stage GP Ltd.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":74166,"kind":"organization","name":"Pontifax Late Stage Fund L.P.","position":8,"cik":"0001793769","reported_name":"Pontifax Late Stage Fund L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2019-11-14T00:10:44.000Z","date":"2019-11-13","kind":"exercise","acquired":true,"shares":884671,"ownership":{"direct":false,"nature":"See footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The Series A Preferred Stock automatically converted into shares of the Issuer's common stock on a one-for-6.217 basis immediately prior the closing of the Issuer's initial public offering on November 13, 2019 and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Includes (a) 668,732 shares held by Pontifax (Israel) V, L.P., (b) 178,623 shares held by Pontifax (Cayman) V, L.P., (c) 259,816 shares held by Pontifax (China) V, L.P. and (d) 27,500 shares held by Late Stage L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Pontifax 5 G.P. L.P. (\"Pontifax 5 GP\") is the general partner of each of the Pontifax Entities, and Pontifax Management 4 G.P. (2015) Ltd. (\"Pontifax Management\") is the general partner of Pontifax 5 GP. Mr. Tomer Kariv is one of two Managing Partners of Pontifax Management and, as a result, may be deemed to share voting and investment power with respect to the shares held by each of the Pontifax Entities. Mr. Kariv disclaims beneficial ownership of those shares held by the Pontifax Entities, except to the extent of his pecuniary interest therein. Late Stage L.P. invests side by side with Pontifax 5 GP pursuant to a Strategic Alliance Agreement with Pontifax 5 GP. Pontifax Late Stage GP Ltd. (\"Late Stage GP\") is the general partner of Late Stage L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"(Continued from footnote 6) and the sole shareholder of Late Stage GP is Mr. Shlomo Karako. By virtue of the strategic relationship, each of Pontifax 5 GP, Pontifax Management, Ran Nussbaum, and Tomer Kariv may be deemed to share voting and dispositive power with respect to the shares held by Late Stage L.P. in a manner similar to the voting and investment power with respect to the shares held by each of the Pontifax Entities. In that context, Mr. Kariv disclaims beneficial ownership of such shares, and the inclusion of the shares in this report shall not be deemed to be an admission of beneficial ownership of the reported shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."}],"balance_after":1134671,"source":{"system":"sec-edgar","filing":"0000899243-19-027228","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1726334/000089924319027228/doc4.xml","form_type":"4"}},{"id":3373049,"issuer":{"id":73682,"kind":"organization","name":"89bio, Inc.","symbol":"ETNB"},"owners":[{"id":74168,"kind":"person","name":"Kariv Tomer","position":1,"cik":"0001568077","reported_name":"Kariv Tomer","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153848,"kind":"organization","name":"Pontifax (Israel) V, L.P.","position":2,"cik":"0001792890","reported_name":"Pontifax (Israel) V, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153849,"kind":"organization","name":"Pontifax (Cayman) V, L.P.","position":3,"cik":"0001792893","reported_name":"Pontifax (Cayman) V, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153850,"kind":"organization","name":"Pontifax (China) V, L.P.","position":4,"cik":"0001792891","reported_name":"Pontifax (China) V, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":153851,"kind":"organization","name":"Pontifax 5 G.P. L.P.","position":5,"cik":"0001792892","reported_name":"Pontifax 5 G.P. L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":74162,"kind":"organization","name":"Pontifax Management 4 G.P. (2015) Ltd.","position":6,"cik":"0001726334","reported_name":"Pontifax Management 4 G.P. (2015) Ltd.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":74167,"kind":"organization","name":"Pontifax Late Stage GP Ltd.","position":7,"cik":"0001793770","reported_name":"Pontifax Late Stage GP Ltd.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":74166,"kind":"organization","name":"Pontifax Late Stage Fund L.P.","position":8,"cik":"0001793769","reported_name":"Pontifax Late Stage Fund L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2019-11-14T00:10:44.000Z","date":"2019-11-11","kind":"purchase","acquired":true,"shares":250000,"price":16,"value":4000000.0,"ownership":{"direct":false,"nature":"See footnotes"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"On November 11, 2019, Pontifax (Israel) V, L.P. purchased 134,390 shares of the Issuer's common stock, Pontifax (Cayman) V, L.P. purchased 35,897 shares of the Issuer's common stock, Pontifax (China) V, L.P. (collectively, the \"Pontifax Entities\") purchased 52,213 shares of the Issuer's common stock and Pontifax Late Stage Fund L.P. (\"Late Stage L.P.\") purchased 27,500 shares of the Issuer's common stock at a price of $16.00 per share in the Issuer's initial public offering."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Includes (a) 134,390 shares held by Pontifax (Israel) V, L.P., (b) 35,897 shares held by Pontifax (Cayman) V, L.P., (c) 52,213 shares held by Pontifax (China) V, L.P. and (d) 27,500 shares held by Late Stage L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Pontifax 5 G.P. L.P. (\"Pontifax 5 GP\") is the general partner of each of the Pontifax Entities, and Pontifax Management 4 G.P. (2015) Ltd. (\"Pontifax Management\") is the general partner of Pontifax 5 GP. Mr. Tomer Kariv is one of two Managing Partners of Pontifax Management and, as a result, may be deemed to share voting and investment power with respect to the shares held by each of the Pontifax Entities. Mr. Kariv disclaims beneficial ownership of those shares held by the Pontifax Entities, except to the extent of his pecuniary interest therein. Late Stage L.P. invests side by side with Pontifax 5 GP pursuant to a Strategic Alliance Agreement with Pontifax 5 GP. Pontifax Late Stage GP Ltd. (\"Late Stage GP\") is the general partner of Late Stage L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"(Continued from footnote 6) and the sole shareholder of Late Stage GP is Mr. Shlomo Karako. By virtue of the strategic relationship, each of Pontifax 5 GP, Pontifax Management, Ran Nussbaum, and Tomer Kariv may be deemed to share voting and dispositive power with respect to the shares held by Late Stage L.P. in a manner similar to the voting and investment power with respect to the shares held by each of the Pontifax Entities. In that context, Mr. Kariv disclaims beneficial ownership of such shares, and the inclusion of the shares in this report shall not be deemed to be an admission of beneficial ownership of the reported shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."}],"balance_after":250000,"source":{"system":"sec-edgar","filing":"0000899243-19-027228","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1726334/000089924319027228/doc4.xml","form_type":"4"}}]}