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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214779163,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996887,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":1772,"price":1.27,"value":2250.44,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214566555,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996886,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":15000,"price":1.265,"value":18975.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214564783,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996885,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"grant","planned":false,"acquired":true,"shares":46700,"price":1.26,"value":58842.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214549783,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996884,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":66635,"price":1.255,"value":83626.925,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214503083,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996883,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":49590,"price":1.25,"value":61987.5,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214436448,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996882,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":410,"price":1.245,"value":510.45,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214386858,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":1010940,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-10-31T21:15:41.000Z","date":"2025-10-31","kind":"purchase","planned":false,"acquired":true,"shares":150000,"price":1.4229,"value":213435.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.415 to $1.4299, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214386448,"source":{"system":"sec-edgar","filing":"0001193125-25-260956","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525260956/ownership.xml","form_type":"4"}},{"id":1040953,"issuer":{"id":7657,"kind":"organization","name":"NOCOPI TECHNOLOGIES INC/MD/","symbol":"NNUP"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-09-15T21:00:16.000Z","date":"2025-09-11","kind":"grant","planned":false,"acquired":true,"shares":21930,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares of the Issuer's common stock acquired by the Reporting Person from the Issuer as consideration rendered pursuant advisory services provided by the Reporting Person pursuant to that certain Stock Purchase Agreement by and between the Issuer and Frost Gamma Investments Trust, dated September 11, 2023."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by Frost Gamma Investments Trust, of which the Reporting Person is the trustee. Frost Gamma Limited Partnership is the sole and exclusive beneficiary of Frost Gamma Investments Trust. The Reporting Person is one of two limited partners of Frost Gamma Limited Partnership. The general partner of Frost Gamma Limited Partnership is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation, of which the Reporting Person is the sole shareholder. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1489712,"source":{"system":"sec-edgar","filing":"0001104659-25-090057","document":"tm2526128-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/888981/000110465925090057/tm2526128-1_4seq1.xml","form_type":"4"}},{"id":1042204,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-09-12T20:30:19.000Z","date":"2025-09-04","kind":"other","planned":false,"acquired":true,"shares":571429,"price":0.0005,"value":285.7145,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"On September 8, 2025, the reporting person filed a Form 4 reporting ownership of 7,294,403 shares of Common Stock following the reported transaction. The reporting person's ownership of Common Stock following the transaction should have been reported as 6,318,439."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":6318439,"source":{"system":"sec-edgar","filing":"0001104659-25-089560","document":"tm2526015-1_4aseq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925089560/tm2526015-1_4aseq1.xml","form_type":"4/A","original_submission_date":"2025-09-08"}},{"id":1046371,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrants","published_at":"2025-09-08T21:03:53.000Z","date":"2025-09-04","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":571429,"price":1.75,"value":1000000.75,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The Pre-Funded Warrants were immediately exercisable when issued and were exercised on September 4, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants expire when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-08-19","underlying":"Common Stock","underlying_shares":571429},"source":{"system":"sec-edgar","filing":"0001104659-25-088314","document":"tm2525555-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925088314/tm2525555-1_4seq1.xml","form_type":"4"}},{"id":1046370,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-09-08T21:03:53.000Z","date":"2025-09-04","kind":"other","planned":false,"acquired":true,"shares":571429,"price":0.0005,"value":285.7145,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":7294403,"source":{"system":"sec-edgar","filing":"0001104659-25-088314","document":"tm2525555-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925088314/tm2525555-1_4seq1.xml","form_type":"4"}},{"id":1059654,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Warrants","published_at":"2025-08-21T21:02:52.000Z","date":"2025-08-19","kind":"grant","planned":false,"acquired":true,"shares":571429,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"Each Warrant will be exercisable for one share of Common Stock at any time on or after the date that is six months and one day following the date of issuance for a period of five and one-half years from the date of issuance. Notwithstanding the foregoing, the Warrants shall be exercisable at any time on or after the date that applicable stockholder approval is obtained and deemed effective and such Warrants shall be exercisable until the expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"Each Warrant will be exercisable for one share of Common Stock at any time on or after the date that is six months and one day following the date of issuance for a period of five and one-half years from the date of issuance. Notwithstanding the foregoing, the Warrants shall be exercisable at any time on or after the date that applicable stockholder approval is obtained and deemed effective and such Warrants shall be exercisable until the expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":571429,"derivative":{"exercise_price":2.21,"underlying":"Common Stock","underlying_shares":571429},"source":{"system":"sec-edgar","filing":"0001104659-25-081461","document":"tm2524023-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925081461/tm2524023-1_4seq1.xml","form_type":"4"}},{"id":1059653,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrants","published_at":"2025-08-21T21:02:52.000Z","date":"2025-08-19","kind":"grant","planned":false,"acquired":true,"shares":571429,"price":1.75,"value":1000000.75,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"Each Pre-Funded Warrant is immediately exercisable for one share of the issuer's common stock, $0.0005 par value per share (the \"Common Stock\"), and will expire when exercised in full."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"Each Pre-Funded Warrant is immediately exercisable for one share of the issuer's common stock, $0.0005 par value per share (the \"Common Stock\"), and will expire when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":571429,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-08-19","underlying":"Common Stock","underlying_shares":571429},"source":{"system":"sec-edgar","filing":"0001104659-25-081461","document":"tm2524023-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925081461/tm2524023-1_4seq1.xml","form_type":"4"}},{"id":1062942,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-08-19T20:08:47.000Z","date":"2025-08-18","kind":"gift","planned":false,"acquired":false,"shares":440000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214236448,"source":{"system":"sec-edgar","filing":"0000950170-25-110094","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025110094/ownership.xml","form_type":"4"}},{"id":1071763,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-08-08T20:56:12.000Z","date":"2025-08-08","kind":"purchase","planned":false,"acquired":true,"shares":675000,"price":1.32,"value":891000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214676448,"source":{"system":"sec-edgar","filing":"0000950170-25-105971","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025105971/ownership.xml","form_type":"4"}},{"id":1116948,"issuer":{"id":7657,"kind":"organization","name":"NOCOPI TECHNOLOGIES INC/MD/","symbol":"NNUP"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-06-11T01:00:20.000Z","date":"2025-06-06","kind":"purchase","planned":false,"acquired":true,"shares":195852,"price":1.1,"value":215437.2,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"These securities were acquired by the Reporting Person from a non-affiliate shareholder of Nocopi Technologies, Inc. in a private secondary transaction exempt from the registration requirements of the Securities Act of 1933, as amended."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by Frost Gamma Investments Trust, of which the Reporting Person is the trustee. Frost Gamma Limited Partnership is the sole and exclusive beneficiary of Frost Gamma Investments Trust. The Reporting Person is one of two limited partners of Frost Gamma Limited Partnership. The general partner of Frost Gamma Limited Partnership is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation, of which the Reporting Person is the sole shareholder. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1467782,"source":{"system":"sec-edgar","filing":"0001104659-25-058297","document":"tm2517672-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/888981/000110465925058297/tm2517672-1_4seq1.xml","form_type":"4"}},{"id":1139559,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrants","published_at":"2025-05-21T20:15:11.000Z","date":"2025-05-19","kind":"disposition_to_issuer","planned":false,"acquired":true,"shares":909297,"price":2.1995,"value":1999998.7515,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The Pre-Funded Warrants were immediately exercisable when issued and were exercised on May 19, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants expire when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-05-19","underlying":"Common Stock","underlying_shares":909297},"source":{"system":"sec-edgar","filing":"0001104659-25-051611","document":"tm2515842-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925051611/tm2515842-1_4seq1.xml","form_type":"4"}},{"id":1139558,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Warrants","published_at":"2025-05-21T20:15:11.000Z","date":"2025-05-19","kind":"grant","planned":false,"acquired":true,"shares":909297,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"The Warrants will expire three years from the date of issuance."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":909297,"derivative":{"exercise_price":2.2,"exercise_date":"2025-05-19","underlying":"Common Stock","underlying_shares":909297},"source":{"system":"sec-edgar","filing":"0001104659-25-051611","document":"tm2515842-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925051611/tm2515842-1_4seq1.xml","form_type":"4"}},{"id":1139557,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrants","published_at":"2025-05-21T20:15:11.000Z","date":"2025-05-19","kind":"grant","planned":false,"acquired":true,"shares":909297,"price":2.1995,"value":1999998.7515,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The Pre-Funded Warrants were immediately exercisable when issued and were exercised on May 19, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants expire when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":909297,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-05-19","underlying":"Common Stock","underlying_shares":909297},"source":{"system":"sec-edgar","filing":"0001104659-25-051611","document":"tm2515842-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925051611/tm2515842-1_4seq1.xml","form_type":"4"}},{"id":1139556,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-21T20:15:11.000Z","date":"2025-05-19","kind":"tax_withholding","planned":false,"acquired":false,"shares":212,"price":2.13,"value":451.56,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":5747010,"source":{"system":"sec-edgar","filing":"0001104659-25-051611","document":"tm2515842-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925051611/tm2515842-1_4seq1.xml","form_type":"4"}},{"id":1139555,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-21T20:15:11.000Z","date":"2025-05-19","kind":"other","planned":false,"acquired":true,"shares":909297,"price":0.0005,"value":454.6485,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":5747222,"source":{"system":"sec-edgar","filing":"0001104659-25-051611","document":"tm2515842-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925051611/tm2515842-1_4seq1.xml","form_type":"4"}},{"id":1174348,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-10T21:07:15.000Z","date":"2025-04-10","kind":"purchase","planned":false,"acquired":true,"shares":125000,"price":1.3577,"value":169712.5,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.35 to $1.36, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214001448,"source":{"system":"sec-edgar","filing":"0000950170-25-052925","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025052925/ownership.xml","form_type":"4"}},{"id":1176056,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-08T21:34:21.000Z","date":"2025-04-08","kind":"purchase","planned":false,"acquired":true,"shares":125000,"price":1.4772,"value":184650.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.46 to $1.495, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213876448,"source":{"system":"sec-edgar","filing":"0000950170-25-052214","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025052214/ownership.xml","form_type":"4"}},{"id":1187140,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-01T21:21:45.000Z","date":"2025-04-01","kind":"purchase","planned":false,"acquired":true,"shares":100000,"price":1.6485,"value":164850.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.645 to $1.65, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213751448,"source":{"system":"sec-edgar","filing":"0000950170-25-048737","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025048737/ownership.xml","form_type":"4"}},{"id":1189196,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-28T21:22:09.000Z","date":"2025-03-28","kind":"purchase","planned":false,"acquired":true,"shares":150000,"price":1.6959,"value":254385.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.685 to $1.70, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213651448,"source":{"system":"sec-edgar","filing":"0000950170-25-046952","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025046952/ownership.xml","form_type":"4"}},{"id":1190162,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrants","published_at":"2025-03-27T16:05:45.000Z","date":"2025-03-20","kind":"exercise","planned":false,"acquired":true,"shares":459981,"price":2.174,"value":999998.694,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The Pre-Funded Warrants were immediately exercisable when issued. The Pre-Funded Warrants were exercised on March 20, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":459981,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-03-20","underlying":"Common Stock","underlying_shares":459981},"source":{"system":"sec-edgar","filing":"0001437749-25-009541","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925009541/rdgdoc.xml","form_type":"4/A","original_submission_date":"2025-03-21"}},{"id":1190161,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrants","published_at":"2025-03-27T16:05:45.000Z","date":"2025-03-19","kind":"grant","planned":false,"acquired":true,"shares":459981,"price":2.174,"value":999998.694,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":459981,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-03-19","underlying":"Common Stock","underlying_shares":459981},"source":{"system":"sec-edgar","filing":"0001437749-25-009541","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925009541/rdgdoc.xml","form_type":"4/A","original_submission_date":"2025-03-21"}},{"id":1190160,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2025-03-27T16:05:45.000Z","date":"2025-03-20","kind":"tax_withholding","planned":false,"acquired":false,"shares":112,"price":2.04,"value":228.48,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":4837925,"source":{"system":"sec-edgar","filing":"0001437749-25-009541","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925009541/rdgdoc.xml","form_type":"4/A","original_submission_date":"2025-03-21"}},{"id":1190159,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2025-03-27T16:05:45.000Z","date":"2025-03-20","kind":"exercise","planned":false,"acquired":true,"shares":459981,"price":0.0005,"value":229.9905,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":4838037,"source":{"system":"sec-edgar","filing":"0001437749-25-009541","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925009541/rdgdoc.xml","form_type":"4/A","original_submission_date":"2025-03-21"}},{"id":1195097,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrants","published_at":"2025-03-21T23:33:39.000Z","date":"2025-03-20","kind":"exercise","planned":false,"acquired":true,"shares":459981,"price":2.174,"value":999998.694,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The Pre-Funded Warrants were immediately exercisable when issued. The Pre-Funded Warrants were exercised on March 20, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":459981,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-03-20","underlying":"Common Stock","underlying_shares":459981},"source":{"system":"sec-edgar","filing":"0001437749-25-008804","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925008804/rdgdoc.xml","form_type":"4"}},{"id":1195096,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrants","published_at":"2025-03-21T23:33:39.000Z","date":"2025-03-19","kind":"grant","planned":false,"acquired":true,"shares":459981,"price":2.174,"value":999998.694,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":459981,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-03-19","underlying":"Common Stock","underlying_shares":459981},"source":{"system":"sec-edgar","filing":"0001437749-25-008804","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925008804/rdgdoc.xml","form_type":"4"}},{"id":1195095,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2025-03-21T23:33:39.000Z","date":"2025-03-20","kind":"tax_withholding","planned":false,"acquired":false,"shares":112,"price":2.04,"value":228.48,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":4837925,"source":{"system":"sec-edgar","filing":"0001437749-25-008804","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925008804/rdgdoc.xml","form_type":"4"}},{"id":1195094,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2025-03-21T23:33:39.000Z","date":"2025-03-20","kind":"exercise","planned":false,"acquired":true,"shares":459981,"price":0.0005,"value":229.9905,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":4838037,"source":{"system":"sec-edgar","filing":"0001437749-25-008804","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925008804/rdgdoc.xml","form_type":"4"}},{"id":1204859,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-17T21:27:48.000Z","date":"2025-03-17","kind":"purchase","planned":false,"acquired":true,"shares":200000,"price":1.7391,"value":347820.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.73 to $1.745, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213501448,"source":{"system":"sec-edgar","filing":"0000950170-25-040497","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025040497/ownership.xml","form_type":"4"}},{"id":1232261,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-04T23:16:02.000Z","date":"2025-03-04","kind":"purchase","planned":false,"acquired":true,"price":436500,"reported_value":250000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":217391},"source":{"system":"sec-edgar","filing":"0000950170-25-032615","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025032615/ownership.xml","form_type":"4"}},{"id":1237131,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-04T00:26:33.000Z","date":"2025-03-03","kind":"purchase","planned":false,"acquired":true,"price":1707125,"reported_value":1000000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":869565},"source":{"system":"sec-edgar","filing":"0000950170-25-031198","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025031198/ownership.xml","form_type":"4"}},{"id":1237130,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-04T00:26:33.000Z","date":"2025-03-03","kind":"purchase","planned":false,"acquired":true,"price":1703250,"reported_value":1000000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":869565},"source":{"system":"sec-edgar","filing":"0000950170-25-031198","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025031198/ownership.xml","form_type":"4"}},{"id":1239494,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-01T00:34:01.000Z","date":"2025-02-28","kind":"purchase","planned":false,"acquired":true,"price":1652750,"reported_value":1000000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":869565},"source":{"system":"sec-edgar","filing":"0000950170-25-030278","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025030278/ownership.xml","form_type":"4"}},{"id":1239493,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-01T00:34:01.000Z","date":"2025-02-28","kind":"purchase","planned":false,"acquired":true,"shares":67434,"price":1.71,"value":115312.14,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213301448,"source":{"system":"sec-edgar","filing":"0000950170-25-030278","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025030278/ownership.xml","form_type":"4"}},{"id":1293531,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-28T22:40:23.000Z","date":"2025-01-28","kind":"purchase","planned":false,"acquired":true,"shares":47537,"price":1.4738,"value":70060.0306,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.465 to $1.475, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213234014,"source":{"system":"sec-edgar","filing":"0000950170-25-009978","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025009978/ownership.xml","form_type":"4"}},{"id":1300928,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-17T22:06:34.000Z","date":"2025-01-17","kind":"purchase","planned":false,"acquired":true,"shares":150000,"price":1.4695,"value":220425.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.465 to $1.47, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213186477,"source":{"system":"sec-edgar","filing":"0000950170-25-006790","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025006790/ownership.xml","form_type":"4"}},{"id":1302919,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-15T22:18:44.000Z","date":"2025-01-15","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":1.4817,"value":740850.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.46 to $1.50, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213036477,"source":{"system":"sec-edgar","filing":"0000950170-25-005908","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025005908/ownership.xml","form_type":"4"}},{"id":1333083,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-13T22:04:40.000Z","date":"2024-12-13","kind":"purchase","planned":false,"acquired":true,"shares":125000,"price":1.595,"value":199375.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.585 to $1.605, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":212536477,"source":{"system":"sec-edgar","filing":"0000950170-24-136264","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024136264/ownership.xml","form_type":"4"}},{"id":1336362,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-11T22:21:28.000Z","date":"2024-12-11","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":1.5621,"value":781050.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.535 to $1.61, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":212411477,"source":{"system":"sec-edgar","filing":"0000950170-24-135471","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024135471/ownership.xml","form_type":"4"}},{"id":1336360,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrant","published_at":"2024-12-11T19:58:20.000Z","date":"2024-12-09","kind":"other","planned":false,"acquired":false,"shares":647892,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"Held by\nFrost\nGamma\nInvestments\nTrust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The Pre-Funded Warrants were immediately exercisable when issued. The Pre-Funded Warrants were exercised on December 9, 2024."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"The Pre-Funded Warrants will terminate when exercised in full."},{"field":"derivative.underlying_shares","element":"underlyingSecurityShares","label":"F2","text":"The Pre-Funded Warrants were immediately exercisable when issued. The Pre-Funded Warrants were exercised on December 9, 2024."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":0.0005,"exercise_date":"2024-12-09","underlying":"Common Stock","underlying_shares":647892},"source":{"system":"sec-edgar","filing":"0001437749-24-037223","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924037223/rdgdoc.xml","form_type":"4"}},{"id":1336359,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2024-12-11T19:58:20.000Z","date":"2024-12-09","kind":"other","planned":false,"acquired":true,"shares":647892,"price":0.0005,"value":323.946,"ownership":{"direct":false,"nature":"Held by\nFrost\nGamma\nInvestments\nTrust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":4378056,"source":{"system":"sec-edgar","filing":"0001437749-24-037223","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924037223/rdgdoc.xml","form_type":"4"}},{"id":1340980,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrant","published_at":"2024-12-06T17:10:46.000Z","date":"2024-12-02","kind":"grant","planned":false,"acquired":true,"shares":647892,"price":2.3147,"value":1499675.6124,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"On December 4, 2024, the reporting person filed a Form 4 which inadvertently reported the transaction code as \"P.\" The transaction code should have been reported as \"A\" for a grant, award or other acquisition pursuant to Rule 16b-3(d)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants will terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":647892,"derivative":{"exercise_price":0.0005,"exercise_date":"2024-12-02","underlying":"Common Stock","underlying_shares":647892},"source":{"system":"sec-edgar","filing":"0001437749-24-036842","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924036842/rdgdoc.xml","form_type":"4/A","original_submission_date":"2024-12-04"}},{"id":1343741,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrant","published_at":"2024-12-04T19:43:20.000Z","date":"2024-12-02","kind":"purchase","planned":false,"acquired":true,"shares":647892,"price":2.3147,"value":1499675.6124,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The Pre-Funded Warrants will terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":647892,"derivative":{"exercise_price":0.0005,"exercise_date":"2024-12-02","underlying":"Common Stock","underlying_shares":647892},"source":{"system":"sec-edgar","filing":"0001437749-24-036682","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924036682/rdgdoc.xml","form_type":"4"}},{"id":1348594,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-29T20:20:16.000Z","date":"2024-11-29","kind":"purchase","planned":false,"acquired":true,"shares":199072,"price":1.534,"value":305376.448,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.525 to $1.54, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211911477,"source":{"system":"sec-edgar","filing":"0000950170-24-131871","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024131871/ownership.xml","form_type":"4"}},{"id":1355037,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-22T22:17:09.000Z","date":"2024-11-22","kind":"purchase","planned":false,"acquired":true,"shares":100000,"price":1.59,"value":159000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.585 to $1.59, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211712405,"source":{"system":"sec-edgar","filing":"0000950170-24-130292","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024130292/ownership.xml","form_type":"4"}},{"id":1357818,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-21T00:21:31.000Z","date":"2024-11-08","kind":"purchase","planned":false,"acquired":true,"shares":280183,"price":1.5045,"value":421535.3235,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.455 to $1.545, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211512405,"source":{"system":"sec-edgar","filing":"0000950170-24-129440","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024129440/ownership.xml","form_type":"4/A","original_submission_date":"2024-11-08"}},{"id":1365707,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-14T22:51:36.000Z","date":"2024-11-14","kind":"purchase","planned":false,"acquired":true,"shares":100000,"price":1.6198,"value":161980.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.615 to $1.6199, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211612405,"source":{"system":"sec-edgar","filing":"0000950170-24-127266","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024127266/ownership.xml","form_type":"4"}},{"id":1372035,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-08T22:40:44.000Z","date":"2024-11-08","kind":"purchase","planned":false,"acquired":true,"shares":280183,"price":1.5045,"value":421535.3235,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.455 to $1.545, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211512405,"source":{"system":"sec-edgar","filing":"0000950170-24-124261","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024124261/ownership.xml","form_type":"4"}},{"id":1388830,"issuer":{"id":7657,"kind":"organization","name":"NOCOPI TECHNOLOGIES INC/MD/","symbol":"NNUP"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-10-09T22:16:07.000Z","date":"2024-09-11","kind":"grant","planned":false,"acquired":true,"shares":21930,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares of the Issuer's common stock acquired by the Reporting Person from the Issuer as consideration rendered pursuant advisory services provided by the Reporting Person pursuant to that certain Stock Purchase Agreement by and between the Issuer and Frost Gamma Investments Trust, dated September 11, 2023."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by Frost Gamma Investments Trust, of which the Reporting Person is the trustee. Frost Gamma Limited Partnership is the sole and exclusive beneficiary of Frost Gamma Investments Trust. The Reporting Person is one of two limited partners of Frost Gamma Limited Partnership. The general partner of Frost Gamma Limited Partnership is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation, of which the Reporting Person is the sole shareholder. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1271930,"source":{"system":"sec-edgar","filing":"0001104659-24-107406","document":"tm2425933-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/888981/000110465924107406/tm2425933-1_4seq1.xml","form_type":"4"}},{"id":1398722,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2024-09-27T21:22:19.000Z","date":"2024-09-27","kind":"purchase","planned":false,"acquired":true,"price":2541737.5,"reported_value":1845000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a\nDelaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances\nand during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion\nprice of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a\nDelaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances\nand during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion\nprice of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":1604347},"source":{"system":"sec-edgar","filing":"0000950170-24-110098","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024110098/ownership.xml","form_type":"4"}},{"id":1398721,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2024-09-27T21:18:35.000Z","date":"2024-09-25","kind":"purchase","planned":false,"acquired":true,"price":1571050,"reported_value":1155000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":1004347},"source":{"system":"sec-edgar","filing":"0000950170-24-110093","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024110093/ownership.xml","form_type":"4/A","original_submission_date":"2024-09-26"}},{"id":1399218,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2024-09-26T21:33:56.000Z","date":"2024-09-25","kind":"purchase","planned":false,"acquired":true,"price":1571050,"reported_value":1155000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Prior to September 15, 2028, holders of the 3.75% Convertible Senior Notes due 2029 will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock"},"source":{"system":"sec-edgar","filing":"0000950170-24-109683","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024109683/ownership.xml","form_type":"4"}},{"id":1426884,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Convertible Subordinated Promissory Note","published_at":"2024-08-21T18:24:40.000Z","date":"2024-08-19","kind":"grant","planned":false,"acquired":true,"price":200000,"reported_value":200000,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The Convertible Subordinated Promissory Note (the \"Note\") accrues interest at 13% per annum and is convertible into shares of the Issuer's common stock at the Conversion Price. \"Conversion Price\" means an amount equal to the lesser of (i) $3.01, subject to adjustment pursuant to the terms of the Note and (ii) the greater of (A) the consolidated closing bid price of the Issuer's common stock as reported on The Nasdaq Capital Market or such other principal market or exchange on which the common stock is then traded (the \"Principal Market\") on the applicable conversion date or, if such date is not a Trading Day, then on the Trading Date that is immediately prior to the applicable conversion date and (B) $1.00, subject to adjustment pursuant to the terms of the Note; provided, however, that the applicable Conversion Price shall in no event be lower than the price established by clause (ii) (continued)"},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"above unless and until the Issuer obtains stockholder approval of the transactions contemplated by the Note, including the conversion features and pricing thereof, in accordance with the applicable rules of the Principal Market (or any other applicable national securities exchange) (the \"Stockholder Approval\"). Notwithstanding the foregoing, the Note is subject to additional limits on conversion until the Stockholder Approval is obtained, including an aggregate limit on the number of shares that may be issued upon conversion of all notes issued to investors on August 19, 2024, including the Note (collectively, the \"August Notes\"), to 19.99% of the Issuer's outstanding shares of common stock and provisions to prevent a change of control as defined in the rules of the Nasdaq Stock Market. (continued)"},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F3","text":"The Issuer has agreed to use its reasonable efforts to secure the Stockholder Approval, including providing a recommendation FOR approval by the Issuer's board of directors. Holders of the August Notes will be permitted to vote on the Stockholder Approval, but may not vote any shares obtained from conversion of the August Notes prior to such vote. \"Trading Day\" means any day during which the Principal Market is open for trading."},{"field":"reported_value","element":"transactionTotalValue","label":"F4","text":"The amount reflected here is in dollars."},{"field":"underlyingValue","element":"underlyingSecurityValue","label":"F1","text":"The Convertible Subordinated Promissory Note (the \"Note\") accrues interest at 13% per annum and is convertible into shares of the Issuer's common stock at the Conversion Price. \"Conversion Price\" means an amount equal to the lesser of (i) $3.01, subject to adjustment pursuant to the terms of the Note and (ii) the greater of (A) the consolidated closing bid price of the Issuer's common stock as reported on The Nasdaq Capital Market or such other principal market or exchange on which the common stock is then traded (the \"Principal Market\") on the applicable conversion date or, if such date is not a Trading Day, then on the Trading Date that is immediately prior to the applicable conversion date and (B) $1.00, subject to adjustment pursuant to the terms of the Note; provided, however, that the applicable Conversion Price shall in no event be lower than the price established by clause (ii) (continued)"},{"field":"underlyingValue","element":"underlyingSecurityValue","label":"F2","text":"above unless and until the Issuer obtains stockholder approval of the transactions contemplated by the Note, including the conversion features and pricing thereof, in accordance with the applicable rules of the Principal Market (or any other applicable national securities exchange) (the \"Stockholder Approval\"). Notwithstanding the foregoing, the Note is subject to additional limits on conversion until the Stockholder Approval is obtained, including an aggregate limit on the number of shares that may be issued upon conversion of all notes issued to investors on August 19, 2024, including the Note (collectively, the \"August Notes\"), to 19.99% of the Issuer's outstanding shares of common stock and provisions to prevent a change of control as defined in the rules of the Nasdaq Stock Market. (continued)"},{"field":"underlyingValue","element":"underlyingSecurityValue","label":"F3","text":"The Issuer has agreed to use its reasonable efforts to secure the Stockholder Approval, including providing a recommendation FOR approval by the Issuer's board of directors. Holders of the August Notes will be permitted to vote on the Stockholder Approval, but may not vote any shares obtained from conversion of the August Notes prior to such vote. \"Trading Day\" means any day during which the Principal Market is open for trading."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_date":"2024-08-19","expiration_date":"2029-04-02","underlying":"Common Stock"},"source":{"system":"sec-edgar","filing":"0001437749-24-027460","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924027460/rdgdoc.xml","form_type":"4"}},{"id":1458538,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrant","published_at":"2024-07-08T19:51:29.000Z","date":"2024-07-05","kind":"other","planned":false,"acquired":false,"shares":591017,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The Pre-Funded Warrants became immediately exercisable after stockholder approval of the offering of the Issuer's Pre-Funded Warrants, which approval was obtained on July 2, 2024. The binding agreement for the transaction was entered into on May 13, 2024."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"The Pre-Funded Warrants will terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":0.0005,"exercise_date":"2024-07-02","underlying":"Common Stock","underlying_shares":591017},"source":{"system":"sec-edgar","filing":"0001437749-24-022293","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924022293/rdgdoc.xml","form_type":"4"}},{"id":1458537,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2024-07-08T19:51:29.000Z","date":"2024-07-05","kind":"other","planned":false,"acquired":true,"shares":591017,"price":0.0005,"value":295.5085,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":3730164,"source":{"system":"sec-edgar","filing":"0001437749-24-022293","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924022293/rdgdoc.xml","form_type":"4"}},{"id":1504439,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-05-24T00:04:15.000Z","date":"2024-05-23","kind":"purchase","planned":false,"acquired":true,"shares":770,"price":1.265,"value":974.05,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211232222,"source":{"system":"sec-edgar","filing":"0000950170-24-064248","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024064248/ownership.xml","form_type":"4"}},{"id":1504438,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-05-24T00:04:15.000Z","date":"2024-05-23","kind":"purchase","planned":false,"acquired":true,"shares":99230,"price":1.2694,"value":125962.562,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211231452,"source":{"system":"sec-edgar","filing":"0000950170-24-064248","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024064248/ownership.xml","form_type":"4"}},{"id":1512549,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-05-17T21:31:27.000Z","date":"2024-05-17","kind":"purchase","planned":false,"acquired":true,"shares":163997,"price":1.2878,"value":211195.3366,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.285 to $1.29, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211132222,"source":{"system":"sec-edgar","filing":"0000950170-24-061910","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024061910/ownership.xml","form_type":"4"}},{"id":1516508,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrant","published_at":"2024-05-16T01:30:18.000Z","date":"2024-05-13","kind":"grant","planned":false,"acquired":true,"shares":591017,"price":3.384,"value":2000001.528,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The Pre-Funded Warrants will be immediately exercisable after stockholder approval of the offering of the Issuer's Pre-Funded Warrants. The binding agreement for the transaction was entered into on May 13, 2024."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"The Pre-Funded Warrants will terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":591017,"derivative":{"exercise_price":0.0005,"underlying":"Common Stock","underlying_shares":591017},"source":{"system":"sec-edgar","filing":"0001437749-24-017188","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924017188/rdgdoc.xml","form_type":"4"}},{"id":1573579,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-03-18T20:45:08.000Z","date":"2024-03-18","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":0.8742,"value":437100.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.8635 to $0.8788, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":210968225,"source":{"system":"sec-edgar","filing":"0000950170-24-032877","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024032877/ownership.xml","form_type":"4"}},{"id":1577352,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-03-14T21:00:41.000Z","date":"2024-03-14","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":0.8886,"value":444300.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.8862 to $0.89, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":210468225,"source":{"system":"sec-edgar","filing":"0000950170-24-031630","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024031630/ownership.xml","form_type":"4"}},{"id":1579476,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-03-13T20:44:17.000Z","date":"2024-03-13","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":0.9275,"value":463750.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9172 to $0.9383, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":209968225,"source":{"system":"sec-edgar","filing":"0000950170-24-030838","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024030838/ownership.xml","form_type":"4"}},{"id":1582401,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-03-12T21:27:29.000Z","date":"2024-03-12","kind":"purchase","planned":false,"acquired":true,"shares":600000,"price":0.9323,"value":559380.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9213 to $0.9398, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":209468225,"source":{"system":"sec-edgar","filing":"0000950170-24-030156","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024030156/ownership.xml","form_type":"4"}},{"id":1613439,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-02-28T22:31:35.000Z","date":"2024-02-28","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":0.9923,"value":496150.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9772 to $1.01, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":208868225,"source":{"system":"sec-edgar","filing":"0000950170-24-022306","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024022306/ownership.xml","form_type":"4"}},{"id":1630908,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-02-21T22:10:47.000Z","date":"2024-02-21","kind":"purchase","planned":false,"acquired":true,"shares":1000000,"price":0.9917,"value":991700.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9507 to $1.03, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":208368225,"source":{"system":"sec-edgar","filing":"0000950170-24-018079","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024018079/ownership.xml","form_type":"4"}},{"id":1655895,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-02-07T22:09:25.000Z","date":"2024-02-07","kind":"purchase","planned":false,"acquired":true,"shares":1500000,"price":0.9752,"value":1462800.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9399 to $1.01, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":207368225,"source":{"system":"sec-edgar","filing":"0000950170-24-012312","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024012312/ownership.xml","form_type":"4"}},{"id":1674593,"issuer":{"id":7752,"kind":"organization","name":"BioCardia, Inc.","symbol":"BCDA"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-01-23T01:38:06.000Z","date":"2024-01-19","kind":"sale","planned":false,"acquired":false,"shares":129802,"price":0.43,"value":55814.86,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"This transaction was executed in multiple trades at prices ranging from $0.38 to $0.57, inclusive. The price reported above reflects the weighted average sale price."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"On June 6, 2019, the Issuer effected a 1-9 reverse stock split of its common stock (the \"Reverse Stock Split\"). The amount of securities reported on this Form 4 have been adjusted to reflect the Reverse Stock Split."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held by Frost Gamma Investments Trust, of which the Reporting Person is the trustee. Frost Gamma Limited Partnership is the sole and exclusive beneficiary of Frost Gamma Investments Trust. The Reporting Person is one of two limited partners of Frost Gamma Limited Partnership. The general partner of Frost Gamma Limited Partnership is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation, of which the Reporting Person is the sole shareholder."}],"balance_after":1896025,"source":{"system":"sec-edgar","filing":"0001104659-24-005661","document":"tm243867-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465924005661/tm243867-1_4seq1.xml","form_type":"4"}}],"next_cursor":"2024-01-23T01:38:06.000000Z,1674593"}