{"transactions":[{"id":965056,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Restricted Stock Units","published_at":"2025-12-17T21:58:51.000Z","date":"2025-12-15","kind":"exercise","planned":false,"acquired":false,"shares":513,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each RSU represents a contingent right to receive one share of common stock of the Issuer."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"On December 14, 2023, the Reporting Person was granted a total of 4,106 RSUs. 50% or 2,053 of the total RSUs are performance-based and all vested on December 10, 2024. An addition of 50% or 2,053 of the total RSUs are time-based. 25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 513 shares vested and 184 shares were withheld for taxes, resulting in a net issuance of 329 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"On December 14, 2023, the Reporting Person was granted a total of 4,106 RSUs. 50% or 2,053 of the total RSUs are performance-based and all vested on December 10, 2024. An addition of 50% or 2,053 of the total RSUs are time-based. 25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 513 shares vested and 184 shares were withheld for taxes, resulting in a net issuance of 329 shares."}],"balance_after":1027,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":513},"source":{"system":"sec-edgar","filing":"0001533302-25-000011","document":"form4-12172025_091247.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000011/form4-12172025_091247.xml","form_type":"4"}},{"id":965055,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Restricted Stock Units","published_at":"2025-12-17T21:58:51.000Z","date":"2025-12-15","kind":"exercise","planned":false,"acquired":false,"shares":496,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each RSU represents a contingent right to receive one share of common stock of the Issuer."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"On December 5, 2022, the Reporting Person was granted 1,986 time-based restricted stock units (\"RSUs\"), subject to a 4-year vesting schedule, with 25% of the total number of RSUs vested on December 15, 2023 (the \"Annual Vesting Date\") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 496 RSUs vested, with 178\nshares withheld for taxes, resulting in a net issuance of 318 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"On December 5, 2022, the Reporting Person was granted 1,986 time-based restricted stock units (\"RSUs\"), subject to a 4-year vesting schedule, with 25% of the total number of RSUs vested on December 15, 2023 (the \"Annual Vesting Date\") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 496 RSUs vested, with 178\nshares withheld for taxes, resulting in a net issuance of 318 shares."}],"balance_after":497,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":496},"source":{"system":"sec-edgar","filing":"0001533302-25-000011","document":"form4-12172025_091247.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000011/form4-12172025_091247.xml","form_type":"4"}},{"id":965054,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Common Stock","published_at":"2025-12-17T21:58:51.000Z","date":"2025-12-15","kind":"tax_withholding","planned":false,"acquired":false,"shares":184,"price":80.67,"value":14843.28,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"On December 14, 2023, the Reporting Person was granted a total of 4,106 RSUs. 50% or 2,053 of the total RSUs are performance-based and all vested on December 10, 2024. An addition of 50% or 2,053 of the total RSUs are time-based. 25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 513 shares vested and 184 shares were withheld for taxes, resulting in a net issuance of 329 shares."}],"balance_after":8263,"source":{"system":"sec-edgar","filing":"0001533302-25-000011","document":"form4-12172025_091247.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000011/form4-12172025_091247.xml","form_type":"4"}},{"id":965053,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Common Stock","published_at":"2025-12-17T21:58:51.000Z","date":"2025-12-15","kind":"exercise","planned":false,"acquired":true,"shares":513,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"On December 14, 2023, the Reporting Person was granted a total of 4,106 RSUs. 50% or 2,053 of the total RSUs are performance-based and all vested on December 10, 2024. An addition of 50% or 2,053 of the total RSUs are time-based. 25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 513 shares vested and 184 shares were withheld for taxes, resulting in a net issuance of 329 shares."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Each RSU represents a contingent right to receive one share of common stock of the Issuer."}],"balance_after":8447,"source":{"system":"sec-edgar","filing":"0001533302-25-000011","document":"form4-12172025_091247.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000011/form4-12172025_091247.xml","form_type":"4"}},{"id":965052,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Common Stock","published_at":"2025-12-17T21:58:51.000Z","date":"2025-12-15","kind":"tax_withholding","planned":false,"acquired":false,"shares":178,"price":80.67,"value":14359.26,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"On December 5, 2022, the Reporting Person was granted 1,986 time-based restricted stock units (\"RSUs\"), subject to a 4-year vesting schedule, with 25% of the total number of RSUs vested on December 15, 2023 (the \"Annual Vesting Date\") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 496 RSUs vested, with 178\nshares withheld for taxes, resulting in a net issuance of 318 shares."}],"balance_after":7934,"source":{"system":"sec-edgar","filing":"0001533302-25-000011","document":"form4-12172025_091247.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000011/form4-12172025_091247.xml","form_type":"4"}},{"id":965051,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Common Stock","published_at":"2025-12-17T21:58:51.000Z","date":"2025-12-15","kind":"exercise","planned":false,"acquired":true,"shares":496,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"On December 5, 2022, the Reporting Person was granted 1,986 time-based restricted stock units (\"RSUs\"), subject to a 4-year vesting schedule, with 25% of the total number of RSUs vested on December 15, 2023 (the \"Annual Vesting Date\") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2025, 496 RSUs vested, with 178\nshares withheld for taxes, resulting in a net issuance of 318 shares."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Each RSU represents a contingent right to receive one share of common stock of the Issuer."}],"balance_after":8112,"source":{"system":"sec-edgar","filing":"0001533302-25-000011","document":"form4-12172025_091247.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000011/form4-12172025_091247.xml","form_type":"4"}},{"id":969481,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-15T23:54:50.000Z","date":"2025-12-11","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":933,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transactions reported herein reflect a one-time stock option repricing (the \"Option Repricing\") effective on December 11, 2025 (the \"Repricing Date\"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"1/48th of the shares vest on a monthly basis from January 3, 2022, subject to Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan)."}],"balance_after":0,"derivative":{"exercise_price":344.25,"expiration_date":"2032-01-02","underlying":"Common Stock","underlying_shares":933},"source":{"system":"sec-edgar","filing":"0001533302-25-000009","document":"form4-12152025_111246.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000009/form4-12152025_111246.xml","form_type":"4"}},{"id":969480,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-15T23:54:50.000Z","date":"2025-12-11","kind":"grant","planned":false,"acquired":true,"shares":933,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transactions reported herein reflect a one-time stock option repricing (the \"Option Repricing\") effective on December 11, 2025 (the \"Repricing Date\"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"1/48th of the shares vest on a monthly basis from January 3, 2022, subject to Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan)."}],"balance_after":933,"derivative":{"exercise_price":104.13,"expiration_date":"2032-01-02","underlying":"Common Stock","underlying_shares":933},"source":{"system":"sec-edgar","filing":"0001533302-25-000009","document":"form4-12152025_111246.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000009/form4-12152025_111246.xml","form_type":"4"}},{"id":969479,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-15T23:54:50.000Z","date":"2025-12-11","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":1933,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transactions reported herein reflect a one-time stock option repricing (the \"Option Repricing\") effective on December 11, 2025 (the \"Repricing Date\"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"1/48th of the shares vest on a monthly basis from December 16, 2021, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan)."}],"balance_after":0,"derivative":{"exercise_price":186,"expiration_date":"2031-12-15","underlying":"Common Stock","underlying_shares":1933},"source":{"system":"sec-edgar","filing":"0001533302-25-000009","document":"form4-12152025_111246.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000009/form4-12152025_111246.xml","form_type":"4"}},{"id":969478,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-15T23:54:50.000Z","date":"2025-12-11","kind":"grant","planned":false,"acquired":true,"shares":1933,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transactions reported herein reflect a one-time stock option repricing (the \"Option Repricing\") effective on December 11, 2025 (the \"Repricing Date\"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"1/48th of the shares vest on a monthly basis from December 16, 2021, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan)."}],"balance_after":1933,"derivative":{"exercise_price":104.13,"expiration_date":"2031-12-15","underlying":"Common Stock","underlying_shares":1933},"source":{"system":"sec-edgar","filing":"0001533302-25-000009","document":"form4-12152025_111246.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000009/form4-12152025_111246.xml","form_type":"4"}},{"id":969477,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-15T23:54:50.000Z","date":"2025-12-11","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":733,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transactions reported herein reflect a one-time stock option repricing (the \"Option Repricing\") effective on December 11, 2025 (the \"Repricing Date\"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option are fully vested and exercisable."}],"balance_after":0,"derivative":{"exercise_price":1506,"expiration_date":"2031-01-27","underlying":"Common Stock","underlying_shares":733},"source":{"system":"sec-edgar","filing":"0001533302-25-000009","document":"form4-12152025_111246.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000009/form4-12152025_111246.xml","form_type":"4"}},{"id":969476,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-15T23:54:50.000Z","date":"2025-12-11","kind":"grant","planned":false,"acquired":true,"shares":733,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transactions reported herein reflect a one-time stock option repricing (the \"Option Repricing\") effective on December 11, 2025 (the \"Repricing Date\"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option are fully vested and exercisable."}],"balance_after":733,"derivative":{"exercise_price":104.13,"expiration_date":"2031-01-27","underlying":"Common Stock","underlying_shares":733},"source":{"system":"sec-edgar","filing":"0001533302-25-000009","document":"form4-12152025_111246.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000009/form4-12152025_111246.xml","form_type":"4"}},{"id":969475,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-15T23:54:50.000Z","date":"2025-12-11","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":953,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transactions reported herein reflect a one-time stock option repricing (the \"Option Repricing\") effective on December 11, 2025 (the \"Repricing Date\"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option are fully vested and exercisable."}],"balance_after":0,"derivative":{"exercise_price":230.25,"expiration_date":"2030-08-06","underlying":"Common Stock","underlying_shares":953},"source":{"system":"sec-edgar","filing":"0001533302-25-000009","document":"form4-12152025_111246.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000009/form4-12152025_111246.xml","form_type":"4"}},{"id":969474,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-15T23:54:50.000Z","date":"2025-12-11","kind":"grant","planned":false,"acquired":true,"shares":953,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transactions reported herein reflect a one-time stock option repricing (the \"Option Repricing\") effective on December 11, 2025 (the \"Repricing Date\"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option are fully vested and exercisable."}],"balance_after":953,"derivative":{"exercise_price":104.13,"expiration_date":"2030-08-06","underlying":"Common Stock","underlying_shares":953},"source":{"system":"sec-edgar","filing":"0001533302-25-000009","document":"form4-12152025_111246.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000009/form4-12152025_111246.xml","form_type":"4"}},{"id":969473,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-15T23:54:50.000Z","date":"2025-12-11","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":1579,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transactions reported herein reflect a one-time stock option repricing (the \"Option Repricing\") effective on December 11, 2025 (the \"Repricing Date\"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option are fully vested and exercisable."}],"balance_after":0,"derivative":{"exercise_price":123,"expiration_date":"2030-06-07","underlying":"Common Stock","underlying_shares":1579},"source":{"system":"sec-edgar","filing":"0001533302-25-000009","document":"form4-12152025_111246.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000009/form4-12152025_111246.xml","form_type":"4"}},{"id":969472,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-15T23:54:50.000Z","date":"2025-12-11","kind":"grant","planned":false,"acquired":true,"shares":1579,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transactions reported herein reflect a one-time stock option repricing (the \"Option Repricing\") effective on December 11, 2025 (the \"Repricing Date\"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option are fully vested and exercisable."}],"balance_after":1579,"derivative":{"exercise_price":104.13,"expiration_date":"2030-06-07","underlying":"Common Stock","underlying_shares":1579},"source":{"system":"sec-edgar","filing":"0001533302-25-000009","document":"form4-12152025_111246.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000009/form4-12152025_111246.xml","form_type":"4"}},{"id":971198,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Restricted Stock Units","published_at":"2025-12-13T00:05:39.000Z","date":"2025-12-11","kind":"exercise","planned":false,"acquired":false,"shares":1900,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each RSU represents a contingent right to receive one share of SPRB common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"25% of the total number of RSUs vested on grant. 25% of the total number of RSUs will vest on December 15, 2026, December 15, 2027 and December 15, 2028, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date. On December 11, 2025, 1,900 shares vested and 680 shares were withheld for taxes, resulting in a net issuance of 1,220 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"25% of the total number of RSUs vested on grant. 25% of the total number of RSUs will vest on December 15, 2026, December 15, 2027 and December 15, 2028, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date. On December 11, 2025, 1,900 shares vested and 680 shares were withheld for taxes, resulting in a net issuance of 1,220 shares."}],"balance_after":5700,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":1900},"source":{"system":"sec-edgar","filing":"0001533302-25-000007","document":"form4-12132025_121236.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000007/form4-12132025_121236.xml","form_type":"4"}},{"id":971197,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Restricted Stock Units","published_at":"2025-12-13T00:05:39.000Z","date":"2025-12-11","kind":"grant","planned":false,"acquired":true,"shares":7600,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each RSU represents a contingent right to receive one share of SPRB common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"25% of the total number of RSUs vested on grant. 25% of the total number of RSUs will vest on December 15, 2026, December 15, 2027 and December 15, 2028, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date. On December 11, 2025, 1,900 shares vested and 680 shares were withheld for taxes, resulting in a net issuance of 1,220 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"25% of the total number of RSUs vested on grant. 25% of the total number of RSUs will vest on December 15, 2026, December 15, 2027 and December 15, 2028, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date. On December 11, 2025, 1,900 shares vested and 680 shares were withheld for taxes, resulting in a net issuance of 1,220 shares."}],"balance_after":7600,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":7600},"source":{"system":"sec-edgar","filing":"0001533302-25-000007","document":"form4-12132025_121236.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000007/form4-12132025_121236.xml","form_type":"4"}},{"id":971196,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Restricted Stock Units","published_at":"2025-12-13T00:05:39.000Z","date":"2025-12-10","kind":"exercise","planned":false,"acquired":false,"shares":514,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each RSU represents a contingent right to receive one share of SPRB common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"On March 14, 2024, the Reporting Person was granted a total of 2,053 RSU's. Subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date, 25% of the total number of RSUs vested on December 10, 2025, the first anniversary of the achievement of a specified clinical development objective. 25% of the total number of the RSUs will vest on each of the second, third and fourth anniversaries of such achievement.  On December 10, 2025, 514 shares vested and 184 shares were withheld for taxes, resulting in a net issuance of 330 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"On March 14, 2024, the Reporting Person was granted a total of 2,053 RSU's. Subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date, 25% of the total number of RSUs vested on December 10, 2025, the first anniversary of the achievement of a specified clinical development objective. 25% of the total number of the RSUs will vest on each of the second, third and fourth anniversaries of such achievement.  On December 10, 2025, 514 shares vested and 184 shares were withheld for taxes, resulting in a net issuance of 330 shares."}],"balance_after":1539,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":514},"source":{"system":"sec-edgar","filing":"0001533302-25-000007","document":"form4-12132025_121236.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000007/form4-12132025_121236.xml","form_type":"4"}},{"id":971195,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Common Stock","published_at":"2025-12-13T00:05:39.000Z","date":"2025-12-11","kind":"tax_withholding","planned":false,"acquired":false,"shares":680,"price":88.41,"value":60118.8,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"25% of the total number of RSUs vested on grant. 25% of the total number of RSUs will vest on December 15, 2026, December 15, 2027 and December 15, 2028, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date. On December 11, 2025, 1,900 shares vested and 680 shares were withheld for taxes, resulting in a net issuance of 1,220 shares."}],"balance_after":7616,"source":{"system":"sec-edgar","filing":"0001533302-25-000007","document":"form4-12132025_121236.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000007/form4-12132025_121236.xml","form_type":"4"}},{"id":971194,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Common Stock","published_at":"2025-12-13T00:05:39.000Z","date":"2025-12-11","kind":"exercise","planned":false,"acquired":true,"shares":1900,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"25% of the total number of RSUs vested on grant. 25% of the total number of RSUs will vest on December 15, 2026, December 15, 2027 and December 15, 2028, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date. On December 11, 2025, 1,900 shares vested and 680 shares were withheld for taxes, resulting in a net issuance of 1,220 shares."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Each RSU represents a contingent right to receive one share of SPRB common stock."}],"balance_after":8296,"source":{"system":"sec-edgar","filing":"0001533302-25-000007","document":"form4-12132025_121236.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000007/form4-12132025_121236.xml","form_type":"4"}},{"id":971193,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Common Stock","published_at":"2025-12-13T00:05:39.000Z","date":"2025-12-10","kind":"tax_withholding","planned":false,"acquired":false,"shares":184,"price":85.67,"value":15763.28,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"On March 14, 2024, the Reporting Person was granted a total of 2,053 RSU's. Subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date, 25% of the total number of RSUs vested on December 10, 2025, the first anniversary of the achievement of a specified clinical development objective. 25% of the total number of the RSUs will vest on each of the second, third and fourth anniversaries of such achievement.  On December 10, 2025, 514 shares vested and 184 shares were withheld for taxes, resulting in a net issuance of 330 shares."}],"balance_after":6396,"source":{"system":"sec-edgar","filing":"0001533302-25-000007","document":"form4-12132025_121236.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000007/form4-12132025_121236.xml","form_type":"4"}},{"id":971192,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Common Stock","published_at":"2025-12-13T00:05:39.000Z","date":"2025-12-10","kind":"exercise","planned":false,"acquired":true,"shares":514,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"On March 14, 2024, the Reporting Person was granted a total of 2,053 RSU's. Subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date, 25% of the total number of RSUs vested on December 10, 2025, the first anniversary of the achievement of a specified clinical development objective. 25% of the total number of the RSUs will vest on each of the second, third and fourth anniversaries of such achievement.  On December 10, 2025, 514 shares vested and 184 shares were withheld for taxes, resulting in a net issuance of 330 shares."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Each RSU represents a contingent right to receive one share of SPRB common stock."}],"balance_after":6580,"source":{"system":"sec-edgar","filing":"0001533302-25-000007","document":"form4-12132025_121236.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000007/form4-12132025_121236.xml","form_type":"4"}},{"id":1014691,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Restricted Stock Units","published_at":"2025-10-22T20:15:07.000Z","date":"2025-10-20","kind":"exercise","planned":false,"acquired":false,"shares":2053,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each Restricted Stock Unit (\"RSU\")  represents a contingent right to receive one share of SPRB common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"On March 14, 2024, the Reporting Person was granted 2,053\n performance-based RSUs. On October 20, 2025, the Issuer's Board of Directors certified that certain specified performance goals were met and all of the RSUs vested. 661 shares were withheld for taxes, resulting in a net issuance of 1,392 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"On March 14, 2024, the Reporting Person was granted 2,053\n performance-based RSUs. On October 20, 2025, the Issuer's Board of Directors certified that certain specified performance goals were met and all of the RSUs vested. 661 shares were withheld for taxes, resulting in a net issuance of 1,392 shares."}],"balance_after":0,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":2053},"source":{"system":"sec-edgar","filing":"0001533302-25-000004","document":"form4-10222025_041003.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000004/form4-10222025_041003.xml","form_type":"4"}},{"id":1014690,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Restricted Stock Units","published_at":"2025-10-22T20:15:07.000Z","date":"2025-10-20","kind":"grant","planned":false,"acquired":true,"shares":2053,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each Restricted Stock Unit (\"RSU\")  represents a contingent right to receive one share of SPRB common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"On March 14, 2024, the Reporting Person was granted 2,053\n performance-based RSUs. On October 20, 2025, the Issuer's Board of Directors certified that certain specified performance goals were met and all of the RSUs vested. 661 shares were withheld for taxes, resulting in a net issuance of 1,392 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"On March 14, 2024, the Reporting Person was granted 2,053\n performance-based RSUs. On October 20, 2025, the Issuer's Board of Directors certified that certain specified performance goals were met and all of the RSUs vested. 661 shares were withheld for taxes, resulting in a net issuance of 1,392 shares."}],"balance_after":2053,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":2053},"source":{"system":"sec-edgar","filing":"0001533302-25-000004","document":"form4-10222025_041003.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000153330225000004/form4-10222025_041003.xml","form_type":"4"}},{"id":1014689,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"PRESIDENT AND CFO"}}],"security":"Common Stock","published_at":"2025-10-22T20:15:07.000Z","date":"2025-10-20","kind":"tax_withholding","planned":false,"acquired":false,"shares":661,"price":148.16,"value":97933.76,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"On March 14, 2024, the Reporting Person was granted 2,053\n performance-based RSUs. 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On December 15, 2024, 37,250 RSUs vested, with 13,291 shares being withheld for taxes, resulting in a net issuance of 23,959 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"On December 5, 2022, the Reporting Person was granted 149,000 time-based restricted stock units (\"RSUs\"), subject to a 4-year vesting schedule, with 25% of the total number of RSUs vested on December 15, 2023 (the \"Annual Vesting Date\") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). 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An additional 50% or 154,000 of the total RSUs are time-based.  25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  On December 15, 2024, 38,500 shares vested and 13,737 shares were withheld for taxes, resulting in a net issuance of 24,763 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"On December 14, 2023, the Reporting Person was granted a total of 308,000 RSUs.  50% or 154,000 of the total RSUs are performance-based and since certain specified performance goals were met, they all vested on December 10, 2024.  An additional 50% or 154,000 of the total RSUs are time-based.  25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  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An additional 50% or 154,000 of the total RSUs are time-based.  25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  On December 15, 2024, 38,500 shares vested and 13,737 shares were withheld for taxes, resulting in a net issuance of 24,763 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"On December 14, 2023, the Reporting Person was granted a total of 308,000 RSUs.  50% or 154,000 of the total RSUs are performance-based and since certain specified performance goals were met, they all vested on December 10, 2024.  An additional 50% or 154,000 of the total RSUs are time-based.  25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  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An additional 50% or 154,000 of the total RSUs are time-based.  25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  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An additional 50% or 154,000 of the total RSUs are time-based.  25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  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An additional 50% or 154,000 of the total RSUs are time-based.  25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  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An additional 50% or 154,000 of the total RSUs are time-based.  25% of which vested on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  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On December 15, 2023, 37,250 RSUs vested, with 12,882 shares being withheld for taxes, resulting in a net issuance of 24,368 shares."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"On December 5, 2022, the Reporting Person was granted 149,000 time-based RSUs, subject to a 4-year vesting schedule, with 25% of the total number of RSUs to vest on December 15, 2023 (the \"Annual Vesting Date\") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2023, 37,250 RSUs vested, with 12,882 shares being withheld for taxes, resulting in a net issuance of 24,368 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"On December 5, 2022, the Reporting Person was granted 149,000 time-based RSUs, subject to a 4-year vesting schedule, with 25% of the total number of RSUs to vest on December 15, 2023 (the \"Annual Vesting Date\") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2023, 37,250 RSUs vested, with 12,882 shares being withheld for taxes, resulting in a net issuance of 24,368 shares."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"Represents the aggregate balance of 111,750 time-based RSUs."}],"balance_after":111750,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":37250},"source":{"system":"sec-edgar","filing":"0001209191-23-059054","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000120919123059054/doc4.xml","form_type":"4"}},{"id":1707252,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President & CFO"}}],"security":"Restricted Stock Units","published_at":"2023-12-19T01:16:35.000Z","date":"2023-12-15","kind":"exercise","planned":false,"acquired":false,"shares":75000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each RSU represents a contingent right to receive one share of SPRB common stock."},{"field":"shares","element":"transactionShares","label":"F1","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based restricted stock units (\"RSUs\"), all of which were fully vested as of June 30, 2023. The Reporting Person was also granted 150,000 performance-based RSUs, which vest in two equal installments upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On November 8, 2023, the Compensation Committee of the Issuer's Board of Directors certified the achievement of certain specified performance goals, resulting in the vesting of 75,000 performance-based RSUs effective December 15, 2023. On December 15, 2023, 23,213 shares were withheld for taxes, resulting in a net issuance of 51,787 shares."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based restricted stock units (\"RSUs\"), all of which were fully vested as of June 30, 2023. The Reporting Person was also granted 150,000 performance-based RSUs, which vest in two equal installments upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On November 8, 2023, the Compensation Committee of the Issuer's Board of Directors certified the achievement of certain specified performance goals, resulting in the vesting of 75,000 performance-based RSUs effective December 15, 2023. On December 15, 2023, 23,213 shares were withheld for taxes, resulting in a net issuance of 51,787 shares."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based restricted stock units (\"RSUs\"), all of which were fully vested as of June 30, 2023. The Reporting Person was also granted 150,000 performance-based RSUs, which vest in two equal installments upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On November 8, 2023, the Compensation Committee of the Issuer's Board of Directors certified the achievement of certain specified performance goals, resulting in the vesting of 75,000 performance-based RSUs effective December 15, 2023. On December 15, 2023, 23,213 shares were withheld for taxes, resulting in a net issuance of 51,787 shares."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F6","text":"Represents the aggregate balance of 75,000 performance-based RSUs."}],"balance_after":75000,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":75000},"source":{"system":"sec-edgar","filing":"0001209191-23-059054","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000120919123059054/doc4.xml","form_type":"4"}},{"id":1707251,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President & CFO"}}],"security":"Restricted Stock Units","published_at":"2023-12-19T01:16:35.000Z","date":"2023-12-14","kind":"grant","planned":false,"acquired":true,"shares":308000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each RSU represents a contingent right to receive one share of SPRB common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"154,000 of the RSUs shall vest as to 25% on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"154,000 of the RSUs shall vest upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"154,000 of the RSUs shall vest as to 25% on December 15, 2024, and in equal annual installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"154,000 of the RSUs shall vest upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan)."}],"balance_after":308000,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":308000},"source":{"system":"sec-edgar","filing":"0001209191-23-059054","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000120919123059054/doc4.xml","form_type":"4"}},{"id":1707250,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President & CFO"}}],"security":"Common Stock","published_at":"2023-12-19T01:16:35.000Z","date":"2023-12-15","kind":"tax_withholding","planned":false,"acquired":false,"shares":12882,"price":1.66,"value":21384.12,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"On December 5, 2022, the Reporting Person was granted 149,000 time-based RSUs, subject to a 4-year vesting schedule, with 25% of the total number of RSUs to vest on December 15, 2023 (the \"Annual Vesting Date\") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2023, 37,250 RSUs vested, with 12,882 shares being withheld for taxes, resulting in a net issuance of 24,368 shares."}],"balance_after":191521,"source":{"system":"sec-edgar","filing":"0001209191-23-059054","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000120919123059054/doc4.xml","form_type":"4"}},{"id":1707249,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President & CFO"}}],"security":"Common Stock","published_at":"2023-12-19T01:16:35.000Z","date":"2023-12-15","kind":"exercise","planned":false,"acquired":true,"shares":37250,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"On December 5, 2022, the Reporting Person was granted 149,000 time-based RSUs, subject to a 4-year vesting schedule, with 25% of the total number of RSUs to vest on December 15, 2023 (the \"Annual Vesting Date\") and 25% of the total number of RSUs to vest in annual installments on each anniversary of the Annual Vesting Date thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On December 15, 2023, 37,250 RSUs vested, with 12,882 shares being withheld for taxes, resulting in a net issuance of 24,368 shares."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Each RSU represents a contingent right to receive one share of SPRB common stock."}],"balance_after":204403,"source":{"system":"sec-edgar","filing":"0001209191-23-059054","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000120919123059054/doc4.xml","form_type":"4"}},{"id":1707248,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President & CFO"}}],"security":"Common Stock","published_at":"2023-12-19T01:16:35.000Z","date":"2023-12-15","kind":"tax_withholding","planned":false,"acquired":false,"shares":23213,"price":1.66,"value":38533.58,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based restricted stock units (\"RSUs\"), all of which were fully vested as of June 30, 2023. The Reporting Person was also granted 150,000 performance-based RSUs, which vest in two equal installments upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On November 8, 2023, the Compensation Committee of the Issuer's Board of Directors certified the achievement of certain specified performance goals, resulting in the vesting of 75,000 performance-based RSUs effective December 15, 2023. On December 15, 2023, 23,213 shares were withheld for taxes, resulting in a net issuance of 51,787 shares."}],"balance_after":167153,"source":{"system":"sec-edgar","filing":"0001209191-23-059054","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000120919123059054/doc4.xml","form_type":"4"}},{"id":1707247,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President & CFO"}}],"security":"Common Stock","published_at":"2023-12-19T01:16:35.000Z","date":"2023-12-15","kind":"exercise","planned":false,"acquired":true,"shares":75000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based restricted stock units (\"RSUs\"), all of which were fully vested as of June 30, 2023. The Reporting Person was also granted 150,000 performance-based RSUs, which vest in two equal installments upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). On November 8, 2023, the Compensation Committee of the Issuer's Board of Directors certified the achievement of certain specified performance goals, resulting in the vesting of 75,000 performance-based RSUs effective December 15, 2023. On December 15, 2023, 23,213 shares were withheld for taxes, resulting in a net issuance of 51,787 shares."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Each RSU represents a contingent right to receive one share of SPRB common stock."}],"balance_after":190366,"source":{"system":"sec-edgar","filing":"0001209191-23-059054","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000120919123059054/doc4.xml","form_type":"4"}},{"id":1743979,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President & CFO"}}],"security":"Restricted Stock Units","published_at":"2023-11-14T00:01:12.000Z","date":"2023-11-08","kind":"grant","planned":false,"acquired":true,"shares":75000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit (\"RSU\") represents a contingent right to receive one share of SPRB common stock."},{"field":"shares","element":"transactionShares","label":"F2","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based RSUs, all of which were fully vested as of June 30, 2023.  The Reporting Person was also granted 150,000 performance-based RSUs, which vest in two equal installments upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  On November 8, 2023, the Compensation Committee of the Issuer's Board of Directors certified the achievement of certain specified performance goals, resulting in the vesting of 75,000 performance-based RSUs effective December 15, 2023."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based RSUs, all of which were fully vested as of June 30, 2023.  The Reporting Person was also granted 150,000 performance-based RSUs, which vest in two equal installments upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  On November 8, 2023, the Compensation Committee of the Issuer's Board of Directors certified the achievement of certain specified performance goals, resulting in the vesting of 75,000 performance-based RSUs effective December 15, 2023."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based RSUs, all of which were fully vested as of June 30, 2023.  The Reporting Person was also granted 150,000 performance-based RSUs, which vest in two equal installments upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  On November 8, 2023, the Compensation Committee of the Issuer's Board of Directors certified the achievement of certain specified performance goals, resulting in the vesting of 75,000 performance-based RSUs effective December 15, 2023."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"Represents the aggregate balance of 75,000 performance-based RSUs."}],"balance_after":75000,"derivative":{"underlying":"Common Stock","underlying_shares":75000},"source":{"system":"sec-edgar","filing":"0001209191-23-055077","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000120919123055077/doc4.xml","form_type":"4"}},{"id":1836250,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President & CFO"}}],"security":"Restricted Stock Units","published_at":"2023-07-05T22:00:08.000Z","date":"2023-06-30","kind":"exercise","planned":false,"acquired":false,"shares":75000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each restricted stock unit (\"RSU\") represents a contingent right to receive one share of SPRB common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based RSUs.  25% of the RSUs vested on each of June 30, 2022 and December 31, 2022 and 50% vested on June 30, 2023, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  The Reporting Person was also granted 150,000 performance-based RSUs on December 16, 2021, which shall vest upon the achievement of specified performance goals."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based RSUs.  25% of the RSUs vested on each of June 30, 2022 and December 31, 2022 and 50% vested on June 30, 2023, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  The Reporting Person was also granted 150,000 performance-based RSUs on December 16, 2021, which shall vest upon the achievement of specified performance goals."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"Represents the aggregate balance of 150,000 performance-based RSUs."}],"balance_after":150000,"derivative":{"underlying":"Common Stock","underlying_shares":75000},"source":{"system":"sec-edgar","filing":"0001209191-23-041250","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000120919123041250/doc4.xml","form_type":"4"}},{"id":1836249,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir 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Issuer's 2020 Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c)."}],"balance_after":66302,"source":{"system":"sec-edgar","filing":"0001209191-23-041250","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1683553/000120919123041250/doc4.xml","form_type":"4"}},{"id":2062740,"issuer":{"id":6471,"kind":"organization","name":"SPRUCE BIOSCIENCES, INC."},"owners":[{"id":71314,"kind":"person","name":"Gharib Samir M.","position":1,"cik":"0001533302","reported_name":"Gharib Samir M.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President & CFO"}}],"security":"Restricted Stock 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The underlying common stock of the RSUs that vested on December 31, 2022, a non-trading date, were settled on January 3, 2023.  The Reporting Person was also granted 150,000 performance-based RSUs on December 16, 2021, which shall vest upon the achievement of specified performance goals."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"On December 16, 2021, the Reporting Person was granted 150,000 time-based RSUs.  25% of the RSUs vested on each of June 30, 2022 and December 31, 2022 and 50% shall vest on June 30, 2023, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan).  The underlying common stock of the RSUs that vested on December 31, 2022, a non-trading date, were settled on January 3, 2023.  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