{"transactions":[{"id":919634,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":67763,"kind":"person","name":"Macomber Lori","position":1,"cik":"0001968671","reported_name":"Macomber Lori","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, CFO & Treasurer"}}],"security":"Common Stock","published_at":"2026-02-04T16:11:52.000Z","date":"2026-02-03","kind":"sale","planned":false,"acquired":false,"shares":1626,"price":6.3,"value":10243.8,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was effected pursuant to a durable automatic sale instruction plan adopted by the reporting person on December 19, 2024, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units. The sale does not represent a discretionary trade by the reporting person."}],"balance_after":85105,"source":{"system":"sec-edgar","filing":"0001193125-26-037584","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1968671/000119312526037584/ownership.xml","form_type":"4"}},{"id":922216,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":67763,"kind":"person","name":"Macomber Lori","position":1,"cik":"0001968671","reported_name":"Macomber Lori","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, CFO & Treasurer"}}],"security":"Common Stock","published_at":"2026-02-03T16:29:25.000Z","date":"2026-01-31","kind":"grant","planned":false,"acquired":true,"shares":32415,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents the award of restricted stock units (\"RSUs\") pursuant to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan, as amended. RSUs convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis. The RSUs vest as to 50% of the shares on January 31, 2027, with the remaining 50% vesting on January 31, 2028."}],"balance_after":86731,"source":{"system":"sec-edgar","filing":"0001193125-26-035663","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1968671/000119312526035663/ownership.xml","form_type":"4"}},{"id":1017692,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":67763,"kind":"person","name":"Macomber Lori","position":1,"cik":"0001968671","reported_name":"Macomber Lori","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, CFO & Treasurer"}}],"security":"Common Stock","published_at":"2025-10-16T16:25:00.000Z","date":"2025-10-15","kind":"grant","planned":false,"acquired":true,"shares":43650,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents the award of restricted stock units (\"RSUs\") pursuant to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan, as amended. RSUs convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis. The RSUs vest 100% on December 31, 2026."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"Amounts reported in this Form 4 reflect the one-for-fifteen reverse stock split effected by the Issuer on February 25, 2025."}],"balance_after":54316,"source":{"system":"sec-edgar","filing":"0001193125-25-241461","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1968671/000119312525241461/ownership.xml","form_type":"4"}},{"id":1287592,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":67763,"kind":"person","name":"Macomber Lori","position":1,"cik":"0001968671","reported_name":"Macomber Lori","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, CFO & Treasurer"}}],"security":"Stock Option (right to buy)","published_at":"2025-02-03T16:15:35.000Z","date":"2025-01-31","kind":"grant","planned":false,"acquired":true,"shares":650000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"This option was granted on January 31, 2025 pursuant to the Plan. The shares underlying this option vest as to 25% of the shares on January 31, 2026, with the remaining 75% vesting in 36 equal monthly installments thereafter."}],"balance_after":650000,"derivative":{"exercise_price":0.6221,"expiration_date":"2035-01-30","underlying":"Common Stock","underlying_shares":650000},"source":{"system":"sec-edgar","filing":"0000950170-25-012326","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1968671/000095017025012326/ownership.xml","form_type":"4"}},{"id":1287591,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":67763,"kind":"person","name":"Macomber Lori","position":1,"cik":"0001968671","reported_name":"Macomber Lori","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, CFO & Treasurer"}}],"security":"Common Stock","published_at":"2025-02-03T16:15:35.000Z","date":"2025-01-31","kind":"grant","planned":false,"acquired":true,"shares":160000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents the award of restricted stock units (\"RSUs\") pursuant to the Karyopharm Therapeutics Inc. 2022 Inducement Stock Incentive Plan, as amended (the \"Plan\"). RSUs convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis. The RSUs vest in three equal annual installments beginning January 31, 2026."}],"balance_after":160000,"source":{"system":"sec-edgar","filing":"0000950170-25-012326","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1968671/000095017025012326/ownership.xml","form_type":"4"}}]}