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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":126307,"source":{"system":"sec-edgar","filing":"0000874015-26-000065","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000065/edgardoc.xml","form_type":"4"}},{"id":936212,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2026-01-21T01:18:32.000Z","date":"2026-01-15","kind":"exercise","planned":false,"acquired":true,"shares":28729,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":139229,"source":{"system":"sec-edgar","filing":"0000874015-26-000065","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000065/edgardoc.xml","form_type":"4"}},{"id":948709,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-01-06T22:34:40.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":25770,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2026 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on\n01/02/2026. 25% of the shares subject to the option will vest and become exercisable on 01/02/2027. 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These shares were sold in multiple transactions at prices ranging from $65.00 to $65.52 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":110500,"source":{"system":"sec-edgar","filing":"0000874015-25-000238","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000238/edgardoc.xml","form_type":"4"}},{"id":1029958,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2025-10-01T20:55:20.000Z","date":"2025-09-30","kind":"exercise","planned":true,"acquired":true,"shares":49800,"price":53.77,"value":2677746.0,"ownership":{"direct":true},"balance_after":160300,"source":{"system":"sec-edgar","filing":"0000874015-25-000238","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000238/edgardoc.xml","form_type":"4"}},{"id":1101270,"issuer":{"id":5404,"kind":"organization","name":"Artiva Biotherapeutics, Inc.","symbol":"ARTV"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Director Stock Option (Right to Buy)","published_at":"2025-06-26T20:30:17.000Z","date":"2025-06-24","kind":"grant","planned":false,"acquired":true,"shares":13750,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option will vest in full on the earlier of  June 24, 2026, or the date of the Issuer's 2026 annual stockholder meeting."}],"balance_after":13750,"derivative":{"exercise_price":1.61,"expiration_date":"2035-06-23","underlying":"Common Stock","underlying_shares":13750},"source":{"system":"sec-edgar","filing":"0001415889-25-018277","document":"form4-06262025_040606.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1074773/000141588925018277/form4-06262025_040606.xml","form_type":"4"}},{"id":1288303,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2025-02-04T00:26:50.000Z","date":"2025-01-31","kind":"sale","planned":false,"acquired":false,"shares":1523,"price":32.4384,"value":49403.6832,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.00 to $32.81 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":110500,"source":{"system":"sec-edgar","filing":"0000874015-25-000077","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000077/edgardoc.xml","form_type":"4"}},{"id":1288302,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2025-02-04T00:26:50.000Z","date":"2025-01-30","kind":"grant","planned":false,"acquired":true,"shares":4138,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the final performance period of the grant to the reporting person reported on January 19, 2022. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 150% of target shares. As reported at grant, the PRSUs could result in a payout of 0% to 150% based on actual achievement of the goal."}],"balance_after":112023,"source":{"system":"sec-edgar","filing":"0000874015-25-000077","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000077/edgardoc.xml","form_type":"4"}},{"id":1300984,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Restricted Stock Unit","published_at":"2025-01-18T00:40:35.000Z","date":"2025-01-15","kind":"exercise","planned":false,"acquired":false,"shares":23887,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F7","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F8","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":84669,"derivative":{"exercise_price":0,"exercise_date":"2025-01-15","underlying":"Common Stock","underlying_shares":23887},"source":{"system":"sec-edgar","filing":"0000874015-25-000060","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000060/edgardoc.xml","form_type":"4"}},{"id":1300983,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Restricted Stock Unit","published_at":"2025-01-18T00:40:35.000Z","date":"2025-01-15","kind":"grant","planned":false,"acquired":true,"shares":46500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F6","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F7","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F8","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":108556,"derivative":{"exercise_price":0,"exercise_date":"2026-01-15","underlying":"Common Stock","underlying_shares":46500},"source":{"system":"sec-edgar","filing":"0000874015-25-000060","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000060/edgardoc.xml","form_type":"4"}},{"id":1300982,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Performance Restricted Stock Units","published_at":"2025-01-18T00:40:35.000Z","date":"2025-01-15","kind":"grant","planned":false,"acquired":true,"shares":31000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F4","text":"Grant to reporting person of Performance Restricted Stock Units (PRSUs) under the Ionis Pharmaceuticals, Inc. 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No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."}],"balance_after":86635,"derivative":{"exercise_price":0,"exercise_date":"2028-01-15","underlying":"Common Stock","underlying_shares":31000},"source":{"system":"sec-edgar","filing":"0000874015-25-000060","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000060/edgardoc.xml","form_type":"4"}},{"id":1300981,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2025-01-18T00:40:35.000Z","date":"2025-01-16","kind":"sale","planned":false,"acquired":false,"shares":8870,"price":32.806,"value":290989.22,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.80 to $32.82 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":107885,"source":{"system":"sec-edgar","filing":"0000874015-25-000060","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000060/edgardoc.xml","form_type":"4"}},{"id":1300980,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2025-01-18T00:40:35.000Z","date":"2025-01-15","kind":"exercise","planned":false,"acquired":true,"shares":23887,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":116755,"source":{"system":"sec-edgar","filing":"0000874015-25-000060","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000060/edgardoc.xml","form_type":"4"}},{"id":1312094,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-01-06T21:55:06.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":31000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2025 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on\n01/02/2025. 25% of the shares subject to the option will vest and become exercisable on 01/02/2026. 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These shares were sold in multiple transactions at prices ranging from $49.53 to $49.55 inclusive. The\nreporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange\nCommission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"The original Form 4 filed on February 2, 2024 reported 2,125 restricted stock units sold by the reporting person which has been revised by this amendment to reflect\nthe actual amount of shares sold and beneficially owned by Ms. Hougen."}],"balance_after":92868,"source":{"system":"sec-edgar","filing":"0000874015-24-000199","document":"primary_doc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000199/primary_doc.xml","form_type":"4/A","original_submission_date":"2024-02-02"}},{"id":1662912,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2024-02-03T00:55:15.000Z","date":"2024-02-02","kind":"sale","planned":false,"acquired":false,"shares":2125,"price":49.5399,"value":105272.2875,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Performance restricted Stock Unit Agreement and Grant Notice."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.53 to $49.55 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":92905,"source":{"system":"sec-edgar","filing":"0000874015-24-000106","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000106/edgardoc.xml","form_type":"4"}},{"id":1662911,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2024-02-03T00:55:15.000Z","date":"2024-02-01","kind":"grant","planned":false,"acquired":true,"shares":4140,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the second performance period of the grant to the reporting person reported on January 19, 2022. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 150% of target shares. 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Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. 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These shares were sold in multiple transactions at prices ranging from $50.35 to $50.43, inclusive. The reporting person undertakes to provide to Ionis\nPharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) of this Form 4."}],"balance_after":90890,"source":{"system":"sec-edgar","filing":"0000874015-24-000075","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000075/edgardoc.xml","form_type":"4"}},{"id":1677155,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2024-01-18T22:48:09.000Z","date":"2024-01-16","kind":"exercise","planned":false,"acquired":true,"shares":22487,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":99573,"source":{"system":"sec-edgar","filing":"0000874015-24-000075","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000075/edgardoc.xml","form_type":"4"}},{"id":1678511,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Restricted Stock Unit","published_at":"2024-01-18T01:50:04.000Z","date":"2024-01-15","kind":"grant","planned":false,"acquired":true,"shares":32400,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 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The reporting person received 1,427 shares of common stock on net exercise of option to purchase 45,225 shares of common stock. Pursuant to the terms of the Company's 2011 Equity Incentive Plan, the Company withheld 43,798 shares of common stock underlying the option for payment of the exercise price and tax withholdings using the closing stock price on December 28, 2023 of $50.50."}],"balance_after":77086,"source":{"system":"sec-edgar","filing":"0000874015-24-000005","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000005/edgardoc.xml","form_type":"4"}},{"id":1697227,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2024-01-02T22:54:31.000Z","date":"2023-12-28","kind":"exercise","planned":false,"acquired":true,"shares":45225,"price":47.34,"value":2140951.5,"ownership":{"direct":true},"balance_after":120884,"source":{"system":"sec-edgar","filing":"0000874015-24-000005","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000005/edgardoc.xml","form_type":"4"}},{"id":1981550,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2023-03-02T22:18:51.000Z","date":"2023-02-28","kind":"other","acquired":true,"shares":163,"price":30.515,"value":4973.945,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":75496,"source":{"system":"sec-edgar","filing":"0000874015-23-000092","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000092/edgardoc.xml","form_type":"4"}},{"id":2029458,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":59557,"kind":"person","name":"HOUGEN ELIZABETH L","position":1,"cik":"0001074773","reported_name":"HOUGEN ELIZABETH L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Finance & CFO"}}],"security":"Common Stock","published_at":"2023-02-07T22:36:43.000Z","date":"2023-02-03","kind":"grant","acquired":true,"shares":4140,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the first performance period of the grant to the reporting person reported on January 19, 2022. 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