{"transactions":[{"id":784375,"issuer":{"id":6828,"kind":"organization","name":"Atara Biotherapeutics, Inc.","symbol":"ATRA"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2026-05-11T21:34:20.000Z","date":"2026-05-07","kind":"purchase","planned":false,"acquired":true,"shares":507407,"price":9.35,"value":4744255.45,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 474,780 of the shares puchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.85 to $9.39 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 1,445,609 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controller owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The reporting persons are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The reporting persons disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":1552000,"source":{"system":"sec-edgar","filing":"0000935836-26-000239","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583626000239/ownership.xml","form_type":"4"}},{"id":802532,"issuer":{"id":4696,"kind":"organization","name":"First Tracks Biotherapeutics, Inc.","symbol":"TRAX"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2026-04-22T21:07:53.000Z","date":"2026-04-20","kind":"sale","planned":false,"acquired":true,"shares":4705575,"price":13.8134,"value":64999989.705,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The Funds sold these share in a private placement described in the Form 8K filed by the Issuer on April 20, 2026."},{"field":"shares","element":"transactionShares","label":"F3","text":"Qualified Fund sold 4,420,064 of the securities in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund holds 2,981,908 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified L.P. (\"Qualified Fund\"). EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interests therein."}],"balance_after":3174519,"source":{"system":"sec-edgar","filing":"0000935836-26-000208","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583626000208/ownership.xml","form_type":"4"}},{"id":941241,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Class A Common Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":true,"shares":86222,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"Each share of Class A Common Stock is convertible into one share of Common Stock at the election of the holder for no additional consideration, subject to a 4.99% beneficial ownership limitation. Each share is immediately exercisable and has no expiration date."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Each share of Class A Common Stock is convertible into one share of Common Stock at the election of the holder for no additional consideration, subject to a 4.99% beneficial ownership limitation. Each share is immediately exercisable and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Each share of Class A Common Stock is convertible into one share of Common Stock at the election of the holder for no additional consideration, subject to a 4.99% beneficial ownership limitation. Each share is immediately exercisable and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held by EcoR1 Capital Fund, L.P. (\"Capital Fund\"). EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":86222,"derivative":{"underlying":"Common Stock","underlying_shares":86222},"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941240,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Class A Common Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":true,"shares":965190,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"Each share of Class A Common Stock is convertible into one share of Common Stock at the election of the holder for no additional consideration, subject to a 4.99% beneficial ownership limitation. Each share is immediately exercisable and has no expiration date."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Each share of Class A Common Stock is convertible into one share of Common Stock at the election of the holder for no additional consideration, subject to a 4.99% beneficial ownership limitation. Each share is immediately exercisable and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Each share of Class A Common Stock is convertible into one share of Common Stock at the election of the holder for no additional consideration, subject to a 4.99% beneficial ownership limitation. Each share is immediately exercisable and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 Capital, LLC (\"EcoR1\") may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":965190,"derivative":{"underlying":"Common Stock","underlying_shares":965190},"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941239,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Series B Redeemable Convertible Preferred Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":false,"shares":102500,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held by EcoR1 Capital Fund, L.P. (\"Capital Fund\"). EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":26942},"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941238,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Series B Redeemable Convertible Preferred Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":false,"shares":2397500,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 Capital, LLC (\"EcoR1\") may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":630191},"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941237,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Series A Redeemable Convertible Preferred Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":false,"shares":488891,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held by EcoR1 Venture Opportunity Fund, L.P. (\"Venture Fund\"). EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":128506},"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941236,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Series A Redeemable Convertible Preferred Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":false,"shares":997299,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held by EcoR1 Capital Fund, L.P. (\"Capital Fund\"). EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":262142},"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941235,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Series A Redeemable Convertible Preferred Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":false,"shares":9913810,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 Capital, LLC (\"EcoR1\") may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":2605878},"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941234,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"purchase","planned":false,"acquired":true,"shares":144443,"price":18,"value":2599974.0,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held by EcoR1 Capital Fund, L.P. (\"Capital Fund\"). EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":347305,"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941233,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"purchase","planned":false,"acquired":true,"shares":2077779,"price":18,"value":37400022.0,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 Capital, LLC (\"EcoR1\") may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":4348658,"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941232,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":true,"shares":128506,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held by EcoR1 Venture Opportunity Fund, L.P. (\"Venture Fund\"). EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":128506,"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941231,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":true,"shares":202862,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held by EcoR1 Capital Fund, L.P. (\"Capital Fund\"). EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":202862,"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":941230,"issuer":{"id":4711,"kind":"organization","name":"Aktis Oncology, Inc.","symbol":"AKTS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-01-13T01:28:36.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":true,"shares":2270879,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The shares of Series A Redeemable Convertible Preferred Stock and Series B Redeemable Convertible Preferred Stock converted into shares of Common Stock and Class A Common Stock on a 3.8044-for-1 basis immediately prior to the closing of the initial public offering of the Issuer's Common Stock for no additional consideration. Each share was immediately exercisable and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 Capital, LLC (\"EcoR1\") may be deemed to indirectly beneficially own them as the investment adviser to and general partner of the fund. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1."}],"balance_after":2270879,"source":{"system":"sec-edgar","filing":"0000935836-26-000031","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2035832/000093583626000031/ownership.xml","form_type":"4"}},{"id":1078949,"issuer":{"id":9824,"kind":"organization","name":"Adaptimmune Therapeutics PLC"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2025-07-30T22:20:32.000Z","date":"2025-07-30","kind":"sale","planned":false,"acquired":false,"shares":27433338,"price":0.1021,"value":2800943.8098,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"These Ordinary Shares are held through American Depositary Shares (\"ADS\") of the Issuer. Each ADS represents 6 Ordinary Shares."},{"field":"shares","element":"transactionShares","label":"F9","text":"The reporting persons sold 4,572,223 ADSs representing 27,433,338 Ordinary Shares. Qualified Fund sold 4,270,000 of those ADSs, representing 25,620,000 Ordinary Shares."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The price reported in Column 4 is the price per ADS sold by the reporting persons."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F10","text":"After this transaction, the reporting persons beneficially owned 16,728,647 ADSs, including 15,881,331 ADSs held by Qualified Fund representing 95,287,986 Ordinary Shares."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The reporting persons are EcoR1 Capital, LLC (\"Ecor1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Fund\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":100371882,"source":{"system":"sec-edgar","filing":"0000935836-25-000476","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000476/ownership.xml","form_type":"4"}},{"id":1078948,"issuer":{"id":9824,"kind":"organization","name":"Adaptimmune Therapeutics PLC"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2025-07-30T22:20:32.000Z","date":"2025-07-29","kind":"sale","planned":false,"acquired":false,"shares":2687460,"price":0.1012,"value":271970.952,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"These Ordinary Shares are held through American Depositary Shares (\"ADS\") of the Issuer. Each ADS represents 6 Ordinary Shares."},{"field":"shares","element":"transactionShares","label":"F6","text":"The reporting persons sold 447,910 ADSs representing 2,687,460 Ordinary Shares. Qualified Fund sold 418,303 of those ADSs, representing 2,509,818 Ordinary Shares."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The price reported in Column 4 is the price per ADS sold by the reporting persons."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F8","text":"After this transaction, the reporting persons beneficially owned 21,300,870 ADSs, including 20,151,331 ADSs held by Qualified Fund representing 120,907,986 Ordinary Shares."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The reporting persons are EcoR1 Capital, LLC (\"Ecor1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Fund\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":127805220,"source":{"system":"sec-edgar","filing":"0000935836-25-000476","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000476/ownership.xml","form_type":"4"}},{"id":1078947,"issuer":{"id":9824,"kind":"organization","name":"Adaptimmune Therapeutics PLC"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2025-07-30T22:20:32.000Z","date":"2025-07-28","kind":"sale","planned":false,"acquired":false,"shares":33931740,"price":0.1125,"value":3817320.75,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"These Ordinary Shares are held through American Depositary Shares (\"ADS\") of the Issuer. Each ADS represents 6 Ordinary Shares."},{"field":"shares","element":"transactionShares","label":"F3","text":"The reporting persons sold 5,655,290 ADSs representing 33,931,740 Ordinary Shares. Qualified Fund sold 5,281,476 of those ADSs, representing 31,688,856 Ordinary Shares."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is the price per ADS sold by the reporting persons. This price is a weighted average price. These ADSs were sold in multiple transactions at prices ranging from $0.1086 to $0.1184, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission upon request, full information regarding the number of ADSs sold at each separate price within the ranges set forth in this footnote."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, the reporting persons beneficially owned 21,748,780 ADSs, including 20,569,634 ADS held by Qualified Fund representing 123,417,804 Ordinary Shares."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The reporting persons are EcoR1 Capital, LLC (\"Ecor1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Fund\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":130492680,"source":{"system":"sec-edgar","filing":"0000935836-25-000476","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000476/ownership.xml","form_type":"4"}},{"id":1100138,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrants (right to acquire)","published_at":"2025-06-27T17:50:21.000Z","date":"2025-06-26","kind":"other","planned":false,"acquired":false,"shares":5086521,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund exercised 4,818,462 of the pre-funded warrants reported in this transaction."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"The pre-funded warrants did not have an expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":0,"derivative":{"exercise_price":0.0001,"exercise_date":"2023-12-26","underlying":"Common Stock","underlying_shares":5086521},"source":{"system":"sec-edgar","filing":"0000935836-25-000438","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000438/ownership.xml","form_type":"4"}},{"id":1100137,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-06-27T17:50:21.000Z","date":"2025-06-26","kind":"tax_withholding","planned":false,"acquired":false,"shares":41,"price":12.71,"value":521.11,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F4","text":"On June 26, 2025,the reporting persons exercised pre-funded warrants to purchase 5,086,521 shares of the Issuer's Common Stock for $0.0001 per share. The reporting persons paid the exercise price on a cashless basis, resulting in the Issuer withholding 41 of the warrant shares (including 38 warrant shares issuable to Qualified Fund) to pay the exercise price and issuing to the reporting persons the remaining 5,086,480 shares."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After the transactions reported herein, Qualified Fund held 21,582,563 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":22970388,"source":{"system":"sec-edgar","filing":"0000935836-25-000438","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000438/ownership.xml","form_type":"4"}},{"id":1100136,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-06-27T17:50:21.000Z","date":"2025-06-26","kind":"other","planned":false,"acquired":true,"shares":5086480,"price":0.0001,"value":508.648,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund acquired 4,818,424 shares of Common Stock in connection with the exercise of the pre-funded warrants."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After the transactions reported herein, Qualified Fund held 21,582,563 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":22970388,"source":{"system":"sec-edgar","filing":"0000935836-25-000438","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000438/ownership.xml","form_type":"4"}},{"id":1142553,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-19T18:35:05.000Z","date":"2025-05-19","kind":"purchase","planned":false,"acquired":true,"shares":5919,"price":11.7821,"value":69738.2499,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 5,550 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 16,764,139 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17883908,"source":{"system":"sec-edgar","filing":"0000935836-25-000389","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000389/ownership.xml","form_type":"4"}},{"id":1142552,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-19T18:35:05.000Z","date":"2025-05-15","kind":"purchase","planned":false,"acquired":true,"shares":49502,"price":11.4308,"value":565847.4616,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 46,405 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 16,758,589 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17877989,"source":{"system":"sec-edgar","filing":"0000935836-25-000389","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000389/ownership.xml","form_type":"4"}},{"id":1145513,"issuer":{"id":75965,"kind":"organization","name":"iTeos Therapeutics, Inc.","symbol":"ITOS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-16T18:52:07.000Z","date":"2025-05-15","kind":"purchase","planned":false,"acquired":true,"shares":3300000,"price":8,"value":26400000.0,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased 3,093,422 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F6","text":"After this transaction, Qualified Fund held 10,020,210 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"Ecor1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":10688978,"source":{"system":"sec-edgar","filing":"0000935836-25-000384","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1808865/000093583625000384/ownership.xml","form_type":"4"}},{"id":1145512,"issuer":{"id":75965,"kind":"organization","name":"iTeos Therapeutics, Inc.","symbol":"ITOS"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-16T18:52:07.000Z","date":"2025-05-14","kind":"purchase","planned":false,"acquired":true,"shares":1658978,"price":7.4055,"value":12285561.579,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 1,555,127 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.35 to $7.60, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 6,926,788 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"Ecor1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":7388978,"source":{"system":"sec-edgar","filing":"0000935836-25-000384","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1808865/000093583625000384/ownership.xml","form_type":"4"}},{"id":1157128,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2025-05-06T23:06:05.000Z","date":"2025-05-06","kind":"sale","planned":false,"acquired":false,"shares":1984053,"price":7.6433,"value":15164712.2949,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F8","text":"Qualified Fund sold 1,859,851 of the shares sold in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.4637 to $8.5939, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F10","text":"After this transaction, Qualified Fund held 4,973,891 of the Issuer's Ordinary Shares."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"Ecor1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Fund\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":5304596,"source":{"system":"sec-edgar","filing":"0000935836-25-000309","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000093583625000309/ownership.xml","form_type":"4"}},{"id":1157127,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2025-05-06T23:06:05.000Z","date":"2025-05-05","kind":"sale","planned":false,"acquired":false,"shares":977693,"price":8.1111,"value":7930165.6923,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund sold 916,492 of the shares of sold in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.1097 to $8.1972, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 6,833,742 shares of the Issuer's Common Stock"},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"Ecor1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Fund\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":7288649,"source":{"system":"sec-edgar","filing":"0000935836-25-000309","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000093583625000309/ownership.xml","form_type":"4"}},{"id":1157126,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2025-05-06T23:06:05.000Z","date":"2025-05-02","kind":"sale","planned":false,"acquired":false,"shares":3317938,"price":8.3621,"value":27744929.3498,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund sold 3,097,619 of the shares sold in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.2715 to $9.1789, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission upon request, full information regarding the number of shares sold at each seperate price within the ranges set forth in this footnote and footnotes 6 and 9."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 7,750,234 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"Ecor1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Fund\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":8266342,"source":{"system":"sec-edgar","filing":"0000935836-25-000309","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000093583625000309/ownership.xml","form_type":"4"}},{"id":1169069,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-18T15:17:11.000Z","date":"2025-04-17","kind":"purchase","planned":false,"acquired":true,"shares":54760,"price":11.5197,"value":630818.772,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased 51,344 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $11.5125 to $11.5214, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 16,712,184 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17828487,"source":{"system":"sec-edgar","filing":"0000935836-25-000292","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000292/ownership.xml","form_type":"4"}},{"id":1169068,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-18T15:17:11.000Z","date":"2025-04-16","kind":"purchase","planned":false,"acquired":true,"shares":73953,"price":11.1637,"value":825589.1061,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 69,339 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $10.9823 to $11.2339 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each seperate price within the ranges set forth in this footnote and footnote 6."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 16,660,840 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17773727,"source":{"system":"sec-edgar","filing":"0000935836-25-000292","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000292/ownership.xml","form_type":"4"}},{"id":1176576,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-07T18:34:11.000Z","date":"2025-04-04","kind":"purchase","planned":false,"acquired":true,"shares":196438,"price":11.1679,"value":2193799.9402,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased 184,181 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $10.9804 to $11.2921, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 16,591,501 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17699774,"source":{"system":"sec-edgar","filing":"0000935836-25-000266","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000266/ownership.xml","form_type":"4"}},{"id":1176575,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-07T18:34:11.000Z","date":"2025-04-03","kind":"purchase","planned":false,"acquired":true,"shares":120770,"price":11.8421,"value":1430170.417,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 113,233 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $11.8101 to $11.9123 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each seperate price within the ranges set forth in this footnote and footnote 6."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 16,407,320 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17503336,"source":{"system":"sec-edgar","filing":"0000935836-25-000266","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000266/ownership.xml","form_type":"4"}},{"id":1183241,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-02T19:02:09.000Z","date":"2025-04-02","kind":"purchase","planned":false,"acquired":true,"shares":74360,"price":11.848,"value":881017.28,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"Qualified Fund purchased 69,720 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 16,294,087 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17382566,"source":{"system":"sec-edgar","filing":"0000935836-25-000259","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000259/ownership.xml","form_type":"4"}},{"id":1183240,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-02T19:02:09.000Z","date":"2025-04-01","kind":"purchase","planned":false,"acquired":true,"shares":48658,"price":11.6044,"value":564646.8952,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 45,622 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 16,224,367 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17308206,"source":{"system":"sec-edgar","filing":"0000935836-25-000259","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000259/ownership.xml","form_type":"4"}},{"id":1183239,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-02T19:02:09.000Z","date":"2025-03-31","kind":"purchase","planned":false,"acquired":true,"shares":4397,"price":11.7485,"value":51658.1545,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 4,129 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 16,178,745 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17259548,"source":{"system":"sec-edgar","filing":"0000935836-25-000259","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000259/ownership.xml","form_type":"4"}},{"id":1189675,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-27T18:53:43.000Z","date":"2025-03-26","kind":"purchase","planned":false,"acquired":true,"shares":43848,"price":12.2436,"value":536857.3728,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 41,177 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.2293 to $12.3537, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F6","text":"After this transaction, Qualified Fund held 16,174,616 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17255151,"source":{"system":"sec-edgar","filing":"0000935836-25-000253","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000253/ownership.xml","form_type":"4"}},{"id":1189674,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-27T18:53:43.000Z","date":"2025-03-25","kind":"purchase","planned":false,"acquired":true,"shares":53501,"price":12.9054,"value":690451.8054,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 50,243 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 16,133,439 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17211303,"source":{"system":"sec-edgar","filing":"0000935836-25-000253","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000253/ownership.xml","form_type":"4"}},{"id":1193344,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-24T17:45:12.000Z","date":"2025-03-24","kind":"purchase","planned":false,"acquired":true,"shares":22689,"price":13.0833,"value":296846.9937,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F7","text":"Qualified Fund purchased 21,307 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F8","text":"After this transaction, Qualified Fund held 16,083,196 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17157802,"source":{"system":"sec-edgar","filing":"0000935836-25-000245","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000245/ownership.xml","form_type":"4"}},{"id":1193343,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-24T17:45:12.000Z","date":"2025-03-21","kind":"purchase","planned":false,"acquired":true,"shares":31033,"price":12.7773,"value":396517.9509,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 29,143 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.6895 to $12.9881 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote with the ranges set forth in this footnote."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F6","text":"After this transaction, Qualified Fund held 16,061,889 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17135113,"source":{"system":"sec-edgar","filing":"0000935836-25-000245","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000245/ownership.xml","form_type":"4"}},{"id":1193342,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-24T17:45:12.000Z","date":"2025-03-20","kind":"purchase","planned":false,"acquired":true,"shares":73476,"price":12.9278,"value":949883.0328,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 69,000 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 16,032,746 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17104080,"source":{"system":"sec-edgar","filing":"0000935836-25-000245","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000245/ownership.xml","form_type":"4"}},{"id":1196988,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-19T18:32:24.000Z","date":"2025-03-19","kind":"purchase","planned":false,"acquired":true,"shares":58306,"price":12.6442,"value":737232.7252,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F8","text":"Qualified Fund purchased 54,758 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.5029 to $12.7711, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F10","text":"After this transaction, Qualified Fund held 15,963,746 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17030604,"source":{"system":"sec-edgar","filing":"0000935836-25-000239","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000239/ownership.xml","form_type":"4"}},{"id":1196987,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-19T18:32:24.000Z","date":"2025-03-18","kind":"purchase","planned":false,"acquired":true,"shares":113880,"price":12.6524,"value":1440855.312,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased 106,944 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.3214 to $12.7045, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 15,908,988 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":16972298,"source":{"system":"sec-edgar","filing":"0000935836-25-000239","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000239/ownership.xml","form_type":"4"}},{"id":1196986,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-19T18:32:24.000Z","date":"2025-03-17","kind":"purchase","planned":false,"acquired":true,"shares":56277,"price":12.2335,"value":688464.6795,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 52,849 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.1287 to $12.2678 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote with the ranges set forth in this footnote."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 15,802,044 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":16858418,"source":{"system":"sec-edgar","filing":"0000935836-25-000239","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000239/ownership.xml","form_type":"4"}},{"id":1207711,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-13T19:35:15.000Z","date":"2025-03-13","kind":"purchase","planned":false,"acquired":true,"shares":468356,"price":12.4846,"value":5847237.3176,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F8","text":"Qualified Fund purchased 439,831 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.26 to $12.55, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F10","text":"After this transaction, Qualified Fund held 15,749,195 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":16802141,"source":{"system":"sec-edgar","filing":"0000935836-25-000225","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000225/ownership.xml","form_type":"4"}},{"id":1207710,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-13T19:35:15.000Z","date":"2025-03-12","kind":"purchase","planned":false,"acquired":true,"shares":292934,"price":12.2479,"value":3587826.3386,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased 275,095 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.0008 to $12.3728, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 15,309,364 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":16333785,"source":{"system":"sec-edgar","filing":"0000935836-25-000225","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000225/ownership.xml","form_type":"4"}},{"id":1207709,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-13T19:35:15.000Z","date":"2025-03-11","kind":"purchase","planned":false,"acquired":true,"shares":320690,"price":11.4935,"value":3685850.515,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 301,160 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $11.115 to $11.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote with the ranges set forth in this footnote and footnote 6 and 9."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 15,034,269 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":16040851,"source":{"system":"sec-edgar","filing":"0000935836-25-000225","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000225/ownership.xml","form_type":"4"}},{"id":1298532,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-21T22:34:28.000Z","date":"2025-01-17","kind":"purchase","planned":false,"acquired":true,"shares":19748,"price":13.8747,"value":273997.5756,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 18,557 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 14,733,109 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15720161,"source":{"system":"sec-edgar","filing":"0000935836-25-000074","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000074/ownership.xml","form_type":"4"}},{"id":1298531,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-21T22:34:28.000Z","date":"2025-01-16","kind":"purchase","planned":false,"acquired":true,"shares":121681,"price":13.885,"value":1689540.685,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 114,344 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 14,714,552 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15700413,"source":{"system":"sec-edgar","filing":"0000935836-25-000074","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000074/ownership.xml","form_type":"4"}},{"id":1302315,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-15T23:12:17.000Z","date":"2025-01-15","kind":"purchase","planned":false,"acquired":true,"shares":39029,"price":14.0068,"value":546671.3972,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"Qualified Fund purchased 36,676 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 14,600,208 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15578732,"source":{"system":"sec-edgar","filing":"0000935836-25-000067","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000067/ownership.xml","form_type":"4"}},{"id":1302314,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-15T23:12:17.000Z","date":"2025-01-14","kind":"purchase","planned":false,"acquired":true,"shares":54500,"price":13.5645,"value":739265.25,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 51,213 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 14,563,532 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15539703,"source":{"system":"sec-edgar","filing":"0000935836-25-000067","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000067/ownership.xml","form_type":"4"}},{"id":1302313,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-15T23:12:17.000Z","date":"2025-01-13","kind":"purchase","planned":false,"acquired":true,"shares":74125,"price":13.3946,"value":992874.725,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 69,655 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 14,512,319 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15485203,"source":{"system":"sec-edgar","filing":"0000935836-25-000067","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000067/ownership.xml","form_type":"4"}},{"id":1304891,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-10T23:27:58.000Z","date":"2025-01-10","kind":"purchase","planned":false,"acquired":true,"shares":204098,"price":13.126,"value":2678990.348,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 191,791 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 14,442,664 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15411078,"source":{"system":"sec-edgar","filing":"0000935836-25-000048","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000048/ownership.xml","form_type":"4"}},{"id":1304890,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-10T23:27:58.000Z","date":"2025-01-08","kind":"purchase","planned":false,"acquired":true,"shares":21021,"price":14.073,"value":295828.533,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 19,752 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 14,250,873 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15206980,"source":{"system":"sec-edgar","filing":"0000935836-25-000048","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000048/ownership.xml","form_type":"4"}},{"id":1318279,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-02T22:51:58.000Z","date":"2025-01-02","kind":"purchase","planned":false,"acquired":true,"shares":157880,"price":14.7796,"value":2333403.248,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"Qualified Fund purchased 152,346 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $14.7789 to $14.78, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote 7."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F8","text":"After this transaction, Qualified Fund held 14,231,121 shares of the Issuer's Common Stock"},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15185959,"source":{"system":"sec-edgar","filing":"0000935836-25-000007","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000007/ownership.xml","form_type":"4"}},{"id":1318278,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-02T22:51:58.000Z","date":"2024-12-31","kind":"purchase","planned":false,"acquired":true,"shares":146501,"price":14.5695,"value":2134446.3195,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 61,501 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 14,078,775 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15028079,"source":{"system":"sec-edgar","filing":"0000935836-25-000007","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000007/ownership.xml","form_type":"4"}},{"id":1318277,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-02T22:51:58.000Z","date":"2024-12-30","kind":"purchase","planned":false,"acquired":true,"shares":58988,"price":14.4661,"value":853326.3068,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 55,513 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 14,017,274 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":14881578,"source":{"system":"sec-edgar","filing":"0000935836-25-000007","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000007/ownership.xml","form_type":"4"}},{"id":1318563,"issuer":{"id":4640,"kind":"organization","name":"ANAPTYSBIO, INC","symbol":"ANAB"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-02T18:17:02.000Z","date":"2025-01-02","kind":"purchase","planned":false,"acquired":true,"shares":6646,"price":12.9506,"value":86069.6876,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F7","text":"Qualified Fund purchased all of the securities in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F8","text":"After this transaction, Qualified Fund held 7,401,972 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified L.P. (\"Qualified Fund\"). EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1 and a director of the Issuer. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interests therein."}],"balance_after":7880094,"source":{"system":"sec-edgar","filing":"0000935836-25-000008","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000008/ownership.xml","form_type":"4"}},{"id":1318562,"issuer":{"id":4640,"kind":"organization","name":"ANAPTYSBIO, INC","symbol":"ANAB"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-02T18:17:02.000Z","date":"2024-12-31","kind":"purchase","planned":false,"acquired":true,"shares":13268,"price":12.9268,"value":171512.7824,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased all of the securities in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F6","text":"After this transaction, Qualified Fund held 7,395,326 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified L.P. (\"Qualified Fund\"). EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1 and a director of the Issuer. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interests therein."}],"balance_after":7873448,"source":{"system":"sec-edgar","filing":"0000935836-25-000008","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000008/ownership.xml","form_type":"4"}},{"id":1318561,"issuer":{"id":4640,"kind":"organization","name":"ANAPTYSBIO, INC","symbol":"ANAB"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-02T18:17:02.000Z","date":"2024-12-30","kind":"purchase","planned":false,"acquired":true,"shares":65184,"price":12.9182,"value":842059.9488,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased all of the securities in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.71 to $12.9552, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote 3."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 7,382,058 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified L.P. (\"Qualified Fund\"). EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1 and a director of the Issuer. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interests therein."}],"balance_after":7860180,"source":{"system":"sec-edgar","filing":"0000935836-25-000008","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000008/ownership.xml","form_type":"4"}},{"id":1320902,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-27T23:41:06.000Z","date":"2024-12-27","kind":"purchase","planned":false,"acquired":true,"shares":101659,"price":14.4914,"value":1473181.2326,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F7","text":"Qualified Fund purchased 95,672 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $14.2405 to $14.50, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F9","text":"After this transaction, Qualified Fund held 13,961,761 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":14822590,"source":{"system":"sec-edgar","filing":"0000935836-24-000785","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583624000785/ownership.xml","form_type":"4"}},{"id":1320901,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-27T23:41:06.000Z","date":"2024-12-26","kind":"purchase","planned":false,"acquired":true,"shares":16692,"price":14.3804,"value":240037.6368,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased 15,707 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F6","text":"After this transaction, Qualified Fund held 13,866,089 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":14720931,"source":{"system":"sec-edgar","filing":"0000935836-24-000785","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583624000785/ownership.xml","form_type":"4"}},{"id":1320900,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-27T23:41:06.000Z","date":"2024-12-24","kind":"purchase","planned":false,"acquired":true,"shares":11958,"price":14.1241,"value":168895.9878,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 11,254 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $13.9473 and $14.14 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes 3 and 8."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 13,850,382 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":14704239,"source":{"system":"sec-edgar","filing":"0000935836-24-000785","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583624000785/ownership.xml","form_type":"4"}},{"id":1321472,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-26T17:46:34.000Z","date":"2024-12-23","kind":"purchase","planned":false,"acquired":true,"shares":251502,"price":14.2508,"value":3584104.7016,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"This transaction was inadvertently omitted from the Form 4 filed on 12/23/2024."},{"field":"shares","element":"transactionShares","label":"F9","text":"Qualified Fund purchased 236,691 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F10","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $14.1957 to $14.2713, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F11","text":"After this transaction, Qualified Fund held 13,839,128 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":14692281,"source":{"system":"sec-edgar","filing":"0000935836-24-000780","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583624000780/ownership.xml","form_type":"4/A","original_submission_date":"2024-12-23"}},{"id":1321471,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-26T17:46:34.000Z","date":"2024-12-20","kind":"purchase","planned":false,"acquired":true,"shares":704488,"price":14.0776,"value":9917500.2688,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"This transaction was inadvertently omitted from the Form 4 filed on 12/23/2024."},{"field":"shares","element":"transactionShares","label":"F6","text":"Qualified Fund purchased 662,995 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $13.6517 to $14.1388, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F8","text":"After this transaction, Qualified Fund held 13,602,437 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":14440779,"source":{"system":"sec-edgar","filing":"0000935836-24-000780","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583624000780/ownership.xml","form_type":"4/A","original_submission_date":"2024-12-23"}},{"id":1321470,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-26T17:46:34.000Z","date":"2024-12-19","kind":"purchase","planned":false,"acquired":true,"shares":298818,"price":13.5289,"value":4042678.8402,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"This transaction was inadvertently omitted from the Form 4 filed on 12/23/2024."},{"field":"shares","element":"transactionShares","label":"F3","text":"Qualified Fund purchased 281,218 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $13.3758 to $13.58, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes 4, 7 and 10."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 12,939,442 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":13736291,"source":{"system":"sec-edgar","filing":"0000935836-24-000780","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583624000780/ownership.xml","form_type":"4/A","original_submission_date":"2024-12-23"}},{"id":1322600,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrants","published_at":"2024-12-24T00:53:03.000Z","date":"2023-12-26","kind":"purchase","planned":false,"acquired":true,"shares":5086521,"price":9.8299,"value":49999992.7779,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 4,818,462 of the pre-funded warrants reported in this transaction."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"The pre-funded warrants do not have an expiration date."},{"field":"derivative.underlying_shares","element":"underlyingSecurityShares","label":"F4","text":"Each pre-funded warrant will be exercisable to purchase one share of Common Stock, except that the pre-funded warrants cannot be exercised if, after giving effect or immediately prior to such exercise, the reporting person, together with its affiliates and any other persons whose beneficial ownership of shares of Common Stock would be aggregated with the reporting person for purposes of Section 13(d) of the Securities Exchange Act of 1934 would beneficially own more than 19.99% of the total number of issued and outstanding shares of Common Stock or voting power of the issuer following such exercise."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund owned 4,818,462 of the pre-funded warrants."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":5086521,"derivative":{"exercise_price":0.0001,"exercise_date":"2023-12-26","underlying":"Common Stock","underlying_shares":5086521},"source":{"system":"sec-edgar","filing":"0000935836-24-000774","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583624000774/ownership.xml","form_type":"4"}},{"id":1322763,"issuer":{"id":69982,"kind":"organization","name":"Mersana Therapeutics, Inc.","symbol":"MRSN"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrants","published_at":"2024-12-24T00:42:08.000Z","date":"2024-12-19","kind":"other","planned":false,"acquired":true,"shares":8036688,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The Funds exchanged 8,036,688 shares of Common Stock for pre-funded warrants to acquire 8,036,688 shares of Common Stock"},{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund acquired 7,578,596 of the pre-funded warrants acquired in this exchange."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The Funds exchanged 8,036,688 shares of Common Stock for pre-funded warrants to acquire 8,036,688 shares of Common Stock"},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"The pre-funded warrants do not have an expiration date."},{"field":"derivative.underlying_shares","element":"underlyingSecurityShares","label":"F7","text":"Each pre-funded warrant is exercisable to purchase one share of Common Stock, except that a holder of a pre-funded warrant will not be entitled to exercise any pre-funded warrant if, upon giving effect or immediately prior to such exercise, such exercise would result in (i) the aggregate number of shares of Common Stock beneficially owned by such holder (together with its affiliates) exceeding 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise, or (ii) the combined voting power of Company securities beneficially owned by such holder (together with its affiliates) exceeding 9.99% of the combined voting power of all Company securities outstanding immediately after giving effect to such exercise, as such percentage ownership is determined in accordance with the terms of the pre-funded warrants."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F8","text":"After this transaction, Qualified Fund owned 7,578,596 of the pre-funded warrants."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":8036688,"derivative":{"exercise_price":0.0001,"exercise_date":"2024-12-20","underlying":"Common Stock","underlying_shares":8036688},"source":{"system":"sec-edgar","filing":"0000935836-24-000771","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1442836/000093583624000771/ownership.xml","form_type":"4"}},{"id":1322762,"issuer":{"id":69982,"kind":"organization","name":"Mersana Therapeutics, Inc.","symbol":"MRSN"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-24T00:42:08.000Z","date":"2024-12-19","kind":"other","planned":false,"acquired":false,"shares":8036688,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The Funds exchanged 8,036,688 shares of Common Stock for pre-funded warrants to acquire 8,036,688 shares of Common Stock"},{"field":"shares","element":"transactionShares","label":"F3","text":"Qualified Fund disposed of 7,578,596 shares of Common Stock disposed of in this exchange"},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The Funds exchanged 8,036,688 shares of Common Stock for pre-funded warrants to acquire 8,036,688 shares of Common Stock"},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund owns 10,682,303 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":11328000,"source":{"system":"sec-edgar","filing":"0000935836-24-000771","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1442836/000093583624000771/ownership.xml","form_type":"4"}},{"id":1371534,"issuer":{"id":1497,"kind":"organization","name":"Tango Therapeutics, Inc.","symbol":"TNGX"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-09T00:24:48.000Z","date":"2024-11-07","kind":"sale","planned":false,"acquired":false,"shares":1143124,"price":2.9171,"value":3334607.0204,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"Qualified Fund sold 1,075,794 of the shares sold in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 10,022,411 shares of Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filers are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Qualified Fund and Mr. Nodelman. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim ownership of such securities except to the extent of their respective pecuniary interests therein."}],"balance_after":10630736,"source":{"system":"sec-edgar","filing":"0000935836-24-000649","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1819133/000093583624000649/ownership.xml","form_type":"4"}},{"id":1371533,"issuer":{"id":1497,"kind":"organization","name":"Tango Therapeutics, Inc.","symbol":"TNGX"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-09T00:24:48.000Z","date":"2024-11-07","kind":"sale","planned":false,"acquired":false,"shares":62318,"price":3.2914,"value":205113.4652,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund sold 58,647 of the shares sold in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 11,098,205 shares of Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filers are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Qualified Fund and Mr. Nodelman. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim ownership of such securities except to the extent of their respective pecuniary interests therein."}],"balance_after":11773860,"source":{"system":"sec-edgar","filing":"0000935836-24-000649","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1819133/000093583624000649/ownership.xml","form_type":"4"}},{"id":1371532,"issuer":{"id":1497,"kind":"organization","name":"Tango Therapeutics, Inc.","symbol":"TNGX"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-09T00:24:48.000Z","date":"2024-11-06","kind":"sale","planned":false,"acquired":false,"shares":1494558,"price":3.2759,"value":4896022.5522,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund sold 1,406,529 of the shares sold in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 11,156,852 shares of Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filers are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Qualified Fund and Mr. Nodelman. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim ownership of such securities except to the extent of their respective pecuniary interests therein."}],"balance_after":11836178,"source":{"system":"sec-edgar","filing":"0000935836-24-000649","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1819133/000093583624000649/ownership.xml","form_type":"4"}},{"id":1431020,"issuer":{"id":4640,"kind":"organization","name":"ANAPTYSBIO, INC","symbol":"ANAB"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-08-16T16:04:31.000Z","date":"2024-08-14","kind":"purchase","planned":false,"acquired":true,"shares":273972,"price":36.5,"value":9999978.0,"ownership":{"direct":false,"nature":"See Notes"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased all of the shares acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund holds 7,316,874 shares of Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filers are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund (\"the Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1 and a director of the Issuer. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold shares directly for the benefit of their investors. EcoR1 may be deemed to beneficially own the shares indirectly as the investment adviser to the Fund, and Mr. Nodelman may be deemed to beneficially own them indirectly as the control person of EcoR1. The filers disclaim beneficial ownership of the shares except to the extent of their pecuniary interest therein."}],"balance_after":7794996,"source":{"system":"sec-edgar","filing":"0000935836-24-000532","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1370053/000093583624000532/ownership.xml","form_type":"4"}},{"id":1698422,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrants","published_at":"2023-12-28T17:11:24.000Z","date":"2023-12-26","kind":"purchase","planned":false,"acquired":true,"shares":5086521,"price":9.8299,"value":49999992.7779,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 4,818,462 of the pre-funded warrants reported in this transaction."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"The pre-funded warrants do not have an expiration date."},{"field":"derivative.underlying_shares","element":"underlyingSecurityShares","label":"F4","text":"Each pre-funded warrant will be exercisable to purchase one share of Common Stock, except that the pre-funded warrants cannot be exercised if, after giving effect or immediately prior to such exercise, the reporting person, together with its affiliates and any other persons whose beneficial ownership of shares of Common Stock would be aggregated with the reporting person for purposes of Section 13(d) of the Securities Exchange Act of 1934 would beneficially own more than 19.99% of the total number of issued and outstanding shares of Common Stock or voting power of the issuer following such exercise."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund owned 4,818,462 of the pre-funded warrants."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":5086521,"derivative":{"exercise_price":0.0001,"exercise_date":"2023-12-26","underlying":"Common Stock","underlying_shares":5086521},"source":{"system":"sec-edgar","filing":"0000935836-23-000743","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583623000743/ownership.xml","form_type":"4"}},{"id":1774697,"issuer":{"id":4384,"kind":"organization","name":"Nuvation Bio Inc."},"owners":[{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":1,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":2,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109484,"kind":"person","name":"EcoR1 Capital Fund, L.P.","position":3,"cik":"0001567938","reported_name":"EcoR1 Capital Fund, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109485,"kind":"person","name":"EcoR1 Capital Fund Qualified, L.P.","position":4,"cik":"0001598292","reported_name":"EcoR1 Capital Fund Qualified, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109486,"kind":"person","name":"EcoR1 Venture Opportunity Fund, LP","position":5,"cik":"0001778011","reported_name":"EcoR1 Venture Opportunity Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109487,"kind":"person","name":"Biotech Opportunity GP, LLC","position":6,"cik":"0001816370","reported_name":"Biotech Opportunity GP, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Class A Common Stock","published_at":"2023-09-22T15:44:37.000Z","date":"2023-09-21","kind":"purchase","planned":false,"acquired":true,"shares":53000,"price":1.3611,"value":72138.3,"ownership":{"direct":false,"nature":"See Notes"},"footnotes":[{"field":"date","element":"transactionDate","label":"F5","text":"Original Form 4 inadvertently identified the date of this transaction as 2/21/2023.  As reported in this amendment, the date of this transaction was 9/21/2023."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"EcoR1 Capital, LLC (\"EcoR1\") is the investment adviser to EcoR1 Capital Fund, L.P. (\"Capital Fund\"), EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\") and EcoR1 Venture Opportunity Fund, L.P. (\"Venture Fund\"). EcoR1 is the general partner of Capital Fund and Qualified Fund, and Biotech Opportunity GP, LLC (\"Biotech\") is the general partner of Venture Fund. Mr. Nodelman is the manager and controlling owner of EcoR1 and Biotech. The funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the funds. Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The reporting persons disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Qualified Fund is the record holder of these securities."}],"balance_after":12674775,"source":{"system":"sec-edgar","filing":"0000935836-23-000621","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1816370/000093583623000621/ownership.xml","form_type":"4/A","original_submission_date":"2023-09-21"}},{"id":1774696,"issuer":{"id":4384,"kind":"organization","name":"Nuvation Bio Inc."},"owners":[{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":1,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":2,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109484,"kind":"person","name":"EcoR1 Capital Fund, L.P.","position":3,"cik":"0001567938","reported_name":"EcoR1 Capital Fund, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109485,"kind":"person","name":"EcoR1 Capital Fund Qualified, L.P.","position":4,"cik":"0001598292","reported_name":"EcoR1 Capital Fund Qualified, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109486,"kind":"person","name":"EcoR1 Venture Opportunity Fund, LP","position":5,"cik":"0001778011","reported_name":"EcoR1 Venture Opportunity Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109487,"kind":"person","name":"Biotech Opportunity GP, LLC","position":6,"cik":"0001816370","reported_name":"Biotech Opportunity GP, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Class A Common Stock","published_at":"2023-09-22T15:44:37.000Z","date":"2023-09-20","kind":"purchase","planned":false,"acquired":true,"shares":117100,"price":1.362,"value":159490.2,"ownership":{"direct":false,"nature":"See Notes"},"footnotes":[{"field":"date","element":"transactionDate","label":"F4","text":"The Original Form 4 inadvertently identified the date of this transaction as 2/20/2023.  As reported in this amendment, the date of this transaction was 9/20/2023."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"EcoR1 Capital, LLC (\"EcoR1\") is the investment adviser to EcoR1 Capital Fund, L.P. (\"Capital Fund\"), EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\") and EcoR1 Venture Opportunity Fund, L.P. (\"Venture Fund\"). EcoR1 is the general partner of Capital Fund and Qualified Fund, and Biotech Opportunity GP, LLC (\"Biotech\") is the general partner of Venture Fund. Mr. Nodelman is the manager and controlling owner of EcoR1 and Biotech. The funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the funds. Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The reporting persons disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Qualified Fund is the record holder of these securities."}],"balance_after":12621775,"source":{"system":"sec-edgar","filing":"0000935836-23-000621","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1816370/000093583623000621/ownership.xml","form_type":"4/A","original_submission_date":"2023-09-21"}},{"id":1774695,"issuer":{"id":4384,"kind":"organization","name":"Nuvation Bio Inc."},"owners":[{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":1,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":2,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109484,"kind":"person","name":"EcoR1 Capital Fund, L.P.","position":3,"cik":"0001567938","reported_name":"EcoR1 Capital Fund, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109485,"kind":"person","name":"EcoR1 Capital Fund Qualified, L.P.","position":4,"cik":"0001598292","reported_name":"EcoR1 Capital Fund Qualified, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109486,"kind":"person","name":"EcoR1 Venture Opportunity Fund, LP","position":5,"cik":"0001778011","reported_name":"EcoR1 Venture Opportunity Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109487,"kind":"person","name":"Biotech Opportunity GP, LLC","position":6,"cik":"0001816370","reported_name":"Biotech Opportunity GP, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Class A Common Stock","published_at":"2023-09-22T15:44:37.000Z","date":"2023-09-19","kind":"purchase","planned":false,"acquired":true,"shares":5143000,"price":1.2562,"value":6460636.6,"ownership":{"direct":false,"nature":"See Notes"},"footnotes":[{"field":"date","element":"transactionDate","label":"F3","text":"On 9/21/2023, the reporting persons filed a Form 4 (the \"Original Form 4\") that inadvertently identified the date of this transaction as 2/19/2023.  As reported in this amendment, the date of this transaction was 9/19/2023. The Original Form 4 also inadvertently identified the date of the earliest transaction reported in the Original Form 4 as 2/19/2023.  As reported in this amendment, the date of the earliest transaction was 9/19/2023."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"EcoR1 Capital, LLC (\"EcoR1\") is the investment adviser to EcoR1 Capital Fund, L.P. (\"Capital Fund\"), EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\") and EcoR1 Venture Opportunity Fund, L.P. (\"Venture Fund\"). EcoR1 is the general partner of Capital Fund and Qualified Fund, and Biotech Opportunity GP, LLC (\"Biotech\") is the general partner of Venture Fund. Mr. Nodelman is the manager and controlling owner of EcoR1 and Biotech. The funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the funds. Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The reporting persons disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Qualified Fund is the record holder of these securities."}],"balance_after":12504675,"source":{"system":"sec-edgar","filing":"0000935836-23-000621","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1816370/000093583623000621/ownership.xml","form_type":"4/A","original_submission_date":"2023-09-21"}},{"id":1775513,"issuer":{"id":4384,"kind":"organization","name":"Nuvation Bio Inc."},"owners":[{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":1,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":2,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109484,"kind":"person","name":"EcoR1 Capital Fund, L.P.","position":3,"cik":"0001567938","reported_name":"EcoR1 Capital Fund, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109485,"kind":"person","name":"EcoR1 Capital Fund Qualified, L.P.","position":4,"cik":"0001598292","reported_name":"EcoR1 Capital Fund Qualified, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109486,"kind":"person","name":"EcoR1 Venture Opportunity Fund, LP","position":5,"cik":"0001778011","reported_name":"EcoR1 Venture Opportunity Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109487,"kind":"person","name":"Biotech Opportunity GP, LLC","position":6,"cik":"0001816370","reported_name":"Biotech Opportunity GP, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Class A Common Stock","published_at":"2023-09-21T20:08:36.000Z","date":"2023-02-21","kind":"purchase","planned":false,"acquired":true,"shares":53000,"price":1.3611,"value":72138.3,"ownership":{"direct":false,"nature":"See Notes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"EcoR1 Capital, LLC (\"EcoR1\") is the investment adviser to EcoR1 Capital Fund, L.P. (\"Capital Fund\"), EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\") and EcoR1 Venture Opportunity Fund, L.P. (\"Venture Fund\"). EcoR1 is the general partner of Capital Fund and Qualified Fund, and Biotech Opportunity GP, LLC (\"Biotech\") is the general partner of Venture Fund. Mr. Nodelman is the manager and controlling owner of EcoR1 and Biotech. The funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the funds. Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The reporting persons disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Qualified Fund is the record holder of these securities."}],"balance_after":12674775,"source":{"system":"sec-edgar","filing":"0000935836-23-000619","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1816370/000093583623000619/ownership.xml","form_type":"4"}},{"id":1775512,"issuer":{"id":4384,"kind":"organization","name":"Nuvation Bio Inc."},"owners":[{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":1,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":2,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109484,"kind":"person","name":"EcoR1 Capital Fund, L.P.","position":3,"cik":"0001567938","reported_name":"EcoR1 Capital Fund, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109485,"kind":"person","name":"EcoR1 Capital Fund Qualified, L.P.","position":4,"cik":"0001598292","reported_name":"EcoR1 Capital Fund Qualified, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109486,"kind":"person","name":"EcoR1 Venture Opportunity Fund, LP","position":5,"cik":"0001778011","reported_name":"EcoR1 Venture Opportunity Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109487,"kind":"person","name":"Biotech Opportunity GP, LLC","position":6,"cik":"0001816370","reported_name":"Biotech Opportunity GP, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Class A Common Stock","published_at":"2023-09-21T20:08:36.000Z","date":"2023-02-20","kind":"purchase","planned":false,"acquired":true,"shares":117100,"price":1.362,"value":159490.2,"ownership":{"direct":false,"nature":"See Notes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"EcoR1 Capital, LLC (\"EcoR1\") is the investment adviser to EcoR1 Capital Fund, L.P. (\"Capital Fund\"), EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\") and EcoR1 Venture Opportunity Fund, L.P. (\"Venture Fund\"). EcoR1 is the general partner of Capital Fund and Qualified Fund, and Biotech Opportunity GP, LLC (\"Biotech\") is the general partner of Venture Fund. Mr. Nodelman is the manager and controlling owner of EcoR1 and Biotech. The funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the funds. Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The reporting persons disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Qualified Fund is the record holder of these securities."}],"balance_after":12621775,"source":{"system":"sec-edgar","filing":"0000935836-23-000619","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1816370/000093583623000619/ownership.xml","form_type":"4"}},{"id":1775511,"issuer":{"id":4384,"kind":"organization","name":"Nuvation Bio Inc."},"owners":[{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":1,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":2,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109484,"kind":"person","name":"EcoR1 Capital Fund, L.P.","position":3,"cik":"0001567938","reported_name":"EcoR1 Capital Fund, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109485,"kind":"person","name":"EcoR1 Capital Fund Qualified, L.P.","position":4,"cik":"0001598292","reported_name":"EcoR1 Capital Fund Qualified, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109486,"kind":"person","name":"EcoR1 Venture Opportunity Fund, LP","position":5,"cik":"0001778011","reported_name":"EcoR1 Venture Opportunity Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":109487,"kind":"person","name":"Biotech Opportunity GP, LLC","position":6,"cik":"0001816370","reported_name":"Biotech Opportunity GP, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Class A Common Stock","published_at":"2023-09-21T20:08:36.000Z","date":"2023-02-19","kind":"purchase","planned":false,"acquired":true,"shares":5143000,"price":1.2562,"value":6460636.6,"ownership":{"direct":false,"nature":"See Notes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"EcoR1 Capital, LLC (\"EcoR1\") is the investment adviser to EcoR1 Capital Fund, L.P. (\"Capital Fund\"), EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\") and EcoR1 Venture Opportunity Fund, L.P. (\"Venture Fund\"). EcoR1 is the general partner of Capital Fund and Qualified Fund, and Biotech Opportunity GP, LLC (\"Biotech\") is the general partner of Venture Fund. Mr. Nodelman is the manager and controlling owner of EcoR1 and Biotech. The funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the funds. Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The reporting persons disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Qualified Fund is the record holder of these securities."}],"balance_after":12504675,"source":{"system":"sec-edgar","filing":"0000935836-23-000619","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1816370/000093583623000619/ownership.xml","form_type":"4"}},{"id":1847528,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-06-21T20:04:17.000Z","date":"2023-06-16","kind":"purchase","planned":false,"acquired":true,"shares":3350000,"price":8.12,"value":27202000.0,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 3,157,542 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund directly owned 12,658,224 shares of the Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group withn the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":13437473,"source":{"system":"sec-edgar","filing":"0000935836-23-000469","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583623000469/ownership.xml","form_type":"4"}},{"id":1908441,"issuer":{"id":114006,"kind":"organization","name":"Panacea Acquisition Corp. II","symbol":"PANA"},"owners":[{"id":114007,"kind":"person","name":"EcoR1 Panacea Holdings II, LLC","position":1,"cik":"0001842055","reported_name":"EcoR1 Panacea Holdings II, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":109484,"kind":"person","name":"EcoR1 Capital Fund, L.P.","position":2,"cik":"0001567938","reported_name":"EcoR1 Capital Fund, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":109485,"kind":"person","name":"EcoR1 Capital Fund Qualified, L.P.","position":3,"cik":"0001598292","reported_name":"EcoR1 Capital Fund Qualified, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":109486,"kind":"person","name":"EcoR1 Venture Opportunity Fund, LP","position":4,"cik":"0001778011","reported_name":"EcoR1 Venture Opportunity Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":5,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":109487,"kind":"person","name":"Biotech Opportunity GP, LLC","position":6,"cik":"0001816370","reported_name":"Biotech Opportunity GP, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":7,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Class A ordinary shares","published_at":"2023-05-02T17:15:46.000Z","date":"2023-04-28","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":545000,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"On April 10, 2023, Panacea Acquisition Corp. II (the \"Company\") announced that it did not consummate an initial business combination by April 9, 2023, the deadline under its Amended and Restated Memorandum and Articles of Association. In connection with the winding up of the Company, the Class A ordinary shares, par value $0.0001 per share, held by the Reporting Persons were surrendered for no consideration on April 28, 2023."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"On April 10, 2023, Panacea Acquisition Corp. II (the \"Company\") announced that it did not consummate an initial business combination by April 9, 2023, the deadline under its Amended and Restated Memorandum and Articles of Association. In connection with the winding up of the Company, the Class A ordinary shares, par value $0.0001 per share, held by the Reporting Persons were surrendered for no consideration on April 28, 2023."},{"field":"ownership.direct","element":"directOrIndirectOwnership","label":"F2","text":"The reporting owner, EcoR1 Panacea Holdings II, LLC (the \"Sponsor\"), in whose name the securities reported herein were held, is managed by its managing members, EcoR1 Capital Fund, L.P., EcoR1 Capital Fund Qualified, L.P. and EcoR1 Venture Opportunity Fund, L.P. The general partner of EcoR1 Capital Fund, L.P. and EcoR1 Capital Fund Qualified, L.P. is EcoR1 Capital, LLC and the general partner of EcoR1 Venture Opportunity Fund, L.P. is Biotech Opportunity GP, LLC (together with EcoR1 Capital, LLC, the \"General Partners\"). Oleg Nodelman is the manager of each of the General Partners. Each of the Reporting Persons may have been deemed to be a beneficial owner of the shares held by the Sponsor but each (other than the Sponsor) disclaims beneficial ownership of any such shares except to the extent of its respective pecuniary interest therein."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001209191-23-026595","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1816370/000120919123026595/doc4.xml","form_type":"4"}},{"id":1934779,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2023-03-30T21:47:37.000Z","date":"2023-03-28","kind":"purchase","planned":false,"acquired":true,"shares":200000,"price":8,"value":1600000.0,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 188,520 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund directly owned 9,500,682 shares of the Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":10087473,"source":{"system":"sec-edgar","filing":"0000935836-23-000348","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583623000348/form4.xml","form_type":"4"}},{"id":2048418,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-01-23T23:00:39.000Z","date":"2023-01-20","kind":"purchase","acquired":true,"shares":163400,"price":9.8843,"value":1615094.62,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 153,906 shares of the Common Stock acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund directly owned 9,312,162 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":9887473,"source":{"system":"sec-edgar","filing":"0001567619-23-001148","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000156761923001148/doc1.xml","form_type":"4"}},{"id":2048417,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-01-23T23:00:39.000Z","date":"2023-01-19","kind":"purchase","acquired":true,"shares":144100,"price":9.4909,"value":1367638.69,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 135,728 shares of the Common Stock acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund directly owned 9,158,256 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":9724073,"source":{"system":"sec-edgar","filing":"0001567619-23-001148","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000156761923001148/doc1.xml","form_type":"4"}},{"id":2052089,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-01-18T23:27:16.000Z","date":"2023-01-18","kind":"purchase","acquired":true,"shares":203000,"price":9.9953,"value":2029045.9,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"Qualified Fund purchased 191,206 shares of the Common Stock acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund directly owned 9,022,528 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":9579973,"source":{"system":"sec-edgar","filing":"0001567619-23-000997","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000156761923000997/doc1.xml","form_type":"4"}},{"id":2052088,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-01-18T23:27:16.000Z","date":"2023-01-17","kind":"purchase","acquired":true,"shares":440000,"price":9.8042,"value":4313848.0,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 414,436 shares of the Common Stock acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund directly owned 8,831,322 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":9376973,"source":{"system":"sec-edgar","filing":"0001567619-23-000997","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000156761923000997/doc1.xml","form_type":"4"}},{"id":2052087,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-01-18T23:27:16.000Z","date":"2023-01-13","kind":"purchase","acquired":true,"shares":342100,"price":9.806,"value":3354632.6,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 322,224 shares of the Common Stock acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund directly owned 8,416,886 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":8936973,"source":{"system":"sec-edgar","filing":"0001567619-23-000997","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000156761923000997/doc1.xml","form_type":"4"}},{"id":2055427,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-01-12T21:47:35.000Z","date":"2023-01-11","kind":"purchase","acquired":true,"shares":106300,"price":7.8731,"value":836910.53,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 100,124 shares of the Common Stock acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund directly owned 8,094,662 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":8594873,"source":{"system":"sec-edgar","filing":"0001567619-23-000896","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000156761923000896/doc1.xml","form_type":"4"}},{"id":2055426,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-01-12T21:47:35.000Z","date":"2023-01-10","kind":"purchase","acquired":true,"shares":920000,"price":7.6491,"value":7037172.0,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 861,156 shares of the Common Stock acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund directly owned 7,994,538 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":8488573,"source":{"system":"sec-edgar","filing":"0001567619-23-000896","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000156761923000896/doc1.xml","form_type":"4"}},{"id":2056465,"issuer":{"id":6271,"kind":"organization","name":"Voyager Therapeutics, Inc."},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-01-11T23:26:21.000Z","date":"2023-01-11","kind":"sale","acquired":false,"shares":110000,"price":8.4965,"value":934615.0,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"Qualified Fund sold 103,609 shares of the Common Stock sold in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund directly owned 3,627,339 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds, and Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their respective pecuniary interests the"}],"balance_after":3851507,"source":{"system":"sec-edgar","filing":"0001567619-23-000839","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1640266/000156761923000839/doc1.xml","form_type":"4"}},{"id":2056464,"issuer":{"id":6271,"kind":"organization","name":"Voyager Therapeutics, Inc."},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-01-11T23:26:21.000Z","date":"2023-01-10","kind":"sale","acquired":false,"shares":336400,"price":8.0542,"value":2709432.88,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund sold 268,985 shares of the Common Stock sold in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund directly owned 3,730,948 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds, and Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their respective pecuniary interests the"}],"balance_after":3961507,"source":{"system":"sec-edgar","filing":"0001567619-23-000839","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1640266/000156761923000839/doc1.xml","form_type":"4"}},{"id":2056463,"issuer":{"id":6271,"kind":"organization","name":"Voyager Therapeutics, Inc."},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-01-11T23:26:21.000Z","date":"2023-01-09","kind":"sale","acquired":false,"shares":456000,"price":7.6717,"value":3498295.2,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund sold 429,505 shares of the Common Stock sold in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund directly owned 3,999,933 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds, and Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their respective pecuniary interests the"}],"balance_after":4297907,"source":{"system":"sec-edgar","filing":"0001567619-23-000839","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1640266/000156761923000839/doc1.xml","form_type":"4"}},{"id":2223056,"issuer":{"id":6271,"kind":"organization","name":"Voyager Therapeutics, Inc."},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2022-06-23T21:21:44.000Z","date":"2022-06-23","kind":"purchase","acquired":true,"shares":376000,"price":5.6557,"value":2126543.2,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 354,041 shares of the Common Stock acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund directly owned 4,429,438 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds, and Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their respective pecuniary interests the"}],"balance_after":4753907,"source":{"system":"sec-edgar","filing":"0001567619-22-013333","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1640266/000156761922013333/doc1.xml","form_type":"4"}},{"id":2223055,"issuer":{"id":6271,"kind":"organization","name":"Voyager Therapeutics, Inc."},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2022-06-23T21:21:44.000Z","date":"2022-06-21","kind":"purchase","acquired":true,"shares":101400,"price":5.2811,"value":535503.54,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 95,478 shares of the Common Stock acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund directly owned 4,075,397 shares of Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds, and Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their respective pecuniary interests the"}],"balance_after":4377907,"source":{"system":"sec-edgar","filing":"0001567619-22-013333","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1640266/000156761922013333/doc1.xml","form_type":"4"}},{"id":2277270,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2022-05-09T10:01:38.000Z","date":"2022-05-05","kind":"sale","acquired":false,"shares":1062736,"price":29.02,"value":30840598.72,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"EcoR1 Capital Fund, L.P. (\"Capital Fund\") and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\") are private investment funds managed by EcoR1 Capital, LLC (\"EcoR1\") on a parri passu basis. These securities were transferred from Capital Fund to Qualified Fund as part of a periodic rebalancing of the portfolios of the funds."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The filing persons (the \"Filers\") are EcoR1, Oleg Nodelman and Qualified Fund. EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund and Capital Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to beneficially own the securities indirectly as the investment adviser to the Funds, and Mr. Nodelman may be deemed to beneficially own them indirectly as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."}],"balance_after":11584280,"source":{"system":"sec-edgar","filing":"0001567619-22-009730","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000156761922009730/doc1.xml","form_type":"4"}},{"id":2277269,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2022-05-09T10:01:38.000Z","date":"2022-05-05","kind":"purchase","acquired":true,"shares":1062736,"price":29.02,"value":30840598.72,"ownership":{"direct":false,"nature":"See Notes"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"EcoR1 Capital Fund, L.P. (\"Capital Fund\") and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\") are private investment funds managed by EcoR1 Capital, LLC (\"EcoR1\") on a parri passu basis. These securities were transferred from Capital Fund to Qualified Fund as part of a periodic rebalancing of the portfolios of the funds."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The filing persons (the \"Filers\") are EcoR1, Oleg Nodelman and Qualified Fund. EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund and Capital Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to beneficially own the securities indirectly as the investment adviser to the Funds, and Mr. Nodelman may be deemed to beneficially own them indirectly as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"After this transaction, Qualified Fund held 10,847,852 of the Issuer's Ordinary Shares."}],"balance_after":11584280,"source":{"system":"sec-edgar","filing":"0001567619-22-009730","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000156761922009730/doc1.xml","form_type":"4"}},{"id":2277618,"issuer":{"id":4640,"kind":"organization","name":"ANAPTYSBIO, INC","symbol":"ANAB"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2022-05-09T06:04:35.000Z","date":"2022-05-05","kind":"sale","acquired":false,"shares":668237,"price":21.63,"value":14453966.31,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"EcoR1 Capital Fund, L.P. (\"Capital Fund\") and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\") are private investment funds managed by EcoR1 Capital, LLC (\"EcoR1\") on a parri passu basis. These securities were transferred from Capital Fund to Qualified Fund as part of a periodic rebalancing of the portfolios of the funds."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The filing persons (the \"Filers\") are EcoR1, Oleg Nodelman and Qualified Fund. EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund and Capital Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1 and a director of the Issuer. EcoR1 is filing this Form 4 for itself and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to beneficially own the securities indirectly as the investment adviser to the Funds, and Mr. Nodelman may be deemed to beneficially own them indirectly as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."}],"balance_after":7521024,"source":{"system":"sec-edgar","filing":"0001567619-22-009732","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000156761922009732/doc1.xml","form_type":"4"}},{"id":2277617,"issuer":{"id":4640,"kind":"organization","name":"ANAPTYSBIO, INC","symbol":"ANAB"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2022-05-09T06:04:35.000Z","date":"2022-05-05","kind":"purchase","acquired":true,"shares":668237,"price":21.63,"value":14453966.31,"ownership":{"direct":false,"nature":"See Notes"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"EcoR1 Capital Fund, L.P. (\"Capital Fund\") and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\") are private investment funds managed by EcoR1 Capital, LLC (\"EcoR1\") on a parri passu basis. These securities were transferred from Capital Fund to Qualified Fund as part of a periodic rebalancing of the portfolios of the funds."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The filing persons (the \"Filers\") are EcoR1, Oleg Nodelman and Qualified Fund. EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund and Capital Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1 and a director of the Issuer. EcoR1 is filing this Form 4 for itself and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to beneficially own the securities indirectly as the investment adviser to the Funds, and Mr. Nodelman may be deemed to beneficially own them indirectly as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"After this transaction, Qualified Fund held 7,042,903 shares of the Issuer's Common Stock."}],"balance_after":7521024,"source":{"system":"sec-edgar","filing":"0001567619-22-009732","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000156761922009732/doc1.xml","form_type":"4"}},{"id":2436509,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2022-01-12T23:12:52.000Z","date":"2022-01-12","kind":"purchase","acquired":true,"shares":300000,"price":37.501,"value":11250300.0,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased all of the Ordinary Shares acquired in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund directly owned 9,785,116 Ordinary Shares."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the Funds, and Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein."}],"balance_after":11584280,"source":{"system":"sec-edgar","filing":"0001567619-22-001133","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000156761922001133/doc1.xml","form_type":"4"}},{"id":2476790,"issuer":{"id":132524,"kind":"organization","name":"Odonate Therapeutics, Inc.","symbol":"ODT"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2021-12-10T23:50:07.000Z","date":"2021-12-10","kind":"sale","acquired":false,"shares":545000,"price":1.5549,"value":847420.5,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund sold 495,707 of these shares.  After this transaction, Qualified Fund held no shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds held these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owned them as the investment adviser to the Funds, and Mr. Nodelman indirectly beneficially owned them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their respective pecuniary interests therein."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001567619-21-021902","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000156761921021902/doc1.xml","form_type":"4"}},{"id":2476789,"issuer":{"id":132524,"kind":"organization","name":"Odonate Therapeutics, Inc.","symbol":"ODT"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2021-12-10T23:50:07.000Z","date":"2021-12-10","kind":"sale","acquired":false,"shares":5000000,"price":1.66,"value":8300000.0,"ownership":{"direct":false,"nature":"See Note 1"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund sold 4,547,500 of these shares.  After this transaction, Qualified Fund held 495,707 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The filing persons (the \"Filers\") are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds held these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owned them as the investment adviser to the Funds, and Mr. Nodelman indirectly beneficially owned them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their respective pecuniary interests therein."}],"balance_after":545000,"source":{"system":"sec-edgar","filing":"0001567619-21-021902","document":"doc1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000156761921021902/doc1.xml","form_type":"4"}}],"next_cursor":"2021-12-10T23:50:07.000000Z,2476789"}