{"transactions":[{"id":4613296,"issuer":{"id":9597,"kind":"organization","name":"Barinthus Biotherapeutics plc.","symbol":"BRNS"},"owners":[{"id":46694,"kind":"person","name":"DAWES KAREN A","position":1,"cik":"0001261506","reported_name":"DAWES KAREN A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2026-09-09T20:15:12.000Z","date":"2026-09-09","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":20174,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"This Form 4 reports securities transacted in connection with the Agreement and Plan of Merger, dated September 29, 2025, as amended (the \"Merger Agreement\") by and among the Issuer, Beacon Topco, Inc. 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On September 9, 2026 (the \"Effective Time\"), in connection with the effectiveness of the scheme of arrangement under Part 26 of the United Kingdom Companies Act 2006 (the \"Scheme\") contemplated by the Merger Agreement, Topco acquired the entire issued share capital of the Issuer, resulting in the Issuer becoming a direct wholly owned subsidiary of Topco."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"Pursuant to the Merger Agreement, at the Effective Time, each option to acquire Shares under the Issuer's equity plans that was outstanding as of immediately prior to the Effective Time ceased to represent a right to acquire Shares of the Issuer, and was converted into an option to acquire shares of Topco Common Stock and assumed by Topco on the same terms and conditions (including applicable vesting and exercisability conditions) as were applicable to such option immediately prior to the Effective Time."},{"field":"derivative.underlying","element":"underlyingSecurityTitle","label":"F1","text":"The Ordinary Shares may be represented by American Depositary Shares (\"ADSs\" and together with the Ordinary Shares, the \"Shares\"), each of which currently represents one Ordinary Share."}],"balance_after":0,"derivative":{"exercise_price":1,"expiration_date":"2035-06-10","underlying":"Ordinary Shares","underlying_shares":20174},"source":{"system":"sec-edgar","filing":"0001104659-26-106323","document":"tm2625057-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1828185/000110465926106323/tm2625057-1_4seq1.xml","form_type":"4"}},{"id":4613295,"issuer":{"id":9597,"kind":"organization","name":"Barinthus Biotherapeutics plc.","symbol":"BRNS"},"owners":[{"id":46694,"kind":"person","name":"DAWES KAREN A","position":1,"cik":"0001261506","reported_name":"DAWES KAREN A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2026-09-09T20:15:12.000Z","date":"2026-09-09","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":19516,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"This Form 4 reports securities transacted in connection with the Agreement and Plan of Merger, dated September 29, 2025, as amended (the \"Merger Agreement\") by and among the Issuer, Beacon Topco, Inc. 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(\"Topco\"), a Delaware corporation and a direct wholly owned subsidiary of the Issuer, Cdog Merger Sub, Inc., a Delaware corporation and a direct wholly owned subsidiary of Topco, and Clywedog Therapeutics, Inc., a Delaware corporation. 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(\"Topco\"), a Delaware corporation and a direct wholly owned subsidiary of the Issuer, Cdog Merger Sub, Inc., a Delaware corporation and a direct wholly owned subsidiary of Topco, and Clywedog Therapeutics, Inc., a Delaware corporation. 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(\"Topco\"), a Delaware corporation and a direct wholly owned subsidiary of the Issuer, Cdog Merger Sub, Inc., a Delaware corporation and a direct wholly owned subsidiary of Topco, and Clywedog Therapeutics, Inc., a Delaware corporation. On September 9, 2026 (the \"Effective Time\"), in connection with the effectiveness of the scheme of arrangement under Part 26 of the United Kingdom Companies Act 2006 (the \"Scheme\") contemplated by the Merger Agreement, Topco acquired the entire issued share capital of the Issuer, resulting in the Issuer becoming a direct wholly owned subsidiary of Topco."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"Pursuant to the Merger Agreement, at the Effective Time, each option to acquire Shares under the Issuer's equity plans that was outstanding as of immediately prior to the Effective Time ceased to represent a right to acquire Shares of the Issuer, and was converted into an option to acquire shares of Topco Common Stock and assumed by Topco on the same terms and conditions (including applicable vesting and exercisability conditions) as were applicable to such option immediately prior to the Effective Time."},{"field":"derivative.underlying","element":"underlyingSecurityTitle","label":"F1","text":"The Ordinary Shares may be represented by American Depositary Shares (\"ADSs\" and together with the Ordinary Shares, the \"Shares\"), each of which currently represents one Ordinary Share."}],"balance_after":0,"derivative":{"exercise_price":17,"expiration_date":"2031-05-01","underlying":"Ordinary Shares","underlying_shares":34328},"source":{"system":"sec-edgar","filing":"0001104659-26-106323","document":"tm2625057-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1828185/000110465926106323/tm2625057-1_4seq1.xml","form_type":"4"}},{"id":4613291,"issuer":{"id":9597,"kind":"organization","name":"Barinthus Biotherapeutics plc.","symbol":"BRNS"},"owners":[{"id":46694,"kind":"person","name":"DAWES KAREN A","position":1,"cik":"0001261506","reported_name":"DAWES KAREN A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Ordinary Shares","published_at":"2026-09-09T20:15:12.000Z","date":"2026-09-09","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":1700,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"The Ordinary Shares may be represented by American Depositary Shares (\"ADSs\" and together with the Ordinary Shares, the \"Shares\"), each of which currently represents one Ordinary Share."},{"field":"kind","element":"transactionCoding","label":"F2","text":"This Form 4 reports securities transacted in connection with the Agreement and Plan of Merger, dated September 29, 2025, as amended (the \"Merger Agreement\") by and among the Issuer, Beacon Topco, Inc. (\"Topco\"), a Delaware corporation and a direct wholly owned subsidiary of the Issuer, Cdog Merger Sub, Inc., a Delaware corporation and a direct wholly owned subsidiary of Topco, and Clywedog Therapeutics, Inc., a Delaware corporation. On September 9, 2026 (the \"Effective Time\"), in connection with the effectiveness of the scheme of arrangement under Part 26 of the United Kingdom Companies Act 2006 (the \"Scheme\") contemplated by the Merger Agreement, Topco acquired the entire issued share capital of the Issuer, resulting in the Issuer becoming a direct wholly owned subsidiary of Topco."},{"field":"shares","element":"transactionShares","label":"F3","text":"Pursuant to the Merger Agreement and in connection with the effectiveness of the Scheme, at the Effective Time, each Share of the Issuer was converted into the right to receive 0.111 shares of common stock, $0.0001 par value per share, of Topco (the \"Topco Common Stock\")."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"Pursuant to the Merger Agreement and in connection with the effectiveness of the Scheme, at the Effective Time, each Share of the Issuer was converted into the right to receive 0.111 shares of common stock, $0.0001 par value per share, of Topco (the \"Topco Common Stock\")."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001104659-26-106323","document":"tm2625057-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1828185/000110465926106323/tm2625057-1_4seq1.xml","form_type":"4"}},{"id":776216,"issuer":{"id":486,"kind":"organization","name":"REPLIGEN CORP","symbol":"RGEN"},"owners":[{"id":46694,"kind":"person","name":"DAWES KAREN A","position":1,"cik":"0001261506","reported_name":"DAWES KAREN A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2026-05-18T20:05:04.000Z","date":"2026-05-14","kind":"grant","planned":false,"acquired":true,"shares":2239,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"Award vests in full on the earlier of May 14, 2027, one year from grant date, or on the date of the next annual meeting of the Company's shareholders, which has not yet been determined."}],"balance_after":2239,"derivative":{"exercise_price":103.38,"exercise_date":"2027-05-14","expiration_date":"2036-05-14","underlying":"Common Stock","underlying_shares":2239},"source":{"system":"sec-edgar","filing":"0001193125-26-228884","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/730272/000119312526228884/ownership.xml","form_type":"4"}},{"id":776215,"issuer":{"id":486,"kind":"organization","name":"REPLIGEN CORP","symbol":"RGEN"},"owners":[{"id":46694,"kind":"person","name":"DAWES KAREN A","position":1,"cik":"0001261506","reported_name":"DAWES KAREN A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-05-18T20:05:04.000Z","date":"2026-05-14","kind":"grant","planned":false,"acquired":true,"shares":995,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Ms. Dawes was awarded 995 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of Repligen Corporation's Common Stock. The restricted stock units vest on the earlier of May 14, 2027, one year from the grant date, or the date of the next annual meeting of the Company's shareholders, which has not yet been determined. The restricted stock units may be settled only by delivering shares of Repligen Corporation's Common Stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance."}],"balance_after":92816,"source":{"system":"sec-edgar","filing":"0001193125-26-228884","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/730272/000119312526228884/ownership.xml","form_type":"4"}},{"id":963890,"issuer":{"id":486,"kind":"organization","name":"REPLIGEN CORP","symbol":"RGEN"},"owners":[{"id":46694,"kind":"person","name":"DAWES KAREN A","position":1,"cik":"0001261506","reported_name":"DAWES KAREN A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2025-12-18T21:30:18.000Z","date":"2025-12-17","kind":"sale","planned":false,"acquired":false,"shares":275,"price":161,"value":44275.0,"ownership":{"direct":true},"balance_after":91821,"source":{"system":"sec-edgar","filing":"0001193125-25-324912","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/730272/000119312525324912/ownership.xml","form_type":"4"}},{"id":1114765,"issuer":{"id":9597,"kind":"organization","name":"Barinthus Biotherapeutics plc.","symbol":"BRNS"},"owners":[{"id":46694,"kind":"person","name":"DAWES KAREN A","position":1,"cik":"0001261506","reported_name":"DAWES KAREN A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2025-06-11T17:10:29.000Z","date":"2025-06-10","kind":"grant","planned":false,"acquired":true,"shares":20174,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares underlying this option shall vest in full on the earlier of (i) June 10, 2026 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date."},{"field":"derivative.underlying","element":"underlyingSecurityTitle","label":"F2","text":"The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share."}],"balance_after":20174,"derivative":{"exercise_price":1,"expiration_date":"2035-06-10","underlying":"Ordinary Shares","underlying_shares":20174},"source":{"system":"sec-edgar","filing":"0001828185-25-000039","document":"wk-form4_1749676222.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1261506/000182818525000039/wk-form4_1749676222.xml","form_type":"4"}},{"id":1144320,"issuer":{"id":486,"kind":"organization","name":"REPLIGEN CORP","symbol":"RGEN"},"owners":[{"id":46694,"kind":"person","name":"DAWES KAREN A","position":1,"cik":"0001261506","reported_name":"DAWES KAREN A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2025-05-19T19:27:23.000Z","date":"2025-05-15","kind":"grant","planned":false,"acquired":true,"shares":1800,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"Award vests in full on the earlier of May 15, 2026, one year from grant date, or on the date of the next annual meeting of the Company's shareholders, which has not yet been determined."}],"balance_after":1800,"derivative":{"exercise_price":123.26,"exercise_date":"2026-05-15","expiration_date":"2035-05-15","underlying":"Common Stock","underlying_shares":1800},"source":{"system":"sec-edgar","filing":"0000950170-25-074251","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/730272/000095017025074251/ownership.xml","form_type":"4"}},{"id":1144319,"issuer":{"id":486,"kind":"organization","name":"REPLIGEN CORP","symbol":"RGEN"},"owners":[{"id":46694,"kind":"person","name":"DAWES KAREN A","position":1,"cik":"0001261506","reported_name":"DAWES KAREN A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2025-05-19T19:27:23.000Z","date":"2025-05-15","kind":"grant","planned":false,"acquired":true,"shares":973,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Ms. Dawes was awarded 973 restricted stock units. 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