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For purposes of the foregoing, the \"Milestone Event\" means the public announcement via press release or the filing of a Current Report on Form 8-K by the Issuer of topline data from the cohorts treated with single ascending doses of PMN310."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"The warrants to purchase Common Shares (the \"Warrants\") are exercisable immediately and will expire upon the earlier of (i) within 60 days of the Milestone Event or (ii) February 3, 2031. For purposes of the foregoing, the \"Milestone Event\" means the public announcement via press release or the filing of a Current Report on Form 8-K by the Issuer of topline data from the cohorts treated with single ascending doses of PMN310."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Mr. Fan Yu is the controlling stockholder of ABG Management Ltd., which is the sole member of Ally Bridge Group (NY) LLC, which manages the investments of Ally Bridge MedAlpha Master Fund L.P. As such, each of the foregoing entities and Mr. Fan Yu may be deemed to share beneficial ownership of the securities held of record by Ally Bridge MedAlpha Master Fund L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Mr. Fan Yu is also the indirect controlling stockholder of ABG Global Life Science Capital Partners V GP Limited, which is the general partner of ABG Global Life Science Capital Partners V GP, L.P., which is the general partner of Ally Bridge Group Global Life Science Capital Partners V, L.P., which is the controlling shareholder of ABG V-SIV IX Limited. As such, each of the foregoing entities and Mr. Fan Yu may be deemed to share beneficial ownership of the securities held of record by ABG V-SIV IX Limited."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Mr. Fan Yu is also the controlling stockholder of ABG V-SIV X Limited. As such, Mr. Fan Yu may be deemed to share beneficial ownership of the securities held of record by ABG V-SIV X Limited."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"The Warrants reported herein include: (i) Warrants to purchase 164,881 Common Shares held of record by Ally Bridge MedAlpha Master Fund L.P., (ii) Warrants to purchase 329,760 Common Shares held of record by ABG V-SIV IX Limited and (iii) Warrants to purchase 206,100 Common Shares held of record by ABG V-SIV X Limited."}],"balance_after":700741,"derivative":{"exercise_price":14.4,"underlying":"Common Shares","underlying_shares":700741},"source":{"system":"sec-edgar","filing":"0001493152-26-005410","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1668029/000149315226005410/ownership.xml","form_type":"4"}},{"id":917712,"issuer":{"id":6643,"kind":"organization","name":"ProMIS Neurosciences Inc.","symbol":"PMN"},"owners":[{"id":67584,"kind":"organization","name":"ABG Management Ltd.","position":1,"cik":"0001832106","reported_name":"ABG Management Ltd.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":67585,"kind":"organization","name":"Ally Bridge MedAlpha Master Fund L.P.","position":2,"cik":"0001831963","reported_name":"Ally Bridge MedAlpha Master Fund L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":67586,"kind":"organization","name":"Ally Bridge Group (NY) LLC","position":3,"cik":"0001822947","reported_name":"Ally Bridge Group (NY) LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":67587,"kind":"person","name":"Yu Fan","position":4,"cik":"0001668029","reported_name":"Yu Fan","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":44676,"kind":"person","name":"Alex Slanix Paul","position":5,"cik":"0002092283","reported_name":"Alex Slanix Paul","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Shares","published_at":"2026-02-06T00:00:01.000Z","date":"2026-02-03","kind":"purchase","planned":false,"acquired":true,"shares":700741,"price":12.13,"value":8499988.33,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The Warrants were purchased together with the Common Shares reported herein for an aggregate purchase price of $12.13 per Common Share."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The Common Shares reported herein include: (i) 407,230 Common Shares held of record by Ally Bridge MedAlpha Master Fund L.P., (ii) 329,760 Common Shares held of record by ABG V-SIV IX Limited and (iii) 206,100 Common Shares held of record by ABG V-SIV X Limited."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Mr. Fan Yu is the controlling stockholder of ABG Management Ltd., which is the sole member of Ally Bridge Group (NY) LLC, which manages the investments of Ally Bridge MedAlpha Master Fund L.P. As such, each of the foregoing entities and Mr. Fan Yu may be deemed to share beneficial ownership of the securities held of record by Ally Bridge MedAlpha Master Fund L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Mr. Fan Yu is also the indirect controlling stockholder of ABG Global Life Science Capital Partners V GP Limited, which is the general partner of ABG Global Life Science Capital Partners V GP, L.P., which is the general partner of Ally Bridge Group Global Life Science Capital Partners V, L.P., which is the controlling shareholder of ABG V-SIV IX Limited. As such, each of the foregoing entities and Mr. Fan Yu may be deemed to share beneficial ownership of the securities held of record by ABG V-SIV IX Limited."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Mr. Fan Yu is also the controlling stockholder of ABG V-SIV X Limited. As such, Mr. Fan Yu may be deemed to share beneficial ownership of the securities held of record by ABG V-SIV X Limited."}],"balance_after":943090,"source":{"system":"sec-edgar","filing":"0001493152-26-005410","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1668029/000149315226005410/ownership.xml","form_type":"4"}},{"id":1013832,"issuer":{"id":6643,"kind":"organization","name":"ProMIS Neurosciences Inc.","symbol":"PMN"},"owners":[{"id":67584,"kind":"organization","name":"ABG Management Ltd.","position":1,"cik":"0001832106","reported_name":"ABG Management Ltd.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":67585,"kind":"organization","name":"Ally Bridge MedAlpha Master Fund L.P.","position":2,"cik":"0001831963","reported_name":"Ally Bridge MedAlpha Master Fund L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":67586,"kind":"organization","name":"Ally Bridge Group (NY) LLC","position":3,"cik":"0001822947","reported_name":"Ally Bridge Group (NY) LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":67587,"kind":"person","name":"Yu Fan","position":4,"cik":"0001668029","reported_name":"Yu Fan","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":44676,"kind":"person","name":"Alex Slanix Paul","position":5,"cik":"0002092283","reported_name":"Alex Slanix Paul","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Option (right to buy)","published_at":"2025-10-24T20:34:08.000Z","date":"2025-10-22","kind":"grant","planned":false,"acquired":true,"shares":40000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"25% of the shares subject to this option vested on the date of grant and the remaining shares shall vest in thirty-six equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date."},{"field":"ownership.direct","element":"directOrIndirectOwnership","label":"F2","text":"This option was granted to Slanix Alex, a director of the Issuer and an employee of Ally Bridge Group (NY) LLC, which manages the investments of Ally Bridge MedAlpha Master Fund L.P. Dr. Alex holds any equity-based compensation awarded to him for his service as a director of the Issuer for the benefit of Ally Bridge MedAlpha Master Fund L.P. Any proceeds from the sale of shares upon exercise of this award shall be remitted to Ally Bridge MedAlpha Master Fund L.P. The Reporting Person disclaims beneficial ownership of such securities for purposes of Section 16 except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that such securities are beneficially owned by him for Section 16 or any other purpose."}],"balance_after":40000,"derivative":{"exercise_price":0.45,"expiration_date":"2035-10-22","underlying":"Common Shares","underlying_shares":40000},"source":{"system":"sec-edgar","filing":"0001493152-25-019320","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1668029/000149315225019320/ownership.xml","form_type":"4"}}]}