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These shares were sold in multiple transactions at prices ranging from $56.00 to $56.01, inclusive.  The reporting person undertakes to provide to Spark Therapeutics, Inc., any security holder of Spark Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) to this Form 4."}],"balance_after":210000,"source":{"system":"sec-edgar","filing":"0001609351-17-000029","document":"wf-form4_149324329172915.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1631248/000160935117000029/wf-form4_149324329172915.xml","form_type":"4"}},{"id":4344584,"issuer":{"id":153045,"kind":"organization","name":"Spark Therapeutics, Inc.","symbol":"ONCE"},"owners":[{"id":39853,"kind":"person","name":"High Katherine A","position":1,"cik":"0001631248","reported_name":"High Katherine A","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Common Stock","published_at":"2017-04-26T21:48:28.000Z","date":"2017-04-25","kind":"sale","acquired":false,"shares":12830,"price":55.38,"value":710525.4,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 28, 2017."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price.  These shares were sold in multiple transactions at prices ranging from $55.00 to $55.96, inclusive.  The reporting person undertakes to provide to Spark Therapeutics, Inc., any security holder of Spark Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) to this Form 4."}],"balance_after":210110,"source":{"system":"sec-edgar","filing":"0001609351-17-000029","document":"wf-form4_149324329172915.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1631248/000160935117000029/wf-form4_149324329172915.xml","form_type":"4"}},{"id":4344583,"issuer":{"id":153045,"kind":"organization","name":"Spark Therapeutics, Inc.","symbol":"ONCE"},"owners":[{"id":39853,"kind":"person","name":"High Katherine A","position":1,"cik":"0001631248","reported_name":"High Katherine A","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Common Stock","published_at":"2017-04-26T21:48:28.000Z","date":"2017-04-25","kind":"exercise","acquired":true,"shares":12940,"price":3.45,"value":44643.0,"ownership":{"direct":true},"balance_after":222940,"source":{"system":"sec-edgar","filing":"0001609351-17-000029","document":"wf-form4_149324329172915.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1631248/000160935117000029/wf-form4_149324329172915.xml","form_type":"4"}},{"id":4344582,"issuer":{"id":153045,"kind":"organization","name":"Spark Therapeutics, Inc.","symbol":"ONCE"},"owners":[{"id":39853,"kind":"person","name":"High Katherine A","position":1,"cik":"0001631248","reported_name":"High Katherine A","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Common Stock","published_at":"2017-04-26T21:48:28.000Z","date":"2017-04-24","kind":"sale","acquired":false,"shares":2060,"price":55.01,"value":113320.6,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 28, 2017."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price.  These shares were sold in multiple transactions at prices ranging from $55.00 to $55.02, inclusive.  The reporting person undertakes to provide to Spark Therapeutics, Inc., any security holder of Spark Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) to this Form 4."}],"balance_after":210000,"source":{"system":"sec-edgar","filing":"0001609351-17-000029","document":"wf-form4_149324329172915.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1631248/000160935117000029/wf-form4_149324329172915.xml","form_type":"4"}},{"id":4344581,"issuer":{"id":153045,"kind":"organization","name":"Spark Therapeutics, Inc.","symbol":"ONCE"},"owners":[{"id":39853,"kind":"person","name":"High Katherine A","position":1,"cik":"0001631248","reported_name":"High Katherine A","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Common Stock","published_at":"2017-04-26T21:48:28.000Z","date":"2017-04-24","kind":"exercise","acquired":true,"shares":2060,"price":3.45,"value":7107.0,"ownership":{"direct":true},"balance_after":212060,"source":{"system":"sec-edgar","filing":"0001609351-17-000029","document":"wf-form4_149324329172915.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1631248/000160935117000029/wf-form4_149324329172915.xml","form_type":"4"}},{"id":4485280,"issuer":{"id":153045,"kind":"organization","name":"Spark Therapeutics, Inc.","symbol":"ONCE"},"owners":[{"id":39853,"kind":"person","name":"High Katherine A","position":1,"cik":"0001631248","reported_name":"High Katherine A","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Restricted Stock Units","published_at":"2017-01-20T21:05:57.000Z","date":"2017-01-18","kind":"grant","acquired":true,"shares":9000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each restricted stock unit represents a contingent right to receive one share of Spark Therapeutics common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The restricted stock units vest in four equal annual installments beginning January 18, 2018.  Vested shares will be delivered to the reporting person annually on the vesting date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"The restricted stock units vest in four equal annual installments beginning January 18, 2018.  Vested shares will be delivered to the reporting person annually on the vesting date."}],"balance_after":18000,"derivative":{"underlying":"Common Stock","underlying_shares":9000},"source":{"system":"sec-edgar","filing":"0001609351-17-000011","document":"wf-form4_148494634366185.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1631248/000160935117000011/wf-form4_148494634366185.xml","form_type":"4"}},{"id":4485279,"issuer":{"id":153045,"kind":"organization","name":"Spark Therapeutics, Inc.","symbol":"ONCE"},"owners":[{"id":39853,"kind":"person","name":"High Katherine A","position":1,"cik":"0001631248","reported_name":"High Katherine A","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Employee Stock Option (right to buy)","published_at":"2017-01-20T21:05:57.000Z","date":"2017-01-18","kind":"grant","acquired":true,"shares":31500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"25% vests January 18, 2018 and the remainder vests in equal annual installments over the following three years."}],"balance_after":31500,"derivative":{"exercise_price":56.17,"expiration_date":"2027-01-17","underlying":"Common Stock","underlying_shares":31500},"source":{"system":"sec-edgar","filing":"0001609351-17-000011","document":"wf-form4_148494634366185.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1631248/000160935117000011/wf-form4_148494634366185.xml","form_type":"4"}},{"id":4552967,"issuer":{"id":153045,"kind":"organization","name":"Spark Therapeutics, Inc.","symbol":"ONCE"},"owners":[{"id":39853,"kind":"person","name":"High Katherine A","position":1,"cik":"0001631248","reported_name":"High Katherine A","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Common Stock","published_at":"2016-11-16T23:09:52.000Z","date":"2016-11-14","kind":"sale","acquired":false,"shares":10000,"price":60.3,"value":603000.0,"ownership":{"direct":true},"footnotes":[{"field":"date","element":"transactionDate","label":"F1","text":"The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 3, 2016."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price.  These shares were sold in multiple transactions at prices ranging from $60.00 to $60.90, inclusive.  The reporting person undertakes to provide to Spark Therapeutics, Inc., any security holder of Spark Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) to this Form 4."}],"balance_after":210000,"source":{"system":"sec-edgar","filing":"0001609351-16-000109","document":"wf-form4_147933777931827.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1631248/000160935116000109/wf-form4_147933777931827.xml","form_type":"4"}}],"next_cursor":"2016-11-16T23:09:52.000000Z,4552967"}