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These shares were sold in multiple transactions at prices ranging from $49.60 to $49.62 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":35825,"source":{"system":"sec-edgar","filing":"0000874015-24-000104","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000104/edgardoc.xml","form_type":"4"}},{"id":1662907,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Common Stock","published_at":"2024-02-03T00:54:54.000Z","date":"2024-02-01","kind":"grant","planned":false,"acquired":true,"shares":4140,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the second performance period of the grant to the reporting person reported on January 19, 2022. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 150% of target shares. As reported at grant, the PRSUs could result in a payout of 0% to 150% based on actual achievement of the goal."}],"balance_after":37950,"source":{"system":"sec-edgar","filing":"0000874015-24-000104","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000104/edgardoc.xml","form_type":"4"}},{"id":1673176,"issuer":{"id":62843,"kind":"organization","name":"Ventyx Biosciences, Inc.","symbol":"VTYX"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2024-01-23T22:10:06.000Z","date":"2024-01-21","kind":"grant","planned":false,"acquired":true,"shares":20000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option shall vest on the one-year anniversary of January 21, 2024, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2021 Equity Incentive Plan, the \"Plan\") through such date, provided that in the event of a Change in Control (as such term is defined in the Plan), one hundred percent (100%) of the then-unvested and outstanding shares subject to the Option will accelerate and fully vest, subject to the reporting person continuing to be an Outside Director (as the term is defined in the Company's Amended and Restated Outside Director Compensation Policy) through the date of the Change in Control."}],"balance_after":20000,"derivative":{"exercise_price":1.97,"expiration_date":"2034-01-21","underlying":"Common Stock","underlying_shares":20000},"source":{"system":"sec-edgar","filing":"0001209191-24-002088","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1851194/000120919124002088/doc4.xml","form_type":"4"}},{"id":1677178,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Restricted Stock Unit","published_at":"2024-01-18T23:07:45.000Z","date":"2024-01-16","kind":"exercise","planned":false,"acquired":false,"shares":15062,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":66997,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":15062},"source":{"system":"sec-edgar","filing":"0000874015-24-000081","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000081/edgardoc.xml","form_type":"4"}},{"id":1677177,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Common Stock","published_at":"2024-01-18T23:07:45.000Z","date":"2024-01-17","kind":"sale","planned":false,"acquired":false,"shares":5564,"price":50.417,"value":280520.188,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.35 to $50.43, inclusive. The reporting person undertakes to provide to Ionis\nPharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) of this Form 4."}],"balance_after":33810,"source":{"system":"sec-edgar","filing":"0000874015-24-000081","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000081/edgardoc.xml","form_type":"4"}},{"id":1677176,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Common Stock","published_at":"2024-01-18T23:07:45.000Z","date":"2024-01-16","kind":"exercise","planned":false,"acquired":true,"shares":15062,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":39374,"source":{"system":"sec-edgar","filing":"0000874015-24-000081","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000081/edgardoc.xml","form_type":"4"}},{"id":1678507,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Restricted Stock Unit","published_at":"2024-01-18T01:49:43.000Z","date":"2024-01-15","kind":"grant","planned":false,"acquired":true,"shares":32400,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":82059,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":32400},"source":{"system":"sec-edgar","filing":"0000874015-24-000052","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000052/edgardoc.xml","form_type":"4"}},{"id":1678506,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Performance Restricted Stock Units","published_at":"2024-01-18T01:49:43.000Z","date":"2024-01-15","kind":"grant","planned":false,"acquired":true,"shares":27000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"Grant to reporting person of Performance Restricted Stock Units (PRSUs) under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."}],"balance_after":55635,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":27000},"source":{"system":"sec-edgar","filing":"0000874015-24-000052","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000052/edgardoc.xml","form_type":"4"}},{"id":1689428,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2024-01-04T22:23:18.000Z","date":"2024-01-02","kind":"grant","planned":false,"acquired":true,"shares":43200,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2024 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on\n01/02/2024. 25% of the shares subject to the option will vest and become exercisable on 01/02/2025. Thereafter, the remaining shares subject to the option will vest and become exercisable in 36 equal monthly installments over the next 3 years."}],"balance_after":43200,"derivative":{"exercise_price":52.87,"exercise_date":"2025-01-02","expiration_date":"2034-01-01","underlying":"Common Stock","underlying_shares":43200},"source":{"system":"sec-edgar","filing":"0000874015-24-000020","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000020/edgardoc.xml","form_type":"4"}},{"id":1852570,"issuer":{"id":62843,"kind":"organization","name":"Ventyx Biosciences, Inc.","symbol":"VTYX"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2023-06-17T01:10:59.000Z","date":"2023-06-15","kind":"grant","planned":false,"acquired":true,"shares":15937,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option shall vest on the earlier of (i) the one-year anniversary of the Vesting Commencement Date (as defined below) or, (ii) the day prior to the date of the Annual Meeting of the Issuer's stockholders next following the date the option was granted, in each case, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2021 Equity Incentive Plan) through the applicable vesting date. The \"Vesting Commencement Date\" shall mean June 7, 2023."}],"balance_after":15937,"derivative":{"exercise_price":34.83,"expiration_date":"2033-06-15","underlying":"Common Stock","underlying_shares":15937},"source":{"system":"sec-edgar","filing":"0001209191-23-038184","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1851194/000120919123038184/doc4.xml","form_type":"4"}},{"id":1852458,"issuer":{"id":4972,"kind":"organization","name":"ARDELYX, INC."},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2023-06-16T22:31:13.000Z","date":"2023-06-15","kind":"grant","planned":false,"acquired":true,"shares":49237,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date."}],"balance_after":49237,"derivative":{"exercise_price":3.92,"exercise_date":"2023-06-15","expiration_date":"2033-06-15","underlying":"Common Stock","underlying_shares":49237},"source":{"system":"sec-edgar","filing":"0001628280-23-022557","document":"wk-form4_1686954661.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1799355/000162828023022557/wk-form4_1686954661.xml","form_type":"4"}},{"id":1852457,"issuer":{"id":4972,"kind":"organization","name":"ARDELYX, INC."},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2023-06-16T22:31:13.000Z","date":"2023-06-15","kind":"grant","planned":false,"acquired":true,"shares":12755,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The shares were issued pursuant to the Issuer's Non-Employee Director Compensation Program. The Reporting Person elected to receive stock in lieu of cash as permitted under the program."}],"balance_after":110150,"source":{"system":"sec-edgar","filing":"0001628280-23-022557","document":"wk-form4_1686954661.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1799355/000162828023022557/wk-form4_1686954661.xml","form_type":"4"}},{"id":1912429,"issuer":{"id":62843,"kind":"organization","name":"Ventyx Biosciences, Inc.","symbol":"VTYX"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2023-04-27T21:11:39.000Z","date":"2023-01-11","kind":"grant","planned":false,"acquired":true,"shares":20427,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The Form 4 filed on January 12, 2023, erroneously reported that reporting person received an option award for 12,880 shares on January 11, 2023. The correct option award amount is for 20,427 shares."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"One-thirty sixth (1/36th) of the Shares subject to the option will be scheduled to vest each month following the grant date, in each case subject to the reporting person continuing to be a Service Provider (as defined in the Company's 2021 Equity Incentive Plan) through the applicable vesting date."},{"field":"derivative.underlying_shares","element":"underlyingSecurityShares","label":"F1","text":"The Form 4 filed on January 12, 2023, erroneously reported that reporting person received an option award for 12,880 shares on January 11, 2023. The correct option award amount is for 20,427 shares."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"The Form 4 filed on January 12, 2023, erroneously reported that reporting person received an option award for 12,880 shares on January 11, 2023. The correct option award amount is for 20,427 shares."}],"balance_after":20427,"derivative":{"exercise_price":34.16,"expiration_date":"2033-01-11","underlying":"Common Stock","underlying_shares":20427},"source":{"system":"sec-edgar","filing":"0000899243-23-011815","document":"doc4a.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1851194/000089924323011815/doc4a.xml","form_type":"4/A","original_submission_date":"2023-01-12"}},{"id":1917565,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Restricted Stock Unit","published_at":"2023-04-20T00:18:43.000Z","date":"2023-04-17","kind":"exercise","planned":false,"acquired":false,"shares":5667,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":49659,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":5667},"source":{"system":"sec-edgar","filing":"0000874015-23-000131","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000131/edgardoc.xml","form_type":"4"}},{"id":1917564,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Common Stock","published_at":"2023-04-20T00:18:43.000Z","date":"2023-04-18","kind":"sale","planned":false,"acquired":false,"shares":2582,"price":36.5026,"value":94249.7132,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $36.19 to $36.50953 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":24312,"source":{"system":"sec-edgar","filing":"0000874015-23-000131","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000131/edgardoc.xml","form_type":"4"}},{"id":1917563,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Common Stock","published_at":"2023-04-20T00:18:43.000Z","date":"2023-04-17","kind":"exercise","planned":false,"acquired":true,"shares":5667,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."}],"balance_after":26894,"source":{"system":"sec-edgar","filing":"0000874015-23-000131","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000131/edgardoc.xml","form_type":"4"}},{"id":2029451,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chf GL Pdt Str & Oper Ofc"}}],"security":"Common Stock","published_at":"2023-02-07T22:36:24.000Z","date":"2023-02-06","kind":"sale","acquired":false,"shares":1451,"price":40.6595,"value":58996.9345,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.60 to $40.70 inclusive.  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Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."}],"balance_after":22667,"derivative":{"underlying":"Common Stock","underlying_shares":22667},"source":{"system":"sec-edgar","filing":"0000874015-20-000026","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000026/edgar.xml","form_type":"4"}},{"id":3312821,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":36828,"kind":"person","name":"Cadoret-Manier Onaiza","position":1,"cik":"0001799355","reported_name":"Cadoret-Manier Onaiza","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Corp Development Officer"}}],"security":"Employee Stock Option (right to buy)","published_at":"2020-01-14T00:01:56.000Z","date":"2020-01-09","kind":"grant","acquired":true,"shares":51000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/09/2020 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on 01/09/2020. 25% of the shares subject to the option will vest and become exercisable on 01/09/2021.  Thereafter, the remaining shares subject to the option will vest and become exercisable in 36 equal monthly installments over the next 3 years."}],"balance_after":51000,"derivative":{"exercise_price":63.27,"exercise_date":"2021-01-09","expiration_date":"2027-01-08","underlying":"Common Stock","underlying_shares":51000},"source":{"system":"sec-edgar","filing":"0000874015-20-000022","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000022/edgar.xml","form_type":"4"}}]}