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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":47747,"source":{"system":"sec-edgar","filing":"0000874015-26-000102","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000102/edgardoc.xml","form_type":"4"}},{"id":926048,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Common Stock","published_at":"2026-02-03T01:52:12.000Z","date":"2026-01-29","kind":"grant","planned":false,"acquired":true,"shares":11991,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the performance period of the grant to the reporting person reported on January 18, 2023. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":41935,"source":{"system":"sec-edgar","filing":"0000874015-26-000072","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000072/edgardoc.xml","form_type":"4"}},{"id":936238,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Common Stock","published_at":"2026-01-21T01:21:37.000Z","date":"2026-01-15","kind":"exercise","planned":false,"acquired":true,"shares":21366,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":51819,"source":{"system":"sec-edgar","filing":"0000874015-26-000072","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000072/edgardoc.xml","form_type":"4"}},{"id":948722,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-01-06T22:35:26.000Z","date":"2026-01-02","kind":"grant","planned":true,"acquired":true,"shares":150,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"by Son"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Grant on 01/02/2026 to reporting person's son of stock options under the Ionis Pharmaceuticals, Inc. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":30453,"source":{"system":"sec-edgar","filing":"0000874015-26-000026","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000026/edgardoc.xml","form_type":"4"}},{"id":948717,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Common Stock","published_at":"2026-01-06T22:35:26.000Z","date":"2026-01-02","kind":"exercise","planned":true,"acquired":true,"shares":18338,"price":60.89,"value":1116600.82,"ownership":{"direct":true},"balance_after":48791,"source":{"system":"sec-edgar","filing":"0000874015-26-000026","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000026/edgardoc.xml","form_type":"4"}},{"id":948716,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Common Stock","published_at":"2026-01-06T22:35:26.000Z","date":"2026-01-02","kind":"sale","planned":true,"acquired":false,"shares":5125,"price":78.57,"value":402671.25,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 14, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.155 to $78.88 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":30453,"source":{"system":"sec-edgar","filing":"0000874015-26-000026","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000026/edgardoc.xml","form_type":"4"}},{"id":948715,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Common Stock","published_at":"2026-01-06T22:35:26.000Z","date":"2026-01-02","kind":"exercise","planned":true,"acquired":true,"shares":5125,"price":60.89,"value":312061.25,"ownership":{"direct":true},"balance_after":35578,"source":{"system":"sec-edgar","filing":"0000874015-26-000026","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000026/edgardoc.xml","form_type":"4"}},{"id":1017891,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Restricted Stock Unit","published_at":"2025-10-17T00:16:46.000Z","date":"2025-10-15","kind":"exercise","planned":false,"acquired":false,"shares":125,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"by Son"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F3","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"Restricted Stock Units vest in four equal annual installments. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":30453,"source":{"system":"sec-edgar","filing":"0000874015-25-000254","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000254/edgardoc.xml","form_type":"4"}},{"id":1028496,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-10-02T23:36:11.000Z","date":"2025-10-02","kind":"exercise","planned":true,"acquired":false,"shares":12972,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":53.77,"exercise_date":"2021-01-02","expiration_date":"2026-01-01","underlying":"Common Stock","underlying_shares":12972},"source":{"system":"sec-edgar","filing":"0000874015-25-000245","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000245/edgardoc.xml","form_type":"4"}},{"id":1028495,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-10-02T23:36:11.000Z","date":"2025-10-01","kind":"exercise","planned":true,"acquired":false,"shares":14142,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":12972,"derivative":{"exercise_price":53.77,"exercise_date":"2020-01-02","expiration_date":"2026-01-01","underlying":"Common Stock","underlying_shares":14142},"source":{"system":"sec-edgar","filing":"0000874015-25-000245","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000245/edgardoc.xml","form_type":"4"}},{"id":1028494,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Common Stock","published_at":"2025-10-02T23:36:11.000Z","date":"2025-10-02","kind":"sale","planned":true,"acquired":false,"shares":12972,"price":66.2259,"value":859082.3748,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 14, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":37302,"source":{"system":"sec-edgar","filing":"0000874015-25-000224","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000224/edgardoc.xml","form_type":"4"}},{"id":1048790,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Common Stock","published_at":"2025-09-05T00:41:06.000Z","date":"2025-09-02","kind":"sale","planned":true,"acquired":false,"shares":10000,"price":49.22,"value":492200.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 14, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. 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These shares were sold in multiple transactions at prices ranging from $32.835 to $32.85 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":45670,"source":{"system":"sec-edgar","filing":"0000874015-25-000065","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000065/edgardoc.xml","form_type":"4"}},{"id":1301000,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Common Stock","published_at":"2025-01-18T00:41:39.000Z","date":"2025-01-15","kind":"exercise","planned":false,"acquired":true,"shares":19111,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":52824,"source":{"system":"sec-edgar","filing":"0000874015-25-000065","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000065/edgardoc.xml","form_type":"4"}},{"id":1312099,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":35281,"kind":"person","name":"Swayze Eric","position":1,"cik":"0001791058","reported_name":"Swayze Eric","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP Research"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-01-06T21:55:46.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":163,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"by Son"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"Grant on 01/02/2025 to reporting person's son of stock options under the Ionis Pharmaceuticals, Inc. 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