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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":40431,"source":{"system":"sec-edgar","filing":"0000874015-26-000061","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000061/edgardoc.xml","form_type":"4"}},{"id":936183,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":34616,"kind":"person","name":"Baroldi Joseph","position":1,"cik":"0001813775","reported_name":"Baroldi Joseph","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Business Officer"}}],"security":"Common Stock","published_at":"2026-01-21T01:18:04.000Z","date":"2026-01-15","kind":"exercise","planned":false,"acquired":true,"shares":17037,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":47338,"source":{"system":"sec-edgar","filing":"0000874015-26-000061","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000061/edgardoc.xml","form_type":"4"}},{"id":948702,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":34616,"kind":"person","name":"Baroldi Joseph","position":1,"cik":"0001813775","reported_name":"Baroldi Joseph","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Business Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-01-06T22:34:07.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":2600,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"by Spouse"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"Grant on 01/02/2026 to reporting person's spouse  of stock options under the Ionis Pharmaceuticals, Inc. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":10571,"source":{"system":"sec-edgar","filing":"0000874015-23-000130","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000130/edgardoc.xml","form_type":"4"}},{"id":1917560,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":34616,"kind":"person","name":"Baroldi Joseph","position":1,"cik":"0001813775","reported_name":"Baroldi Joseph","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Business Officer"}}],"security":"Common Stock","published_at":"2023-04-20T00:18:34.000Z","date":"2023-04-17","kind":"exercise","planned":false,"acquired":true,"shares":10838,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."}],"balance_after":14451,"source":{"system":"sec-edgar","filing":"0000874015-23-000130","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000130/edgardoc.xml","form_type":"4"}},{"id":2051584,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":34616,"kind":"person","name":"Baroldi Joseph","position":1,"cik":"0001813775","reported_name":"Baroldi Joseph","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Business Officer"}}],"security":"Restricted Stock Unit","published_at":"2023-01-20T01:19:05.000Z","date":"2023-01-17","kind":"exercise","acquired":false,"shares":904,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"by Spouse"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. 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These shares were sold in multiple transactions at prices ranging from $39.76975 to $39.79032 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":851,"source":{"system":"sec-edgar","filing":"0000874015-23-000061","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000061/edgardoc.xml","form_type":"4"}},{"id":2051582,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":34616,"kind":"person","name":"Baroldi Joseph","position":1,"cik":"0001813775","reported_name":"Baroldi Joseph","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Business Officer"}}],"security":"Common Stock","published_at":"2023-01-20T01:19:05.000Z","date":"2023-01-17","kind":"exercise","acquired":true,"shares":904,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"by Spouse"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":1226,"source":{"system":"sec-edgar","filing":"0000874015-23-000061","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000061/edgardoc.xml","form_type":"4"}},{"id":2053152,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":34616,"kind":"person","name":"Baroldi Joseph","position":1,"cik":"0001813775","reported_name":"Baroldi Joseph","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Business Officer"}}],"security":"Restricted Stock Unit","published_at":"2023-01-19T01:15:56.000Z","date":"2023-01-15","kind":"grant","acquired":true,"shares":1800,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"by Spouse"},"footnotes":[{"field":"security","element":"securityTitle","label":"F6","text":"Grant to reporting person's spouse of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 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The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."}],"balance_after":12290,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":12290},"source":{"system":"sec-edgar","filing":"0000874015-23-000042","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000042/edgardoc.xml","form_type":"4"}},{"id":2064219,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":34616,"kind":"person","name":"Baroldi Joseph","position":1,"cik":"0001813775","reported_name":"Baroldi Joseph","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Business Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2023-01-05T23:11:50.000Z","date":"2023-01-03","kind":"grant","acquired":true,"shares":2400,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"by Spouse"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"Grant on 01/03/2023 to reporting person's spouse of stock options under the Ionis Pharmaceuticals, Inc. 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Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."}],"balance_after":43350,"derivative":{"underlying":"Common Stock","underlying_shares":43350},"source":{"system":"sec-edgar","filing":"0000874015-22-000098","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000098/edgardoc.xml","form_type":"4"}},{"id":2417693,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":34616,"kind":"person","name":"Baroldi Joseph","position":1,"cik":"0001813775","reported_name":"Baroldi Joseph","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Business Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2022-02-03T00:26:14.000Z","date":"2022-01-31","kind":"grant","acquired":true,"shares":86700,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/31/2022 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan.  Following this transaction, the option was exercisable as to 0 shares on\n01/31/2022.  25% of the shares subject to the option will vest and become exercisable on 01/31/2023. 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