{"transactions":[{"id":722996,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-06-30T23:01:37.000Z","date":"2026-06-29","kind":"exercise","planned":true,"acquired":false,"shares":2178,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date."}],"balance_after":20865,"derivative":{"exercise_price":6.81,"expiration_date":"2034-09-22","underlying":"Common Stock","underlying_shares":2178},"source":{"system":"sec-edgar","filing":"0001193125-26-291059","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526291059/ownership.xml","form_type":"4"}},{"id":722995,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-06-30T23:01:37.000Z","date":"2026-06-29","kind":"sale","planned":true,"acquired":false,"shares":2178,"price":35.18,"value":76622.04,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."}],"balance_after":793,"source":{"system":"sec-edgar","filing":"0001193125-26-291059","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526291059/ownership.xml","form_type":"4"}},{"id":722994,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-06-30T23:01:37.000Z","date":"2026-06-29","kind":"exercise","planned":true,"acquired":true,"shares":2178,"price":6.81,"value":14832.18,"ownership":{"direct":true},"balance_after":2971,"source":{"system":"sec-edgar","filing":"0001193125-26-291059","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526291059/ownership.xml","form_type":"4"}},{"id":736489,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-06-17T00:31:54.000Z","date":"2026-06-12","kind":"exercise","planned":true,"acquired":false,"shares":6250,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date."}],"balance_after":23750,"derivative":{"exercise_price":11.7,"expiration_date":"2035-08-06","underlying":"Common Stock","underlying_shares":6250},"source":{"system":"sec-edgar","filing":"0001193125-26-273126","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526273126/ownership.xml","form_type":"4"}},{"id":736488,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-06-17T00:31:54.000Z","date":"2026-06-12","kind":"sale","planned":true,"acquired":false,"shares":6250,"price":35.0759,"value":219224.375,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.00 to $35.19. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range."}],"balance_after":793,"source":{"system":"sec-edgar","filing":"0001193125-26-273126","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526273126/ownership.xml","form_type":"4"}},{"id":736487,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-06-17T00:31:54.000Z","date":"2026-06-12","kind":"exercise","planned":true,"acquired":true,"shares":6250,"price":11.7,"value":73125.0,"ownership":{"direct":true},"balance_after":7043,"source":{"system":"sec-edgar","filing":"0001193125-26-273126","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526273126/ownership.xml","form_type":"4"}},{"id":752338,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-06-03T23:11:42.000Z","date":"2026-06-01","kind":"exercise","planned":true,"acquired":false,"shares":637,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date."}],"balance_after":4464,"derivative":{"exercise_price":2.76,"expiration_date":"2034-03-19","underlying":"Common Stock","underlying_shares":637},"source":{"system":"sec-edgar","filing":"0001193125-26-255997","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526255997/ownership.xml","form_type":"4"}},{"id":752337,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-06-03T23:11:42.000Z","date":"2026-06-01","kind":"exercise","planned":true,"acquired":false,"shares":943,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such date."}],"balance_after":2517,"derivative":{"exercise_price":2.76,"expiration_date":"2033-11-11","underlying":"Common Stock","underlying_shares":943},"source":{"system":"sec-edgar","filing":"0001193125-26-255997","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526255997/ownership.xml","form_type":"4"}},{"id":752336,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-06-03T23:11:42.000Z","date":"2026-06-01","kind":"exercise","planned":true,"acquired":false,"shares":4355,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such date."}],"balance_after":11614,"derivative":{"exercise_price":1.55,"expiration_date":"2033-03-30","underlying":"Common Stock","underlying_shares":4355},"source":{"system":"sec-edgar","filing":"0001193125-26-255997","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526255997/ownership.xml","form_type":"4"}},{"id":752335,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-06-03T23:11:42.000Z","date":"2026-06-01","kind":"sale","planned":true,"acquired":false,"shares":2889,"price":29.6629,"value":85696.1181,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.29 to $30.08. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range."}],"balance_after":793,"source":{"system":"sec-edgar","filing":"0001193125-26-255997","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526255997/ownership.xml","form_type":"4"}},{"id":752334,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-06-03T23:11:42.000Z","date":"2026-06-01","kind":"sale","planned":true,"acquired":false,"shares":1346,"price":28.7928,"value":38755.1088,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.25 to $29.15. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range."}],"balance_after":3682,"source":{"system":"sec-edgar","filing":"0001193125-26-255997","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526255997/ownership.xml","form_type":"4"}},{"id":752333,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-06-03T23:11:42.000Z","date":"2026-06-01","kind":"sale","planned":true,"acquired":false,"shares":1700,"price":27.7831,"value":47231.27,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.24 to $28.23. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range."}],"balance_after":5028,"source":{"system":"sec-edgar","filing":"0001193125-26-255997","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526255997/ownership.xml","form_type":"4"}},{"id":752332,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-06-03T23:11:42.000Z","date":"2026-06-01","kind":"exercise","planned":true,"acquired":true,"shares":637,"price":2.76,"value":1758.12,"ownership":{"direct":true},"balance_after":6728,"source":{"system":"sec-edgar","filing":"0001193125-26-255997","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526255997/ownership.xml","form_type":"4"}},{"id":752331,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-06-03T23:11:42.000Z","date":"2026-06-01","kind":"exercise","planned":true,"acquired":true,"shares":943,"price":2.76,"value":2602.68,"ownership":{"direct":true},"balance_after":6091,"source":{"system":"sec-edgar","filing":"0001193125-26-255997","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526255997/ownership.xml","form_type":"4"}},{"id":752330,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-06-03T23:11:42.000Z","date":"2026-06-01","kind":"exercise","planned":true,"acquired":true,"shares":4355,"price":1.55,"value":6750.25,"ownership":{"direct":true},"balance_after":5148,"source":{"system":"sec-edgar","filing":"0001193125-26-255997","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526255997/ownership.xml","form_type":"4"}},{"id":760474,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-05-28T23:02:03.000Z","date":"2026-05-26","kind":"exercise","planned":true,"acquired":false,"shares":11798,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date."}],"balance_after":23043,"derivative":{"exercise_price":6.81,"expiration_date":"2034-09-22","underlying":"Common Stock","underlying_shares":11798},"source":{"system":"sec-edgar","filing":"0001193125-26-245713","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526245713/ownership.xml","form_type":"4"}},{"id":760473,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-05-28T23:02:03.000Z","date":"2026-05-26","kind":"sale","planned":true,"acquired":false,"shares":11798,"price":30.0607,"value":354656.1386,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.00 to $30.24. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range."}],"balance_after":793,"source":{"system":"sec-edgar","filing":"0001193125-26-245713","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526245713/ownership.xml","form_type":"4"}},{"id":760472,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-05-28T23:02:03.000Z","date":"2026-05-26","kind":"exercise","planned":true,"acquired":true,"shares":11798,"price":6.81,"value":80344.38,"ownership":{"direct":true},"balance_after":12591,"source":{"system":"sec-edgar","filing":"0001193125-26-245713","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526245713/ownership.xml","form_type":"4"}},{"id":862334,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-03-05T00:00:54.000Z","date":"2026-03-02","kind":"exercise","planned":true,"acquired":false,"shares":5101,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date."}],"balance_after":5101,"derivative":{"exercise_price":2.76,"expiration_date":"2034-03-19","underlying":"Common Stock","underlying_shares":5101},"source":{"system":"sec-edgar","filing":"0001193125-26-092050","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526092050/ownership.xml","form_type":"4"}},{"id":862333,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-03-05T00:00:54.000Z","date":"2026-03-02","kind":"exercise","planned":true,"acquired":false,"shares":11638,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such vesting date."}],"balance_after":3460,"derivative":{"exercise_price":2.76,"expiration_date":"2033-11-11","underlying":"Common Stock","underlying_shares":11638},"source":{"system":"sec-edgar","filing":"0001193125-26-092050","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526092050/ownership.xml","form_type":"4"}},{"id":862332,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-03-05T00:00:54.000Z","date":"2026-03-02","kind":"exercise","planned":true,"acquired":false,"shares":53714,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such vesting date."}],"balance_after":15969,"derivative":{"exercise_price":1.55,"expiration_date":"2033-03-30","underlying":"Common Stock","underlying_shares":53714},"source":{"system":"sec-edgar","filing":"0001193125-26-092050","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526092050/ownership.xml","form_type":"4"}},{"id":862331,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-03-05T00:00:54.000Z","date":"2026-03-02","kind":"sale","planned":true,"acquired":false,"shares":66363,"price":28.1383,"value":1867342.0029,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $27.90 to $28.70. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range."}],"balance_after":793,"source":{"system":"sec-edgar","filing":"0001193125-26-092050","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526092050/ownership.xml","form_type":"4"}},{"id":862330,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-03-05T00:00:54.000Z","date":"2026-03-02","kind":"sale","planned":true,"acquired":false,"shares":4090,"price":27.5052,"value":112496.268,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $26.90 to $27.89. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range."}],"balance_after":67156,"source":{"system":"sec-edgar","filing":"0001193125-26-092050","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526092050/ownership.xml","form_type":"4"}},{"id":862329,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-03-05T00:00:54.000Z","date":"2026-03-02","kind":"exercise","planned":true,"acquired":true,"shares":5101,"price":2.76,"value":14078.76,"ownership":{"direct":true},"balance_after":71246,"source":{"system":"sec-edgar","filing":"0001193125-26-092050","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526092050/ownership.xml","form_type":"4"}},{"id":862328,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-03-05T00:00:54.000Z","date":"2026-03-02","kind":"exercise","planned":true,"acquired":true,"shares":11638,"price":2.76,"value":32120.88,"ownership":{"direct":true},"balance_after":66145,"source":{"system":"sec-edgar","filing":"0001193125-26-092050","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526092050/ownership.xml","form_type":"4"}},{"id":862327,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Common Stock","published_at":"2026-03-05T00:00:54.000Z","date":"2026-03-02","kind":"exercise","planned":true,"acquired":true,"shares":53714,"price":1.55,"value":83256.7,"ownership":{"direct":true},"footnotes":[{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"Includes 793 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on October 31, 2025 in a transaction that was exempt under Rule 16b-3(c)."}],"balance_after":54507,"source":{"system":"sec-edgar","filing":"0001193125-26-092050","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526092050/ownership.xml","form_type":"4"}},{"id":912427,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-02-11T00:13:39.000Z","date":"2026-02-06","kind":"grant","planned":false,"acquired":true,"shares":80000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date."}],"balance_after":80000,"derivative":{"exercise_price":25.41,"expiration_date":"2036-02-05","underlying":"Common Stock","underlying_shares":80000},"source":{"system":"sec-edgar","filing":"0001193125-26-045112","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000119312526045112/ownership.xml","form_type":"4"}},{"id":1070383,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34519,"kind":"person","name":"Shaikhly Samira","position":1,"cik":"0002040363","reported_name":"Shaikhly Samira","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief People Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-08-11T23:11:23.000Z","date":"2025-08-07","kind":"grant","planned":false,"acquired":true,"shares":30000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date."}],"balance_after":30000,"derivative":{"exercise_price":11.7,"expiration_date":"2035-08-06","underlying":"Common Stock","underlying_shares":30000},"source":{"system":"sec-edgar","filing":"0000950170-25-106799","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040363/000095017025106799/ownership.xml","form_type":"4"}}]}