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These shares were sold in multiple transactions at prices ranging from $80.035 to $81.01 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":36330,"source":{"system":"sec-edgar","filing":"0000874015-26-000138","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000138/edgardoc.xml","form_type":"4"}},{"id":859812,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32406,"kind":"person","name":"LOSCALZO JOSEPH","position":1,"cik":"0001276128","reported_name":"LOSCALZO JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-03-05T23:14:30.000Z","date":"2026-03-03","kind":"exercise","planned":true,"acquired":true,"shares":832,"price":38.06,"value":31665.92,"ownership":{"direct":true},"balance_after":37162,"source":{"system":"sec-edgar","filing":"0000874015-26-000138","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000138/edgardoc.xml","form_type":"4"}},{"id":957057,"issuer":{"id":6392,"kind":"organization","name":"CYPHERPUNK TECHNOLOGIES INC.","symbol":"CYPH"},"owners":[{"id":32406,"kind":"person","name":"LOSCALZO JOSEPH","position":1,"cik":"0001276128","reported_name":"LOSCALZO JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Restricted Stock Units","published_at":"2025-12-30T21:36:06.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":94050,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Represents restricted stock units (\"RSUs\") to be settled on a 1 for 1 basis for shares of Cypherpunk Technologies Inc. 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Subject to the terms of the RSU award and applicable tax withholdings, the Company shall settle the RSUs for Common Stock as soon as practicable following the earlier to occur of (i) the fifth (5th) business day after the date the reporting person ceases for any reason to be a member of the Company's Board of Directors or (ii) the date of the first annual meeting of stockholders of the Company that occurs following the Grant Date."}],"balance_after":94050,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":94050},"source":{"system":"sec-edgar","filing":"0001104659-25-125260","document":"tm2534450-7_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1276128/000110465925125260/tm2534450-7_4seq1.xml","form_type":"4"}},{"id":999992,"issuer":{"id":6392,"kind":"organization","name":"CYPHERPUNK TECHNOLOGIES INC.","symbol":"CYPH"},"owners":[{"id":32406,"kind":"person","name":"LOSCALZO JOSEPH","position":1,"cik":"0001276128","reported_name":"LOSCALZO JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Restricted Stock Units","published_at":"2025-11-13T21:56:16.000Z","date":"2025-11-11","kind":"grant","planned":false,"acquired":true,"shares":74700,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Represents restricted stock units (\"RSUs\") to be settled on a 1 for 1 basis for shares of Cypherpunk Technologies Inc. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":36330,"source":{"system":"sec-edgar","filing":"0000874015-25-000271","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000271/edgardoc.xml","form_type":"4"}},{"id":1010156,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32406,"kind":"person","name":"LOSCALZO JOSEPH","position":1,"cik":"0001276128","reported_name":"LOSCALZO JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2025-11-04T01:14:50.000Z","date":"2025-10-31","kind":"exercise","planned":true,"acquired":true,"shares":16000,"price":52.22,"value":835520.0,"ownership":{"direct":true},"balance_after":52330,"source":{"system":"sec-edgar","filing":"0000874015-25-000271","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000271/edgardoc.xml","form_type":"4"}},{"id":1048729,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32406,"kind":"person","name":"LOSCALZO JOSEPH","position":1,"cik":"0001276128","reported_name":"LOSCALZO JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-09-05T00:28:42.000Z","date":"2025-09-03","kind":"exercise","planned":false,"acquired":false,"shares":16000,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":24.42,"exercise_date":"2017-07-01","expiration_date":"2026-06-30","underlying":"Common Stock","underlying_shares":16000},"source":{"system":"sec-edgar","filing":"0000874015-25-000212","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000212/edgardoc.xml","form_type":"4"}},{"id":1048728,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32406,"kind":"person","name":"LOSCALZO JOSEPH","position":1,"cik":"0001276128","reported_name":"LOSCALZO JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2025-09-05T00:28:42.000Z","date":"2025-09-03","kind":"sale","planned":false,"acquired":false,"shares":16000,"price":60.1482,"value":962371.2,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. 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Restricted Stock Units vest in four equal annual installments, the first installment vesting on July 2, 2019. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on July 2, 2022. The RSU is vested as to 0 shares on July 2, 2018."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"Grant of July 2, 2018 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on July 2, 2019. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on July 2, 2022. The RSU is vested as to 0 shares on July 2, 2018."}],"balance_after":3555,"derivative":{"underlying":"Common Stock","underlying_shares":3555},"source":{"system":"sec-edgar","filing":"0000874015-18-000087","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401518000087/edgar.xml","form_type":"4"}},{"id":3877094,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32406,"kind":"person","name":"LOSCALZO JOSEPH","position":1,"cik":"0001276128","reported_name":"LOSCALZO JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Restricted Stock Units","published_at":"2018-07-03T19:20:17.000Z","date":"2018-07-03","kind":"exercise","acquired":false,"shares":667,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":2000,"derivative":{"underlying":"Common Stock","underlying_shares":667},"source":{"system":"sec-edgar","filing":"0000874015-18-000087","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401518000087/edgar.xml","form_type":"4"}}],"next_cursor":"2018-07-03T19:20:17.000000Z,3877094"}