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These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier; however, the reporting person has elected to defer delivery of such shares until the earlier to occur of the 30th day following the reporting person's Separation from Service from the Company or the date of a Change in Control of the Company, both as defined in Treasury Regulation Section 1.409A. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":11014,"source":{"system":"sec-edgar","filing":"0000874015-26-000229","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000229/edgardoc.xml","form_type":"4"}},{"id":716459,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32405,"kind":"person","name":"KLEIN JOSEPH III","position":1,"cik":"0001206369","reported_name":"KLEIN JOSEPH III","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-07-06T22:49:29.000Z","date":"2026-07-01","kind":"sale","planned":true,"acquired":false,"shares":99,"price":79.45,"value":7865.55,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on November 25, 2025."}],"balance_after":22433,"source":{"system":"sec-edgar","filing":"0000874015-26-000229","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000229/edgardoc.xml","form_type":"4"}},{"id":716458,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32405,"kind":"person","name":"KLEIN JOSEPH III","position":1,"cik":"0001206369","reported_name":"KLEIN JOSEPH III","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-07-06T22:49:29.000Z","date":"2026-07-01","kind":"exercise","planned":true,"acquired":true,"shares":11518,"price":39.94,"value":460028.92,"ownership":{"direct":true},"balance_after":22532,"source":{"system":"sec-edgar","filing":"0000874015-26-000229","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000229/edgardoc.xml","form_type":"4"}},{"id":792843,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32405,"kind":"person","name":"KLEIN JOSEPH III","position":1,"cik":"0001206369","reported_name":"KLEIN JOSEPH III","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-05-05T20:30:25.000Z","date":"2026-05-01","kind":"exercise","planned":true,"acquired":false,"shares":10111,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":47.11,"exercise_date":"2025-07-01","expiration_date":"2034-06-30","underlying":"Common Stock","underlying_shares":10111},"source":{"system":"sec-edgar","filing":"0000874015-26-000182","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000182/edgardoc.xml","form_type":"4"}},{"id":792842,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32405,"kind":"person","name":"KLEIN JOSEPH III","position":1,"cik":"0001206369","reported_name":"KLEIN JOSEPH III","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-05-05T20:30:25.000Z","date":"2026-05-01","kind":"sale","planned":true,"acquired":false,"shares":1431,"price":74.4474,"value":106534.2294,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on November 25, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":11014,"source":{"system":"sec-edgar","filing":"0000874015-26-000182","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000182/edgardoc.xml","form_type":"4"}},{"id":792841,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32405,"kind":"person","name":"KLEIN JOSEPH III","position":1,"cik":"0001206369","reported_name":"KLEIN JOSEPH III","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-05-05T20:30:25.000Z","date":"2026-05-01","kind":"sale","planned":true,"acquired":false,"shares":8680,"price":73.353,"value":636704.04,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on November 25, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":11014,"source":{"system":"sec-edgar","filing":"0000874015-26-000161","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000161/edgardoc.xml","form_type":"4"}},{"id":821560,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32405,"kind":"person","name":"KLEIN JOSEPH III","position":1,"cik":"0001206369","reported_name":"KLEIN JOSEPH III","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-04-02T23:43:46.000Z","date":"2026-04-01","kind":"sale","planned":true,"acquired":false,"shares":20105,"price":75.503,"value":1517987.815,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on November 26, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. 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Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F7","text":"Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":12219,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":889},"source":{"system":"sec-edgar","filing":"0000874015-21-000136","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000136/edgardoc.xml","form_type":"4"}},{"id":2631132,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32405,"kind":"person","name":"KLEIN JOSEPH III","position":1,"cik":"0001206369","reported_name":"KLEIN JOSEPH III","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Restricted Stock Unit","published_at":"2021-07-20T00:14:14.000Z","date":"2021-07-15","kind":"exercise","acquired":false,"shares":5333,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":13108,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":5333},"source":{"system":"sec-edgar","filing":"0000874015-21-000136","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000136/edgardoc.xml","form_type":"4"}},{"id":2631131,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32405,"kind":"person","name":"KLEIN JOSEPH III","position":1,"cik":"0001206369","reported_name":"KLEIN JOSEPH III","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2021-07-20T00:14:14.000Z","date":"2021-07-15","kind":"sale","acquired":false,"shares":4334,"price":35.2998,"value":152989.3332,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on September 18, 2020."},{"field":"shares","element":"transactionShares","label":"F2","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on September 18, 2020."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $34.78 to $35.68 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":18126,"source":{"system":"sec-edgar","filing":"0000874015-21-000136","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000136/edgardoc.xml","form_type":"4"}},{"id":2631130,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":32405,"kind":"person","name":"KLEIN JOSEPH III","position":1,"cik":"0001206369","reported_name":"KLEIN JOSEPH III","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common 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These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2021."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"Grant of July 1, 2021 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) of this Form 4"}],"balance_after":13794,"source":{"system":"sec-edgar","filing":"0000874015-20-000138","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000138/edgar.xml","form_type":"4"}},{"id":3008034,"issuer":{"id":145982,"kind":"organization","name":"AKCEA THERAPEUTICS, INC.","symbol":"AKCA"},"owners":[{"id":32405,"kind":"person","name":"KLEIN JOSEPH III","position":1,"cik":"0001206369","reported_name":"KLEIN JOSEPH III","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2020-10-13T19:37:57.000Z","date":"2020-10-12","kind":"disposition_to_issuer","acquired":false,"shares":26400,"price":2.01,"value":53064.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option, which provided for vesting of the shares on the 12-month anniversary of the date of grant, was cancelled in connection with the merger of the Issuer with a wholly owned subsidiary of Ionis Pharmaceuticals, Inc. in exchange for a cash payment of $53,064.00, representing the difference between the exercise price of the option and the acquisition price of $18.15."}],"balance_after":0,"derivative":{"exercise_price":16.14,"expiration_date":"2030-04-12","underlying":"Common Stock","underlying_shares":26400},"source":{"system":"sec-edgar","filing":"0001209191-20-054608","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1206369/000120919120054608/doc4.xml","form_type":"4"}}],"next_cursor":"2020-10-13T19:37:57.000000Z,3008034"}