{"transactions":[{"id":4617306,"issuer":{"id":7657,"kind":"organization","name":"NOCOPI TECHNOLOGIES INC/MD/","symbol":"NNUP"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2026-09-14T21:30:44.000Z","date":"2026-09-11","kind":"grant","planned":false,"acquired":true,"shares":21930,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares of the Issuer's common stock acquired by the Reporting Person from the Issuer as consideration rendered pursuant advisory services provided by the Reporting Person pursuant to that certain Stock Purchase Agreement by and between the Issuer and Frost Gamma Investments Trust, dated September 11, 2023."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by Frost Gamma Investments Trust, of which the Reporting Person is the trustee. Frost Gamma Limited Partnership is the sole and exclusive beneficiary of Frost Gamma Investments Trust. The Reporting Person is one of two limited partners of Frost Gamma Limited Partnership. The general partner of Frost Gamma Limited Partnership is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation, of which the Reporting Person is the sole shareholder. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1511642,"source":{"system":"sec-edgar","filing":"0001493152-26-042620","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1380896/000149315226042620/ownership.xml","form_type":"4"}},{"id":694698,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2026-08-06T21:11:40.000Z","date":"2026-08-05","kind":"purchase","planned":false,"acquired":true,"shares":10000,"price":0.9816,"value":9816.0,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions ranging from $0.972 to $0.9898, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares purchased at each separate price within the ranges set forth in the preceding sentence."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1993551,"source":{"system":"sec-edgar","filing":"0001493152-26-036396","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315226036396/ownership.xml","form_type":"4"}},{"id":696305,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2026-08-05T20:10:26.000Z","date":"2026-08-03","kind":"purchase","planned":false,"acquired":true,"shares":75000,"price":0.9412,"value":70590.0,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions ranging from $0.87 to $0.9499, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares purchased at each separate price within the ranges set forth in the preceding sentence."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1983551,"source":{"system":"sec-edgar","filing":"0001493152-26-036169","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315226036169/ownership.xml","form_type":"4"}},{"id":882724,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2026-02-25T21:10:11.000Z","date":"2026-02-24","kind":"purchase","planned":false,"acquired":true,"shares":20000,"price":0.9976,"value":19952.0,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions ranging from $0.98 to $1.00, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares purchased at each separate price within the ranges set forth in the preceding sentence."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1908551,"source":{"system":"sec-edgar","filing":"0001493152-26-008039","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315226008039/ownership.xml","form_type":"4"}},{"id":915077,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2026-02-09T21:10:05.000Z","date":"2026-02-06","kind":"purchase","planned":false,"acquired":true,"shares":50000,"price":0.9456,"value":47280.0,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions ranging from $0.8899 to $0.9880, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares purchased at each separate price within the ranges set forth in the preceding sentence."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1888551,"source":{"system":"sec-edgar","filing":"0001493152-26-005773","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315226005773/ownership.xml","form_type":"4"}},{"id":940386,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Options (Right to Buy)","published_at":"2026-01-13T21:10:05.000Z","date":"2026-01-09","kind":"grant","planned":false,"acquired":true,"shares":24615,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"The grant of the Issuer's non-qualified stock options was exempt from Section 16(b) of the Securities Exchange Act of 1934 by virtue of Rule 16b-3 promulgated thereunder, as it was approved by the Issuer's Compensation Committee of the Board of Directors. The non-qualified stock options are granted under the Issuer's 2025 Equity Incentive Plan and the exercisability shall be subject to execution of the Issuer's form of Non-Qualified Stock Option Agreement. The non-qualified stock options shall vest as follows: one-half shall vest and become exercisable on January 9, 2027 and the remaining half shall vest and become exercisable in eight equal quarterly installments commencing on March 31, 2027, subject to the Reporting Person continuing to serve as a director of the Issuer on each applicable vesting date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The grant of the Issuer's non-qualified stock options was exempt from Section 16(b) of the Securities Exchange Act of 1934 by virtue of Rule 16b-3 promulgated thereunder, as it was approved by the Issuer's Compensation Committee of the Board of Directors. The non-qualified stock options are granted under the Issuer's 2025 Equity Incentive Plan and the exercisability shall be subject to execution of the Issuer's form of Non-Qualified Stock Option Agreement. The non-qualified stock options shall vest as follows: one-half shall vest and become exercisable on January 9, 2027 and the remaining half shall vest and become exercisable in eight equal quarterly installments commencing on March 31, 2027, subject to the Reporting Person continuing to serve as a director of the Issuer on each applicable vesting date."}],"balance_after":24615,"derivative":{"exercise_price":1.1,"expiration_date":"2036-01-09","underlying":"Common Stock","underlying_shares":24615},"source":{"system":"sec-edgar","filing":"0001493152-26-002035","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315226002035/ownership.xml","form_type":"4"}},{"id":955763,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2026-01-02T21:10:19.000Z","date":"2025-12-31","kind":"purchase","planned":false,"acquired":true,"shares":50000,"price":0.9455,"value":47275.0,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions ranging from $0.9370 to $0.9519, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares sold at each separate price within the ranges set forth in the preceding sentence."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1838551,"source":{"system":"sec-edgar","filing":"0001493152-26-000114","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315226000114/ownership.xml","form_type":"4"}},{"id":956782,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-12-31T21:10:17.000Z","date":"2025-12-30","kind":"purchase","planned":false,"acquired":true,"shares":20000,"price":0.9655,"value":19310.0,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions ranging from $0.9635 to $0.9700, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares sold at each separate price within the ranges set forth in the preceding sentence."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1788551,"source":{"system":"sec-edgar","filing":"0001493152-25-029796","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315225029796/ownership.xml","form_type":"4"}},{"id":958995,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-12-29T14:24:10.000Z","date":"2025-12-26","kind":"purchase","planned":false,"acquired":true,"shares":40000,"price":0.9736,"value":38944.0,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 for December 24, 2025 is a weighted average price. These securities were sold in multiple transactions ranging from $0.9641 to $0.9803, inclusive. The price reported in Column 4 for December 26, 2025 is a weighted average price. These securities were sold in multiple transactions ranging from $0.9596 to $0.9837, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares sold at each separate price within the ranges set forth in the preceding sentence."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1768551,"source":{"system":"sec-edgar","filing":"0001493152-25-029257","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315225029257/ownership.xml","form_type":"4"}},{"id":958994,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-12-29T14:24:10.000Z","date":"2025-12-24","kind":"purchase","planned":false,"acquired":true,"shares":25000,"price":0.9703,"value":24257.5,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 for December 24, 2025 is a weighted average price. These securities were sold in multiple transactions ranging from $0.9641 to $0.9803, inclusive. The price reported in Column 4 for December 26, 2025 is a weighted average price. These securities were sold in multiple transactions ranging from $0.9596 to $0.9837, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares sold at each separate price within the ranges set forth in the preceding sentence."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1728551,"source":{"system":"sec-edgar","filing":"0001493152-25-029257","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315225029257/ownership.xml","form_type":"4"}},{"id":986370,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-28T14:00:02.000Z","date":"2025-11-26","kind":"purchase","planned":false,"acquired":true,"shares":2500,"price":0.99,"value":2475.0,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1703551,"source":{"system":"sec-edgar","filing":"0001493152-25-025314","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315225025314/ownership.xml","form_type":"4"}},{"id":986369,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-28T14:00:02.000Z","date":"2025-11-26","kind":"purchase","planned":false,"acquired":true,"shares":1500,"price":1,"value":1500.0,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1701051,"source":{"system":"sec-edgar","filing":"0001493152-25-025314","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315225025314/ownership.xml","form_type":"4"}},{"id":989291,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-26T01:17:04.000Z","date":"2025-11-25","kind":"purchase","planned":false,"acquired":true,"shares":20000,"price":0.9406,"value":18812.0,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions ranging from $0.937 to $0.943, inclusive. The reporting person undertakes to provide to Cocrystal Pharma, Inc., any security holder of Cocrystal Pharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the shares sold at each separate price within the ranges set forth in the preceding sentence."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1699551,"source":{"system":"sec-edgar","filing":"0001493152-25-025048","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315225025048/ownership.xml","form_type":"4"}},{"id":991798,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-21T22:07:09.000Z","date":"2025-11-21","kind":"purchase","planned":false,"acquired":true,"shares":192870,"price":1.335,"value":257481.45,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":216706448,"source":{"system":"sec-edgar","filing":"0001193125-25-291590","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525291590/ownership.xml","form_type":"4"}},{"id":991797,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-21T22:07:09.000Z","date":"2025-11-21","kind":"purchase","planned":false,"acquired":true,"shares":191490,"price":1.33,"value":254681.7,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":216322088,"source":{"system":"sec-edgar","filing":"0001193125-25-291590","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525291590/ownership.xml","form_type":"4"}},{"id":991795,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-21T22:07:09.000Z","date":"2025-11-21","kind":"purchase","planned":false,"acquired":true,"shares":3894,"price":1.32,"value":5140.08,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":216232713,"source":{"system":"sec-edgar","filing":"0001193125-25-291590","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525291590/ownership.xml","form_type":"4"}},{"id":991794,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-21T22:07:09.000Z","date":"2025-11-21","kind":"purchase","planned":false,"acquired":true,"shares":102371,"price":1.3,"value":133082.3,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":216228819,"source":{"system":"sec-edgar","filing":"0001193125-25-291590","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525291590/ownership.xml","form_type":"4"}},{"id":993060,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-20T23:10:53.000Z","date":"2025-11-20","kind":"purchase","planned":false,"acquired":true,"shares":13664,"price":1.35,"value":18446.4,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":216126448,"source":{"system":"sec-edgar","filing":"0001193125-25-290115","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525290115/ownership.xml","form_type":"4"}},{"id":993059,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-20T23:10:53.000Z","date":"2025-11-20","kind":"purchase","planned":false,"acquired":true,"shares":1757,"price":1.345,"value":2363.165,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":216112784,"source":{"system":"sec-edgar","filing":"0001193125-25-290115","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525290115/ownership.xml","form_type":"4"}},{"id":993058,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-20T23:10:53.000Z","date":"2025-11-20","kind":"purchase","planned":false,"acquired":true,"shares":24579,"price":1.34,"value":32935.86,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":216111027,"source":{"system":"sec-edgar","filing":"0001193125-25-290115","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525290115/ownership.xml","form_type":"4"}},{"id":993057,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-20T23:10:53.000Z","date":"2025-11-20","kind":"purchase","planned":false,"acquired":true,"shares":161818,"price":1.335,"value":216027.03,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":216086448,"source":{"system":"sec-edgar","filing":"0001193125-25-290115","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525290115/ownership.xml","form_type":"4"}},{"id":993056,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-20T23:10:53.000Z","date":"2025-11-20","kind":"purchase","planned":false,"acquired":true,"shares":211948,"price":1.33,"value":281890.84,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":215924630,"source":{"system":"sec-edgar","filing":"0001193125-25-290115","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525290115/ownership.xml","form_type":"4"}},{"id":993055,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-20T23:10:53.000Z","date":"2025-11-20","kind":"purchase","planned":false,"acquired":true,"shares":47105,"price":1.325,"value":62414.125,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":215712682,"source":{"system":"sec-edgar","filing":"0001193125-25-290115","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525290115/ownership.xml","form_type":"4"}},{"id":993054,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-20T23:10:53.000Z","date":"2025-11-20","kind":"purchase","planned":false,"acquired":true,"shares":119129,"price":1.32,"value":157250.28,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":215665577,"source":{"system":"sec-edgar","filing":"0001193125-25-290115","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525290115/ownership.xml","form_type":"4"}},{"id":994581,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-19T22:02:21.000Z","date":"2025-11-19","kind":"purchase","planned":false,"acquired":true,"shares":155496,"price":1.32,"value":205254.72,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214848891,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996888,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":212608,"price":1.275,"value":271075.2,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214779163,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996887,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":1772,"price":1.27,"value":2250.44,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214566555,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996886,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":15000,"price":1.265,"value":18975.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214564783,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996885,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"grant","planned":false,"acquired":true,"shares":46700,"price":1.26,"value":58842.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214549783,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996884,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":66635,"price":1.255,"value":83626.925,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214503083,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996883,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":49590,"price":1.25,"value":61987.5,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214436448,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996882,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":410,"price":1.245,"value":510.45,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214386858,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":1010940,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-10-31T21:15:41.000Z","date":"2025-10-31","kind":"purchase","planned":false,"acquired":true,"shares":150000,"price":1.4229,"value":213435.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.415 to $1.4299, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214386448,"source":{"system":"sec-edgar","filing":"0001193125-25-260956","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525260956/ownership.xml","form_type":"4"}},{"id":1011601,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Warrants","published_at":"2025-10-30T20:15:25.000Z","date":"2025-10-28","kind":"grant","planned":false,"acquired":true,"shares":719426,"price":1.39,"value":1000002.14,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"The Reporting Person purchased units at $1.39 per unit with each unit consisting of one share of common stock and a warrant to purchase two shares of common stock. The shares of common stock and warrants purchased are exempt from Section 16(b) of the Securities Exchange Act of 1934 by virtue of Rule 16b-3 thereunder, as it was approved by a Special Committee of the Board of Directors of the Issuer, which Special Committee consisted of two non-employee directors. The warrants were exercisable upon issuance."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The Reporting Person purchased units at $1.39 per unit with each unit consisting of one share of common stock and a warrant to purchase two shares of common stock. The shares of common stock and warrants purchased are exempt from Section 16(b) of the Securities Exchange Act of 1934 by virtue of Rule 16b-3 thereunder, as it was approved by a Special Committee of the Board of Directors of the Issuer, which Special Committee consisted of two non-employee directors. The warrants were exercisable upon issuance."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":719426,"derivative":{"exercise_price":1.24,"expiration_date":"2028-01-28","underlying":"Common Stock","underlying_shares":719426},"source":{"system":"sec-edgar","filing":"0001493152-25-020222","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315225020222/ownership.xml","form_type":"4"}},{"id":1011600,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-10-30T20:15:25.000Z","date":"2025-10-28","kind":"grant","planned":false,"acquired":true,"shares":359713,"price":1.39,"value":500001.07,"ownership":{"direct":false,"nature":"By Frost Gamma Investments Trust"},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"The Reporting Person purchased units at $1.39 per unit with each unit consisting of one share of common stock and a warrant to purchase two shares of common stock. The shares of common stock and warrants purchased are exempt from Section 16(b) of the Securities Exchange Act of 1934 by virtue of Rule 16b-3 thereunder, as it was approved by a Special Committee of the Board of Directors of the Issuer, which Special Committee consisted of two non-employee directors. The warrants were exercisable upon issuance."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1679551,"source":{"system":"sec-edgar","filing":"0001493152-25-020222","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315225020222/ownership.xml","form_type":"4"}},{"id":1040953,"issuer":{"id":7657,"kind":"organization","name":"NOCOPI TECHNOLOGIES INC/MD/","symbol":"NNUP"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-09-15T21:00:16.000Z","date":"2025-09-11","kind":"grant","planned":false,"acquired":true,"shares":21930,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares of the Issuer's common stock acquired by the Reporting Person from the Issuer as consideration rendered pursuant advisory services provided by the Reporting Person pursuant to that certain Stock Purchase Agreement by and between the Issuer and Frost Gamma Investments Trust, dated September 11, 2023."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by Frost Gamma Investments Trust, of which the Reporting Person is the trustee. Frost Gamma Limited Partnership is the sole and exclusive beneficiary of Frost Gamma Investments Trust. The Reporting Person is one of two limited partners of Frost Gamma Limited Partnership. The general partner of Frost Gamma Limited Partnership is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation, of which the Reporting Person is the sole shareholder. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1489712,"source":{"system":"sec-edgar","filing":"0001104659-25-090057","document":"tm2526128-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/888981/000110465925090057/tm2526128-1_4seq1.xml","form_type":"4"}},{"id":1042204,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-09-12T20:30:19.000Z","date":"2025-09-04","kind":"other","planned":false,"acquired":true,"shares":571429,"price":0.0005,"value":285.7145,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"On September 8, 2025, the reporting person filed a Form 4 reporting ownership of 7,294,403 shares of Common Stock following the reported transaction. The reporting person's ownership of Common Stock following the transaction should have been reported as 6,318,439."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":6318439,"source":{"system":"sec-edgar","filing":"0001104659-25-089560","document":"tm2526015-1_4aseq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925089560/tm2526015-1_4aseq1.xml","form_type":"4/A","original_submission_date":"2025-09-08"}},{"id":1046371,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrants","published_at":"2025-09-08T21:03:53.000Z","date":"2025-09-04","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":571429,"price":1.75,"value":1000000.75,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The Pre-Funded Warrants were immediately exercisable when issued and were exercised on September 4, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants expire when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. 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Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. 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Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  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Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  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Frost Gamma Limited Partnership is the sole and exclusive beneficiary of Frost Gamma Investments Trust. The Reporting Person is one of two limited partners of Frost Gamma Limited Partnership. The general partner of Frost Gamma Limited Partnership is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation, of which the Reporting Person is the sole shareholder. 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Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. 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The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":5747010,"source":{"system":"sec-edgar","filing":"0001104659-25-051611","document":"tm2515842-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925051611/tm2515842-1_4seq1.xml","form_type":"4"}},{"id":1139555,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-21T20:15:11.000Z","date":"2025-05-19","kind":"other","planned":false,"acquired":true,"shares":909297,"price":0.0005,"value":454.6485,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":5747222,"source":{"system":"sec-edgar","filing":"0001104659-25-051611","document":"tm2515842-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000110465925051611/tm2515842-1_4seq1.xml","form_type":"4"}},{"id":1174348,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-10T21:07:15.000Z","date":"2025-04-10","kind":"purchase","planned":false,"acquired":true,"shares":125000,"price":1.3577,"value":169712.5,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.35 to $1.36, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214001448,"source":{"system":"sec-edgar","filing":"0000950170-25-052925","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025052925/ownership.xml","form_type":"4"}},{"id":1176056,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-08T21:34:21.000Z","date":"2025-04-08","kind":"purchase","planned":false,"acquired":true,"shares":125000,"price":1.4772,"value":184650.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.46 to $1.495, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213876448,"source":{"system":"sec-edgar","filing":"0000950170-25-052214","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025052214/ownership.xml","form_type":"4"}},{"id":1187140,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-01T21:21:45.000Z","date":"2025-04-01","kind":"purchase","planned":false,"acquired":true,"shares":100000,"price":1.6485,"value":164850.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.645 to $1.65, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213751448,"source":{"system":"sec-edgar","filing":"0000950170-25-048737","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025048737/ownership.xml","form_type":"4"}},{"id":1189196,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-28T21:22:09.000Z","date":"2025-03-28","kind":"purchase","planned":false,"acquired":true,"shares":150000,"price":1.6959,"value":254385.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.685 to $1.70, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213651448,"source":{"system":"sec-edgar","filing":"0000950170-25-046952","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025046952/ownership.xml","form_type":"4"}},{"id":1190162,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrants","published_at":"2025-03-27T16:05:45.000Z","date":"2025-03-20","kind":"exercise","planned":false,"acquired":true,"shares":459981,"price":2.174,"value":999998.694,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The Pre-Funded Warrants were immediately exercisable when issued.  The Pre-Funded Warrants were exercised on March 20, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":459981,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-03-20","underlying":"Common Stock","underlying_shares":459981},"source":{"system":"sec-edgar","filing":"0001437749-25-009541","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925009541/rdgdoc.xml","form_type":"4/A","original_submission_date":"2025-03-21"}},{"id":1190161,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrants","published_at":"2025-03-27T16:05:45.000Z","date":"2025-03-19","kind":"grant","planned":false,"acquired":true,"shares":459981,"price":2.174,"value":999998.694,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":459981,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-03-19","underlying":"Common Stock","underlying_shares":459981},"source":{"system":"sec-edgar","filing":"0001437749-25-009541","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925009541/rdgdoc.xml","form_type":"4/A","original_submission_date":"2025-03-21"}},{"id":1190160,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2025-03-27T16:05:45.000Z","date":"2025-03-20","kind":"tax_withholding","planned":false,"acquired":false,"shares":112,"price":2.04,"value":228.48,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":4837925,"source":{"system":"sec-edgar","filing":"0001437749-25-009541","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925009541/rdgdoc.xml","form_type":"4/A","original_submission_date":"2025-03-21"}},{"id":1190159,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2025-03-27T16:05:45.000Z","date":"2025-03-20","kind":"exercise","planned":false,"acquired":true,"shares":459981,"price":0.0005,"value":229.9905,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":4838037,"source":{"system":"sec-edgar","filing":"0001437749-25-009541","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925009541/rdgdoc.xml","form_type":"4/A","original_submission_date":"2025-03-21"}},{"id":1195097,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrants","published_at":"2025-03-21T23:33:39.000Z","date":"2025-03-20","kind":"exercise","planned":false,"acquired":true,"shares":459981,"price":2.174,"value":999998.694,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The Pre-Funded Warrants were immediately exercisable when issued.  The Pre-Funded Warrants were exercised on March 20, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":459981,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-03-20","underlying":"Common Stock","underlying_shares":459981},"source":{"system":"sec-edgar","filing":"0001437749-25-008804","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925008804/rdgdoc.xml","form_type":"4"}},{"id":1195096,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrants","published_at":"2025-03-21T23:33:39.000Z","date":"2025-03-19","kind":"grant","planned":false,"acquired":true,"shares":459981,"price":2.174,"value":999998.694,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":459981,"derivative":{"exercise_price":0.0005,"exercise_date":"2025-03-19","underlying":"Common Stock","underlying_shares":459981},"source":{"system":"sec-edgar","filing":"0001437749-25-008804","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925008804/rdgdoc.xml","form_type":"4"}},{"id":1195095,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2025-03-21T23:33:39.000Z","date":"2025-03-20","kind":"tax_withholding","planned":false,"acquired":false,"shares":112,"price":2.04,"value":228.48,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":4837925,"source":{"system":"sec-edgar","filing":"0001437749-25-008804","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925008804/rdgdoc.xml","form_type":"4"}},{"id":1195094,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2025-03-21T23:33:39.000Z","date":"2025-03-20","kind":"exercise","planned":false,"acquired":true,"shares":459981,"price":0.0005,"value":229.9905,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":4838037,"source":{"system":"sec-edgar","filing":"0001437749-25-008804","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774925008804/rdgdoc.xml","form_type":"4"}},{"id":1204859,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-17T21:27:48.000Z","date":"2025-03-17","kind":"purchase","planned":false,"acquired":true,"shares":200000,"price":1.7391,"value":347820.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.73 to $1.745, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213501448,"source":{"system":"sec-edgar","filing":"0000950170-25-040497","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025040497/ownership.xml","form_type":"4"}},{"id":1232261,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-04T23:16:02.000Z","date":"2025-03-04","kind":"purchase","planned":false,"acquired":true,"price":436500,"reported_value":250000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":217391},"source":{"system":"sec-edgar","filing":"0000950170-25-032615","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025032615/ownership.xml","form_type":"4"}},{"id":1237131,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-04T00:26:33.000Z","date":"2025-03-03","kind":"purchase","planned":false,"acquired":true,"price":1707125,"reported_value":1000000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":869565},"source":{"system":"sec-edgar","filing":"0000950170-25-031198","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025031198/ownership.xml","form_type":"4"}},{"id":1237130,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-04T00:26:33.000Z","date":"2025-03-03","kind":"purchase","planned":false,"acquired":true,"price":1703250,"reported_value":1000000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":869565},"source":{"system":"sec-edgar","filing":"0000950170-25-031198","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025031198/ownership.xml","form_type":"4"}},{"id":1239494,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-01T00:34:01.000Z","date":"2025-02-28","kind":"purchase","planned":false,"acquired":true,"price":1652750,"reported_value":1000000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":869565},"source":{"system":"sec-edgar","filing":"0000950170-25-030278","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025030278/ownership.xml","form_type":"4"}},{"id":1239493,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-01T00:34:01.000Z","date":"2025-02-28","kind":"purchase","planned":false,"acquired":true,"shares":67434,"price":1.71,"value":115312.14,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213301448,"source":{"system":"sec-edgar","filing":"0000950170-25-030278","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025030278/ownership.xml","form_type":"4"}},{"id":1293531,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-28T22:40:23.000Z","date":"2025-01-28","kind":"purchase","planned":false,"acquired":true,"shares":47537,"price":1.4738,"value":70060.0306,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.465 to $1.475, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213234014,"source":{"system":"sec-edgar","filing":"0000950170-25-009978","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025009978/ownership.xml","form_type":"4"}},{"id":1300928,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-17T22:06:34.000Z","date":"2025-01-17","kind":"purchase","planned":false,"acquired":true,"shares":150000,"price":1.4695,"value":220425.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.465 to $1.47, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213186477,"source":{"system":"sec-edgar","filing":"0000950170-25-006790","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025006790/ownership.xml","form_type":"4"}},{"id":1302919,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-15T22:18:44.000Z","date":"2025-01-15","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":1.4817,"value":740850.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.46 to $1.50, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213036477,"source":{"system":"sec-edgar","filing":"0000950170-25-005908","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025005908/ownership.xml","form_type":"4"}},{"id":1333083,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-13T22:04:40.000Z","date":"2024-12-13","kind":"purchase","planned":false,"acquired":true,"shares":125000,"price":1.595,"value":199375.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.585 to $1.605, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":212536477,"source":{"system":"sec-edgar","filing":"0000950170-24-136264","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024136264/ownership.xml","form_type":"4"}},{"id":1336362,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-11T22:21:28.000Z","date":"2024-12-11","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":1.5621,"value":781050.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.535 to $1.61, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":212411477,"source":{"system":"sec-edgar","filing":"0000950170-24-135471","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024135471/ownership.xml","form_type":"4"}},{"id":1336360,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrant","published_at":"2024-12-11T19:58:20.000Z","date":"2024-12-09","kind":"other","planned":false,"acquired":false,"shares":647892,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"Held by\nFrost\nGamma\nInvestments\nTrust"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The Pre-Funded Warrants were immediately exercisable when issued. The Pre-Funded Warrants were exercised on December 9, 2024."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"The Pre-Funded Warrants will terminate when exercised in full."},{"field":"derivative.underlying_shares","element":"underlyingSecurityShares","label":"F2","text":"The Pre-Funded Warrants were immediately exercisable when issued. The Pre-Funded Warrants were exercised on December 9, 2024."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":0.0005,"exercise_date":"2024-12-09","underlying":"Common Stock","underlying_shares":647892},"source":{"system":"sec-edgar","filing":"0001437749-24-037223","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924037223/rdgdoc.xml","form_type":"4"}},{"id":1336359,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Common Stock","published_at":"2024-12-11T19:58:20.000Z","date":"2024-12-09","kind":"other","planned":false,"acquired":true,"shares":647892,"price":0.0005,"value":323.946,"ownership":{"direct":false,"nature":"Held by\nFrost\nGamma\nInvestments\nTrust"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":4378056,"source":{"system":"sec-edgar","filing":"0001437749-24-037223","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924037223/rdgdoc.xml","form_type":"4"}},{"id":1340980,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrant","published_at":"2024-12-06T17:10:46.000Z","date":"2024-12-02","kind":"grant","planned":false,"acquired":true,"shares":647892,"price":2.3147,"value":1499675.6124,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"On December 4, 2024, the reporting person filed a Form 4 which inadvertently reported the transaction code as \"P.\" The transaction code should have been reported as \"A\" for a grant, award or other acquisition pursuant to Rule 16b-3(d)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants will terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":647892,"derivative":{"exercise_price":0.0005,"exercise_date":"2024-12-02","underlying":"Common Stock","underlying_shares":647892},"source":{"system":"sec-edgar","filing":"0001437749-24-036842","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924036842/rdgdoc.xml","form_type":"4/A","original_submission_date":"2024-12-04"}},{"id":1343741,"issuer":{"id":6736,"kind":"organization","name":"Fluent, Inc.","symbol":"FLNT"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"ten_percent_owner":true}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"ten_percent_owner":true}}],"security":"Pre-Funded Warrant","published_at":"2024-12-04T19:43:20.000Z","date":"2024-12-02","kind":"purchase","planned":false,"acquired":true,"shares":647892,"price":2.3147,"value":1499675.6124,"ownership":{"direct":false,"nature":"Held by Frost Gamma Investments Trust"},"footnotes":[{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The Pre-Funded Warrants will terminate when exercised in full."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole stockholder of Frost-Nevada Corporation. The reporting persons disclaim beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that any reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":647892,"derivative":{"exercise_price":0.0005,"exercise_date":"2024-12-02","underlying":"Common Stock","underlying_shares":647892},"source":{"system":"sec-edgar","filing":"0001437749-24-036682","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000143774924036682/rdgdoc.xml","form_type":"4"}},{"id":1348594,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-29T20:20:16.000Z","date":"2024-11-29","kind":"purchase","planned":false,"acquired":true,"shares":199072,"price":1.534,"value":305376.448,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.525 to $1.54, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211911477,"source":{"system":"sec-edgar","filing":"0000950170-24-131871","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024131871/ownership.xml","form_type":"4"}},{"id":1355037,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-22T22:17:09.000Z","date":"2024-11-22","kind":"purchase","planned":false,"acquired":true,"shares":100000,"price":1.59,"value":159000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.585 to $1.59, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211712405,"source":{"system":"sec-edgar","filing":"0000950170-24-130292","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024130292/ownership.xml","form_type":"4"}},{"id":1357818,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-21T00:21:31.000Z","date":"2024-11-08","kind":"purchase","planned":false,"acquired":true,"shares":280183,"price":1.5045,"value":421535.3235,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.455 to $1.545, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211512405,"source":{"system":"sec-edgar","filing":"0000950170-24-129440","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024129440/ownership.xml","form_type":"4/A","original_submission_date":"2024-11-08"}},{"id":1365707,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-14T22:51:36.000Z","date":"2024-11-14","kind":"purchase","planned":false,"acquired":true,"shares":100000,"price":1.6198,"value":161980.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.615 to $1.6199, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211612405,"source":{"system":"sec-edgar","filing":"0000950170-24-127266","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024127266/ownership.xml","form_type":"4"}},{"id":1372035,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-08T22:40:44.000Z","date":"2024-11-08","kind":"purchase","planned":false,"acquired":true,"shares":280183,"price":1.5045,"value":421535.3235,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.455 to $1.545, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211512405,"source":{"system":"sec-edgar","filing":"0000950170-24-124261","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024124261/ownership.xml","form_type":"4"}},{"id":1387811,"issuer":{"id":7621,"kind":"organization","name":"Cocrystal Pharma, Inc."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-10-11T20:06:00.000Z","date":"2024-10-09","kind":"grant","planned":false,"acquired":true,"shares":27100,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"Represents restricted stock units (\"RSUs\"). Each RSU represents a contingent right to receive one share of the Issuer's common stock. The grant is exempt from Section 16(b) of the Securities Exchange Act of 1934 by virtue of Rule 16b-3 thereunder, as it was approved by the Board of Directors of the Issuer. One half of the RSUs are fully vested, with the balance vesting in eight equal quarterly installments on the last day of each quarter commencing with the quarter ending September 30, 2025, subject to continued services for the Company as of each applicable vesting date. Shares of common stock will be delivered to the Reporting Person promptly upon vesting, unless the Reporting Person elects to defer delivery. The RSUs were granted under the Issuer's 2015 Equity Incentive Plan and will vest in full upon a Change of Control as defined in such Plan."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents restricted stock units (\"RSUs\"). Each RSU represents a contingent right to receive one share of the Issuer's common stock. The grant is exempt from Section 16(b) of the Securities Exchange Act of 1934 by virtue of Rule 16b-3 thereunder, as it was approved by the Board of Directors of the Issuer. One half of the RSUs are fully vested, with the balance vesting in eight equal quarterly installments on the last day of each quarter commencing with the quarter ending September 30, 2025, subject to continued services for the Company as of each applicable vesting date. Shares of common stock will be delivered to the Reporting Person promptly upon vesting, unless the Reporting Person elects to defer delivery. The RSUs were granted under the Issuer's 2015 Equity Incentive Plan and will vest in full upon a Change of Control as defined in such Plan."}],"balance_after":27100,"source":{"system":"sec-edgar","filing":"0001493152-24-040901","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000149315224040901/ownership.xml","form_type":"4"}},{"id":1388830,"issuer":{"id":7657,"kind":"organization","name":"NOCOPI TECHNOLOGIES INC/MD/","symbol":"NNUP"},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-10-09T22:16:07.000Z","date":"2024-09-11","kind":"grant","planned":false,"acquired":true,"shares":21930,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares of the Issuer's common stock acquired by the Reporting Person from the Issuer as consideration rendered pursuant advisory services provided by the Reporting Person  pursuant to that certain Stock Purchase Agreement by and between the Issuer and Frost Gamma Investments Trust, dated September 11, 2023."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held by Frost Gamma Investments Trust, of which the Reporting Person is the trustee. Frost Gamma Limited Partnership is the sole and exclusive beneficiary of Frost Gamma Investments Trust. The Reporting Person is one of two limited partners of Frost Gamma Limited Partnership. The general partner of Frost Gamma Limited Partnership is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation, of which the Reporting Person is the sole shareholder. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":1271930,"source":{"system":"sec-edgar","filing":"0001104659-24-107406","document":"tm2425933-1_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/888981/000110465924107406/tm2425933-1_4seq1.xml","form_type":"4"}},{"id":1398722,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2024-09-27T21:22:19.000Z","date":"2024-09-27","kind":"purchase","planned":false,"acquired":true,"price":2541737.5,"reported_value":1845000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a\nDelaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances\nand during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion\nprice of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a\nDelaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances\nand during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion\nprice of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":1604347},"source":{"system":"sec-edgar","filing":"0000950170-24-110098","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024110098/ownership.xml","form_type":"4"}},{"id":1398721,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2024-09-27T21:18:35.000Z","date":"2024-09-25","kind":"purchase","planned":false,"acquired":true,"price":1571050,"reported_value":1155000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee.  Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee.  Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":1004347},"source":{"system":"sec-edgar","filing":"0000950170-24-110093","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024110093/ownership.xml","form_type":"4/A","original_submission_date":"2024-09-26"}}],"next_cursor":"2024-09-27T21:18:35.000000Z,1398721"}