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The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range."}],"balance_after":103412,"source":{"system":"sec-edgar","filing":"0001193125-26-281461","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/2040349/000119312526281461/ownership.xml","form_type":"4"}},{"id":727925,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":2453,"kind":"person","name":"Long Daniel D.","position":1,"cik":"0002040349","reported_name":"Long Daniel D.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Drug Discovery"}}],"security":"Common Stock","published_at":"2026-06-24T23:24:27.000Z","date":"2026-06-22","kind":"exercise","planned":true,"acquired":true,"shares":4471,"price":11.7,"value":52310.7,"ownership":{"direct":true},"balance_after":111412,"source":{"system":"sec-edgar","filing":"0001193125-26-281461","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2040349/000119312526281461/ownership.xml","form_type":"4"}},{"id":727924,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":2453,"kind":"person","name":"Long Daniel D.","position":1,"cik":"0002040349","reported_name":"Long Daniel D.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Drug Discovery"}}],"security":"Common Stock","published_at":"2026-06-24T23:24:27.000Z","date":"2026-06-22","kind":"exercise","planned":true,"acquired":true,"shares":10529,"price":2.76,"value":29060.04,"ownership":{"direct":true},"footnotes":[{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"Includes 3,501 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on April 30, 2026 in a transaction that was exempt under Rule 16b-3(c)."}],"balance_after":106941,"source":{"system":"sec-edgar","filing":"0001193125-26-281461","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040349/000119312526281461/ownership.xml","form_type":"4"}},{"id":912429,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":2453,"kind":"person","name":"Long Daniel D.","position":1,"cik":"0002040349","reported_name":"Long Daniel D.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Drug Discovery"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-02-11T00:17:29.000Z","date":"2026-02-06","kind":"grant","planned":false,"acquired":true,"shares":80000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date."}],"balance_after":80000,"derivative":{"exercise_price":25.41,"expiration_date":"2036-02-05","underlying":"Common Stock","underlying_shares":80000},"source":{"system":"sec-edgar","filing":"0001193125-26-045118","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040349/000119312526045118/ownership.xml","form_type":"4"}},{"id":1000533,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":2453,"kind":"person","name":"Long Daniel D.","position":1,"cik":"0002040349","reported_name":"Long Daniel D.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Drug Discovery"}}],"security":"Common Stock","published_at":"2025-11-14T01:13:18.000Z","date":"2025-11-10","kind":"sale","planned":false,"acquired":false,"shares":3501,"price":18.0586,"value":63223.1586,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. 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The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"Includes 3,501 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on October 31, 2025 in transactions that were exempt under Rule 16b-3(c)."}],"balance_after":92911,"source":{"system":"sec-edgar","filing":"0001193125-25-280756","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040349/000119312525280756/ownership.xml","form_type":"4"}},{"id":1070385,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":2453,"kind":"person","name":"Long Daniel D.","position":1,"cik":"0002040349","reported_name":"Long Daniel D.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Drug Discovery"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-08-11T23:03:34.000Z","date":"2025-08-07","kind":"grant","planned":false,"acquired":true,"shares":30000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date."}],"balance_after":30000,"derivative":{"exercise_price":11.7,"expiration_date":"2035-08-06","underlying":"Common Stock","underlying_shares":30000},"source":{"system":"sec-edgar","filing":"0000950170-25-106792","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2040349/000095017025106792/ownership.xml","form_type":"4"}}]}