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The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date."}],"balance_after":35875,"derivative":{"exercise_price":6.8,"expiration_date":"2032-02-08","underlying":"Common Stock","underlying_shares":46625},"source":{"system":"sec-edgar","filing":"0001649904-26-000007","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000164990426000007/form4.xml","form_type":"4"}},{"id":686464,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"officer":true,"officer_title":"EVP, Head of International"}}],"security":"Common Stock","published_at":"2026-08-14T23:01:59.000Z","date":"2026-08-12","kind":"sale","planned":true,"acquired":false,"shares":17319,"price":117.4686,"value":2034438.6834,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $117.01 to $117.60 per share. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":55655,"source":{"system":"sec-edgar","filing":"0001649904-26-000007","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000164990426000007/form4.xml","form_type":"4"}},{"id":686463,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"officer":true,"officer_title":"EVP, Head of International"}}],"security":"Common Stock","published_at":"2026-08-14T23:01:59.000Z","date":"2026-08-12","kind":"sale","planned":true,"acquired":false,"shares":18208,"price":116.4941,"value":2121124.5728,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $116.01 to $117.00 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":72974,"source":{"system":"sec-edgar","filing":"0001649904-26-000007","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000164990426000007/form4.xml","form_type":"4"}},{"id":686462,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"officer":true,"officer_title":"EVP, Head of International"}}],"security":"Common Stock","published_at":"2026-08-14T23:01:59.000Z","date":"2026-08-12","kind":"sale","planned":true,"acquired":false,"shares":14568,"price":115.427,"value":1681540.536,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $115.01 to $116.00 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":91182,"source":{"system":"sec-edgar","filing":"0001649904-26-000007","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000164990426000007/form4.xml","form_type":"4"}},{"id":686461,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"officer":true,"officer_title":"EVP, Head of International"}}],"security":"Common Stock","published_at":"2026-08-14T23:01:59.000Z","date":"2026-08-12","kind":"sale","planned":true,"acquired":false,"shares":3605,"price":114.6955,"value":413477.2775,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $114.01 to $115.00 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":105750,"source":{"system":"sec-edgar","filing":"0001649904-26-000007","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000164990426000007/form4.xml","form_type":"4"}},{"id":686460,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"officer":true,"officer_title":"EVP, Head of International"}}],"security":"Common Stock","published_at":"2026-08-14T23:01:59.000Z","date":"2026-08-12","kind":"sale","planned":true,"acquired":false,"shares":1000,"price":112.856,"value":112856.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $112.84 to $112.92 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":109355,"source":{"system":"sec-edgar","filing":"0001649904-26-000007","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000164990426000007/form4.xml","form_type":"4"}},{"id":686459,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"officer":true,"officer_title":"EVP, Head of International"}}],"security":"Common Stock","published_at":"2026-08-14T23:01:59.000Z","date":"2026-08-12","kind":"sale","planned":true,"acquired":false,"shares":2300,"price":111.7992,"value":257138.16,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $111.58 to $112.30 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":110355,"source":{"system":"sec-edgar","filing":"0001649904-26-000007","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000164990426000007/form4.xml","form_type":"4"}},{"id":686458,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"officer":true,"officer_title":"EVP, Head of International"}}],"security":"Common Stock","published_at":"2026-08-14T23:01:59.000Z","date":"2026-08-12","kind":"exercise","planned":true,"acquired":true,"shares":46625,"price":6.8,"value":317050.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2026."}],"balance_after":112655,"source":{"system":"sec-edgar","filing":"0001649904-26-000007","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000164990426000007/form4.xml","form_type":"4"}},{"id":815545,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Head of International"}}],"security":"Restricted Stock Units","published_at":"2026-04-03T21:36:14.000Z","date":"2026-04-01","kind":"exercise","planned":false,"acquired":false,"shares":2500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit represents a contingent right to receive one share of Issuer common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The restricted stock units vest or have vested as to 25% of the total shares on each of April 15, 2025, April 1, 2026, April 1, 2027 and April 1, 2028. The restricted stock units have no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"The restricted stock units vest or have vested as to 25% of the total shares on each of April 15, 2025, April 1, 2026, April 1, 2027 and April 1, 2028. 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The restricted stock units have no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The restricted stock units vest or have vested as to 25% of the total shares on each of April 14, 2024, April 14, 2025, April 1, 2026 and April 1, 2027. 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The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date."}],"balance_after":35000,"derivative":{"exercise_price":94.94,"expiration_date":"2036-03-01","underlying":"Common Stock","underlying_shares":35000},"source":{"system":"sec-edgar","filing":"0001104659-26-023659","document":"tm268041-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000110465926023659/tm268041-1_4seq1.xml","form_type":"4"}},{"id":895706,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Head of International"}}],"security":"Restricted Stock Units","published_at":"2026-02-18T21:30:22.000Z","date":"2026-02-14","kind":"exercise","planned":false,"acquired":false,"shares":10000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit represents a contingent right to receive one share of Issuer common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The restricted stock units vest as to 25% of the total shares on each of February 14, 2026, February 1, 2027, February 1, 2028 and February 1, 2029. The restricted stock units have no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The restricted stock units vest as to 25% of the total shares on each of February 14, 2026, February 1, 2027, February 1, 2028 and February 1, 2029. 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The restricted stock units have no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The restricted stock units vest as to 25% of the total shares on each of March 1, 2027, February 1, 2028, February 1, 2029 and February 1, 2030. The restricted stock units have no expiration date."}],"balance_after":23350,"derivative":{"underlying":"Common Stock","underlying_shares":23350},"source":{"system":"sec-edgar","filing":"0001104659-26-015400","document":"tm266366-5_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000110465926015400/tm266366-5_4seq1.xml","form_type":"4"}},{"id":920999,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Head of International"}}],"security":"Restricted Stock Units","published_at":"2026-02-03T21:38:11.000Z","date":"2026-02-01","kind":"exercise","planned":false,"acquired":false,"shares":5500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit represents a contingent right to receive one share of Issuer common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 1, 2026, February 1, 2027 and February 1, 2028. The restricted stock units have no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 1, 2026, February 1, 2027 and February 1, 2028. 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The securities were sold in multiple transactions at prices ranging from $65.00 to $65.22 per common stock. 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The securities were sold in multiple transactions at prices ranging from $61.04 to $62.00 per common stock. 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These shares were sold in multiple transactions at per share prices ranging from $39.10 to $39.22. 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The restricted stock units have no expiration date"},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The restricted stock units vest as to 25% of the total shares on each of February 11, 2022, February 11, 2023, February 11, 2024 and February 11, 2025. The restricted stock units have no expiration date"}],"balance_after":8125,"derivative":{"underlying":"Common Stock","underlying_shares":8125},"source":{"system":"sec-edgar","filing":"0001104659-21-024415","document":"tm216849-4_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000110465921024415/tm216849-4_4seq1.xml","form_type":"4"}},{"id":3011363,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Head of International"}}],"security":"Stock Option (Right to Buy)","published_at":"2020-10-06T20:10:44.000Z","date":"2020-10-05","kind":"grant","acquired":true,"shares":100000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock options were granted on October 5, 2020. 25% of the shares subject to the option will vest and become exercisable on October 5, 2021 and the remaining 75% of the shares subject to the option shall vest and become exercisable in 12 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer thereafter."}],"balance_after":100000,"derivative":{"exercise_price":22.28,"expiration_date":"2030-10-04","underlying":"Common Stock","underlying_shares":100000},"source":{"system":"sec-edgar","filing":"0001104659-20-112638","document":"a4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1649904/000110465920112638/a4.xml","form_type":"4"}},{"id":3266114,"issuer":{"id":4387,"kind":"organization","name":"Trevi Therapeutics, Inc.","symbol":"TRVI"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Stock Option (right to buy)","published_at":"2020-02-18T21:22:37.000Z","date":"2020-02-13","kind":"grant","acquired":true,"shares":70000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option was granted on February 13, 2020. The 70,000 shares of common stock underlying the option are scheduled to vest as to 25% of the shares on February 13, 2021 and as to the remaining 75% of the shares in equal monthly installments thereafter through February 13, 2024."}],"balance_after":70000,"derivative":{"exercise_price":5.5,"expiration_date":"2030-02-12","underlying":"Common Stock","underlying_shares":70000},"source":{"system":"sec-edgar","filing":"0000899243-20-004875","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1563880/000089924320004875/doc4.xml","form_type":"4"}},{"id":3500005,"issuer":{"id":4387,"kind":"organization","name":"Trevi Therapeutics, Inc.","symbol":"TRVI"},"owners":[{"id":23226,"kind":"person","name":"Mazabraud Yann","position":1,"cik":"0001774702","reported_name":"Mazabraud Yann","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Stock Option (right to buy)","published_at":"2019-06-05T21:04:49.000Z","date":"2019-06-03","kind":"grant","acquired":true,"shares":50000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option was granted on June 3, 2019. The 50,000 shares of common stock underlying the option are scheduled to vest as to 25% of the shares on June 3, 2020 and as to the remaining 75% of the shares in equal monthly installments thereafter through June 3, 2023."}],"balance_after":50000,"derivative":{"exercise_price":10.12,"expiration_date":"2029-06-02","underlying":"Common Stock","underlying_shares":50000},"source":{"system":"sec-edgar","filing":"0000899243-19-015601","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1563880/000089924319015601/doc4.xml","form_type":"4"}}]}