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(the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager to the Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":11246516,"source":{"system":"sec-edgar","filing":"0001193125-26-371237","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1809196/000119312526371237/ownership.xml","form_type":"4"}},{"id":704857,"issuer":{"id":4644,"kind":"organization","name":"Freenome, Inc.","symbol":"FRNM"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2026-07-23T01:08:08.000Z","date":"2026-07-20","kind":"grant","planned":false,"acquired":true,"shares":5500000,"price":10,"value":55000000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of the Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his or its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purpose."}],"balance_after":10871847,"source":{"system":"sec-edgar","filing":"0001193125-26-312798","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526312798/ownership.xml","form_type":"4"}},{"id":710780,"issuer":{"id":4569,"kind":"organization","name":"Kardigan, Inc."},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":30861,"kind":"person","name":"Perceptive Capital Solutions Holdings LP","position":3,"cik":"0002142326","reported_name":"Perceptive Capital Solutions Holdings LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":4,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-07-13T20:44:47.000Z","date":"2026-06-17","kind":"grant","planned":false,"acquired":true,"shares":20706,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Each share is represented by a restricted stock unit (\"RSU\"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on June 17, 2028, subject to Douglas E. Giordano's (\"Mr. Giordano\") continuous service as of the applicable vesting date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Mr. Giordano is a Managing Director and Co-Head of Capital Solutions at Perceptive Advisors LLC (the \"Advisor\"). The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Capital Solutions Advisors LP (\"PCS Advisors\", together with the Advisor, the \"Advisors\"), a relying adviser of the Advisor, serves as the investment manager to Perceptive Capital Solutions Holdings LP (\"PCS Holdings\"), and Perceptive Capital Solutions GP LLC (\"PCS GP\") serves as the general partner of PCS Holdings. Mr. Edelman is the managing member of PCS GP and the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The Advisors may be deemed to have an indirect pecuniary interest in the options reported herein because the Advisors have the right to receive the director compensation attributable to Mr. Giordano's board service through a partial management fee offset. Each of Mr. Edelman, the Master Fund, PCS Holdings, and the Advisors disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his or its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Mr. Edelman, the Master Fund, PCS Holdings, or the Advisors is the beneficial owner of such securities for purposes of Section 16 or for any other purpose."}],"balance_after":20706,"source":{"system":"sec-edgar","filing":"0001193125-26-302095","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526302095/ownership.xml","form_type":"4"}},{"id":711389,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2026-07-10T20:05:13.000Z","date":"2026-04-09","kind":"grant","planned":false,"acquired":true,"shares":28000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option shall be scheduled to vest monthly over a term of 24 months on the monthly anniversaries of the grant date, subject to the optionee continuing to be a Service Provider (as defined in the Issuer's 2026 Equity Incentive Plan) through the applicable vesting dates."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Joseph Edelman (\"Mr. Edelman\") is the managing member of Perceptive Advisors LLC (the \"Advisor\"). The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). The Advisor may be deemed to have an indirect pecuniary interest in the securities reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Edelman's board service through a partial management fee offset. Each of the Master Fund and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of its indirect pecuniary interest therein, and this report shall not be deemed an admission that either the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purpose."}],"balance_after":28000,"derivative":{"exercise_price":9.54,"expiration_date":"2036-04-08","underlying":"Common Stock","underlying_shares":28000},"source":{"system":"sec-edgar","filing":"0001193125-26-300876","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526300876/ownership.xml","form_type":"4"}},{"id":712026,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2026-07-09T22:48:01.000Z","date":"2026-06-23","kind":"grant","planned":false,"acquired":true,"shares":28000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option will vest on the earlier of (i) June 23, 2027, or (ii) the day immediately before the date of the next annual meeting of the Issuer's stockholders that occurs after June 22, 2026. The option reported was granted pursuant to the terms of the Issuer's Outside Director Compensation Policy."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Joseph Edelman (\"Mr. Edelman\") is the managing member of Perceptive Advisors LLC (the \"Advisor\"). The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). The Advisor may be deemed to have an indirect pecuniary interest in the securities reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Edelman's board service through a partial management fee offset. Each of the Master Fund and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of its indirect pecuniary interest therein, and this report shall not be deemed an admission that either the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purpose."}],"balance_after":28000,"derivative":{"exercise_price":8.35,"expiration_date":"2036-06-22","underlying":"Common Stock","underlying_shares":28000},"source":{"system":"sec-edgar","filing":"0001193125-26-299927","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526299927/ownership.xml","form_type":"4"}},{"id":727992,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":1,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2026-06-24T22:31:10.000Z","date":"2026-06-23","kind":"grant","planned":false,"acquired":true,"shares":28000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option will vest on the earlier of (i) June 23, 2027, or (ii) the day immediately before the date of the next annual meeting of the Issuer's stockholders that occurs after June 22, 2026. The option reported was granted pursuant to the terms of the Issuer's Outside Director Compensation Policy."}],"balance_after":28000,"derivative":{"exercise_price":8.35,"expiration_date":"2036-06-22","underlying":"Common Stock","underlying_shares":28000},"source":{"system":"sec-edgar","filing":"0001164426-26-000003","document":"form4-06242026_100602.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000116442626000003/form4-06242026_100602.xml","form_type":"4"}},{"id":738195,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Restricted Share Units","published_at":"2026-06-15T20:30:09.000Z","date":"2026-06-11","kind":"grant","planned":false,"acquired":true,"shares":60000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted share unit converts into one ordinary share of the Issuer upon settlement. The restricted share units become settleable when Ellen Hukkelhoven (\"Ms. Hukkelhoven\") ceases to be a director of the Issuer."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The restricted share units shall vest in a single annual installment upon the earlier of (i) June 11, 2027 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2027."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The restricted share units shall vest in a single annual installment upon the earlier of (i) June 11, 2027 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2027."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Ms. Hukkelhoven is a Managing Director of Perceptive Advisors, LLC (the \"Advisor\"). The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). The Advisor may be deemed to have an indirect pecuniary interest in the securities reported herein because the Advisor has the right to receive the director compensation provided in respect of Ms. Hukkelhoven's board service through a partial management fee offset. Joseph Edelman (\"Mr. Edelman\") is the managing member of the Advisor. Each of Mr. Edelman, the Master Fund and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman, the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":60000,"derivative":{"underlying":"Ordinary Shares","underlying_shares":60000},"source":{"system":"sec-edgar","filing":"0001193125-26-271152","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526271152/ownership.xml","form_type":"4"}},{"id":742049,"issuer":{"id":4915,"kind":"organization","name":"Solid Biosciences Inc.","symbol":"SLDB"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Director Stock Option (Right to Buy)","published_at":"2026-06-11T20:05:22.000Z","date":"2026-06-10","kind":"grant","planned":false,"acquired":true,"shares":77500,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option was granted on June 10, 2026 and vests in full on the earlier to occur of the one-year anniversary of the grant date and immediately prior to the Issuer's next annual meeting of stockholders occurring after the grant date, and will vest automatically as to 100% of the unvested portion of such option upon specified change in control events."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Consists of options to purchase shares of the Issuer's common stock awarded to Adam Stone in connection with his role as a member of the Issuer's Board of Directors. Mr. Stone is the Chief Investment Officer of Perceptive Advisors, LLC (the \"Advisor\"). The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase common stock of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Stone's board service through a partial management fee offset."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Joseph Edelman is the managing member of the Advisor. The Advisor serves as the investment manager to Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Each of Mr. Edelman, the Advisor and the Master Fund disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that Mr. Edelman, the Advisor or the Master Fund is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":77500,"derivative":{"exercise_price":6.61,"expiration_date":"2036-06-10","underlying":"Common Stock","underlying_shares":77500},"source":{"system":"sec-edgar","filing":"0001193125-26-267501","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526267501/ownership.xml","form_type":"4"}},{"id":801995,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Warrant (Right to Buy)","published_at":"2026-04-24T00:59:00.000Z","date":"2026-03-25","kind":"grant","planned":false,"acquired":true,"shares":300000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"On March 25, 2026, the Issuer, Credit Fund III, and the other parties to the Financing Agreement entered into an agreement whereby the exercise price of the warrants was adjusted to $8.00 per share."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Issued to Perceptive Credit Holdings III, LP (\"Credit Fund III\") in connection with the senior secured financing arrangement (the \"Financing Agreement\") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC (\"Perceptive Credit Advisors\") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":300000,"derivative":{"exercise_price":8,"exercise_date":"2026-03-25","expiration_date":"2027-08-02","underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001193125-26-174407","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526174407/ownership.xml","form_type":"4"}},{"id":801994,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Warrant (Right to Buy)","published_at":"2026-04-24T00:59:00.000Z","date":"2026-03-25","kind":"grant","planned":false,"acquired":true,"shares":400000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"On March 25, 2026, the Issuer, Credit Fund III, and the other parties to the Financing Agreement entered into an agreement whereby the exercise price of the warrants was adjusted to $8.00 per share."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Issued to Perceptive Credit Holdings III, LP (\"Credit Fund III\") in connection with the senior secured financing arrangement (the \"Financing Agreement\") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC (\"Perceptive Credit Advisors\") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":400000,"derivative":{"exercise_price":8,"exercise_date":"2026-03-25","expiration_date":"2027-08-02","underlying":"Ordinary Shares","underlying_shares":400000},"source":{"system":"sec-edgar","filing":"0001193125-26-174407","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526174407/ownership.xml","form_type":"4"}},{"id":801993,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Warrant (Right to Buy)","published_at":"2026-04-24T00:59:00.000Z","date":"2026-03-25","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":300000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"On March 25, 2026, the Issuer, Credit Fund III, and the other parties to the Financing Agreement entered into an agreement whereby the exercise price of the warrants was adjusted to $8.00 per share."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Issued to Perceptive Credit Holdings III, LP (\"Credit Fund III\") in connection with the senior secured financing arrangement (the \"Financing Agreement\") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC (\"Perceptive Credit Advisors\") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":0,"derivative":{"exercise_price":20,"exercise_date":"2022-08-02","expiration_date":"2027-08-02","underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001193125-26-174407","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526174407/ownership.xml","form_type":"4"}},{"id":801992,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Warrant (Right to Buy)","published_at":"2026-04-24T00:59:00.000Z","date":"2026-03-25","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":400000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"On March 25, 2026, the Issuer, Credit Fund III, and the other parties to the Financing Agreement entered into an agreement whereby the exercise price of the warrants was adjusted to $8.00 per share."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Issued to Perceptive Credit Holdings III, LP (\"Credit Fund III\") in connection with the senior secured financing arrangement (the \"Financing Agreement\") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC (\"Perceptive Credit Advisors\") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":0,"derivative":{"exercise_price":15,"exercise_date":"2022-08-02","expiration_date":"2027-08-02","underlying":"Ordinary Shares","underlying_shares":400000},"source":{"system":"sec-edgar","filing":"0001193125-26-174407","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526174407/ownership.xml","form_type":"4"}},{"id":801991,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Warrant (Right to Buy)","published_at":"2026-04-24T00:59:00.000Z","date":"2022-08-02","kind":"grant","planned":false,"acquired":true,"shares":300000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Issued to Perceptive Credit Holdings III, LP (\"Credit Fund III\") in connection with the senior secured financing arrangement (the \"Financing Agreement\") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC (\"Perceptive Credit Advisors\") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Issued to Perceptive Credit Holdings III, LP (\"Credit Fund III\") in connection with the senior secured financing arrangement (the \"Financing Agreement\") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC (\"Perceptive Credit Advisors\") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":300000,"derivative":{"exercise_price":20,"exercise_date":"2022-08-02","expiration_date":"2027-08-02","underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001193125-26-174407","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526174407/ownership.xml","form_type":"4"}},{"id":801990,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Warrant (Right to Buy)","published_at":"2026-04-24T00:59:00.000Z","date":"2022-08-02","kind":"grant","planned":false,"acquired":true,"shares":400000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Issued to Perceptive Credit Holdings III, LP (\"Credit Fund III\") in connection with the senior secured financing arrangement (the \"Financing Agreement\") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC (\"Perceptive Credit Advisors\") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Issued to Perceptive Credit Holdings III, LP (\"Credit Fund III\") in connection with the senior secured financing arrangement (the \"Financing Agreement\") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC (\"Perceptive Credit Advisors\") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":400000,"derivative":{"exercise_price":15,"exercise_date":"2022-08-02","expiration_date":"2027-08-02","underlying":"Ordinary Shares","underlying_shares":400000},"source":{"system":"sec-edgar","filing":"0001193125-26-174407","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526174407/ownership.xml","form_type":"4"}},{"id":801989,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2026-04-24T00:59:00.000Z","date":"2026-04-17","kind":"grant","planned":false,"acquired":true,"shares":555555,"price":9,"value":4999995.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":10786658,"source":{"system":"sec-edgar","filing":"0001193125-26-174407","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526174407/ownership.xml","form_type":"4"}},{"id":809806,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":1,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2026-04-13T20:52:15.000Z","date":"2026-04-09","kind":"grant","planned":false,"acquired":true,"shares":28000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option shall be scheduled to vest monthly over a term of 24 months on the monthly anniversaries of the grant date, subject to the optionee continuing to be a Service Provider (as defined in the Issuer's 2026 Equity Incentive Plan) through the applicable vesting dates."}],"balance_after":28000,"derivative":{"exercise_price":9.54,"expiration_date":"2036-04-08","underlying":"Common Stock","underlying_shares":28000},"source":{"system":"sec-edgar","filing":"0001164426-26-000002","document":"form4-04132026_080406.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000116442626000002/form4-04132026_080406.xml","form_type":"4"}},{"id":849192,"issuer":{"id":4915,"kind":"organization","name":"Solid Biosciences Inc.","symbol":"SLDB"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrant (right to buy)","published_at":"2026-03-11T20:00:03.000Z","date":"2026-03-09","kind":"grant","planned":false,"acquired":true,"shares":8912655,"price":5.609,"value":49991081.895,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The terms of the Pre-Funded Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 9.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund (as defined herein) to exercise any of its Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Pre-Funded Warrants do not expire."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Each of Mr. Edelman, the Advisor, and the Master Fund disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":8912655,"derivative":{"exercise_price":0.001,"exercise_date":"2026-03-09","underlying":"Common Stock","underlying_shares":8912655},"source":{"system":"sec-edgar","filing":"0001193125-26-102076","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526102076/ownership.xml","form_type":"4"}},{"id":955460,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":2,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":3,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2026-01-02T21:15:45.000Z","date":"2025-12-31","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":2300000,"price":7.91,"value":18193000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":10231103,"source":{"system":"sec-edgar","filing":"0001193125-26-000939","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312526000939/ownership.xml","form_type":"4"}},{"id":959955,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":5502402,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The securities were issued to Sermonix Pharmaceuticals, Inc. (\"Sermonix\") in exchange for the grant of certain licenses and rights by Sermonix to the Issuer. The Pre-Funded Warrants will become exercisable upon receipt by the Issuer of stockholder approval such that the Pre-Funded Warrants can be exercised at any time without restriction or additional stockholder approval. The Pre-Funded Warrants do not expire."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"The securities were issued to Sermonix Pharmaceuticals, Inc. (\"Sermonix\") in exchange for the grant of certain licenses and rights by Sermonix to the Issuer. The Pre-Funded Warrants will become exercisable upon receipt by the Issuer of stockholder approval such that the Pre-Funded Warrants can be exercised at any time without restriction or additional stockholder approval. The Pre-Funded Warrants do not expire."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F11","text":"The terms of the Pre-Funded Warrants provide that such warrants may not be exercised if, after such exercise, Sermonix, together with its Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 4.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Sermonix Beneficial Ownership Limitation\"). As of the date hereof, the Sermonix Beneficial Ownership Limitation does not permit Sermonix to exercise any of its Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F7","text":"The securities were issued to Sermonix Pharmaceuticals, Inc. (\"Sermonix\") in exchange for the grant of certain licenses and rights by Sermonix to the Issuer. The Pre-Funded Warrants will become exercisable upon receipt by the Issuer of stockholder approval such that the Pre-Funded Warrants can be exercised at any time without restriction or additional stockholder approval. The Pre-Funded Warrants do not expire."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"The securities are directly held by Sermonix. An affiliate of the Advisor currently holds approximately 29% of the outstanding capital stock of Sermonix (excluding securities convertible into shares of Sermonix capital stock). Pursuant to General Instruction 4.b.(iv) of Form 4, the Reporting Persons with this filing have reported the entire amount of Sermonix's interest in the securities, rather than the Reporting Person's proportionate interest in the securities held by Sermonix."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":5502402,"derivative":{"exercise_price":0.001,"underlying":"Common Stock","underlying_shares":5502402},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959954,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series B Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":1181101,"price":6.35,"value":7499991.35,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying Series A Warrant and Series B Warrant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"The Series B Warrants will be exercisable after the later of (1) June 30, 2026 and (2) the date of the completion of the public readout of topline results of the Issuer's ELAINE-3 trial. (the \"Series B Expiration Date\") and expire on the earlier of (1) the 30th day following the Series B Expiration Date and (2) December 23, 2030."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"The Series B Warrants will be exercisable after the later of (1) June 30, 2026 and (2) the date of the completion of the public readout of topline results of the Issuer's ELAINE-3 trial. (the \"Series B Expiration Date\") and expire on the earlier of (1) the 30th day following the Series B Expiration Date and (2) December 23, 2030."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Xontogeny Venture Fund II, LP (\"PXV II\"). Perceptive Venture Advisors, LLC (the \"Venture Advisor\") serves as the investment manager of PXV II and is controlled by the Advisor, and Perceptive Xontogeny Venture II GP, LLC (\"PXV GP\") is the general partner of PXV II. Mr. Edelman is the managing member of PXV GP and the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1181101,"derivative":{"exercise_price":7.62,"underlying":"Common Stock","underlying_shares":1181101},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959953,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series A Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":1279526,"price":6.35,"value":8124990.1,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying Series A Warrant and Series B Warrant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The Series A Warrants will be exercisable after the earlier of (1) the latest of (a) June 30, 2026, (b) the date on which the Issuer announces the enrollment of the 500th subject or the last subject, whichever is earlier, in its ELAINE-3 trial, and (c) the date on which the U.S. Food and Drug Administration approves or issues a complete response letter to Eli Lilly & Co.'s marketing application for imlunestrant in combination with abemaciclib in breast cancer, and (2) October 31, 2026 (the \"Series A Expiration Date\") and expire on the earlier of (1) the 30th day following the Series A Expiration Date and (2) December 23, 2030."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The Series A Warrants will be exercisable after the earlier of (1) the latest of (a) June 30, 2026, (b) the date on which the Issuer announces the enrollment of the 500th subject or the last subject, whichever is earlier, in its ELAINE-3 trial, and (c) the date on which the U.S. Food and Drug Administration approves or issues a complete response letter to Eli Lilly & Co.'s marketing application for imlunestrant in combination with abemaciclib in breast cancer, and (2) October 31, 2026 (the \"Series A Expiration Date\") and expire on the earlier of (1) the 30th day following the Series A Expiration Date and (2) December 23, 2030."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Xontogeny Venture Fund II, LP (\"PXV II\"). Perceptive Venture Advisors, LLC (the \"Venture Advisor\") serves as the investment manager of PXV II and is controlled by the Advisor, and Perceptive Xontogeny Venture II GP, LLC (\"PXV GP\") is the general partner of PXV II. Mr. Edelman is the managing member of PXV GP and the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1279526,"derivative":{"exercise_price":6.35,"underlying":"Common Stock","underlying_shares":1279526},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959952,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":457645,"price":6.349,"value":2905588.105,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"The Pre-Funded Warrants do not expire."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Xontogeny Venture Fund II, LP (\"PXV II\"). Perceptive Venture Advisors, LLC (the \"Venture Advisor\") serves as the investment manager of PXV II and is controlled by the Advisor, and Perceptive Xontogeny Venture II GP, LLC (\"PXV GP\") is the general partner of PXV II. Mr. Edelman is the managing member of PXV GP and the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":457645,"derivative":{"exercise_price":0.001,"exercise_date":"2025-12-23","underlying":"Common Stock","underlying_shares":457645},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959951,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series B Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":3543307,"price":6.35,"value":22499999.45,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying Series A Warrant and Series B Warrant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"The Series B Warrants will be exercisable after the later of (1) June 30, 2026 and (2) the date of the completion of the public readout of topline results of the Issuer's ELAINE-3 trial. (the \"Series B Expiration Date\") and expire on the earlier of (1) the 30th day following the Series B Expiration Date and (2) December 23, 2030."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"The Series B Warrants will be exercisable after the later of (1) June 30, 2026 and (2) the date of the completion of the public readout of topline results of the Issuer's ELAINE-3 trial. (the \"Series B Expiration Date\") and expire on the earlier of (1) the 30th day following the Series B Expiration Date and (2) December 23, 2030."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":3543307,"derivative":{"exercise_price":7.62,"underlying":"Common Stock","underlying_shares":3543307},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959950,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series A Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":3838583,"price":6.35,"value":24375002.05,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying Series A Warrant and Series B Warrant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The Series A Warrants will be exercisable after the earlier of (1) the latest of (a) June 30, 2026, (b) the date on which the Issuer announces the enrollment of the 500th subject or the last subject, whichever is earlier, in its ELAINE-3 trial, and (c) the date on which the U.S. Food and Drug Administration approves or issues a complete response letter to Eli Lilly & Co.'s marketing application for imlunestrant in combination with abemaciclib in breast cancer, and (2) October 31, 2026 (the \"Series A Expiration Date\") and expire on the earlier of (1) the 30th day following the Series A Expiration Date and (2) December 23, 2030."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The Series A Warrants will be exercisable after the earlier of (1) the latest of (a) June 30, 2026, (b) the date on which the Issuer announces the enrollment of the 500th subject or the last subject, whichever is earlier, in its ELAINE-3 trial, and (c) the date on which the U.S. Food and Drug Administration approves or issues a complete response letter to Eli Lilly & Co.'s marketing application for imlunestrant in combination with abemaciclib in breast cancer, and (2) October 31, 2026 (the \"Series A Expiration Date\") and expire on the earlier of (1) the 30th day following the Series A Expiration Date and (2) December 23, 2030."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":3838583,"derivative":{"exercise_price":6.35,"underlying":"Common Stock","underlying_shares":3838583},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959949,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":1372935,"price":6.349,"value":8716764.315,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"The Pre-Funded Warrants do not expire."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. 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These shares were purchased in multiple transactions at prices ranging from $4.61 to $4.9 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within such range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Perceptive Advisors, LLC (the \"Advisor\") serves as the investment advisor to Perceptive Life Sciences Master Fund, Ltd. (the \"Master Fund\"). Perceptive LS GP, LLC (\"GP\") is the manager of Perceptive LS (A), LLC (\"Perceptive LS\"). Joseph Edelman is the managing member of the Advisor and the sole member of GP. 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Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1344999,"derivative":{"exercise_price":1.71,"underlying":"Common Stock or Pre-Funded Warrants","underlying_shares":1344999},"source":{"system":"sec-edgar","filing":"0001193125-25-246871","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312525246871/ownership.xml","form_type":"4"}},{"id":1014922,"issuer":{"id":7926,"kind":"organization","name":"Adagio Medical Holdings, Inc.","symbol":"ADGM"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Tranche B Warrant (\"Common Warrant\" right to buy)","published_at":"2025-10-22T20:33:15.000Z","date":"2025-10-20","kind":"purchase","planned":false,"acquired":true,"shares":1344999,"price":0.1846,"value":248286.8154,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Represents the purchase price for each common warrant purchased by the Reporting Person in the Issuer's registered public offering that closed on October 20, 2025."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The common warrants are immediately exercisable, subject to the Beneficial Ownership Limitation (as defined below), and will expire on the fifth anniversary of their issuance. 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Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1344999,"derivative":{"exercise_price":1.71,"underlying":"Common Stock or Pre-Funded Warrants","underlying_shares":1344999},"source":{"system":"sec-edgar","filing":"0001193125-25-246871","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312525246871/ownership.xml","form_type":"4"}},{"id":1014921,"issuer":{"id":7926,"kind":"organization","name":"Adagio Medical Holdings, Inc.","symbol":"ADGM"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Tranche A Warrant (\"Common Warrant\" right to buy)","published_at":"2025-10-22T20:33:15.000Z","date":"2025-10-20","kind":"purchase","planned":false,"acquired":true,"shares":1344999,"price":0.1846,"value":248286.8154,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Represents the purchase price for each common warrant purchased by the Reporting Person in the Issuer's registered public offering that closed on October 20, 2025."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The common warrants are immediately exercisable, subject to the Beneficial Ownership Limitation (as defined below), and will expire on the fifth anniversary of their issuance. Pursuant to the terms of the common warrants, the common warrant cannot be exercised to the extent that, upon giving effect to or immediately prior to such exercise, would cause either (i) the aggregate number of shares of Common Stock beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise or (ii) the combined voting power of the Issuer's securities beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the combined voting power of all of the Issuer's securities outstanding immediately after giving effect to the exercise (the \"Beneficial Ownership Limitation\")."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The common warrants are immediately exercisable, subject to the Beneficial Ownership Limitation (as defined below), and will expire on the fifth anniversary of their issuance. Pursuant to the terms of the common warrants, the common warrant cannot be exercised to the extent that, upon giving effect to or immediately prior to such exercise, would cause either (i) the aggregate number of shares of Common Stock beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise or (ii) the combined voting power of the Issuer's securities beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the combined voting power of all of the Issuer's securities outstanding immediately after giving effect to the exercise (the \"Beneficial Ownership Limitation\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1344999,"derivative":{"exercise_price":1.71,"underlying":"Common Stock or Pre-Funded Warrants","underlying_shares":1344999},"source":{"system":"sec-edgar","filing":"0001193125-25-246871","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000119312525246871/ownership.xml","form_type":"4"}},{"id":1075096,"issuer":{"id":434,"kind":"organization","name":"Orchestra BioMed Holdings, Inc.","symbol":"OBIO"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-funded Warrants (right to buy)","published_at":"2025-08-05T14:46:24.000Z","date":"2025-08-01","kind":"purchase","planned":false,"acquired":true,"shares":1500000,"price":2.7499,"value":4124850.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"Represents the purchase price for each pre-funded warrant purchased by the Reporting Person in the Issuer's registered public offering that closed on August 1, 2025."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The pre-funded warrants are immediately exercisable and will expire on the date they are exercised in full, subject to the Beneficial Ownership Limitation."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"The pre-funded warrants are immediately exercisable and will expire on the date they are exercised in full, subject to the Beneficial Ownership Limitation."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of the Master Fund. Joseph Edelman (\"Mr. Edelman\") serves as the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of their indirect pecuniary interest therein, and this report shall not be deemed an admission that the Advisor or Mr. Edelman are beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1500000,"derivative":{"exercise_price":0.0001,"underlying":"Common Stock","underlying_shares":1500000},"source":{"system":"sec-edgar","filing":"0000950170-25-102537","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000095017025102537/ownership.xml","form_type":"4"}},{"id":1075095,"issuer":{"id":434,"kind":"organization","name":"Orchestra BioMed Holdings, Inc.","symbol":"OBIO"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-08-05T14:46:24.000Z","date":"2025-08-01","kind":"purchase","planned":false,"acquired":true,"shares":700000,"price":2.75,"value":1925000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the purchase price for each share of Common Stock purchased by the Reporting Person in the Issuer's registered public offering that closed on August 1, 2025."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of the Master Fund. Joseph Edelman (\"Mr. Edelman\") serves as the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of their indirect pecuniary interest therein, and this report shall not be deemed an admission that the Advisor or Mr. Edelman are beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":5292556,"source":{"system":"sec-edgar","filing":"0000950170-25-102537","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000095017025102537/ownership.xml","form_type":"4"}},{"id":1110160,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Restricted Share Units","published_at":"2025-06-16T20:31:05.000Z","date":"2025-06-12","kind":"grant","planned":false,"acquired":true,"shares":45000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted share unit converts into one ordinary share of the Issuer upon settlement. The restricted share units become settleable when Ellen Hukkelhoven (\"Ms. Hukkelhoven\") ceases to be a director of the Issuer."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Ms. Hukkelhoven is a Managing Director of Perceptive Advisors, LLC (the \"Advisor\"). The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). The Advisor may be deemed to have an indirect pecuniary interest in the securities reported herein because the Advisor has the right to receive the director compensation provided in respect of Ms. Hukkelhoven's board service through a partial management fee offset. Joseph Edelman (\"Mr. Edelman\") is the managing member of the Advisor. Each of Mr. Edelman, the Master Fund and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman, the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":45000,"derivative":{"underlying":"Ordinary Shares","underlying_shares":45000},"source":{"system":"sec-edgar","filing":"0001062993-25-011743","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299325011743/form4.xml","form_type":"4"}},{"id":1112173,"issuer":{"id":4915,"kind":"organization","name":"Solid Biosciences Inc.","symbol":"SLDB"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Director Stock Option (Right to Buy)","published_at":"2025-06-13T21:05:50.000Z","date":"2025-06-12","kind":"grant","planned":false,"acquired":true,"shares":77500,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option was granted on June 12, 2025 and vests in full on the earlier to occur of the one-year anniversary of the grant date and immediately prior to the Issuer's next annual meeting of stockholders occurring after the grant date, and will vest automatically as to 100% of the unvested portion of such option upon specified change in control events."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Consists of options to purchase shares of the Issuer's common stock awarded to Adam Stone in connection with his role as a member of the Issuer's Board of Directors. Mr. Stone is the Chief Investment Officer of Perceptive Advisors, LLC (the \"Advisor\"). The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase common stock of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Stone's board service through a partial management fee offset."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Joseph Edelman is the managing member of the Advisor. The Advisor serves as the investment manager to Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Each of Mr. Edelman, the Advisor and the Master Fund disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that Mr. Edelman, the Advisor or the Master Fund is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":77500,"derivative":{"exercise_price":4.58,"expiration_date":"2035-06-12","underlying":"Common Stock","underlying_shares":77500},"source":{"system":"sec-edgar","filing":"0001062993-25-011688","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299325011688/form4.xml","form_type":"4"}},{"id":1125689,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":1,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2025-06-03T21:34:57.000Z","date":"2025-05-30","kind":"grant","planned":false,"acquired":true,"shares":20900,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option will vest on the earlier of (i) May 30, 2026, or (ii) the day immediately before the date of the next annual meeting of the Issuer's stockholders that occurs after May 30, 2025. The option reported was granted pursuant to the terms of the Issuer's Outside Director Compensation Policy."}],"balance_after":20900,"derivative":{"exercise_price":0.3125,"expiration_date":"2035-05-29","underlying":"Common Stock","underlying_shares":20900},"source":{"system":"sec-edgar","filing":"0001415889-25-015438","document":"form4-06032025_090642.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000141588925015438/form4-06032025_090642.xml","form_type":"4"}},{"id":1162672,"issuer":{"id":573,"kind":"organization","name":"Acrivon Therapeutics, Inc.","symbol":"ACRV"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-01T23:07:20.000Z","date":"2025-05-01","kind":"sale","planned":false,"acquired":false,"shares":298886,"price":1.34,"value":400507.24,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The reported price is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.33 to $1.39 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within such range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":3104139,"source":{"system":"sec-edgar","filing":"0001062993-25-008341","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299325008341/form4.xml","form_type":"4"}},{"id":1162671,"issuer":{"id":573,"kind":"organization","name":"Acrivon Therapeutics, Inc.","symbol":"ACRV"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-01T23:07:20.000Z","date":"2025-04-30","kind":"sale","planned":false,"acquired":false,"shares":437881,"price":1.41,"value":617412.21,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The reported price is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.40 to $1.53 inclusive. The reporting persons undertake to provide Acrivon Therapeutics, Inc. (the \"Issuer\"), any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within such range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":3403025,"source":{"system":"sec-edgar","filing":"0001062993-25-008341","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299325008341/form4.xml","form_type":"4"}},{"id":1164064,"issuer":{"id":573,"kind":"organization","name":"Acrivon Therapeutics, Inc.","symbol":"ACRV"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-29T23:26:12.000Z","date":"2025-04-29","kind":"sale","planned":false,"acquired":false,"shares":250000,"price":1.41,"value":352500.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The reported price is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.40 to $1.49 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within such range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":3840906,"source":{"system":"sec-edgar","filing":"0001062993-25-008214","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299325008214/form4.xml","form_type":"4"}},{"id":1164063,"issuer":{"id":573,"kind":"organization","name":"Acrivon Therapeutics, Inc.","symbol":"ACRV"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-29T23:26:12.000Z","date":"2025-04-28","kind":"sale","planned":false,"acquired":false,"shares":215283,"price":1.56,"value":335841.48,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The reported price is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.54 to $1.65 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within such range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":4090906,"source":{"system":"sec-edgar","filing":"0001062993-25-008214","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299325008214/form4.xml","form_type":"4"}},{"id":1164062,"issuer":{"id":573,"kind":"organization","name":"Acrivon Therapeutics, Inc.","symbol":"ACRV"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-29T23:26:12.000Z","date":"2025-04-25","kind":"sale","planned":false,"acquired":false,"shares":1054669,"price":1.95,"value":2056604.55,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The reported price is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.61 to $2.39 inclusive. The reporting persons undertake to provide Acrivon Therapeutics, Inc. (the \"Issuer\"), any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within such range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":4306189,"source":{"system":"sec-edgar","filing":"0001062993-25-008214","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299325008214/form4.xml","form_type":"4"}},{"id":1176883,"issuer":{"id":6839,"kind":"organization","name":"Aldeyra Therapeutics, Inc."},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-07T22:43:07.000Z","date":"2025-04-03","kind":"sale","planned":false,"acquired":false,"shares":3400000,"price":1.42,"value":4828000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The reported price is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.18 to $1.78 inclusive. The reporting persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within such range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\").  Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund.  Joseph Edelman is the managing member of the Advisor.  Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":5875851,"source":{"system":"sec-edgar","filing":"0001062993-25-007163","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299325007163/form4.xml","form_type":"4"}},{"id":1253543,"issuer":{"id":4915,"kind":"organization","name":"Solid Biosciences Inc.","symbol":"SLDB"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":82935,"kind":"person","name":"Perceptive Xontogeny Venture Fund, LP","position":3,"cik":"0001757940","reported_name":"Perceptive Xontogeny Venture Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":4,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-02-21T21:17:42.000Z","date":"2025-02-19","kind":"purchase","planned":false,"acquired":true,"shares":5000000,"price":4.03,"value":20150000.0,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager to the Master Fund. Mr. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":11833539,"source":{"system":"sec-edgar","filing":"0001062993-25-003153","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299325003153/form4.xml","form_type":"4"}},{"id":1267849,"issuer":{"id":7926,"kind":"organization","name":"Adagio Medical Holdings, Inc.","symbol":"ADGM"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":83219,"kind":"person","name":"C2 Life Sciences LLC","position":4,"cik":"0001890152","reported_name":"C2 Life Sciences LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-02-14T21:35:06.000Z","date":"2025-01-22","kind":"grant","planned":false,"acquired":true,"shares":64167,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"On January 22, 2025, the Reporting Persons were issued 64,167 shares of Common Stock of the Issuer at a price of $2.00 per share pursuant to the terms of the Convert Waiver, dated December 26, 2024, by and between the Issuer and the Reporting Persons in exchange for the waiver by the Reporting Persons of certain rights related to the Issuer's default under its Senior Secured Convertible Notes."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"On January 22, 2025, the Reporting Persons were issued 64,167 shares of Common Stock of the Issuer at a price of $2.00 per share pursuant to the terms of the Convert Waiver, dated December 26, 2024, by and between the Issuer and the Reporting Persons in exchange for the waiver by the Reporting Persons of certain rights related to the Issuer's default under its Senior Secured Convertible Notes."},{"field":"ownership.direct","element":"directOrIndirectOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of the Master Fund. Joseph Edelman (\"Mr. Edelman\") serves as the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of their indirect pecuniary interest therein, and this report shall not be deemed an admission that the Advisor or Mr. Edelman are beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":9675684,"source":{"system":"sec-edgar","filing":"0001062993-25-002547","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299325002547/form4.xml","form_type":"4"}},{"id":1359862,"issuer":{"id":4915,"kind":"organization","name":"Solid Biosciences Inc.","symbol":"SLDB"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Director Stock Option (Right to Buy)","published_at":"2024-11-19T21:20:03.000Z","date":"2024-06-11","kind":"grant","planned":false,"acquired":true,"shares":34400,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option was granted on June 11, 2024 and vests in full on the earlier to occur of the one-year anniversary of the grant date and immediately prior to the Issuer's next annual meeting of stockholders occurring after the grant date, and will vest automatically as to 100% of the unvested portion of such option upon specified change in control events."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Consists of options to purchase shares of the Issuer's common stock awarded to Adam Stone in connection with his role as a member of the Issuer's Board of Directors. Mr. Stone is the Chief Investment Officer of Perceptive Advisors, LLC (the \"Advisor\"). The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase common stock of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Stone's board service through a partial management fee offset."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Joseph Edelman is the managing member of the Advisor. 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Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":12531103,"source":{"system":"sec-edgar","filing":"0001062993-24-015109","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299324015109/form4.xml","form_type":"4"}},{"id":1477645,"issuer":{"id":6679,"kind":"organization","name":"Nautilus Biotechnology, Inc."},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2024-06-17T22:02:16.000Z","date":"2024-06-14","kind":"grant","planned":false,"acquired":true,"shares":45000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Subject to the continuous status of Mr. Altman as a \"Service Provider\" (as defined in the Issuer's 2021 Equity Incentive Plan) through each applicable vesting date, one-twelfth (1/12th) of the shares subject to the Option shall vest on a monthly basis following the date of the grant on the same day of the month as such grant date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Consists of options to purchase shares of the Issuer's common stock awarded to Michael Altman in connection with his role as a member of the Issuer's Board of Directors. Mr. Altman is affiliated with Perceptive Advisors LLC (the \"Advisor\"). The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase common stock of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Altman's board service through a partial management fee offset."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Joseph Edelman is the managing member of the Advisor. The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Each of Mr. Edelman, the Master Fund and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of the securities reported on this form, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman, the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":45000,"derivative":{"exercise_price":2.56,"expiration_date":"2034-06-14","underlying":"Common Stock","underlying_shares":45000},"source":{"system":"sec-edgar","filing":"0001062993-24-012726","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299324012726/form4.xml","form_type":"4"}},{"id":1487268,"issuer":{"id":4734,"kind":"organization","name":"MeiraGTx Holdings plc","symbol":"MGTX"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Restricted Share Units","published_at":"2024-06-07T22:48:58.000Z","date":"2024-06-06","kind":"grant","planned":false,"acquired":true,"shares":45000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted share unit converts into one ordinary share of the Issuer upon settlement. The restricted share units become settleable when Ellen Hukkelhoven (\"Ms. Hukkelhoven\") ceases to be a director of the Issuer."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The restricted share units shall vest in a single annual installment upon the earlier of (i) June 6, 2025 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The restricted share units shall vest in a single annual installment upon the earlier of (i) June 6, 2025 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2025."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Ms. Hukkelhoven is a Managing Director of Perceptive Advisors, LLC (the \"Advisor\"). The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). The Advisor may be deemed to have an indirect pecuniary interest in the securities reported herein because the Advisor has the right to receive the director compensation provided in respect of Ms. Hukkelhoven's board service through a partial management fee offset. Joseph Edelman (\"Mr. Edelman\") is the managing member of the Advisor. Each of Mr. Edelman, the Master Fund and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman, the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":45000,"derivative":{"underlying":"Ordinary Shares","underlying_shares":45000},"source":{"system":"sec-edgar","filing":"0001062993-24-012219","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299324012219/form4.xml","form_type":"4"}},{"id":1502295,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":1,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2024-05-24T23:01:52.000Z","date":"2024-05-24","kind":"grant","planned":false,"acquired":true,"shares":20900,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option will vest on the earlier of (i) May 24, 2025, or (ii) the day immediately before the date of the next annual meeting of the Issuer's stockholders that occurs after May 24, 2024. 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Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":7099182,"source":{"system":"sec-edgar","filing":"0001062993-23-023292","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299323023292/form4.xml","form_type":"4"}},{"id":1698117,"issuer":{"id":6823,"kind":"organization","name":"Verrica Pharmaceuticals Inc."},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-12-29T22:27:30.000Z","date":"2023-12-28","kind":"purchase","planned":false,"acquired":true,"shares":126116,"price":7.08,"value":892901.28,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The reported price is a weighted average price. 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Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":6983408,"source":{"system":"sec-edgar","filing":"0001062993-23-023292","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299323023292/form4.xml","form_type":"4"}},{"id":1698116,"issuer":{"id":6823,"kind":"organization","name":"Verrica Pharmaceuticals Inc."},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-12-29T22:27:30.000Z","date":"2023-12-27","kind":"purchase","planned":false,"acquired":true,"shares":79726,"price":7.2,"value":574027.2,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The reported price is a weighted average price. 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Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":8593586,"source":{"system":"sec-edgar","filing":"0001062993-23-019546","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299323019546/form4.xml","form_type":"4"}},{"id":1758290,"issuer":{"id":6839,"kind":"organization","name":"Aldeyra Therapeutics, Inc."},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2023-10-18T21:15:49.000Z","date":"2023-10-16","kind":"sale","planned":false,"acquired":false,"shares":2450000,"price":1.6,"value":3920000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The reported price is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.45 to $2.03 inclusive. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of sold at each separate price within such range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\").  Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund.  Joseph Edelman is the managing member of the Advisor.  Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":8900085,"source":{"system":"sec-edgar","filing":"0001062993-23-019546","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299323019546/form4.xml","form_type":"4"}},{"id":1758286,"issuer":{"id":68888,"kind":"organization","name":"Astria Therapeutics, Inc.","symbol":"ATXS"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":82935,"kind":"person","name":"Perceptive Xontogeny Venture Fund, LP","position":3,"cik":"0001757940","reported_name":"Perceptive Xontogeny Venture Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":4,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Warrants (right to buy)","published_at":"2023-10-18T20:11:36.000Z","date":"2023-10-16","kind":"purchase","planned":false,"acquired":true,"shares":460546,"price":6.514,"value":2999996.644,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying common warrant purchased by the Reporting Person in the Issuer's registered public offering that closed on October 16, 2023."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The common warrants are immediately exercisable and will expire on the fifth anniversary of their issuance, subject to the Beneficial Ownership Limitation (as defined below). Pursuant to the terms of the common warrants, the common warrant cannot be exercised to the extent that, upon giving effect to or immediately prior to such exercise, would cause either (i) the aggregate number of shares of Common Stock beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise or (ii) the combined voting power of the Issuer's securities beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the combined voting power of all of the Issuer's securities outstanding immediately after giving effect to the exercise."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The common warrants are immediately exercisable and will expire on the fifth anniversary of their issuance, subject to the Beneficial Ownership Limitation (as defined below). Pursuant to the terms of the common warrants, the common warrant cannot be exercised to the extent that, upon giving effect to or immediately prior to such exercise, would cause either (i) the aggregate number of shares of Common Stock beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise or (ii) the combined voting power of the Issuer's securities beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the combined voting power of all of the Issuer's securities outstanding immediately after giving effect to the exercise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"The securities are directly held by Perceptive Xontogeny Ventures, L.P. (\"PXV\").  The Advisor serves as the investment manager of PXV, and Perceptive Xontogeny Ventures GP, LLC (\"PXV GP\") is the general partner of PXV. 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The Advisor, PXV GP and Mr. Edelman disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his or its indirect pecuniary interest therein, and this report shall not be deemed an admission that they are the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":345409,"derivative":{"exercise_price":8.025,"underlying":"Common Stock","underlying_shares":345409},"source":{"system":"sec-edgar","filing":"0001062993-23-019533","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299323019533/form4.xml","form_type":"4"}},{"id":1758285,"issuer":{"id":68888,"kind":"organization","name":"Astria Therapeutics, Inc.","symbol":"ATXS"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":82935,"kind":"person","name":"Perceptive Xontogeny Venture Fund, LP","position":3,"cik":"0001757940","reported_name":"Perceptive Xontogeny Venture Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":4,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Pre-funded Warrants (right to buy)","published_at":"2023-10-18T20:11:36.000Z","date":"2023-10-16","kind":"purchase","planned":false,"acquired":true,"shares":921093,"price":6.513,"value":5999078.709,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Represents the combined purchase price for each pre-funded warrant and accompanying common warrant purchased by the Reporting Person in the Issuer's registered public offering that closed on October 16, 2023."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"The pre-funded warrants are immediately exercisable and will expire on the date they are exercised in full, subject to the Beneficial Ownership Limitation."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"The pre-funded warrants are immediately exercisable and will expire on the date they are exercised in full, subject to the Beneficial Ownership Limitation."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. 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Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":921093,"derivative":{"exercise_price":0.001,"underlying":"Common Stock","underlying_shares":921093},"source":{"system":"sec-edgar","filing":"0001062993-23-019533","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299323019533/form4.xml","form_type":"4"}},{"id":1758284,"issuer":{"id":68888,"kind":"organization","name":"Astria Therapeutics, Inc.","symbol":"ATXS"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":82935,"kind":"person","name":"Perceptive Xontogeny Venture Fund, LP","position":3,"cik":"0001757940","reported_name":"Perceptive Xontogeny Venture Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":4,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Warrants (right to buy)","published_at":"2023-10-18T20:11:36.000Z","date":"2023-10-16","kind":"purchase","planned":false,"acquired":true,"shares":921093,"price":6.513,"value":5999078.709,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Represents the combined purchase price for each pre-funded warrant and accompanying common warrant purchased by the Reporting Person in the Issuer's registered public offering that closed on October 16, 2023."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The common warrants are immediately exercisable and will expire on the fifth anniversary of their issuance, subject to the Beneficial Ownership Limitation (as defined below). 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Pursuant to the terms of the common warrants, the common warrant cannot be exercised to the extent that, upon giving effect to or immediately prior to such exercise, would cause either (i) the aggregate number of shares of Common Stock beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise or (ii) the combined voting power of the Issuer's securities beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the combined voting power of all of the Issuer's securities outstanding immediately after giving effect to the exercise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\").  Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund.  Joseph Edelman is the managing member of the Advisor.  Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1151366.25,"derivative":{"exercise_price":8.025,"underlying":"Common Stock","underlying_shares":690819},"source":{"system":"sec-edgar","filing":"0001062993-23-019533","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299323019533/form4.xml","form_type":"4"}},{"id":1758283,"issuer":{"id":68888,"kind":"organization","name":"Astria Therapeutics, Inc.","symbol":"ATXS"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":82935,"kind":"person","name":"Perceptive Xontogeny Venture Fund, LP","position":3,"cik":"0001757940","reported_name":"Perceptive Xontogeny Venture Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":4,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Warrants (right to buy)","published_at":"2023-10-18T20:11:36.000Z","date":"2023-10-16","kind":"purchase","planned":false,"acquired":true,"shares":614062,"price":6.514,"value":3999999.868,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying common warrant purchased by the Reporting Person in the Issuer's registered public offering that closed on October 16, 2023."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The common warrants are immediately exercisable and will expire on the fifth anniversary of their issuance, subject to the Beneficial Ownership Limitation (as defined below). Pursuant to the terms of the common warrants, the common warrant cannot be exercised to the extent that, upon giving effect to or immediately prior to such exercise, would cause either (i) the aggregate number of shares of Common Stock beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise or (ii) the combined voting power of the Issuer's securities beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the combined voting power of all of the Issuer's securities outstanding immediately after giving effect to the exercise."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The common warrants are immediately exercisable and will expire on the fifth anniversary of their issuance, subject to the Beneficial Ownership Limitation (as defined below). Pursuant to the terms of the common warrants, the common warrant cannot be exercised to the extent that, upon giving effect to or immediately prior to such exercise, would cause either (i) the aggregate number of shares of Common Stock beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise or (ii) the combined voting power of the Issuer's securities beneficially owned by such holder (together with its affiliates) would exceed 9.99% of the combined voting power of all of the Issuer's securities outstanding immediately after giving effect to the exercise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\").  Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund.  Joseph Edelman is the managing member of the Advisor.  Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":460546,"derivative":{"exercise_price":8.025,"underlying":"Common Stock","underlying_shares":460546},"source":{"system":"sec-edgar","filing":"0001062993-23-019533","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299323019533/form4.xml","form_type":"4"}},{"id":1758282,"issuer":{"id":68888,"kind":"organization","name":"Astria Therapeutics, Inc.","symbol":"ATXS"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":82935,"kind":"person","name":"Perceptive Xontogeny Venture Fund, LP","position":3,"cik":"0001757940","reported_name":"Perceptive Xontogeny Venture Fund, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":4,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2023-10-18T20:11:36.000Z","date":"2023-10-16","kind":"purchase","planned":false,"acquired":true,"shares":460546,"price":6.514,"value":2999996.644,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying common warrant purchased by the Reporting Person in the Issuer's registered public offering that closed on October 16, 2023."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"The securities are directly held by Perceptive Xontogeny Ventures, L.P. (\"PXV\").  The Advisor serves as the investment manager of PXV, and Perceptive Xontogeny Ventures GP, LLC (\"PXV GP\") is the general partner of PXV. Mr. Edelman is the managing member of PXV GP and the Advisor. The Advisor, PXV GP and Mr. Edelman disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his or its indirect pecuniary interest therein, and this report shall not be deemed an admission that they are the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1611699,"source":{"system":"sec-edgar","filing":"0001062993-23-019533","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000106299323019533/form4.xml","form_type":"4"}}],"next_cursor":"2023-10-18T20:11:36.000000Z,1758282"}