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These sales were automatic and not in the discretion of the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $8.08 to $8.32. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, on request, full information regarding the number of shares sold at each separate price within the range set forth above."}],"balance_after":137170,"source":{"system":"sec-edgar","filing":"0001193125-26-421834","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1661998/000119312526421834/ownership.xml","form_type":"4"}},{"id":673764,"issuer":{"id":5594,"kind":"organization","name":"Q32 Bio Inc.","symbol":"QTTB"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CFO and President"}}],"security":"Common Stock","published_at":"2026-08-27T20:10:05.000Z","date":"2026-08-25","kind":"sale","planned":false,"acquired":false,"shares":3972,"price":16.56,"value":65776.32,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. 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Such PSUs are also subject to a time-based condition, which provides that the PSUs shall vest in equal quarterly installments over three years from July 1, 2026, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date. 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These sales were automatic and not in the discretion of the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.35 to $4.69. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, on request, full information regarding the number of shares sold at each separate price within the range set forth above."}],"balance_after":35943,"source":{"system":"sec-edgar","filing":"0001193125-26-083588","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000119312526083588/ownership.xml","form_type":"4"}},{"id":980200,"issuer":{"id":5594,"kind":"organization","name":"Q32 Bio Inc.","symbol":"QTTB"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CFO and President"}}],"security":"Common Stock","published_at":"2025-12-05T00:00:04.000Z","date":"2025-12-02","kind":"sale","planned":false,"acquired":false,"shares":9072,"price":3.4607,"value":31395.4704,"ownership":{"direct":true},"balance_after":39938,"source":{"system":"sec-edgar","filing":"0001193125-25-308327","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000119312525308327/ownership.xml","form_type":"4"}},{"id":1053576,"issuer":{"id":5594,"kind":"organization","name":"Q32 Bio Inc.","symbol":"QTTB"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CFO and President"}}],"security":"Common Stock","published_at":"2025-08-28T23:20:44.000Z","date":"2025-08-26","kind":"sale","planned":false,"acquired":false,"shares":4240,"price":1.801,"value":7636.24,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. These sales were automatic and not in the discretion of the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported is a weighted average price. The securities were sold in multiple transactions over two consecutive trading days, at per share prices ranging from $1.81 to $1.96 and $1.73 to $1.83, respectively. The Reporting Person undertakes to provide upon request the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote 2."}],"balance_after":49010,"source":{"system":"sec-edgar","filing":"0001193125-25-191442","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000119312525191442/ownership.xml","form_type":"4"}},{"id":1240664,"issuer":{"id":5594,"kind":"organization","name":"Q32 Bio Inc.","symbol":"QTTB"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CFO and President"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-02-27T11:01:13.000Z","date":"2025-02-24","kind":"grant","planned":false,"acquired":true,"shares":161323,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"The exercise price of the option is $2.54 per share, representing the fair market value per share of the Issuer's Common Stock on the Repricing Date; provided that in the event (i) the option is exercised prior to the one-year anniversary of the Repricing Date, (ii) the Reporting Person's employment is terminated by the Company prior to the one-year anniversary of the Repricing Date due to Cause (as defined in the 2024 Plan) or (iii) the Reporting Person resigns for any reason prior to the one-year anniversary of the Repricing Date, the exercise price will be increased to the exercise price of the cancelled option in exchange for which this option was granted."},{"field":"kind","element":"transactionCoding","label":"F2","text":"On February 24, 2025, the Issuer's board of directors approved an option repricing (\"Repricing Date\"). All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the Exchange Act, as applicable."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"On February 24, 2025, the Issuer's board of directors approved an option repricing (\"Repricing Date\"). All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the Exchange Act, as applicable."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"This stock option award was issued pursuant to the Q32 Bio Inc. 2017 Stock Option and Grant Plan (the \"2017 Plan\") or the Q32 Bio Inc. 2024 Stock Option and Incentive Plan (the \"2024 Plan\"), as applicable, and becomes exercisable in accordance with the vesting schedule specified in the award agreement and as previously reported on applicable Form 4, subject to the Reporting Person's continued service with the Issuer as of the applicable vesting date."}],"balance_after":161323,"derivative":{"exercise_price":2.54,"expiration_date":"2033-10-12","underlying":"Common Stock","underlying_shares":161323},"source":{"system":"sec-edgar","filing":"0000950170-25-028269","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000095017025028269/ownership.xml","form_type":"4"}},{"id":1240663,"issuer":{"id":5594,"kind":"organization","name":"Q32 Bio Inc.","symbol":"QTTB"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CFO and President"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-02-27T11:01:13.000Z","date":"2025-02-24","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":161323,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"On February 24, 2025, the Issuer's board of directors approved an option repricing (\"Repricing Date\"). 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Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the Exchange Act, as applicable."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"This stock option award was issued pursuant to the Q32 Bio Inc. 2017 Stock Option and Grant Plan (the \"2017 Plan\") or the Q32 Bio Inc. 2024 Stock Option and Incentive Plan (the \"2024 Plan\"), as applicable, and becomes exercisable in accordance with the vesting schedule specified in the award agreement and as previously reported on applicable Form 4, subject to the Reporting Person's continued service with the Issuer as of the applicable vesting date."}],"balance_after":0,"derivative":{"exercise_price":16.82,"expiration_date":"2033-10-12","underlying":"Common Stock","underlying_shares":161323},"source":{"system":"sec-edgar","filing":"0000950170-25-028269","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000095017025028269/ownership.xml","form_type":"4"}},{"id":1240662,"issuer":{"id":5594,"kind":"organization","name":"Q32 Bio Inc.","symbol":"QTTB"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CFO and President"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-02-27T11:01:13.000Z","date":"2025-02-24","kind":"grant","planned":false,"acquired":true,"shares":16901,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"The exercise price of the option is $2.54 per share, representing the fair market value per share of the Issuer's Common Stock on the Repricing Date; provided that in the event (i) the option is exercised prior to the one-year anniversary of the Repricing Date, (ii) the Reporting Person's employment is terminated by the Company prior to the one-year anniversary of the Repricing Date due to Cause (as defined in the 2024 Plan) or (iii) the Reporting Person resigns for any reason prior to the one-year anniversary of the Repricing Date, the exercise price will be increased to the exercise price of the cancelled option in exchange for which this option was granted."},{"field":"kind","element":"transactionCoding","label":"F2","text":"On February 24, 2025, the Issuer's board of directors approved an option repricing (\"Repricing Date\"). 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Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the Exchange Act, as applicable."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"This stock option award was issued pursuant to the Q32 Bio Inc. 2017 Stock Option and Grant Plan (the \"2017 Plan\") or the Q32 Bio Inc. 2024 Stock Option and Incentive Plan (the \"2024 Plan\"), as applicable, and becomes exercisable in accordance with the vesting schedule specified in the award agreement and as previously reported on applicable Form 4, subject to the Reporting Person's continued service with the Issuer as of the applicable vesting date."}],"balance_after":16901,"derivative":{"exercise_price":2.54,"expiration_date":"2033-11-08","underlying":"Common Stock","underlying_shares":16901},"source":{"system":"sec-edgar","filing":"0000950170-25-028269","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000095017025028269/ownership.xml","form_type":"4"}},{"id":1240661,"issuer":{"id":5594,"kind":"organization","name":"Q32 Bio Inc.","symbol":"QTTB"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CFO and President"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-02-27T11:01:13.000Z","date":"2025-02-24","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":16901,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"On February 24, 2025, the Issuer's board of directors approved an option repricing (\"Repricing Date\"). 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This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $21.03 to $21.15 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":30309,"source":{"system":"sec-edgar","filing":"0001209191-23-023347","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919123023347/doc4.xml","form_type":"4"}},{"id":2062623,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2023-01-06T02:12:36.000Z","date":"2023-01-03","kind":"grant","acquired":true,"shares":35000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"This option shall vest one-fourth (1/4) of the total number of shares underlying the option on January 3, 2024 and the remaining shares in 36 equal monthly installments thereafter."}],"balance_after":35000,"derivative":{"exercise_price":29.6,"expiration_date":"2033-01-03","underlying":"Ordinary Shares","underlying_shares":35000},"source":{"system":"sec-edgar","filing":"0001209191-23-002190","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919123002190/doc4.xml","form_type":"4"}},{"id":2062622,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2023-01-06T02:12:36.000Z","date":"2023-01-03","kind":"sale","acquired":false,"shares":1815,"price":29.06,"value":52743.9,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting and settlement of the RSUs. This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.00 to $29.545 inclusive. 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These shares were sold in multiple transactions at prices ranging from $35.01 to $35.05 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3) and (5)."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001209191-21-053710","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919121053710/doc4.xml","form_type":"4"}},{"id":2588158,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2021-08-27T22:31:57.000Z","date":"2021-08-26","kind":"exercise","acquired":true,"shares":550,"price":8.76,"value":4818.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"This exercise price is in US Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.374675 to GBP 1.00 as of August 26, 2021."}],"balance_after":550,"source":{"system":"sec-edgar","filing":"0001209191-21-053710","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919121053710/doc4.xml","form_type":"4"}},{"id":2590848,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2021-08-25T21:45:36.000Z","date":"2021-08-23","kind":"exercise","acquired":false,"shares":7500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"This exercise price is in US Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.366815 to GBP 1.00 as of August 23, 2021."},{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"20% of the shares subject to the option vested on July 24, 2018, 60% of the shares subject to the option will vest each month thereafter in 36\nequal monthly installments, and the remaining 20% of the shares subject to the option will vest on the earlier of (i) the fourth anniversary of the\ngrant date and (ii) the date on which the Issuer's board of directors determines that the Issuer has satisfied certain performance vesting\nmilestones, in all cases provided that the Reporting Person remains continuously employed with us through each applicable vesting date."}],"balance_after":59774,"derivative":{"exercise_price":1.6,"expiration_date":"2027-07-23","underlying":"Ordinary Shares","underlying_shares":7500},"source":{"system":"sec-edgar","filing":"0001209191-21-053350","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919121053350/doc4.xml","form_type":"4"}},{"id":2590847,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2021-08-25T21:45:36.000Z","date":"2021-08-23","kind":"sale","acquired":false,"shares":7500,"price":33.02,"value":247650.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.00 to\n$33.056 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and\nExchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this\nfootnote."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001209191-21-053350","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919121053350/doc4.xml","form_type":"4"}},{"id":2590846,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2021-08-25T21:45:36.000Z","date":"2021-08-23","kind":"exercise","acquired":true,"shares":7500,"price":1.6,"value":12000.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"This exercise price is in US Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.366815 to GBP 1.00 as of August 23, 2021."}],"balance_after":7500,"source":{"system":"sec-edgar","filing":"0001209191-21-053350","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919121053350/doc4.xml","form_type":"4"}},{"id":2621226,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2021-07-30T22:21:09.000Z","date":"2021-07-29","kind":"exercise","acquired":false,"shares":12500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"This exercise price is in US Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.39511 to GBP 1.00 as of July 29, 2021."},{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"20% of the shares subject to the option vested on July 24, 2018, 60% of the shares subject to the option will vest each month thereafter in 36 equal monthly installments, and the remaining 20% of the shares subject to the option will vest on the earlier of (i) the fourth anniversary of the grant date and (ii) the date on which the Issuer's board of directors determines that the Issuer has satisfied certain performance vesting milestones, in all cases provided that the Reporting Person remains continuously employed with us through each applicable vesting date."}],"balance_after":67274,"derivative":{"exercise_price":1.63,"expiration_date":"2027-07-23","underlying":"Ordinary Shares","underlying_shares":12500},"source":{"system":"sec-edgar","filing":"0001209191-21-048919","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919121048919/doc4.xml","form_type":"4"}},{"id":2621225,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2021-07-30T22:21:09.000Z","date":"2021-07-29","kind":"sale","acquired":false,"shares":300,"price":32.81,"value":9843.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.78 to $32.86 inclusive."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001209191-21-048919","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919121048919/doc4.xml","form_type":"4"}},{"id":2621224,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2021-07-30T22:21:09.000Z","date":"2021-07-29","kind":"sale","acquired":false,"shares":3204,"price":32.13,"value":102944.52,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $31.77 to $32.76 inclusive."}],"balance_after":300,"source":{"system":"sec-edgar","filing":"0001209191-21-048919","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919121048919/doc4.xml","form_type":"4"}},{"id":2621223,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2021-07-30T22:21:09.000Z","date":"2021-07-29","kind":"sale","acquired":false,"shares":8996,"price":31.24,"value":281035.04,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.73 to\n$31.72 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and\nExchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in\nfootnotes (3), (4) and (5)."}],"balance_after":3504,"source":{"system":"sec-edgar","filing":"0001209191-21-048919","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919121048919/doc4.xml","form_type":"4"}},{"id":2621222,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary 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thereafter in 36 equal monthly installments, and the remaining 20% of the shares subject to the option will vest on the earlier of (i) the fourth anniversary of the grant date and (ii) the date on which the Issuer's board of directors determines that the Issuer has satisfied certain performance vesting milestones, in all cases provided that the Reporting Person remains continuously employed with us through each applicable vesting date."}],"balance_after":79774,"derivative":{"exercise_price":1.59,"expiration_date":"2027-07-23","underlying":"Ordinary Shares","underlying_shares":15000},"source":{"system":"sec-edgar","filing":"0001209191-21-004665","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919121004665/doc4.xml","form_type":"4"}},{"id":2900697,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS 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Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.36521 to GBP 1.00 as of January 14, 2021."},{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"20% of the shares subject to the option vested on July 24, 2018, 60% of the shares subject to the option will vest each month thereafter in 36 equal monthly installments, and the remaining 20% of the shares subject to the option will vest on the earlier of (i) the fourth anniversary of the grant date and (ii) the date on which the Issuer's board of directors determines that the Issuer has satisfied certain performance vesting milestones, in all cases provided that the Reporting Person remains continuously employed with us through each applicable vesting 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These shares were sold in multiple transactions at prices ranging from $20.00 to $20.24 inclusive."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001209191-20-060598","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919120060598/doc4.xml","form_type":"4"}},{"id":2966162,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2020-11-26T01:31:45.000Z","date":"2020-11-25","kind":"exercise","acquired":true,"shares":9781,"price":1.56,"value":15258.36,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"This exercise price is in US Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.33434 to GBP 1.00 as of November 25, 2020."}],"balance_after":9781,"source":{"system":"sec-edgar","filing":"0001209191-20-060598","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919120060598/doc4.xml","form_type":"4"}},{"id":2966161,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2020-11-26T01:31:45.000Z","date":"2020-11-23","kind":"sale","acquired":false,"shares":213,"price":20.38,"value":4340.94,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $20.24 to $20.50 inclusive."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001209191-20-060598","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919120060598/doc4.xml","form_type":"4"}},{"id":2966160,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2020-11-26T01:31:45.000Z","date":"2020-11-23","kind":"sale","acquired":false,"shares":16976,"price":19.82,"value":336464.32,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.24 to $20.19 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3), (4) and (6)."}],"balance_after":213,"source":{"system":"sec-edgar","filing":"0001209191-20-060598","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919120060598/doc4.xml","form_type":"4"}},{"id":2966159,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Ordinary Shares","published_at":"2020-11-26T01:31:45.000Z","date":"2020-11-23","kind":"exercise","acquired":true,"shares":17189,"price":1.56,"value":26814.84,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Shares exercised and sold pursuant to a Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"This exercise price is in US Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.33651 to GBP 1.00 as of November 23, 2020."}],"balance_after":17189,"source":{"system":"sec-edgar","filing":"0001209191-20-060598","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919120060598/doc4.xml","form_type":"4"}},{"id":3169073,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2020-04-27T20:45:45.000Z","date":"2019-06-28","kind":"grant","acquired":true,"shares":283414,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"date","element":"transactionDate","label":"F1","text":"The original Form 4 inadvertently listed the incorrect date of earliest transaction, transaction date and expiration date. This Form 4 amendment is being filed to accurately reflect the appropriates dates."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"This option shall vest in 36 equal monthly installments at the end of each calendar month following the date of the grant."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The original Form 4 inadvertently listed the incorrect date of earliest transaction, transaction date and expiration date. This Form 4 amendment is being filed to accurately reflect the appropriates dates."}],"balance_after":283414,"derivative":{"exercise_price":14,"expiration_date":"2029-06-28","underlying":"Ordinary Shares","underlying_shares":283414},"source":{"system":"sec-edgar","filing":"0001209191-20-025812","document":"doc4a.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919120025812/doc4a.xml","form_type":"4/A","original_submission_date":"2019-05-30"}},{"id":3318480,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2020-01-06T22:02:50.000Z","date":"2020-01-02","kind":"grant","acquired":true,"shares":60000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest one-fourth (1/4) of the total number of shares under option on January 2, 2021 and the remaining shares in 36 equal monthly installments at the end of each calendar month therafter."}],"balance_after":60000,"derivative":{"exercise_price":9.82,"expiration_date":"2030-01-02","underlying":"Ordinary Shares","underlying_shares":60000},"source":{"system":"sec-edgar","filing":"0001209191-20-001967","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000120919120001967/doc4.xml","form_type":"4"}},{"id":3507550,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":19082,"kind":"person","name":"Kalowski Lee","position":1,"cik":"0001618273","reported_name":"Kalowski Lee","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CFO"}}],"security":"Stock Option (Right to Buy)","published_at":"2019-05-31T01:24:55.000Z","date":"2019-05-28","kind":"grant","acquired":true,"shares":283414,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in 36 equal monthly installments at the end of each calendar month following the date of the grant."}],"balance_after":283414,"derivative":{"exercise_price":14,"expiration_date":"2029-05-28","underlying":"Ordinary Shares","underlying_shares":283414},"source":{"system":"sec-edgar","filing":"0001104659-19-032910","document":"a4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1618273/000110465919032910/a4.xml","form_type":"4"}}]}