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The reporting person undertakes to provide to Monopar Therapeutics Inc., any security holder of Monopar Therapeutics Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (4) through (9) to this Form 4."}],"balance_after":590,"source":{"system":"sec-edgar","filing":"0001437749-26-029235","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1333516/000143774926029235/rdgdoc.xml","form_type":"4/A","original_submission_date":"2026-08-27"}},{"id":672848,"issuer":{"id":5152,"kind":"organization","name":"Monopar Therapeutics","symbol":"MNPR"},"owners":[{"id":18684,"kind":"person","name":"Tsuchimoto Kim R","position":1,"cik":"0001333516","reported_name":"Tsuchimoto Kim R","relationship":{"director":true}}],"security":"Common Stock","published_at":"2026-08-29T00:18:00.000Z","date":"2026-08-26","kind":"sale","planned":true,"acquired":false,"shares":1098,"price":111.84,"value":122800.32,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was effected pursuant to a Rule 10b5-1 Plan executed by the reporting person on May 27, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The price reported in Column 4 is a weighted average price. 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The reporting person undertakes to provide to Monopar Therapeutics Inc., any security holder of Monopar Therapeutics Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (4) through (9) to this Form 4."}],"balance_after":2290,"source":{"system":"sec-edgar","filing":"0001437749-26-029235","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1333516/000143774926029235/rdgdoc.xml","form_type":"4/A","original_submission_date":"2026-08-27"}},{"id":672846,"issuer":{"id":5152,"kind":"organization","name":"Monopar Therapeutics","symbol":"MNPR"},"owners":[{"id":18684,"kind":"person","name":"Tsuchimoto Kim R","position":1,"cik":"0001333516","reported_name":"Tsuchimoto Kim R","relationship":{"director":true}}],"security":"Common Stock","published_at":"2026-08-29T00:18:00.000Z","date":"2026-08-26","kind":"sale","planned":true,"acquired":false,"shares":615,"price":109.56,"value":67379.4,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was effected pursuant to a Rule 10b5-1 Plan executed by the reporting person on May 27, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. 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The reporting person undertakes to provide to Monopar Therapeutics Inc., any security holder of Monopar Therapeutics Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (7) to this Form 4."}],"balance_after":11001,"source":{"system":"sec-edgar","filing":"0001437749-26-029116","document":"rdgdoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1333516/000143774926029116/rdgdoc.xml","form_type":"4"}},{"id":977400,"issuer":{"id":5152,"kind":"organization","name":"Monopar Therapeutics","symbol":"MNPR"},"owners":[{"id":18684,"kind":"person","name":"Tsuchimoto Kim R","position":1,"cik":"0001333516","reported_name":"Tsuchimoto Kim R","relationship":{"director":true}}],"security":"Stock Options","published_at":"2025-12-08T21:47:37.000Z","date":"2025-12-02","kind":"grant","planned":false,"acquired":true,"shares":2924,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Options vest 25% quarterly on March 31, 2026, June 30, 2026, September 30, 2026 and December 31, 2026."}],"balance_after":2924,"derivative":{"exercise_price":75.94,"expiration_date":"2035-12-02","underlying":"Common Stock","underlying_shares":2924},"source":{"system":"sec-edgar","filing":"0001437749-25-037165","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1333516/000143774925037165/rdgdoc.xml","form_type":"4"}},{"id":1086399,"issuer":{"id":5152,"kind":"organization","name":"Monopar Therapeutics","symbol":"MNPR"},"owners":[{"id":18684,"kind":"person","name":"Tsuchimoto Kim R","position":1,"cik":"0001333516","reported_name":"Tsuchimoto Kim R","relationship":{"director":true}}],"security":"Stock Options","published_at":"2025-07-17T01:06:13.000Z","date":"2025-07-14","kind":"other","planned":false,"acquired":false,"shares":4704,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"Reflects options to purchase a total of 4,704 shares of common stock granted to Ms. Tsuchimoto on February 20, 2017, for her services as a director and prior officer of Monopar Therapeutics. The options vested 6/48ths upon the 6-month anniversary of the grant date and 1/48th per month thereafter."}],"balance_after":0,"derivative":{"exercise_price":0.005,"expiration_date":"2027-02-20","underlying":"Common Stock","underlying_shares":4704},"source":{"system":"sec-edgar","filing":"0001437749-25-022863","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1333516/000143774925022863/rdgdoc.xml","form_type":"4"}},{"id":1086398,"issuer":{"id":5152,"kind":"organization","name":"Monopar Therapeutics","symbol":"MNPR"},"owners":[{"id":18684,"kind":"person","name":"Tsuchimoto Kim R","position":1,"cik":"0001333516","reported_name":"Tsuchimoto Kim R","relationship":{"director":true}}],"security":"Stock Options","published_at":"2025-07-17T01:06:13.000Z","date":"2025-07-14","kind":"other","planned":false,"acquired":false,"shares":4200,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"Reflects options to purchase a total of 4,200 shares of common stock granted to Ms. Tsuchimoto on April 4, 2016, for her services as a director and prior officer of Monopar Therapeutics.The options vested 6/12ths upon the grant date and 3/12th every 6 months thereafter."}],"balance_after":0,"derivative":{"exercise_price":0.005,"expiration_date":"2026-04-04","underlying":"Common Stock","underlying_shares":4200},"source":{"system":"sec-edgar","filing":"0001437749-25-022863","document":"rdgdoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1333516/000143774925022863/rdgdoc.xml","form_type":"4"}},{"id":1086397,"issuer":{"id":5152,"kind":"organization","name":"Monopar Therapeutics","symbol":"MNPR"},"owners":[{"id":18684,"kind":"person","name":"Tsuchimoto Kim R","position":1,"cik":"0001333516","reported_name":"Tsuchimoto Kim R","relationship":{"director":true}}],"security":"Common Stock","published_at":"2025-07-17T01:06:13.000Z","date":"2025-07-14","kind":"sale","planned":false,"acquired":false,"shares":8904,"price":40.0012,"value":356170.6848,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The shares were sold in multiple transactions at prices ranging from $40.00 to $40.25, inclusive. This amount represents the weighted average sale price of such transactions. 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Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"On February 2, 2022, the reporting person was granted 61,532 restricted stock units, vesting 6/48ths (7,692 shares) on June 30, 2022, and 3/48ths (3,846 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2025. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"On February 1, 2023, the reporting person was granted 78,234 restricted stock units, vesting 6/48ths (9,779 shares) on June 30, 2023, and 3/48ths (4,890 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2026. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"On January 26, 2021, the reporting person was granted 19,536 restricted stock units, vesting 6/48ths (2,442 shares) on June 30, 2021, and 3/48ths (1,221 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2024. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"On February 2, 2022, the reporting person was granted 61,532 restricted stock units, vesting 6/48ths (7,692 shares) on June 30, 2022, and 3/48ths (3,846 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2025. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"On February 1, 2023, the reporting person was granted 78,234 restricted stock units, vesting 6/48ths (9,779 shares) on June 30, 2023, and 3/48ths (4,890 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2026. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. 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Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"On February 2, 2022, the reporting person was granted 61,532 restricted stock units, vesting 6/48ths (7,692 shares) on June 30, 2022, and 3/48ths (3,846 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2025. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"On February 1, 2023, the reporting person was granted 78,234 restricted stock units, vesting 6/48ths (9,779 shares) on June 30, 2023, and 3/48ths (4,890 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2026. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"On January 26, 2021, the reporting person was granted 19,536 restricted stock units, vesting 6/48ths (2,442 shares) on June 30, 2021, and 3/48ths (1,221 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2024. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"On February 2, 2022, the reporting person was granted 61,532 restricted stock units, vesting 6/48ths (7,692 shares) on June 30, 2022, and 3/48ths (3,846 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2025. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"On February 1, 2023, the reporting person was granted 78,234 restricted stock units, vesting 6/48ths (9,779 shares) on June 30, 2023, and 3/48ths (4,890 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2026. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. 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Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"On January 31, 2020 the reporting person was granted 4,923 restricted stock units, vesting in four equal annual installments with vesting dates on January 1, 2021, January 1, 2022, January 1, 2023, and January 1, 2024. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. 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Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"On February 2, 2022, the reporting person was granted 61,532 restricted stock units, vesting 6/48ths (7,692 shares) on June 30, 2022, and 3/48ths (3,846 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2025. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"On February 1, 2023, the reporting person was granted 78,234 restricted stock units, vesting 6/48ths (9,779 shares) on June 30, 2023, and 3/48ths (4,890 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2026. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"On January 26, 2021, the reporting person was granted 19,536 restricted stock units, vesting 6/48ths (2,442 shares) on June 30, 2021, and 3/48ths (1,221 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2024. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"On February 2, 2022, the reporting person was granted 61,532 restricted stock units, vesting 6/48ths (7,692 shares) on June 30, 2022, and 3/48ths (3,846 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2025. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"On February 1, 2023, the reporting person was granted 78,234 restricted stock units, vesting 6/48ths (9,779 shares) on June 30, 2023, and 3/48ths (4,890 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2026. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. 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