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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":51878,"source":{"system":"sec-edgar","filing":"0000874015-26-000172","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000172/edgardoc.xml","form_type":"4"}},{"id":875152,"issuer":{"id":3528,"kind":"organization","name":"CYTOKINETICS INC","symbol":"CYTK"},"owners":[{"id":18114,"kind":"person","name":"PARSHALL B LYNNE","position":1,"cik":"0001073385","reported_name":"PARSHALL B LYNNE","relationship":{"director":true}}],"security":"Common Stock","published_at":"2026-03-02T21:29:56.000Z","date":"2026-03-02","kind":"sale","planned":true,"acquired":false,"shares":5000,"price":61.21,"value":306050.0,"ownership":{"direct":true},"balance_after":17933,"source":{"system":"sec-edgar","filing":"0001061983-26-000014","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1073385/000106198326000014/form4.xml","form_type":"4"}},{"id":906265,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":18114,"kind":"person","name":"PARSHALL B LYNNE","position":1,"cik":"0001073385","reported_name":"PARSHALL B LYNNE","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-02-14T00:40:10.000Z","date":"2026-02-11","kind":"sale","planned":true,"acquired":false,"shares":5000,"price":82.7177,"value":413588.5,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on May 6, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. 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