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These shares were sold in multiple transactions at prices ranging from $16.95 per share to $17.30 per share, inclusive.  The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":36175,"source":{"system":"sec-edgar","filing":"0001209191-17-024065","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1571498/000120919117024065/doc4.xml","form_type":"4"}},{"id":4390332,"issuer":{"id":12703,"kind":"organization","name":"Epizyme, Inc.","symbol":"EPZM"},"owners":[{"id":173872,"kind":"person","name":"Singer Andrew E.","position":1,"cik":"0001632720","reported_name":"Singer Andrew E.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP & CFO"}}],"security":"Restricted Stock Units","published_at":"2017-03-10T14:45:04.000Z","date":"2017-03-09","kind":"exercise","acquired":false,"shares":777,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"This award, granted on February 9, 2015, pursuant to the Company's 2013 Stock Inventive Plan, vests as to 25% of the total award on February 9, 2016, with the remaining 75% vesting in 36 substantially equal monthly installments thereafter.  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The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":28931,"source":{"system":"sec-edgar","filing":"0001209191-16-145682","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1571498/000120919116145682/doc4.xml","form_type":"4"}},{"id":4580552,"issuer":{"id":12703,"kind":"organization","name":"Epizyme, Inc.","symbol":"EPZM"},"owners":[{"id":173872,"kind":"person","name":"Singer Andrew E.","position":1,"cik":"0001632720","reported_name":"Singer Andrew E.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP & CFO"}}],"security":"Common Stock, par value $0.0001","published_at":"2016-10-12T13:42:15.000Z","date":"2016-10-10","kind":"exercise","acquired":true,"shares":777,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each restricted stock unit represents the contingent right to receive one share of Epizyme, Inc. common stock upon vesting."}],"balance_after":29944,"source":{"system":"sec-edgar","filing":"0001209191-16-145682","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1571498/000120919116145682/doc4.xml","form_type":"4"}},{"id":4580551,"issuer":{"id":12703,"kind":"organization","name":"Epizyme, Inc.","symbol":"EPZM"},"owners":[{"id":173872,"kind":"person","name":"Singer Andrew E.","position":1,"cik":"0001632720","reported_name":"Singer Andrew E.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP & CFO"}}],"security":"Common Stock, par value $0.0001","published_at":"2016-10-12T13:42:15.000Z","date":"2016-10-10","kind":"exercise","acquired":true,"shares":1682,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each restricted stock unit represents the contingent right to receive one share of Epizyme, Inc. common stock upon vesting."}],"balance_after":29167,"source":{"system":"sec-edgar","filing":"0001209191-16-145682","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1571498/000120919116145682/doc4.xml","form_type":"4"}},{"id":4605593,"issuer":{"id":12703,"kind":"organization","name":"Epizyme, Inc.","symbol":"EPZM"},"owners":[{"id":173872,"kind":"person","name":"Singer Andrew E.","position":1,"cik":"0001632720","reported_name":"Singer Andrew E.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP & CFO"}}],"security":"Restricted Stock Units","published_at":"2016-09-12T20:18:28.000Z","date":"2016-09-09","kind":"exercise","acquired":false,"shares":777,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit represents the contingent right to receive one share of Epizyme, Inc. common stock upon vesting."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"This award, granted on February 9, 2015, pursuant to the Company's 2013 Stock Inventive Plan, vests as to 25% of the total award on February 9, 2016, with the remaining 75% vesting in 36 substantially equal monthly installments thereafter.  Vested shares will be delivered to the reporting person."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"This award, granted on February 9, 2015, pursuant to the Company's 2013 Stock Inventive Plan, vests as to 25% of the total award on February 9, 2016, with the remaining 75% vesting in 36 substantially equal monthly installments thereafter.  Vested shares will be delivered to the reporting person."}],"balance_after":22543,"derivative":{"underlying":"Common Stock","underlying_shares":777},"source":{"system":"sec-edgar","filing":"0001209191-16-140997","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1571498/000120919116140997/doc4.xml","form_type":"4"}},{"id":4605592,"issuer":{"id":12703,"kind":"organization","name":"Epizyme, Inc.","symbol":"EPZM"},"owners":[{"id":173872,"kind":"person","name":"Singer Andrew E.","position":1,"cik":"0001632720","reported_name":"Singer Andrew E.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP & CFO"}}],"security":"Restricted Stock Units","published_at":"2016-09-12T20:18:28.000Z","date":"2016-09-09","kind":"exercise","acquired":false,"shares":1682,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit represents the contingent right to receive one share of Epizyme, Inc. common stock upon vesting."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"This award, granted on February 9, 2016, pursuant to the Company's 2013 Stock Incentive plan, vests as to 25% of the total award on February 9, 2016, a year from the commencement of employment, with the remaining 75% vesting in 36 substantially equal monthly installments thereafter.  Vested shares will be delivered to the reporting person."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"This award, granted on February 9, 2016, pursuant to the Company's 2013 Stock Incentive plan, vests as to 25% of the total award on February 9, 2016, a year from the commencement of employment, with the remaining 75% vesting in 36 substantially equal monthly installments thereafter.  Vested shares will be delivered to the reporting person."}],"balance_after":48775,"derivative":{"underlying":"Common Stock","underlying_shares":1682},"source":{"system":"sec-edgar","filing":"0001209191-16-140997","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1571498/000120919116140997/doc4.xml","form_type":"4"}},{"id":4605591,"issuer":{"id":12703,"kind":"organization","name":"Epizyme, Inc.","symbol":"EPZM"},"owners":[{"id":173872,"kind":"person","name":"Singer Andrew E.","position":1,"cik":"0001632720","reported_name":"Singer Andrew E.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP & CFO"}}],"security":"Common Stock, par value $0.0001","published_at":"2016-09-12T20:18:28.000Z","date":"2016-09-09","kind":"sale","acquired":false,"shares":1013,"price":7.553,"value":7651.189,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person to cover taxes associated with the vesting of his restricted stock."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price.  These shares were sold in multiple transactions at prices ranging from $7.40 per share to $7.72 per share, inclusive.  The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":27485,"source":{"system":"sec-edgar","filing":"0001209191-16-140997","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1571498/000120919116140997/doc4.xml","form_type":"4"}},{"id":4605590,"issuer":{"id":12703,"kind":"organization","name":"Epizyme, Inc.","symbol":"EPZM"},"owners":[{"id":173872,"kind":"person","name":"Singer Andrew E.","position":1,"cik":"0001632720","reported_name":"Singer Andrew E.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP & CFO"}}],"security":"Common Stock, par value $0.0001","published_at":"2016-09-12T20:18:28.000Z","date":"2016-09-09","kind":"exercise","acquired":true,"shares":777,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each restricted stock unit represents the contingent right to receive one share of Epizyme, Inc. common stock upon vesting."}],"balance_after":28498,"source":{"system":"sec-edgar","filing":"0001209191-16-140997","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1571498/000120919116140997/doc4.xml","form_type":"4"}},{"id":4605589,"issuer":{"id":12703,"kind":"organization","name":"Epizyme, Inc.","symbol":"EPZM"},"owners":[{"id":173872,"kind":"person","name":"Singer Andrew E.","position":1,"cik":"0001632720","reported_name":"Singer Andrew E.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP & CFO"}}],"security":"Common Stock, par value $0.0001","published_at":"2016-09-12T20:18:28.000Z","date":"2016-09-09","kind":"exercise","acquired":true,"shares":1682,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each restricted stock unit represents the contingent right to receive one share of Epizyme, Inc. common stock upon vesting."}],"balance_after":27721,"source":{"system":"sec-edgar","filing":"0001209191-16-140997","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1571498/000120919116140997/doc4.xml","form_type":"4"}}]}