{"transactions":[{"id":4100657,"issuer":{"id":7964,"kind":"organization","name":"KALA BIO, Inc."},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":51517,"kind":"person","name":"OrbiMed Capital GP VI LLC","position":2,"cik":"0001682115","reported_name":"OrbiMed Capital GP VI LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-01-12T22:29:55.000Z","date":"2018-01-12","kind":"purchase","acquired":true,"shares":28446,"price":15.4,"value":438068.4,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These Shares were purchased in multiple transactions at prices ranging from $14.85 to $15.60 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Private Investments VI, LP (\"OPI VI\"). OrbiMed Capital GP VI LLC (\"GP VI\") is the sole general partner of OPI VI, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the sole managing member of GP VI. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP VI, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI VI noted above and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP VI, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purposes of Section 16 of the Exchange Act, or for any other purposes."}],"balance_after":2692715,"source":{"system":"sec-edgar","filing":"0000947871-18-000035","document":"ss75283_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000035/ss75283_4.xml","form_type":"4"}},{"id":4100656,"issuer":{"id":7964,"kind":"organization","name":"KALA BIO, Inc."},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":51517,"kind":"person","name":"OrbiMed Capital GP VI LLC","position":2,"cik":"0001682115","reported_name":"OrbiMed Capital GP VI LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-01-12T22:29:55.000Z","date":"2018-01-11","kind":"purchase","acquired":true,"shares":41700,"price":13.65,"value":569205.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were purchased in multiple transactions at prices ranging from $13.09 to $13.95 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Private Investments VI, LP (\"OPI VI\"). OrbiMed Capital GP VI LLC (\"GP VI\") is the sole general partner of OPI VI, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the sole managing member of GP VI. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP VI, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI VI noted above and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP VI, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purposes of Section 16 of the Exchange Act, or for any other purposes."}],"balance_after":2664269,"source":{"system":"sec-edgar","filing":"0000947871-18-000035","document":"ss75283_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000035/ss75283_4.xml","form_type":"4"}},{"id":4100655,"issuer":{"id":7964,"kind":"organization","name":"KALA BIO, Inc."},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":51517,"kind":"person","name":"OrbiMed Capital GP VI LLC","position":2,"cik":"0001682115","reported_name":"OrbiMed Capital GP VI LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-01-12T22:29:55.000Z","date":"2018-01-10","kind":"purchase","acquired":true,"shares":170338,"price":12.83,"value":2185436.54,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were purchased in multiple transactions at prices ranging from $12.30 to $13.15 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Private Investments VI, LP (\"OPI VI\"). OrbiMed Capital GP VI LLC (\"GP VI\") is the sole general partner of OPI VI, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the sole managing member of GP VI. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP VI, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI VI noted above and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP VI, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purposes of Section 16 of the Exchange Act, or for any other purposes."}],"balance_after":2622569,"source":{"system":"sec-edgar","filing":"0000947871-18-000035","document":"ss75283_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000035/ss75283_4.xml","form_type":"4"}},{"id":4108342,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-01-04T20:23:36.000Z","date":"2018-01-03","kind":"sale","acquired":false,"shares":16128,"price":7.35,"value":118540.8,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"These shares of the Issuer's common stock (\"Shares\") were sold in a block order at a price of $7.35."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":49270,"source":{"system":"sec-edgar","filing":"0000947871-18-000012","document":"ss74180_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000012/ss74180_4.xml","form_type":"4"}},{"id":4108341,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-01-04T20:23:36.000Z","date":"2018-01-03","kind":"sale","acquired":false,"shares":1693492,"price":7.35,"value":12447166.2,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"These shares of the Issuer's common stock (\"Shares\") were sold in a block order at a price of $7.35."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":5500730,"source":{"system":"sec-edgar","filing":"0000947871-18-000012","document":"ss74180_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000012/ss74180_4.xml","form_type":"4"}},{"id":4125291,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":47,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F13","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 5,018 shares of the Issuer's Common Stock and was vested and exercisable on July 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":5.64,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":47},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":54,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125290,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":4971,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F13","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 5,018 shares of the Issuer's Common Stock and was vested and exercisable on July 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":5.64,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":4971},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":53,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125289,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":99,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F12","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 10,546 shares of the Issuer's Common Stock and was vested and exercisable on April 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.32,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":99},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":52,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125288,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":10447,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F12","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 10,546 shares of the Issuer's Common Stock and was vested and exercisable on April 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.32,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":10447},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":51,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125287,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":97,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F11","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 10,313 shares of the Issuer's Common Stock and was vested and exercisable on January 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.01,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":97},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":50,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125286,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":10216,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F11","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 10,313 shares of the Issuer's Common Stock and was vested and exercisable on January 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.01,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":10216},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":49,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125285,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":142,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 20,000 shares of the Issuer's Common Stock and was scheduled to vest in four equal installments on each of March 31, 2017, June 30, 2017, September 30, 2017 and December 31, 2017 with 100% of the total shares vested and exercisable on December 31, 2017, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.01,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":142},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":48,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125284,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":14858,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 20,000 shares of the Issuer's Common Stock and was scheduled to vest in four equal installments on each of March 31, 2017, June 30, 2017, September 30, 2017 and December 31, 2017 with 100% of the total shares vested and exercisable on December 31, 2017, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.01,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":14858},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":47,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125283,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":97,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F9","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on October 25, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 10,279 shares of the Issuer's Common Stock and was vested and exercisable on October 25, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.64,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":97},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":46,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125282,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":10182,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F9","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on October 25, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 10,279 shares of the Issuer's Common Stock and was vested and exercisable on October 25, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.64,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":10182},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":45,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125281,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":92,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 25, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 9,734 shares of the Issuer's Common Stock and was vested and exercisable on July 25, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.73,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":92},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":44,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125280,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":9642,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 25, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 9,734 shares of the Issuer's Common Stock and was vested and exercisable on July 25, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.73,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":9642},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":43,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125279,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":77,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 27, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 8,174 shares of the Issuer's Common Stock and was vested and exercisable on April 27, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.05,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":77},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":42,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125278,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":8097,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 27, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 8,174 shares of the Issuer's Common Stock and was vested and exercisable on April 27, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.05,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":8097},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":41,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125277,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":189,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on February 16, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 20,000 shares of the Issuer's Common Stock and was scheduled to vest in four equal installments on each of March 31, 2016, June 30, 2016, September 30, 2016 and December 31, 2016 with 100% of the total shares vested and exercisable on December 31, 2016, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.59,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":189},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":40,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125276,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":19811,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on February 16, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 20,000 shares of the Issuer's Common Stock and was scheduled to vest in four equal installments on each of March 31, 2016, June 30, 2016, September 30, 2016 and December 31, 2016 with 100% of the total shares vested and exercisable on December 31, 2016, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.59,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":19811},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":39,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125275,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":97,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 15, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 10,277 shares of the Issuer's Common Stock and was vested and exercisable on January 15, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.62,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":97},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":38,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125274,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":10180,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 15, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 10,277 shares of the Issuer's Common Stock and was vested and exercisable on January 15, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.62,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":10180},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":37,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125273,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":83,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on October 15, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 8,800 shares of the Issuer's Common Stock and was vested and exercisable on October 15, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.94,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":83},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":36,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125272,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":8717,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on October 15, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 8,800 shares of the Issuer's Common Stock and was vested and exercisable on October 15, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.94,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":8717},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":35,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125271,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":63,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 15, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 6,717 shares of the Issuer's Common Stock and was vested and exercisable on July 15, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.62,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":63},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":34,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125270,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":6654,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 15, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 6,717 shares of the Issuer's Common Stock and was vested and exercisable on July 15, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.62,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":6654},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":33,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125269,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":50,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 30, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 5,277 shares of the Issuer's Common Stock and was vested and exercisable on April 30, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":3,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":50},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":32,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125268,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":5227,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 30, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 5,277 shares of the Issuer's Common Stock and was vested and exercisable on April 30, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":3,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":5227},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":31,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125267,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":259,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on December 17, 2014 for services as a director of the Issuer. The award included stock options relating to a total of 30,000 shares of the Issuer's Common Stock and was scheduled to vest quarterly over three years beginning March 31, 2015, with 100% of the total shares vested and exercisable on March 31, 2018, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":259},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":30,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125266,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":27241,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on December 17, 2014 for services as a director of the Issuer. The award included stock options relating to a total of 30,000 shares of the Issuer's Common Stock and was scheduled to vest quarterly over three years beginning March 31, 2015, with 100% of the total shares vested and exercisable on March 31, 2018, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":27241},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":29,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125265,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"sale","acquired":false,"shares":1392,"price":5.7,"value":7934.4,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":65398,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":28,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125264,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"sale","acquired":false,"shares":146243,"price":5.7,"value":833585.1,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7194222,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":27,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125263,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":47,"price":5.64,"value":265.08,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":66790,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":26,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125262,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":4971,"price":5.64,"value":28036.44,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7340465,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":25,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125261,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":99,"price":2.32,"value":229.68,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":66743,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":24,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125260,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":10447,"price":2.32,"value":24237.04,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7335494,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":23,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125259,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":97,"price":2.01,"value":194.97,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":66644,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":22,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125258,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":10216,"price":2.01,"value":20534.16,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7325047,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":21,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125257,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":142,"price":2.01,"value":285.42,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":66547,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":20,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125256,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":14858,"price":2.01,"value":29864.58,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7314831,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":19,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125255,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":97,"price":1.64,"value":159.08,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":66405,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":18,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125254,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":10182,"price":1.64,"value":16698.48,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7299973,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":17,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125253,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":92,"price":1.73,"value":159.16,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":66308,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":16,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125252,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":9642,"price":1.73,"value":16680.66,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7289791,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":15,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125251,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":77,"price":2.05,"value":157.85,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":66216,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":14,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125250,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":8097,"price":2.05,"value":16598.85,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7280149,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":13,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125249,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":189,"price":1.59,"value":300.51,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":66139,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125248,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":19811,"price":1.59,"value":31499.49,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7272052,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125247,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":97,"price":1.62,"value":157.14,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":65950,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125246,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":10180,"price":1.62,"value":16491.6,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7252241,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125245,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":83,"price":1.94,"value":161.02,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":65853,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125244,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":8717,"price":1.94,"value":16910.98,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7242061,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125243,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":63,"price":2.62,"value":165.06,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":65770,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125242,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":6654,"price":2.62,"value":17433.48,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7233344,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125241,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":50,"price":3,"value":150.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":65707,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125240,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":5227,"price":3,"value":15681.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7226690,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125239,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":259,"price":2,"value":518.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":65657,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125238,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":true,"shares":27241,"price":2,"value":54482.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7221463,"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4135090,"issuer":{"id":160155,"kind":"organization","name":"Loxo Oncology, Inc.","symbol":"LOXO"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":53130,"kind":"organization","name":"OrbiMed Capital GP V LLC","position":2,"cik":"0001615374","reported_name":"OrbiMed Capital GP V LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2017-12-12T19:02:23.000Z","date":"2017-12-08","kind":"sale","acquired":false,"shares":250000,"price":82.5,"value":20625000.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"These shares of the Issuer's common stock (\"Shares\") were sold in a block order at a price of $82.50."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These Shares are held of record by OrbiMed Private Investments V, LP (\"OPI V\").  OrbiMed Capital GP V LLC (\"GP V\") is the sole general partner of OPI V, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the sole managing member of GP V.  Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and holder of a controlling interest in, Advisors.  By virtue of such relationships, GP V, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI V noted above and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP V, Advisors and Isaly.  Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any.  The Reporting Persons have designated a representative, currently, David P. Bonita, an employee of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":941000,"source":{"system":"sec-edgar","filing":"0000947871-17-000998","document":"ss71524_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000998/ss71524_4.xml","form_type":"4"}},{"id":4151096,"issuer":{"id":160155,"kind":"organization","name":"Loxo Oncology, Inc.","symbol":"LOXO"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":53130,"kind":"organization","name":"OrbiMed Capital GP V LLC","position":2,"cik":"0001615374","reported_name":"OrbiMed Capital GP V LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2017-11-27T20:30:16.000Z","date":"2017-11-22","kind":"sale","acquired":false,"shares":267000,"price":75,"value":20025000.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"These shares of the Issuer's common stock (\"Shares\") were sold in a block order at a price of $75.00."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These Shares are held of record by OrbiMed Private Investments V, LP (\"OPI V\").  OrbiMed Capital GP V LLC (\"GP V\") is the sole general partner of OPI V, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the sole managing member of GP V.  Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and holder of a controlling interest in, Advisors.  By virtue of such relationships, GP V, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI V noted above and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP V, Advisors and Isaly.  Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any.  The Reporting Persons have designated a representative, currently, David P. Bonita, an employee of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":1191000,"source":{"system":"sec-edgar","filing":"0000947871-17-000969","document":"ss69206_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000969/ss69206_4.xml","form_type":"4"}},{"id":4154787,"issuer":{"id":74456,"kind":"organization","name":"scPharmaceuticals Inc.","symbol":"SCPH"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":51517,"kind":"person","name":"OrbiMed Capital GP VI LLC","position":2,"cik":"0001682115","reported_name":"OrbiMed Capital GP VI LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series B Preferred Stock","published_at":"2017-11-22T00:13:50.000Z","date":"2017-11-21","kind":"exercise","acquired":false,"shares":18500000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"All series of Convertible Preferred Stock automatically converted into the Issuer's Common Stock on a 7.180193-for-1 basis on November 21, 2017 and had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"All series of Convertible Preferred Stock automatically converted into the Issuer's Common Stock on a 7.180193-for-1 basis on November 21, 2017 and had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"All series of Convertible Preferred Stock automatically converted into the Issuer's Common Stock on a 7.180193-for-1 basis on November 21, 2017 and had no expiration date."},{"field":"derivative.underlying_shares","element":"underlyingSecurityShares","label":"F4","text":"All series of Convertible Preferred Stock automatically converted into the Issuer's Common Stock on a 7.180193-for-1 basis on November 21, 2017 and had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held of record by OPI VI.  OrbiMed Capital GP VI LLC (\"GP VI\") is the sole general partner of OPI VI, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP VI.  Samuel D. Isaly, a natural person, is a managing member of and owner of a controlling interest in Advisors.  By virtue of such relationships, GP VI, Advisors and Mr. Isaly may be deemed to have voting and investment power over the securities held by OPI VI and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP VI, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any.  This report shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purposes of Section 16 of the Exchange Act, or for any other purposes."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":2576532},"source":{"system":"sec-edgar","filing":"0000899243-17-027185","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027185/doc4.xml","form_type":"4"}},{"id":4154786,"issuer":{"id":74456,"kind":"organization","name":"scPharmaceuticals Inc.","symbol":"SCPH"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":51517,"kind":"person","name":"OrbiMed Capital GP VI LLC","position":2,"cik":"0001682115","reported_name":"OrbiMed Capital GP VI LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-11-22T00:13:50.000Z","date":"2017-11-21","kind":"purchase","acquired":true,"shares":833333,"price":14,"value":11666662.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held of record by OPI VI.  OrbiMed Capital GP VI LLC (\"GP VI\") is the sole general partner of OPI VI, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP VI.  Samuel D. Isaly, a natural person, is a managing member of and owner of a controlling interest in Advisors.  By virtue of such relationships, GP VI, Advisors and Mr. Isaly may be deemed to have voting and investment power over the securities held by OPI VI and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP VI, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any.  This report shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purposes of Section 16 of the Exchange Act, or for any other purposes."}],"balance_after":3409865,"source":{"system":"sec-edgar","filing":"0000899243-17-027185","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027185/doc4.xml","form_type":"4"}},{"id":4154785,"issuer":{"id":74456,"kind":"organization","name":"scPharmaceuticals Inc.","symbol":"SCPH"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":51517,"kind":"person","name":"OrbiMed Capital GP VI LLC","position":2,"cik":"0001682115","reported_name":"OrbiMed Capital GP VI LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-11-22T00:13:50.000Z","date":"2017-11-21","kind":"exercise","acquired":true,"shares":2576532,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the total number of shares of Common Stock received by OrbiMed Private Investments VI, L.P. (\"OPI VI\"),  upon conversion of the Issuer's Series B Preferred Stock in connection with the closing of the Issuer's initial public offering."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held of record by OPI VI.  OrbiMed Capital GP VI LLC (\"GP VI\") is the sole general partner of OPI VI, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP VI.  Samuel D. Isaly, a natural person, is a managing member of and owner of a controlling interest in Advisors.  By virtue of such relationships, GP VI, Advisors and Mr. Isaly may be deemed to have voting and investment power over the securities held by OPI VI and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP VI, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any.  This report shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purposes of Section 16 of the Exchange Act, or for any other purposes."}],"balance_after":2576532,"source":{"system":"sec-edgar","filing":"0000899243-17-027185","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027185/doc4.xml","form_type":"4"}},{"id":4156955,"issuer":{"id":160155,"kind":"organization","name":"Loxo Oncology, Inc.","symbol":"LOXO"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":53130,"kind":"organization","name":"OrbiMed Capital GP V LLC","position":2,"cik":"0001615374","reported_name":"OrbiMed Capital GP V LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2017-11-21T00:31:59.000Z","date":"2017-11-16","kind":"sale","acquired":false,"shares":8377,"price":76.23,"value":638578.71,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $76.00 to $76.69 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"These securities are held of record by OrbiMed Private Investments V, LP (\"OPI V\"). OrbiMed Capital GP V LLC (\"GP V\") is the sole general partner of OPI V, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the sole managing member of GP V. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP V, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI V noted above and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Each of the Reporting Persons, GP V, Advisors and Isaly disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently, David P. Bonita, an employee of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any such entity or person, including the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":1458000,"source":{"system":"sec-edgar","filing":"0000947871-17-000953","document":"ss68467_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000953/ss68467_4.xml","form_type":"4"}},{"id":4156954,"issuer":{"id":160155,"kind":"organization","name":"Loxo Oncology, Inc.","symbol":"LOXO"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":53130,"kind":"organization","name":"OrbiMed Capital GP V LLC","position":2,"cik":"0001615374","reported_name":"OrbiMed Capital GP V LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2017-11-21T00:31:59.000Z","date":"2017-11-16","kind":"sale","acquired":false,"shares":71598,"price":75.37,"value":5396341.26,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $75.00 to $75.95 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"These securities are held of record by OrbiMed Private Investments V, LP (\"OPI V\"). OrbiMed Capital GP V LLC (\"GP V\") is the sole general partner of OPI V, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the sole managing member of GP V. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP V, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI V noted above and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Each of the Reporting Persons, GP V, Advisors and Isaly disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently, David P. Bonita, an employee of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any such entity or person, including the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":1466377,"source":{"system":"sec-edgar","filing":"0000947871-17-000953","document":"ss68467_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000953/ss68467_4.xml","form_type":"4"}},{"id":4156953,"issuer":{"id":160155,"kind":"organization","name":"Loxo Oncology, Inc.","symbol":"LOXO"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":53130,"kind":"organization","name":"OrbiMed Capital GP V LLC","position":2,"cik":"0001615374","reported_name":"OrbiMed Capital GP V LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2017-11-21T00:31:59.000Z","date":"2017-11-16","kind":"sale","acquired":false,"shares":100045,"price":74.49,"value":7452352.05,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $74.00 to $74.99 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"These securities are held of record by OrbiMed Private Investments V, LP (\"OPI V\"). OrbiMed Capital GP V LLC (\"GP V\") is the sole general partner of OPI V, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the sole managing member of GP V. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP V, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI V noted above and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Each of the Reporting Persons, GP V, Advisors and Isaly disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently, David P. Bonita, an employee of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any such entity or person, including the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":1537975,"source":{"system":"sec-edgar","filing":"0000947871-17-000953","document":"ss68467_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000953/ss68467_4.xml","form_type":"4"}},{"id":4156952,"issuer":{"id":160155,"kind":"organization","name":"Loxo Oncology, Inc.","symbol":"LOXO"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":53130,"kind":"organization","name":"OrbiMed Capital GP V LLC","position":2,"cik":"0001615374","reported_name":"OrbiMed Capital GP V LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2017-11-21T00:31:59.000Z","date":"2017-11-16","kind":"sale","acquired":false,"shares":43300,"price":73.48,"value":3181684.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $73.00 to $73.97 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"These securities are held of record by OrbiMed Private Investments V, LP (\"OPI V\"). OrbiMed Capital GP V LLC (\"GP V\") is the sole general partner of OPI V, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the sole managing member of GP V. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP V, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI V noted above and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Each of the Reporting Persons, GP V, Advisors and Isaly disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently, David P. Bonita, an employee of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any such entity or person, including the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":1638020,"source":{"system":"sec-edgar","filing":"0000947871-17-000953","document":"ss68467_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000953/ss68467_4.xml","form_type":"4"}},{"id":4156951,"issuer":{"id":160155,"kind":"organization","name":"Loxo Oncology, Inc.","symbol":"LOXO"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":53130,"kind":"organization","name":"OrbiMed Capital GP V LLC","position":2,"cik":"0001615374","reported_name":"OrbiMed Capital GP V LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2017-11-21T00:31:59.000Z","date":"2017-11-16","kind":"sale","acquired":false,"shares":46680,"price":72.46,"value":3382432.8,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were purchased in multiple transactions at prices ranging from $72.00 to $72.99 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"These securities are held of record by OrbiMed Private Investments V, LP (\"OPI V\"). OrbiMed Capital GP V LLC (\"GP V\") is the sole general partner of OPI V, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the sole managing member of GP V. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP V, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI V noted above and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\")."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Each of the Reporting Persons, GP V, Advisors and Isaly disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently, David P. Bonita, an employee of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any such entity or person, including the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":1681320,"source":{"system":"sec-edgar","filing":"0000947871-17-000953","document":"ss68467_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000953/ss68467_4.xml","form_type":"4"}},{"id":4156950,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series D Convertible Preferred Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":false,"shares":2232014,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"The Series D Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series D Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The Series D Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series D Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The Series D Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series D Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":653974},"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4156949,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series C Convertible Preferred Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":false,"shares":229412,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"The Series C Convertible Preferred Stock converted into Common Stock on a 0.49832-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series C Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"The Series C Convertible Preferred Stock converted into Common Stock on a 0.49832-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series C Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"The Series C Convertible Preferred Stock converted into Common Stock on a 0.49832-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series C Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":114320},"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4156948,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series B Convertible Preferred Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":false,"shares":736648,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F3","text":"The Series B Convertible Preferred Stock converted into Common Stock on a 0.44650-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series B Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The Series B Convertible Preferred Stock converted into Common Stock on a 0.44650-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series B Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"The Series B Convertible Preferred Stock converted into Common Stock on a 0.44650-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series B Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":328909},"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4156947,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series A-2 Convertible Preferred Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":false,"shares":704846,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"The Series A-2 Convertible Preferred Stock converted into Common Stock on a 0.35785-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-2 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The Series A-2 Convertible Preferred Stock converted into Common Stock on a 0.35785-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-2 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The Series A-2 Convertible Preferred Stock converted into Common Stock on a 0.35785-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-2 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":252230},"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4156946,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series A-1 Convertible Preferred Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":false,"shares":66667,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The Series A-1 Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-1 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The Series A-1 Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-1 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The Series A-1 Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-1 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":19533},"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4156945,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":true,"shares":500000,"price":10,"value":5000000.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":1868966,"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4156944,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":true,"shares":653974,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The Series D Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series D Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":1368966,"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4156943,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":true,"shares":114320,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The Series C Convertible Preferred Stock converted into Common Stock on a 0.49832-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series C Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":714992,"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4156942,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":true,"shares":328909,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The Series B Convertible Preferred Stock converted into Common Stock on a 0.44650-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series B Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":600672,"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4156941,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":true,"shares":252230,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The Series A-2 Convertible Preferred Stock converted into Common Stock on a 0.35785-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-2 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":271763,"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4156940,"issuer":{"id":5638,"kind":"organization","name":"X4 Pharmaceuticals, Inc","symbol":"XFOR"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-11-20T22:32:37.000Z","date":"2017-11-20","kind":"exercise","acquired":true,"shares":19533,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The Series A-1 Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-1 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"The reported securities are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI IV. The Reporting Persons have designated a representative, currently Carl Gordon, a member of Advisors, to serve on the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"This report on Form 4 is jointly filed by GP IV, Advisors and Isaly. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the reporting persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":19533,"source":{"system":"sec-edgar","filing":"0000899243-17-027003","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000089924317027003/doc4.xml","form_type":"4"}},{"id":4189314,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":53130,"kind":"organization","name":"OrbiMed Capital GP V LLC","position":2,"cik":"0001615374","reported_name":"OrbiMed Capital GP V LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series A Convertible Preferred Stock","published_at":"2017-10-10T20:21:41.000Z","date":"2017-10-10","kind":"exercise","acquired":false,"shares":2546295,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"In connection with the closing of the Issuer's initial public offering, each share of the Issuer's series A convertible preferred stock (the \"Series A Preferred\") converted into the Issuer's common stock on a 9.17-for-one basis without payment or consideration.  The Series A Preferred had no expiration date."},{"field":"shares","element":"transactionShares","label":"F4","text":"Reflects the number of shares of Series A Preferred held by the Reporting Person on an as-converted to common stock basis."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"In connection with the closing of the Issuer's initial public offering, each share of the Issuer's series A convertible preferred stock (the \"Series A Preferred\") converted into the Issuer's common stock on a 9.17-for-one basis without payment or consideration.  The Series A Preferred had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"In connection with the closing of the Issuer's initial public offering, each share of the Issuer's series A convertible preferred stock (the \"Series A Preferred\") converted into the Issuer's common stock on a 9.17-for-one basis without payment or consideration.  The Series A Preferred had no expiration date."},{"field":"derivative.underlying_shares","element":"underlyingSecurityShares","label":"F4","text":"Reflects the number of shares of Series A Preferred held by the Reporting Person on an as-converted to common stock basis."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The reportable securities are held of record by OrbiMed Private Investments V, LP (\"OPI V\"). OrbiMed Capital GP V LLC (\"GP V\") is the sole general partner of OPI V and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP V. Samuel D. Isaly (\"Isaly\") a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP V, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI V and as a result, may be deemed to have beneficial ownership over such shares."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP V, Advisors and Isaly. Each of OPI V, GP V, Advisors and Isaly disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any such entity or person is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":2546295},"source":{"system":"sec-edgar","filing":"0001104659-17-061573","document":"a4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000110465917061573/a4.xml","form_type":"4"}},{"id":4189313,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":53130,"kind":"organization","name":"OrbiMed Capital GP V LLC","position":2,"cik":"0001615374","reported_name":"OrbiMed Capital GP V LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-10-10T20:21:41.000Z","date":"2017-10-10","kind":"purchase","acquired":true,"shares":355000,"price":17,"value":6035000.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The reportable securities are held of record by OrbiMed Private Investments V, LP (\"OPI V\"). OrbiMed Capital GP V LLC (\"GP V\") is the sole general partner of OPI V and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP V. Samuel D. Isaly (\"Isaly\") a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP V, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI V and as a result, may be deemed to have beneficial ownership over such shares."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP V, Advisors and Isaly. Each of OPI V, GP V, Advisors and Isaly disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any such entity or person is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":2901295,"source":{"system":"sec-edgar","filing":"0001104659-17-061573","document":"a4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000110465917061573/a4.xml","form_type":"4"}},{"id":4189312,"issuer":{"id":3693,"kind":"organization","name":"RHYTHM PHARMACEUTICALS, INC.","symbol":"RYTM"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":53130,"kind":"organization","name":"OrbiMed Capital GP V LLC","position":2,"cik":"0001615374","reported_name":"OrbiMed Capital GP V LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-10-10T20:21:41.000Z","date":"2017-10-10","kind":"exercise","acquired":true,"shares":2546295,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"In connection with the closing of the Issuer's initial public offering, each share of the Issuer's series A convertible preferred stock (the \"Series A Preferred\") converted into the Issuer's common stock on a 9.17-for-one basis without payment or consideration.  The Series A Preferred had no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The reportable securities are held of record by OrbiMed Private Investments V, LP (\"OPI V\"). OrbiMed Capital GP V LLC (\"GP V\") is the sole general partner of OPI V and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP V. Samuel D. Isaly (\"Isaly\") a natural person, is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationships, GP V, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by OPI V and as a result, may be deemed to have beneficial ownership over such shares."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP V, Advisors and Isaly. Each of OPI V, GP V, Advisors and Isaly disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any such entity or person is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":2546295,"source":{"system":"sec-edgar","filing":"0001104659-17-061573","document":"a4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000110465917061573/a4.xml","form_type":"4"}},{"id":4191263,"issuer":{"id":172682,"kind":"organization","name":"Roka BioScience, Inc.","symbol":"ROKA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2017-10-05T19:52:21.000Z","date":"2017-10-03","kind":"sale","acquired":false,"shares":1899,"price":0.68,"value":1291.32,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price.  These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $0.66 to $0.71 inclusive.  Upon request, the Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\") and may be deemed to be indirectly beneficially owned by Advisors and Isaly. Advisors is the sole general partner of Associates III. Isaly is the managing member of, and holder of a controlling interest in, Advisors.  By virtue of such relationship, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by Associates III noted above. As a result, each of Advisors and Isaly may be deemed to have beneficial ownership of the securities held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0000947871-17-000785","document":"ss62015_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000785/ss62015_4.xml","form_type":"4"}},{"id":4191262,"issuer":{"id":172682,"kind":"organization","name":"Roka BioScience, Inc.","symbol":"ROKA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2017-10-05T19:52:21.000Z","date":"2017-10-03","kind":"sale","acquired":false,"shares":199718,"price":0.68,"value":135808.24,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price.  These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $0.66 to $0.71 inclusive.  Upon request, the Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\") and may be deemed to be indirectly beneficially owned by OrbiMed Capital GP III LLC (\"GP III\"), OrbiMed Advisors LLC (\"Advisors\") and Samuel D. Isaly (\"Isaly\"). GP III is the sole general partner of OPI III. Advisors, a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power with respect to the securities held by OPI III noted above."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Isaly, a natural person, may also be deemed to have voting and investment power with respect to the securities held by OPI III noted above in his capacity as the managing member of, and holder of a controlling interest, in Advisors. As a result, each of GP III, Advisors and Isaly may be deemed to have beneficial ownership of the securities held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0000947871-17-000785","document":"ss62015_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000785/ss62015_4.xml","form_type":"4"}},{"id":4198070,"issuer":{"id":172682,"kind":"organization","name":"Roka BioScience, Inc.","symbol":"ROKA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2017-10-02T20:07:14.000Z","date":"2017-09-29","kind":"sale","acquired":false,"shares":888,"price":0.74,"value":657.12,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price.  These Shares were sold in multiple transactions at prices ranging from $0.70 to $0.82 inclusive.  Upon request, the Reporting Person undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\") and may be deemed to be indirectly beneficially owned by Advisors and Isaly. Advisors is the sole general partner of Associates III. Isaly is the managing member of, and holder of a controlling interest in, Advisors.  By virtue of such relationship, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by Associates III noted above. As a result, each of Advisors and Isaly may be deemed to have beneficial ownership of the securities held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":1899,"source":{"system":"sec-edgar","filing":"0000947871-17-000771","document":"ss61467_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000771/ss61467_4.xml","form_type":"4"}},{"id":4198069,"issuer":{"id":172682,"kind":"organization","name":"Roka BioScience, Inc.","symbol":"ROKA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2017-10-02T20:07:14.000Z","date":"2017-09-29","kind":"sale","acquired":false,"shares":93246,"price":0.74,"value":69002.04,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price.  These Shares were sold in multiple transactions at prices ranging from $0.70 to $0.82 inclusive.  Upon request, the Reporting Person undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\") and may be deemed to be indirectly beneficially owned by OrbiMed Capital GP III LLC (\"GP III\"), OrbiMed Advisors LLC (\"Advisors\") and Samuel D. Isaly (\"Isaly\"). GP III is the sole general partner of OPI III. Advisors, a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power with respect to the securities held by OPI III noted above."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Isaly, a natural person, may also be deemed to have voting and investment power with respect to the securities held by OPI III noted above in his capacity as the managing member of, and holder of a controlling interest, in Advisors. As a result, each of GP III, Advisors and Isaly may be deemed to have beneficial ownership of the securities held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":199718,"source":{"system":"sec-edgar","filing":"0000947871-17-000771","document":"ss61467_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000771/ss61467_4.xml","form_type":"4"}},{"id":4198068,"issuer":{"id":172682,"kind":"organization","name":"Roka BioScience, Inc.","symbol":"ROKA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2017-10-02T20:07:14.000Z","date":"2017-09-28","kind":"sale","acquired":false,"shares":3592,"price":0.72,"value":2586.24,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price.  These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $0.67 to $0.86 inclusive.  Upon request, the Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\") and may be deemed to be indirectly beneficially owned by Advisors and Isaly. Advisors is the sole general partner of Associates III. Isaly is the managing member of, and holder of a controlling interest in, Advisors.  By virtue of such relationship, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by Associates III noted above. As a result, each of Advisors and Isaly may be deemed to have beneficial ownership of the securities held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":2787,"source":{"system":"sec-edgar","filing":"0000947871-17-000771","document":"ss61467_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000771/ss61467_4.xml","form_type":"4"}},{"id":4198067,"issuer":{"id":172682,"kind":"organization","name":"Roka BioScience, Inc.","symbol":"ROKA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2017-10-02T20:07:14.000Z","date":"2017-09-28","kind":"sale","acquired":false,"shares":376950,"price":0.72,"value":271404.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price.  These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $0.67 to $0.86 inclusive.  Upon request, the Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\") and may be deemed to be indirectly beneficially owned by OrbiMed Capital GP III LLC (\"GP III\"), OrbiMed Advisors LLC (\"Advisors\") and Samuel D. Isaly (\"Isaly\"). GP III is the sole general partner of OPI III. Advisors, a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power with respect to the securities held by OPI III noted above."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Isaly, a natural person, may also be deemed to have voting and investment power with respect to the securities held by OPI III noted above in his capacity as the managing member of, and holder of a controlling interest, in Advisors. As a result, each of GP III, Advisors and Isaly may be deemed to have beneficial ownership of the securities held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":292964,"source":{"system":"sec-edgar","filing":"0000947871-17-000771","document":"ss61467_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000771/ss61467_4.xml","form_type":"4"}},{"id":4199305,"issuer":{"id":122788,"kind":"organization","name":"Audentes Therapeutics, Inc."},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-09-29T22:06:57.000Z","date":"2017-09-29","kind":"sale","acquired":false,"shares":672000,"price":28.25,"value":18984000.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"These shares of the Issuer's common stock (\"Shares\") were sold in a block order at a price of $28.25."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These Shares are held of record by OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the general partner of OPI IV and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP IV. Samuel D. Isaly (\"Isaly\") is the managing member of, and owner of a controlling interest in, Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power with respect to the Shares held by OPI IV and as a result may be deemed to have beneficial ownership over such Shares."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is being jointly filed by GP IV, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":4129638,"source":{"system":"sec-edgar","filing":"0000947871-17-000769","document":"ss61044_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000769/ss61044_4.xml","form_type":"4"}},{"id":4200247,"issuer":{"id":172682,"kind":"organization","name":"Roka BioScience, Inc.","symbol":"ROKA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2017-09-28T21:31:21.000Z","date":"2017-09-27","kind":"sale","acquired":false,"shares":498,"price":0.92,"value":458.16,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $0.88 to $0.97 inclusive. Upon request, the Reporting Person undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\") and may be deemed to be indirectly beneficially owned by Advisors and Isaly. Advisors is the sole general partner of Associates III. Isaly is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationship, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by Associates III noted above. As a result, each of Advisors and Isaly may be deemed to have beneficial ownership of the securities held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":6379,"source":{"system":"sec-edgar","filing":"0000947871-17-000762","document":"ss60866_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000762/ss60866_4.xml","form_type":"4"}},{"id":4200246,"issuer":{"id":172682,"kind":"organization","name":"Roka BioScience, Inc.","symbol":"ROKA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2017-09-28T21:31:21.000Z","date":"2017-09-27","kind":"sale","acquired":false,"shares":52301,"price":0.92,"value":48116.92,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $0.88 to $0.97 inclusive. Upon request, the Reporting Person undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\") and may be deemed to be indirectly beneficially owned by OrbiMed Capital GP III LLC (\"GP III\"), OrbiMed Advisors LLC (\"Advisors\") and Samuel D. Isaly (\"Isaly\"). GP III is the sole general partner of OPI III. Advisors, a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power with respect to the securities held by OPI III noted above."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Isaly, a natural person, may also be deemed to have voting and investment power with respect to the securities held by OPI III noted above in his capacity as the managing member of, and holder of a controlling interest, in Advisors. As a result, each of GP III, Advisors and Isaly may be deemed to have beneficial ownership of the securities held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":669914,"source":{"system":"sec-edgar","filing":"0000947871-17-000762","document":"ss60866_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000762/ss60866_4.xml","form_type":"4"}},{"id":4200245,"issuer":{"id":172682,"kind":"organization","name":"Roka BioScience, Inc.","symbol":"ROKA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2017-09-28T21:31:21.000Z","date":"2017-09-26","kind":"sale","acquired":false,"shares":706,"price":1.03,"value":727.18,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $0.92 to $1.13 inclusive. Upon request, the Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\") and may be deemed to be indirectly beneficially owned by Advisors and Isaly. Advisors is the sole general partner of Associates III. Isaly is the managing member of, and holder of a controlling interest in, Advisors. By virtue of such relationship, Advisors and Isaly may be deemed to have voting and investment power with respect to the securities held by Associates III noted above. As a result, each of Advisors and Isaly may be deemed to have beneficial ownership of the securities held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":6877,"source":{"system":"sec-edgar","filing":"0000947871-17-000762","document":"ss60866_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000762/ss60866_4.xml","form_type":"4"}},{"id":4200244,"issuer":{"id":172682,"kind":"organization","name":"Roka BioScience, Inc.","symbol":"ROKA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2017-09-28T21:31:21.000Z","date":"2017-09-26","kind":"sale","acquired":false,"shares":74096,"price":1.03,"value":76318.88,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $0.92 to $1.13 inclusive. Upon request, the Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\") and may be deemed to be indirectly beneficially owned by OrbiMed Capital GP III LLC (\"GP III\"), OrbiMed Advisors LLC (\"Advisors\") and Samuel D. Isaly (\"Isaly\"). GP III is the sole general partner of OPI III. Advisors, a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power with respect to the securities held by OPI III noted above."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Isaly, a natural person, may also be deemed to have voting and investment power with respect to the securities held by OPI III noted above in his capacity as the managing member of, and holder of a controlling interest, in Advisors. As a result, each of GP III, Advisors and Isaly may be deemed to have beneficial ownership of the securities held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III, Advisors and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Persons are beneficial owners for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":722215,"source":{"system":"sec-edgar","filing":"0000947871-17-000762","document":"ss60866_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000762/ss60866_4.xml","form_type":"4"}},{"id":4212926,"issuer":{"id":122788,"kind":"organization","name":"Audentes Therapeutics, Inc."},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-09-11T18:16:57.000Z","date":"2017-09-07","kind":"other","acquired":false,"shares":5000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock options were included in an award to Jonathan Silverstein, an employee of the Reporting Persons, made on August 24, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 18,000 shares of the Issuer's Common Stock and was scheduled to vest as to 2.777% of the total shares monthly, beginning September 24, 2016, with 100% of the total shares vested and exercisable on August 24, 2019, subject to the director's provision of service to the issuer on each vesting date. Mr. Silverstein is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The options whose exercise is reported on herein were held for the benefit of OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI IV and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP IV, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":15.03,"expiration_date":"2017-10-12","underlying":"Common Stock","underlying_shares":5000},"source":{"system":"sec-edgar","filing":"0000947871-17-000705","document":"ss58345_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000705/ss58345_4.xml","form_type":"4"}},{"id":4212925,"issuer":{"id":122788,"kind":"organization","name":"Audentes Therapeutics, Inc."},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-09-11T18:16:57.000Z","date":"2017-09-07","kind":"sale","acquired":false,"shares":5000,"price":22.35,"value":111750.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The options whose exercise is reported on herein were held for the benefit of OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI IV and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP IV, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":4801638,"source":{"system":"sec-edgar","filing":"0000947871-17-000705","document":"ss58345_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000705/ss58345_4.xml","form_type":"4"}},{"id":4212924,"issuer":{"id":122788,"kind":"organization","name":"Audentes Therapeutics, Inc."},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":89303,"kind":"organization","name":"OrbiMed Capital GP IV LLC","position":2,"cik":"0001502240","reported_name":"OrbiMed Capital GP IV LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-09-11T18:16:57.000Z","date":"2017-09-07","kind":"other","acquired":true,"shares":5000,"price":15.03,"value":75150.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The options whose exercise is reported on herein were held for the benefit of OrbiMed Private Investments IV, LP (\"OPI IV\"). OrbiMed Capital GP IV LLC (\"GP IV\") is the sole general partner of OPI IV, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP IV. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP IV, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI IV and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This report on Form 4 is jointly filed by GP IV, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":4806638,"source":{"system":"sec-edgar","filing":"0000947871-17-000705","document":"ss58345_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000705/ss58345_4.xml","form_type":"4"}},{"id":4218254,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2017-09-06T01:27:56.000Z","date":"2017-09-05","kind":"sale","acquired":false,"shares":553,"price":40.77,"value":22545.81,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price.  These Shares were sold in multiple transactions at prices ranging from $40.33 to $41.22 inclusive.  Upon request, the Reporting Person undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7895,"source":{"system":"sec-edgar","filing":"0000947871-17-000698","document":"ss57834_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000698/ss57834_4.xml","form_type":"4"}},{"id":4218253,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2017-09-06T01:27:56.000Z","date":"2017-09-05","kind":"sale","acquired":false,"shares":58047,"price":40.77,"value":2366576.19,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price.  These Shares were sold in multiple transactions at prices ranging from $40.33 to $41.22 inclusive.  Upon request, the Reporting Person undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":828605,"source":{"system":"sec-edgar","filing":"0000947871-17-000698","document":"ss57834_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000698/ss57834_4.xml","form_type":"4"}},{"id":4218252,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2017-09-06T01:27:56.000Z","date":"2017-09-05","kind":"sale","acquired":false,"shares":1808,"price":39.63,"value":71651.04,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price.  These Shares were sold in multiple transactions at prices ranging from $39.33 to $40.30 inclusive.  Upon request, the Reporting Person undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":8448,"source":{"system":"sec-edgar","filing":"0000947871-17-000698","document":"ss57834_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117000698/ss57834_4.xml","form_type":"4"}}],"next_cursor":"2017-09-06T01:27:56.000000Z,4218252"}