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The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. Each Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his or her pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Following the reported transaction, 168,754 shares of the reportable securities are owned directly by Hatteras NC."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Following the reported transaction, in which none of the reportable securities owned directly by HVP IV were sold, 3,067,962 shares of the reportable securities are owned directly by HVP IV."}],"balance_after":3237711,"source":{"system":"sec-edgar","filing":"0001209191-18-034839","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1674107/000120919118034839/doc4.xml","form_type":"4"}},{"id":3910877,"issuer":{"id":87413,"kind":"organization","name":"G1 Therapeutics, Inc.","symbol":"GTHX"},"owners":[{"id":82876,"kind":"person","name":"Thorp Clay","position":1,"cik":"0001592380","reported_name":"Thorp Clay","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166141,"kind":"organization","name":"Hatteras Venture Advisors IV SBIC, LLC","position":2,"cik":"0001675236","reported_name":"Hatteras Venture Advisors IV SBIC, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166142,"kind":"organization","name":"Hatteras Venture Partners IV SBIC, LP","position":3,"cik":"0001675232","reported_name":"Hatteras Venture Partners IV SBIC, LP","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":16884,"kind":"person","name":"INGRAM ROBERT ALEXANDER","position":4,"cik":"0001219890","reported_name":"INGRAM ROBERT ALEXANDER","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162814,"kind":"person","name":"Crumpler John","position":5,"cik":"0001674107","reported_name":"Crumpler John","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":112297,"kind":"person","name":"LEE KENNETH B JR","position":6,"cik":"0001208570","reported_name":"LEE KENNETH B JR","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162813,"kind":"person","name":"Reed Douglas MD","position":7,"cik":"0001291262","reported_name":"Reed Douglas MD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-06-01T18:22:00.000Z","date":"2018-05-30","kind":"sale","acquired":false,"shares":758290,"price":48,"value":36397920.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Following the reported transaction, in which none of the reportable securities owned directly by Hatteras Venture Advisors V, LLC (\"HVA V\") were sold, 995 shares of the reportable securities are owned directly by HVA V. The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. Each Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his or her pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Following the reported transaction, 3,067,962 shares of the reportable securities are owned directly by Hatteras Venture Partners IV SBIC, LP (\"HVP IV\"). Hatteras Venture Advisors IV SBIC, LLC (\"HVA IV SBIC\") is the general partner of HVP IV. The securities directly held by HVP IV are indirectly held by the individual managing members of HVA IV SBIC (each, a \"GP Managing Member\" and collectively, the \"GP Managing Members\"). The GP Managing Members are John Crumpler, Clay Thorp, Ken Lee, Douglas Reed and Robert Ingram. The GP Managing Members may share voting and dispositive power over the securities directly held by HVP IV. Each GP Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any GP Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Following the reported transaction, in which none of the reportable securities owned directly by Hatteras NC Fund, LP (\"Hatteras NC\") were sold, 210,464 shares of the reportable securities are owned directly by Hatteras NC. Hatteras Venture Advisors IV, LLC (\"HVA IV\") is the general partner of Hatteras NC. The securities directly held by Hatteras NC are indirectly held by the individual managing members of HVA IV (each, a \"HVA IV Managing Member\"). The HVA IV Managing Members are John Crumpler, Clay Thorp, Ken Lee, Douglas Reed and Robert Ingram. The HVA IV Managing Members may share voting and dispositive power over the securities directly held by HVP IV. Each HVA IV Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any HVA IV Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his or her pecuniary interest therein."}],"balance_after":3279421,"source":{"system":"sec-edgar","filing":"0001209191-18-034839","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1674107/000120919118034839/doc4.xml","form_type":"4"}},{"id":3920693,"issuer":{"id":87413,"kind":"organization","name":"G1 Therapeutics, Inc.","symbol":"GTHX"},"owners":[{"id":82876,"kind":"person","name":"Thorp Clay","position":1,"cik":"0001592380","reported_name":"Thorp Clay","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166141,"kind":"organization","name":"Hatteras Venture Advisors IV SBIC, LLC","position":2,"cik":"0001675236","reported_name":"Hatteras Venture Advisors IV SBIC, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166142,"kind":"organization","name":"Hatteras Venture Partners IV SBIC, LP","position":3,"cik":"0001675232","reported_name":"Hatteras Venture Partners IV SBIC, LP","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":16884,"kind":"person","name":"INGRAM ROBERT ALEXANDER","position":4,"cik":"0001219890","reported_name":"INGRAM ROBERT ALEXANDER","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162814,"kind":"person","name":"Crumpler John","position":5,"cik":"0001674107","reported_name":"Crumpler John","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":112297,"kind":"person","name":"LEE KENNETH B JR","position":6,"cik":"0001208570","reported_name":"LEE KENNETH B JR","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162813,"kind":"person","name":"Reed Douglas MD","position":7,"cik":"0001291262","reported_name":"Reed Douglas MD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-05-23T20:46:07.000Z","date":"2018-05-23","kind":"sale","acquired":false,"shares":26,"price":50.5,"value":1313.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"995 shares of the reportable securities are owned directly by Hatteras Venture Advisors V, LLC (\"HVA V\"). The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. Each Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his or her pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F12","text":"Following the reported transaction, 3,826,252 shares of the reportable securities are owned directly by HVP IV."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F13","text":"Following the reported transaction, 210,464 shares of the reportable securities are owned directly by Hatteras NC."}],"balance_after":4037711,"source":{"system":"sec-edgar","filing":"0001209191-18-032789","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1674107/000120919118032789/doc4.xml","form_type":"4"}},{"id":3920692,"issuer":{"id":87413,"kind":"organization","name":"G1 Therapeutics, Inc.","symbol":"GTHX"},"owners":[{"id":82876,"kind":"person","name":"Thorp Clay","position":1,"cik":"0001592380","reported_name":"Thorp Clay","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166141,"kind":"organization","name":"Hatteras Venture Advisors IV SBIC, LLC","position":2,"cik":"0001675236","reported_name":"Hatteras Venture Advisors IV SBIC, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166142,"kind":"organization","name":"Hatteras Venture Partners IV SBIC, LP","position":3,"cik":"0001675232","reported_name":"Hatteras Venture Partners IV SBIC, LP","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":16884,"kind":"person","name":"INGRAM ROBERT ALEXANDER","position":4,"cik":"0001219890","reported_name":"INGRAM ROBERT ALEXANDER","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162814,"kind":"person","name":"Crumpler John","position":5,"cik":"0001674107","reported_name":"Crumpler John","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":112297,"kind":"person","name":"LEE KENNETH B JR","position":6,"cik":"0001208570","reported_name":"LEE KENNETH B JR","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162813,"kind":"person","name":"Reed Douglas MD","position":7,"cik":"0001291262","reported_name":"Reed Douglas MD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-05-23T20:46:07.000Z","date":"2018-05-23","kind":"sale","acquired":false,"shares":474,"price":50.5,"value":23937.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"995 shares of the reportable securities are owned directly by Hatteras Venture Advisors V, LLC (\"HVA V\"). The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. Each Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his or her pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"Following the reported transaction, 210,490 shares of the reportable securities are owned directly by Hatteras NC."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F12","text":"Following the reported transaction, 3,826,252 shares of the reportable securities are owned directly by HVP IV."}],"balance_after":4037737,"source":{"system":"sec-edgar","filing":"0001209191-18-032789","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1674107/000120919118032789/doc4.xml","form_type":"4"}},{"id":3920691,"issuer":{"id":87413,"kind":"organization","name":"G1 Therapeutics, Inc.","symbol":"GTHX"},"owners":[{"id":82876,"kind":"person","name":"Thorp Clay","position":1,"cik":"0001592380","reported_name":"Thorp Clay","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166141,"kind":"organization","name":"Hatteras Venture Advisors IV SBIC, LLC","position":2,"cik":"0001675236","reported_name":"Hatteras Venture Advisors IV SBIC, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166142,"kind":"organization","name":"Hatteras Venture Partners IV SBIC, LP","position":3,"cik":"0001675232","reported_name":"Hatteras Venture Partners IV SBIC, LP","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":16884,"kind":"person","name":"INGRAM ROBERT ALEXANDER","position":4,"cik":"0001219890","reported_name":"INGRAM ROBERT ALEXANDER","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162814,"kind":"person","name":"Crumpler John","position":5,"cik":"0001674107","reported_name":"Crumpler John","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":112297,"kind":"person","name":"LEE KENNETH B JR","position":6,"cik":"0001208570","reported_name":"LEE KENNETH B JR","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162813,"kind":"person","name":"Reed Douglas MD","position":7,"cik":"0001291262","reported_name":"Reed Douglas MD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-05-23T20:46:07.000Z","date":"2018-05-22","kind":"sale","acquired":false,"shares":308,"price":50.6851,"value":15611.0108,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The price represents the weighted average price with a low of $50.50 and a high of $51.25."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"995 shares of the reportable securities are owned directly by Hatteras Venture Advisors V, LLC (\"HVA V\"). The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. Each Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his or her pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Following the reported transaction, 3,826,726 shares of the reportable securities are owned directly by HVP IV."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"Following the reported transaction, 210,490 shares of the reportable securities are owned directly by Hatteras NC."}],"balance_after":4038211,"source":{"system":"sec-edgar","filing":"0001209191-18-032789","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1674107/000120919118032789/doc4.xml","form_type":"4"}},{"id":3920690,"issuer":{"id":87413,"kind":"organization","name":"G1 Therapeutics, Inc.","symbol":"GTHX"},"owners":[{"id":82876,"kind":"person","name":"Thorp Clay","position":1,"cik":"0001592380","reported_name":"Thorp Clay","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166141,"kind":"organization","name":"Hatteras Venture Advisors IV SBIC, LLC","position":2,"cik":"0001675236","reported_name":"Hatteras Venture Advisors IV SBIC, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166142,"kind":"organization","name":"Hatteras Venture Partners IV SBIC, LP","position":3,"cik":"0001675232","reported_name":"Hatteras Venture Partners IV SBIC, LP","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":16884,"kind":"person","name":"INGRAM ROBERT ALEXANDER","position":4,"cik":"0001219890","reported_name":"INGRAM ROBERT ALEXANDER","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162814,"kind":"person","name":"Crumpler John","position":5,"cik":"0001674107","reported_name":"Crumpler John","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":112297,"kind":"person","name":"LEE KENNETH B JR","position":6,"cik":"0001208570","reported_name":"LEE KENNETH B JR","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162813,"kind":"person","name":"Reed Douglas MD","position":7,"cik":"0001291262","reported_name":"Reed Douglas MD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-05-23T20:46:07.000Z","date":"2018-05-22","kind":"sale","acquired":false,"shares":5592,"price":50.8593,"value":284405.2056,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The price represents the weighted average price with a low of $50.50 and a high of $51.25."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"995 shares of the reportable securities are owned directly by Hatteras Venture Advisors V, LLC (\"HVA V\"). The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. Each Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his or her pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Following the reported transaction, 210,798 shares of the reportable securities are owned directly by Hatteras NC."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Following the reported transaction, 3,826,726 shares of the reportable securities are owned directly by HVP IV."}],"balance_after":4038519,"source":{"system":"sec-edgar","filing":"0001209191-18-032789","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1674107/000120919118032789/doc4.xml","form_type":"4"}},{"id":3920689,"issuer":{"id":87413,"kind":"organization","name":"G1 Therapeutics, Inc.","symbol":"GTHX"},"owners":[{"id":82876,"kind":"person","name":"Thorp Clay","position":1,"cik":"0001592380","reported_name":"Thorp Clay","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166141,"kind":"organization","name":"Hatteras Venture Advisors IV SBIC, LLC","position":2,"cik":"0001675236","reported_name":"Hatteras Venture Advisors IV SBIC, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166142,"kind":"organization","name":"Hatteras Venture Partners IV SBIC, LP","position":3,"cik":"0001675232","reported_name":"Hatteras Venture Partners IV SBIC, LP","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":16884,"kind":"person","name":"INGRAM ROBERT ALEXANDER","position":4,"cik":"0001219890","reported_name":"INGRAM ROBERT ALEXANDER","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162814,"kind":"person","name":"Crumpler John","position":5,"cik":"0001674107","reported_name":"Crumpler John","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":112297,"kind":"person","name":"LEE KENNETH B JR","position":6,"cik":"0001208570","reported_name":"LEE KENNETH B JR","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162813,"kind":"person","name":"Reed Douglas MD","position":7,"cik":"0001291262","reported_name":"Reed Douglas MD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-05-23T20:46:07.000Z","date":"2018-05-21","kind":"sale","acquired":false,"shares":26,"price":52.13,"value":1355.38,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price represents the weighted average price with a low of $52.12 and a high of $52.14."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"995 shares of the reportable securities are owned directly by Hatteras Venture Advisors V, LLC (\"HVA V\"). The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. Each Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his or her pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Following the reported transaction, 3,832,318 shares of the reportable securities are owned directly by HVP IV."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Following the reported transaction, 210,798 shares of the reportable securities are owned directly by Hatteras NC."}],"balance_after":4044111,"source":{"system":"sec-edgar","filing":"0001209191-18-032789","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1674107/000120919118032789/doc4.xml","form_type":"4"}},{"id":3920688,"issuer":{"id":87413,"kind":"organization","name":"G1 Therapeutics, Inc.","symbol":"GTHX"},"owners":[{"id":82876,"kind":"person","name":"Thorp Clay","position":1,"cik":"0001592380","reported_name":"Thorp Clay","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166141,"kind":"organization","name":"Hatteras Venture Advisors IV SBIC, LLC","position":2,"cik":"0001675236","reported_name":"Hatteras Venture Advisors IV SBIC, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166142,"kind":"organization","name":"Hatteras Venture Partners IV SBIC, LP","position":3,"cik":"0001675232","reported_name":"Hatteras Venture Partners IV SBIC, LP","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":16884,"kind":"person","name":"INGRAM ROBERT ALEXANDER","position":4,"cik":"0001219890","reported_name":"INGRAM ROBERT ALEXANDER","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162814,"kind":"person","name":"Crumpler John","position":5,"cik":"0001674107","reported_name":"Crumpler John","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":112297,"kind":"person","name":"LEE KENNETH B JR","position":6,"cik":"0001208570","reported_name":"LEE KENNETH B JR","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162813,"kind":"person","name":"Reed Douglas MD","position":7,"cik":"0001291262","reported_name":"Reed Douglas MD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-05-23T20:46:07.000Z","date":"2018-05-21","kind":"sale","acquired":false,"shares":474,"price":52.13,"value":24709.62,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price represents the weighted average price with a low of $52.12 and a high of $52.14."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"995 shares of the reportable securities are owned directly by Hatteras Venture Advisors V, LLC (\"HVA V\"). The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. Each Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his or her pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Following the reported transaction, 210,824 shares of the reportable securities are owned directly by Hatteras NC."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Following the reported transaction, 3,832,318 shares of the reportable securities are owned directly by HVP IV."}],"balance_after":4044137,"source":{"system":"sec-edgar","filing":"0001209191-18-032789","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1674107/000120919118032789/doc4.xml","form_type":"4"}},{"id":3920687,"issuer":{"id":87413,"kind":"organization","name":"G1 Therapeutics, Inc.","symbol":"GTHX"},"owners":[{"id":82876,"kind":"person","name":"Thorp Clay","position":1,"cik":"0001592380","reported_name":"Thorp Clay","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166141,"kind":"organization","name":"Hatteras Venture Advisors IV SBIC, LLC","position":2,"cik":"0001675236","reported_name":"Hatteras Venture Advisors IV SBIC, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166142,"kind":"organization","name":"Hatteras Venture Partners IV SBIC, LP","position":3,"cik":"0001675232","reported_name":"Hatteras Venture Partners IV SBIC, LP","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":16884,"kind":"person","name":"INGRAM ROBERT ALEXANDER","position":4,"cik":"0001219890","reported_name":"INGRAM ROBERT ALEXANDER","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162814,"kind":"person","name":"Crumpler John","position":5,"cik":"0001674107","reported_name":"Crumpler John","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":112297,"kind":"person","name":"LEE KENNETH B JR","position":6,"cik":"0001208570","reported_name":"LEE KENNETH B JR","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162813,"kind":"person","name":"Reed Douglas MD","position":7,"cik":"0001291262","reported_name":"Reed Douglas MD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-05-23T20:46:07.000Z","date":"2018-05-21","kind":"sale","acquired":false,"shares":1595,"price":51.0589,"value":81438.9455,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price represents the weighted average price with a low of $51.00 and a high of $51.755. The Reporting Persons undertake to provide G1 Therapeutics, Inc., any security holder of G1 Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Following the reported transaction, 3,832,792 shares of the reportable securities are owned directly by Hatteras Venture Partners IV SBIC, LP (\"HVP IV\"). Hatteras Venture Advisors IV SBIC, LLC (\"HVA IV SBIC\") is the general partner of HVP IV. The securities directly held by HVP IV are indirectly held by the individual managing members of HVA IV SBIC (each, a \"GP Managing Member\" and collectively, the \"GP Managing Members\"). The GP Managing Members are John Crumpler, Clay Thorp, Ken Lee, Douglas Reed and Robert Ingram. The GP Managing Members may share voting and dispositive power over the securities directly held by HVP IV. Each GP Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any GP Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"995 shares of the reportable securities are owned directly by Hatteras Venture Advisors V, LLC (\"HVA V\"). The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. Each Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his or her pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Following the reported transaction, 210,824 shares of the reportable securities are owned directly by Hatteras NC."}],"balance_after":4044611,"source":{"system":"sec-edgar","filing":"0001209191-18-032789","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1674107/000120919118032789/doc4.xml","form_type":"4"}},{"id":3920686,"issuer":{"id":87413,"kind":"organization","name":"G1 Therapeutics, Inc.","symbol":"GTHX"},"owners":[{"id":82876,"kind":"person","name":"Thorp Clay","position":1,"cik":"0001592380","reported_name":"Thorp Clay","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166141,"kind":"organization","name":"Hatteras Venture Advisors IV SBIC, LLC","position":2,"cik":"0001675236","reported_name":"Hatteras Venture Advisors IV SBIC, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":166142,"kind":"organization","name":"Hatteras Venture Partners IV SBIC, LP","position":3,"cik":"0001675232","reported_name":"Hatteras Venture Partners IV SBIC, LP","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":16884,"kind":"person","name":"INGRAM ROBERT ALEXANDER","position":4,"cik":"0001219890","reported_name":"INGRAM ROBERT ALEXANDER","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162814,"kind":"person","name":"Crumpler John","position":5,"cik":"0001674107","reported_name":"Crumpler John","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":112297,"kind":"person","name":"LEE KENNETH B JR","position":6,"cik":"0001208570","reported_name":"LEE KENNETH B JR","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":162813,"kind":"person","name":"Reed Douglas MD","position":7,"cik":"0001291262","reported_name":"Reed Douglas MD","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-05-23T20:46:07.000Z","date":"2018-05-21","kind":"sale","acquired":false,"shares":29005,"price":51.1604,"value":1483907.402,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price represents the weighted average price with a low of $51.00 and a high of $51.755. The Reporting Persons undertake to provide G1 Therapeutics, Inc., any security holder of G1 Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Following the reported transaction, 3,832,792 shares of the reportable securities are owned directly by Hatteras Venture Partners IV SBIC, LP (\"HVP IV\"). Hatteras Venture Advisors IV SBIC, LLC (\"HVA IV SBIC\") is the general partner of HVP IV. The securities directly held by HVP IV are indirectly held by the individual managing members of HVA IV SBIC (each, a \"GP Managing Member\" and collectively, the \"GP Managing Members\"). The GP Managing Members are John Crumpler, Clay Thorp, Ken Lee, Douglas Reed and Robert Ingram. The GP Managing Members may share voting and dispositive power over the securities directly held by HVP IV. Each GP Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any GP Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Following the reported transaction, 212,419 shares of the reportable securities are owned directly by Hatteras NC Fund, LP (\"Hatteras NC\"). Hatteras Venture Advisors IV, LLC (\"HVA IV\") is the general partner of Hatteras NC Fund, LP. The securities directly held by Hatteras NC are indirectly held by the individual managing members of HVA IV (each, a \"HVA IV Managing Member\" and collectively, the \"HVA IV Managing Members\"). The HVA IV Managing Members are John Crumpler, Clay Thorp, Ken Lee, Douglas Reed and Robert Ingram. The HVA IV Managing Members may share voting and dispositive power over the securities directly held by HVP IV. Each HVA IV Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any HVA IV Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"995 shares of the reportable securities are owned directly by Hatteras Venture Advisors V, LLC (\"HVA V\"). The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. 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Hatteras Venture Advisors IV SBIC, LLC (\"HVA IV SBIC\") is the general partner of HVP IV. The securities directly held by HVP IV are indirectly held by the individual managing members of HVA IV SBIC (each, a \"GP Managing Member\" and collectively, the \"GP Managing Members\"). The GP Managing Members are John Crumpler, Clay Thorp, Ken Lee, Douglas Reed and Robert Ingram. The GP Managing Members may share voting and dispositive power over the securities directly held by HVP IV. Each GP Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any GP Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"212,419 shares of the reportable securities are owned directly by Hatteras NC Fund, LP (\"Hatteras NC\"). Hatteras Venture Advisors IV, LLC (\"HVA IV\") is the general partner of Hatteras NC Fund, LP. The securities directly held by Hatteras NC are indirectly held by the individual managing members of HVA IV (each, a \"HVA IV Managing Member\" and collectively, the \"HVA IV Managing Members\"). The HVA IV Managing Members are John Crumpler, Clay Thorp, Ken Lee, Douglas Reed and Robert Ingram. The HVA IV Managing Members may share voting and dispositive power over the securities directly held by HVP IV. Each HVA IV Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any HVA IV Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"995 shares of the reportable securities are owned directly by Hatteras Venture Advisors V, LLC (\"HVA V\"). The securities directly held by HVA V are indirectly held by the individual managing members of HVA V (each, a \"Managing Member\" and collectively, the \"Managing Members\"). The Managing Members are John Crumpler, Clay Thorp, Christy Shaffer, Douglas Reed and Robert Ingram. The Managing Members may share voting and dispositive power over the securities directly held by HVA V. 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