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Following the distribution, Apple Tree Partners II - Annex, L.P. was no longer a holder of record of the Issuer's shares."},{"field":"ownership.direct","element":"directOrIndirectOwnership","label":"F2","text":"Dr. Seth L. Harrison is a principal of the general partner of Apple Tree Partners II - Annex, L.P., and Dr. Harrison disclaims beneficial ownership of the shares previously held by Apple Tree Partners II - Annex, L.P., except to the extent of his pecuniary interest therein. Dr. Harrison had sole voting and investment power over the shares previously held by Apple Tree Partners II - Annex, L.P."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001012975-18-000907","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1420565/000101297518000907/edgar.xml","form_type":"4"}},{"id":4260831,"issuer":{"id":7071,"kind":"organization","name":"Rein Therapeutics, Inc."},"owners":[{"id":165095,"kind":"organization","name":"Apple Tree Partners II - Annex, L.P.","position":1,"cik":"0001553255","reported_name":"Apple Tree Partners II - Annex, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series E-1 Preferred Stock","published_at":"2017-07-08T00:31:05.000Z","date":"2017-07-05","kind":"exercise","acquired":false,"shares":3026920,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The Series E and Series E-1 Preferred Stock converted into Common Stock on a 9.937-for-one-basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series E and Series E-1 Preferred Stock were convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The Series E and Series E-1 Preferred Stock converted into Common Stock on a 9.937-for-one-basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series E and Series E-1 Preferred Stock were convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The Series E and Series E-1 Preferred Stock converted into Common Stock on a 9.937-for-one-basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series E and Series E-1 Preferred Stock were convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.direct","element":"directOrIndirectOwnership","label":"F2","text":"Dr. Seth L. Harrison is a principal of the general partner of Apple Tree Partners II-Annex, L.P., and Dr. Harrison disclaims beneficial ownership of the shares held by Apple Tree Partners II-Annex, L.P., except to the extent of his pecuniary interest therein. Dr. Harrison has sole voting and investment power over the shares held by Apple Tree Partners II-Annex, L.P."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":304611},"source":{"system":"sec-edgar","filing":"0000899243-17-018104","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1420565/000089924317018104/doc4.xml","form_type":"4"}},{"id":4260830,"issuer":{"id":7071,"kind":"organization","name":"Rein Therapeutics, Inc."},"owners":[{"id":165095,"kind":"organization","name":"Apple Tree Partners II - Annex, L.P.","position":1,"cik":"0001553255","reported_name":"Apple Tree Partners II - Annex, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series E Preferred Stock","published_at":"2017-07-08T00:31:05.000Z","date":"2017-07-05","kind":"exercise","acquired":false,"shares":3489740,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The Series E and Series E-1 Preferred Stock converted into Common Stock on a 9.937-for-one-basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series E and Series E-1 Preferred Stock were convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The Series E and Series E-1 Preferred Stock converted into Common Stock on a 9.937-for-one-basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series E and Series E-1 Preferred Stock were convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"The Series E and Series E-1 Preferred Stock converted into Common Stock on a 9.937-for-one-basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series E and Series E-1 Preferred Stock were convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date."},{"field":"ownership.direct","element":"directOrIndirectOwnership","label":"F2","text":"Dr. Seth L. Harrison is a principal of the general partner of Apple Tree Partners II-Annex, L.P., and Dr. Harrison disclaims beneficial ownership of the shares held by Apple Tree Partners II-Annex, L.P., except to the extent of his pecuniary interest therein. Dr. Harrison has sole voting and investment power over the shares held by Apple Tree Partners II-Annex, L.P."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":351186},"source":{"system":"sec-edgar","filing":"0000899243-17-018104","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1420565/000089924317018104/doc4.xml","form_type":"4"}},{"id":4260829,"issuer":{"id":7071,"kind":"organization","name":"Rein Therapeutics, Inc."},"owners":[{"id":165095,"kind":"organization","name":"Apple Tree Partners II - Annex, L.P.","position":1,"cik":"0001553255","reported_name":"Apple Tree Partners II - Annex, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2017-07-08T00:31:05.000Z","date":"2017-07-05","kind":"exercise","acquired":true,"shares":655797,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The Series E and Series E-1 Preferred Stock converted into Common Stock on a 9.937-for-one-basis upon the closing of the Issuer's initial public offering without payment of consideration. 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