{"transactions":[{"id":3837418,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-21T23:44:47.000Z","date":"2018-08-15","kind":"sale","acquired":false,"shares":736,"price":9.93,"value":7308.48,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.90 to $9.97 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":73819,"source":{"system":"sec-edgar","filing":"0000947871-18-000691","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000691/ownership.xml","form_type":"4/A","original_submission_date":"2018-08-15"}},{"id":3837417,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-21T23:44:47.000Z","date":"2018-08-15","kind":"sale","acquired":false,"shares":77314,"price":9.93,"value":767728.02,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.90 to $9.97 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7751662,"source":{"system":"sec-edgar","filing":"0000947871-18-000691","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000691/ownership.xml","form_type":"4/A","original_submission_date":"2018-08-15"}},{"id":3837416,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-21T23:44:47.000Z","date":"2018-08-14","kind":"sale","acquired":false,"shares":198,"price":9.94,"value":1968.12,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.90 to $9.98 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":74555,"source":{"system":"sec-edgar","filing":"0000947871-18-000691","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000691/ownership.xml","form_type":"4/A","original_submission_date":"2018-08-15"}},{"id":3837415,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-21T23:44:47.000Z","date":"2018-08-14","kind":"sale","acquired":false,"shares":20777,"price":9.94,"value":206523.38,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.90 to $9.98 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7828976,"source":{"system":"sec-edgar","filing":"0000947871-18-000691","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000691/ownership.xml","form_type":"4/A","original_submission_date":"2018-08-15"}},{"id":3837414,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-21T23:44:47.000Z","date":"2018-08-13","kind":"sale","acquired":false,"shares":820,"price":9.98,"value":8183.6,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $9.95 to $10.07 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":74753,"source":{"system":"sec-edgar","filing":"0000947871-18-000691","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000691/ownership.xml","form_type":"4/A","original_submission_date":"2018-08-15"}},{"id":3837413,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-21T23:44:47.000Z","date":"2018-08-13","kind":"sale","acquired":false,"shares":86103,"price":9.98,"value":859307.94,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $9.95 to $10.07 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7849753,"source":{"system":"sec-edgar","filing":"0000947871-18-000691","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000691/ownership.xml","form_type":"4/A","original_submission_date":"2018-08-15"}},{"id":3837412,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-21T23:36:02.000Z","date":"2018-08-20","kind":"sale","acquired":false,"shares":153921,"price":9.98,"value":1536131.58,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.95 to $10.01 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":68898,"source":{"system":"sec-edgar","filing":"0000947871-18-000690","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000690/ownership.xml","form_type":"4/A","original_submission_date":"2018-08-20"}},{"id":3837411,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-21T23:36:02.000Z","date":"2018-08-20","kind":"sale","acquired":false,"shares":153921,"price":9.98,"value":1536131.58,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.95 to $10.01 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7234976,"source":{"system":"sec-edgar","filing":"0000947871-18-000690","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000690/ownership.xml","form_type":"4/A","original_submission_date":"2018-08-20"}},{"id":3837410,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-21T23:36:02.000Z","date":"2018-08-16","kind":"sale","acquired":false,"shares":3455,"price":9.94,"value":34342.7,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $9.90 to $10.01 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":70364,"source":{"system":"sec-edgar","filing":"0000947871-18-000690","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000690/ownership.xml","form_type":"4/A","original_submission_date":"2018-08-20"}},{"id":3837409,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-21T23:36:02.000Z","date":"2018-08-16","kind":"sale","acquired":false,"shares":362765,"price":9.94,"value":3605884.1,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $9.90 to $10.01 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7388897,"source":{"system":"sec-edgar","filing":"0000947871-18-000690","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000690/ownership.xml","form_type":"4/A","original_submission_date":"2018-08-20"}},{"id":3838661,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-20T23:19:59.000Z","date":"2018-08-20","kind":"sale","acquired":false,"shares":1466,"price":9.98,"value":14630.68,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.95 to $10.01 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":69617,"source":{"system":"sec-edgar","filing":"0000947871-18-000680","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000680/ownership.xml","form_type":"4"}},{"id":3838660,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-20T23:19:59.000Z","date":"2018-08-20","kind":"sale","acquired":false,"shares":153921,"price":9.98,"value":1536131.58,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.95 to $10.01 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7310457,"source":{"system":"sec-edgar","filing":"0000947871-18-000680","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000680/ownership.xml","form_type":"4"}},{"id":3838659,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-20T23:19:59.000Z","date":"2018-08-16","kind":"sale","acquired":false,"shares":3455,"price":9.94,"value":34342.7,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $9.90 to $10.01 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":71083,"source":{"system":"sec-edgar","filing":"0000947871-18-000680","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000680/ownership.xml","form_type":"4"}},{"id":3838658,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-20T23:19:59.000Z","date":"2018-08-16","kind":"sale","acquired":false,"shares":362765,"price":9.94,"value":3605884.1,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $9.90 to $10.01 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7464378,"source":{"system":"sec-edgar","filing":"0000947871-18-000680","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000680/ownership.xml","form_type":"4"}},{"id":3843723,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-15T23:49:57.000Z","date":"2018-08-15","kind":"sale","acquired":false,"shares":736,"price":9.93,"value":7308.48,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.90 to $9.97 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":74538,"source":{"system":"sec-edgar","filing":"0000947871-18-000672","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000672/ownership.xml","form_type":"4"}},{"id":3843722,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-15T23:49:57.000Z","date":"2018-08-15","kind":"sale","acquired":false,"shares":77314,"price":9.93,"value":767728.02,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.90 to $9.97 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7827143,"source":{"system":"sec-edgar","filing":"0000947871-18-000672","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000672/ownership.xml","form_type":"4"}},{"id":3843721,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-15T23:49:57.000Z","date":"2018-08-14","kind":"sale","acquired":false,"shares":198,"price":9.94,"value":1968.12,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.90 to $9.98 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":75274,"source":{"system":"sec-edgar","filing":"0000947871-18-000672","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000672/ownership.xml","form_type":"4"}},{"id":3843720,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-15T23:49:57.000Z","date":"2018-08-14","kind":"sale","acquired":false,"shares":20777,"price":9.94,"value":206523.38,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.90 to $9.98 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7904457,"source":{"system":"sec-edgar","filing":"0000947871-18-000672","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000672/ownership.xml","form_type":"4"}},{"id":3843719,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-15T23:49:57.000Z","date":"2018-08-13","kind":"sale","acquired":false,"shares":820,"price":9.98,"value":8183.6,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $9.95 to $10.07 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":75472,"source":{"system":"sec-edgar","filing":"0000947871-18-000672","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000672/ownership.xml","form_type":"4"}},{"id":3843718,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-15T23:49:57.000Z","date":"2018-08-13","kind":"sale","acquired":false,"shares":86103,"price":9.98,"value":859307.94,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $9.95 to $10.07 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7925234,"source":{"system":"sec-edgar","filing":"0000947871-18-000672","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000672/ownership.xml","form_type":"4"}},{"id":3847688,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Restricted Stock Unit","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-07","kind":"exercise","acquired":false,"shares":249,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"The restricted stock units were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. Each restricted stock unit represented a contingent right to receive one Share following Mr. Bonita's termination of service from the Issuer's board of directors."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The restricted stock units were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. Each restricted stock unit represented a contingent right to receive one Share following Mr. Bonita's termination of service from the Issuer's board of directors."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The restricted stock units were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. Each restricted stock unit represented a contingent right to receive one Share following Mr. Bonita's termination of service from the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":249},"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":22,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847687,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Restricted Stock Unit","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-07","kind":"exercise","acquired":false,"shares":26139,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"The restricted stock units were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. Each restricted stock unit represented a contingent right to receive one Share following Mr. Bonita's termination of service from the Issuer's board of directors."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The restricted stock units were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. Each restricted stock unit represented a contingent right to receive one Share following Mr. Bonita's termination of service from the Issuer's board of directors."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The restricted stock units were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. Each restricted stock unit represented a contingent right to receive one Share following Mr. Bonita's termination of service from the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":26139},"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":21,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847686,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"exercise","acquired":false,"shares":431,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"The stock options were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 45,633 shares of the Issuer's Common Stock and was vested and exercisable on June 19, 2018. Mr. Bonita is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":8.02,"expiration_date":"2018-09-25","underlying":"Common Stock","underlying_shares":431},"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":20,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847685,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"exercise","acquired":false,"shares":45203,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"The stock options were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 45,633 shares of the Issuer's Common Stock and was vested and exercisable on June 19, 2018. Mr. Bonita is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":8.02,"expiration_date":"2018-09-25","underlying":"Common Stock","underlying_shares":45203},"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":19,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847684,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"exercise","acquired":false,"shares":184,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The stock options were included in an award to David Bonita, an employee of the Reporting Persons, made on July 23, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 19,556 shares of the Issuer's Common Stock and was vested and exercisable on July 23, 2016. Mr. Bonita is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":5,"expiration_date":"2018-09-25","underlying":"Common Stock","underlying_shares":184},"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":18,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847683,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"exercise","acquired":false,"shares":19372,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The stock options were included in an award to David Bonita, an employee of the Reporting Persons, made on July 23, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 19,556 shares of the Issuer's Common Stock and was vested and exercisable on July 23, 2016. Mr. Bonita is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":5,"expiration_date":"2018-09-25","underlying":"Common Stock","underlying_shares":19372},"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":17,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847682,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-10","kind":"sale","acquired":false,"shares":6460,"price":9.96,"value":64341.6,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.88 to $10.03 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":75573,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":16,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847681,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-10","kind":"sale","acquired":false,"shares":678333,"price":9.96,"value":6756196.68,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.88 to $10.03 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":7935856,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":15,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847680,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"sale","acquired":false,"shares":249,"price":9.86,"value":2455.14,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":82033,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":14,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847679,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"sale","acquired":false,"shares":26139,"price":9.86,"value":257730.54,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":8614189,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":13,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847678,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"sale","acquired":false,"shares":615,"price":9.91,"value":6094.65,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":82282,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847677,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"sale","acquired":false,"shares":64575,"price":9.91,"value":639938.25,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":8640328,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847676,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"exercise","acquired":true,"shares":431,"price":5,"value":2155.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":82897,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847675,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"exercise","acquired":true,"shares":45203,"price":5,"value":226015.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":8704903,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847674,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"exercise","acquired":true,"shares":184,"price":5,"value":920.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":82466,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847673,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"exercise","acquired":true,"shares":19372,"price":5,"value":96860.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":8659700,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847672,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"sale","acquired":false,"shares":1036,"price":9.95,"value":10308.2,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.90 to $10.03 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":82282,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847671,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-09","kind":"sale","acquired":false,"shares":108729,"price":9.95,"value":1081853.55,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.90 to $10.03 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":8640328,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847670,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-08","kind":"sale","acquired":false,"shares":4553,"price":10,"value":45530.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $9.98 to $10.07 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":83318,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847669,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-08","kind":"sale","acquired":false,"shares":478107,"price":10,"value":4781070.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $9.98 to $10.07 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":8749057,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847668,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-07","kind":"exercise","acquired":true,"shares":249,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"The restricted stock units were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. Each restricted stock unit represented a contingent right to receive one Share following Mr. Bonita's termination of service from the Issuer's board of directors."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The restricted stock units were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. Each restricted stock unit represented a contingent right to receive one Share following Mr. Bonita's termination of service from the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These securities are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":87871,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3847667,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-10T23:36:50.000Z","date":"2018-08-07","kind":"exercise","acquired":true,"shares":26139,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"The restricted stock units were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. Each restricted stock unit represented a contingent right to receive one Share following Mr. Bonita's termination of service from the Issuer's board of directors."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The restricted stock units were included in an award to David Bonita, an employee of the Reporting Persons, made on November 15, 2017 for services as a director of the Issuer. Each restricted stock unit represented a contingent right to receive one Share following Mr. Bonita's termination of service from the Issuer's board of directors."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"These securities are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":9227164,"source":{"system":"sec-edgar","filing":"0000947871-18-000654","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000654/ownership.xml","form_type":"4"}},{"id":3851000,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-07T22:12:31.000Z","date":"2018-08-07","kind":"sale","acquired":false,"shares":478,"price":10.01,"value":4784.78,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.95 to $10.12 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":87622,"source":{"system":"sec-edgar","filing":"0000947871-18-000632","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000632/ownership.xml","form_type":"4"}},{"id":3850999,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-07T22:12:31.000Z","date":"2018-08-07","kind":"sale","acquired":false,"shares":50149,"price":10.01,"value":501991.49,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $9.95 to $10.12 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":9201025,"source":{"system":"sec-edgar","filing":"0000947871-18-000632","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000632/ownership.xml","form_type":"4"}},{"id":3850998,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-07T22:12:31.000Z","date":"2018-08-03","kind":"sale","acquired":false,"shares":1125,"price":11.71,"value":13173.75,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $11.45 to $12.11 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":88100,"source":{"system":"sec-edgar","filing":"0000947871-18-000632","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000632/ownership.xml","form_type":"4"}},{"id":3850997,"issuer":{"id":111118,"kind":"organization","name":"ViewRay, Inc.","symbol":"VRAY"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-08-07T22:12:31.000Z","date":"2018-08-03","kind":"sale","acquired":false,"shares":118168,"price":11.71,"value":1383747.28,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $11.45 to $12.11 inclusive. Upon request, the Reporting Persons undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares purchased at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":9251174,"source":{"system":"sec-edgar","filing":"0000947871-18-000632","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000632/ownership.xml","form_type":"4"}},{"id":3949993,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"See Remarks"}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"See Remarks"}}],"security":"Common Stock","published_at":"2018-05-02T21:13:48.000Z","date":"2018-04-30","kind":"sale","acquired":false,"shares":10400,"price":6.35,"value":66040.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"These shares of the Issuer's common stock (\"Shares\") were sold in a block order at a price of $6.35."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\").  Advisors is the general partner of Associates III.  By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This report on Form 4 is jointly filed by GP III and Advisors.  Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any.  This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":38870,"source":{"system":"sec-edgar","filing":"0000947871-18-000372","document":"ss90746_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000372/ss90746_4.xml","form_type":"4"}},{"id":3949992,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"See Remarks"}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"See Remarks"}}],"security":"Common Stock","published_at":"2018-05-02T21:13:48.000Z","date":"2018-04-30","kind":"sale","acquired":false,"shares":989600,"price":6.35,"value":6283960.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"These shares of the Issuer's common stock (\"Shares\") were sold in a block order at a price of $6.35."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\").  OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III.  By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\").  Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This report on Form 4 is jointly filed by GP III and Advisors.  Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any.  This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":4511130,"source":{"system":"sec-edgar","filing":"0000947871-18-000372","document":"ss90746_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000372/ss90746_4.xml","form_type":"4"}},{"id":4011959,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-06","kind":"sale","acquired":false,"shares":445,"price":32.06,"value":14266.7,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $31.49 to $32.46 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":14,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011958,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-06","kind":"sale","acquired":false,"shares":46676,"price":32.06,"value":1496432.56,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $31.49 to $32.46 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":13,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011957,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-06","kind":"sale","acquired":false,"shares":192,"price":30.77,"value":5907.84,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $30.48 to $31.47 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":445,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011956,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-06","kind":"sale","acquired":false,"shares":20114,"price":30.77,"value":618907.78,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $30.48 to $31.47 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":46676,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011955,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-06","kind":"sale","acquired":false,"shares":886,"price":30.01,"value":26588.86,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $29.48 to $30.47 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":637,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011954,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-06","kind":"sale","acquired":false,"shares":93008,"price":30.01,"value":2791170.08,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $29.48 to $30.47 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":66790,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011953,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-05","kind":"sale","acquired":false,"shares":768,"price":33.06,"value":25390.08,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $32.64 to $33.39 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":1523,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011952,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-05","kind":"sale","acquired":false,"shares":80516,"price":33.06,"value":2661858.96,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $32.64 to $33.39 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":159798,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011951,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-05","kind":"sale","acquired":false,"shares":1220,"price":32.05,"value":39101.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $31.64 to $32.62 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":2291,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011950,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-05","kind":"sale","acquired":false,"shares":128092,"price":32.05,"value":4105348.6,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $31.64 to $32.62 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":240314,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011949,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-02","kind":"sale","acquired":false,"shares":1851,"price":32.8,"value":60712.8,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $32.42 to $33.40 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":3511,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011948,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-02","kind":"sale","acquired":false,"shares":194433,"price":32.8,"value":6377402.4,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These Shares were sold in multiple transactions at prices ranging from $32.42 to $33.40 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":368406,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011947,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-02","kind":"sale","acquired":false,"shares":2533,"price":31.92,"value":80853.36,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $31.41 to $32.39 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":5362,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4011946,"issuer":{"id":3510,"kind":"organization","name":"GLAUKOS Corp","symbol":"GKOS"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock, par value $0.01 per share","published_at":"2018-03-07T00:36:22.000Z","date":"2018-03-02","kind":"sale","acquired":false,"shares":265766,"price":31.92,"value":8483250.72,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares of the Issuer's common stock (\"Shares\") were sold in multiple transactions at prices ranging from $31.41 to $32.39 inclusive. Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission (the \"SEC\") full information regarding the Shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) of the Exchange Act, except to the extent of its pecuniary interest therein, if any. The Reporting Persons have designated a representative, currently Jonathan T. Silverstein, a member of Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":562839,"source":{"system":"sec-edgar","filing":"0000947871-18-000220","document":"ss82779_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000220/ss82779_4.xml","form_type":"4"}},{"id":4055664,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2018-02-15T21:57:01.000Z","date":"2018-02-13","kind":"exercise","acquired":false,"shares":17,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 25, 2018 for services as a director of the Issuer. The award included stock options relating to a total of 1,782 shares of the Issuer's Common Stock and was vested and exercisable on January 25, 2018. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":5.08,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":17},"source":{"system":"sec-edgar","filing":"0000947871-18-000156","document":"ss80152_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000156/ss80152_4.xml","form_type":"4"}},{"id":4055663,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2018-02-15T21:57:01.000Z","date":"2018-02-13","kind":"exercise","acquired":false,"shares":1765,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 25, 2018 for services as a director of the Issuer. The award included stock options relating to a total of 1,782 shares of the Issuer's Common Stock and was vested and exercisable on January 25, 2018. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":5.08,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":1765},"source":{"system":"sec-edgar","filing":"0000947871-18-000156","document":"ss80152_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000156/ss80152_4.xml","form_type":"4"}},{"id":4055662,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2018-02-15T21:57:01.000Z","date":"2018-02-13","kind":"exercise","acquired":false,"shares":58,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on October 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 6,115 shares of the Issuer's Common Stock and was vested and exercisable on October 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":4.68,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":58},"source":{"system":"sec-edgar","filing":"0000947871-18-000156","document":"ss80152_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000156/ss80152_4.xml","form_type":"4"}},{"id":4055661,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2018-02-15T21:57:01.000Z","date":"2018-02-13","kind":"exercise","acquired":false,"shares":6057,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on October 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 6,115 shares of the Issuer's Common Stock and was vested and exercisable on October 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":4.68,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":6057},"source":{"system":"sec-edgar","filing":"0000947871-18-000156","document":"ss80152_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000156/ss80152_4.xml","form_type":"4"}},{"id":4055660,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-02-15T21:57:01.000Z","date":"2018-02-13","kind":"sale","acquired":false,"shares":75,"price":8.98,"value":673.5,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":49270,"source":{"system":"sec-edgar","filing":"0000947871-18-000156","document":"ss80152_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000156/ss80152_4.xml","form_type":"4"}},{"id":4055659,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-02-15T21:57:01.000Z","date":"2018-02-13","kind":"sale","acquired":false,"shares":7822,"price":8.98,"value":70241.56,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":5500730,"source":{"system":"sec-edgar","filing":"0000947871-18-000156","document":"ss80152_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000156/ss80152_4.xml","form_type":"4"}},{"id":4055658,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-02-15T21:57:01.000Z","date":"2018-02-13","kind":"exercise","acquired":true,"shares":17,"price":5.08,"value":86.36,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":49345,"source":{"system":"sec-edgar","filing":"0000947871-18-000156","document":"ss80152_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000156/ss80152_4.xml","form_type":"4"}},{"id":4055657,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-02-15T21:57:01.000Z","date":"2018-02-13","kind":"exercise","acquired":true,"shares":1765,"price":5.08,"value":8966.2,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":5508552,"source":{"system":"sec-edgar","filing":"0000947871-18-000156","document":"ss80152_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000156/ss80152_4.xml","form_type":"4"}},{"id":4055656,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-02-15T21:57:01.000Z","date":"2018-02-13","kind":"exercise","acquired":true,"shares":58,"price":4.68,"value":271.44,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. By virtue of such relationships, Advisors may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities. Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by Associates III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":49328,"source":{"system":"sec-edgar","filing":"0000947871-18-000156","document":"ss80152_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000156/ss80152_4.xml","form_type":"4"}},{"id":4055655,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-02-15T21:57:01.000Z","date":"2018-02-13","kind":"exercise","acquired":true,"shares":6057,"price":4.68,"value":28346.76,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\"), a registered adviser under the Investment Advisors Act of 1940, as amended, is the managing member of GP III. By virtue of such relationships, GP III and Advisors may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to beneficially own such securities for purposes of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"). Advisors exercised this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI III."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Samuel D. Isaly, who was included as a Reporting Person on previous reports under Section 16 of the Exchange Act filed by GP III and Advisors, is no longer subject to Section 16 with respect to securities of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This report on Form 4 is jointly filed by GP III and Advisors. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Exchange Act, except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":5506787,"source":{"system":"sec-edgar","filing":"0000947871-18-000156","document":"ss80152_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000156/ss80152_4.xml","form_type":"4"}},{"id":4108342,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-01-04T20:23:36.000Z","date":"2018-01-03","kind":"sale","acquired":false,"shares":16128,"price":7.35,"value":118540.8,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"These shares of the Issuer's common stock (\"Shares\") were sold in a block order at a price of $7.35."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":49270,"source":{"system":"sec-edgar","filing":"0000947871-18-000012","document":"ss74180_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000012/ss74180_4.xml","form_type":"4"}},{"id":4108341,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2018-01-04T20:23:36.000Z","date":"2018-01-03","kind":"sale","acquired":false,"shares":1693492,"price":7.35,"value":12447166.2,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"These shares of the Issuer's common stock (\"Shares\") were sold in a block order at a price of $7.35."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":5500730,"source":{"system":"sec-edgar","filing":"0000947871-18-000012","document":"ss74180_4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787118000012/ss74180_4.xml","form_type":"4"}},{"id":4125291,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":47,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F13","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 5,018 shares of the Issuer's Common Stock and was vested and exercisable on July 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":5.64,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":47},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":54,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125290,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":4971,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F13","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 5,018 shares of the Issuer's Common Stock and was vested and exercisable on July 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":5.64,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":4971},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":53,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125289,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":99,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F12","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 10,546 shares of the Issuer's Common Stock and was vested and exercisable on April 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.32,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":99},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":52,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125288,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":10447,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F12","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 10,546 shares of the Issuer's Common Stock and was vested and exercisable on April 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.32,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":10447},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":51,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125287,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":97,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F11","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 10,313 shares of the Issuer's Common Stock and was vested and exercisable on January 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.01,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":97},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":50,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125286,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":10216,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F11","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 10,313 shares of the Issuer's Common Stock and was vested and exercisable on January 25, 2017. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.01,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":10216},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":49,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125285,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":142,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 20,000 shares of the Issuer's Common Stock and was scheduled to vest in four equal installments on each of March 31, 2017, June 30, 2017, September 30, 2017 and December 31, 2017 with 100% of the total shares vested and exercisable on December 31, 2017, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.01,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":142},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":48,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125284,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":14858,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 25, 2017 for services as a director of the Issuer. The award included stock options relating to a total of 20,000 shares of the Issuer's Common Stock and was scheduled to vest in four equal installments on each of March 31, 2017, June 30, 2017, September 30, 2017 and December 31, 2017 with 100% of the total shares vested and exercisable on December 31, 2017, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.01,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":14858},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":47,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125283,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":97,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F9","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on October 25, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 10,279 shares of the Issuer's Common Stock and was vested and exercisable on October 25, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.64,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":97},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":46,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125282,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":10182,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F9","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on October 25, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 10,279 shares of the Issuer's Common Stock and was vested and exercisable on October 25, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.64,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":10182},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":45,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125281,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":92,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 25, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 9,734 shares of the Issuer's Common Stock and was vested and exercisable on July 25, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.73,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":92},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":44,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125280,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":9642,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 25, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 9,734 shares of the Issuer's Common Stock and was vested and exercisable on July 25, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.73,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":9642},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":43,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125279,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":77,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 27, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 8,174 shares of the Issuer's Common Stock and was vested and exercisable on April 27, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.05,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":77},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":42,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125278,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":8097,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 27, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 8,174 shares of the Issuer's Common Stock and was vested and exercisable on April 27, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.05,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":8097},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":41,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125277,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":189,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on February 16, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 20,000 shares of the Issuer's Common Stock and was scheduled to vest in four equal installments on each of March 31, 2016, June 30, 2016, September 30, 2016 and December 31, 2016 with 100% of the total shares vested and exercisable on December 31, 2016, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.59,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":189},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":40,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125276,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":19811,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on February 16, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 20,000 shares of the Issuer's Common Stock and was scheduled to vest in four equal installments on each of March 31, 2016, June 30, 2016, September 30, 2016 and December 31, 2016 with 100% of the total shares vested and exercisable on December 31, 2016, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.59,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":19811},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":39,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125275,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":97,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 15, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 10,277 shares of the Issuer's Common Stock and was vested and exercisable on January 15, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.62,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":97},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":38,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125274,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":10180,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on January 15, 2016 for services as a director of the Issuer. The award included stock options relating to a total of 10,277 shares of the Issuer's Common Stock and was vested and exercisable on January 15, 2016. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.62,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":10180},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":37,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125273,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":83,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on October 15, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 8,800 shares of the Issuer's Common Stock and was vested and exercisable on October 15, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.94,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":83},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":36,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125272,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":8717,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on October 15, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 8,800 shares of the Issuer's Common Stock and was vested and exercisable on October 15, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":1.94,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":8717},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":35,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125271,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":63,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 15, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 6,717 shares of the Issuer's Common Stock and was vested and exercisable on July 15, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.62,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":63},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":34,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125270,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":6654,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on July 15, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 6,717 shares of the Issuer's Common Stock and was vested and exercisable on July 15, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2.62,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":6654},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":33,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125269,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":50,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 30, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 5,277 shares of the Issuer's Common Stock and was vested and exercisable on April 30, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":3,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":50},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":32,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125268,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":5227,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on April 30, 2015 for services as a director of the Issuer. The award included stock options relating to a total of 5,277 shares of the Issuer's Common Stock and was vested and exercisable on April 30, 2015. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":3,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":5227},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":31,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125267,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":259,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on December 17, 2014 for services as a director of the Issuer. The award included stock options relating to a total of 30,000 shares of the Issuer's Common Stock and was scheduled to vest quarterly over three years beginning March 31, 2015, with 100% of the total shares vested and exercisable on March 31, 2018, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F15","text":"These Shares are held of record by OrbiMed Associates III, LP (\"Associates III\"). Advisors is the general partner of Associates III. Isaly is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, Advisors and Isaly may be deemed to have voting and investment power over the securities held by Associates III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":259},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":30,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}},{"id":4125266,"issuer":{"id":4452,"kind":"organization","name":"PALVELLA THERAPEUTICS, INC.","symbol":"PVLA"},"owners":[{"id":24290,"kind":"person","name":"ORBIMED ADVISORS LLC","position":1,"cik":"0001055951","reported_name":"ORBIMED ADVISORS LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":164153,"kind":"organization","name":"OrbiMed Capital GP III LLC","position":2,"cik":"0001432241","reported_name":"OrbiMed Capital GP III LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":170199,"kind":"person","name":"ISALY SAMUEL D","position":3,"cik":"0001055949","reported_name":"ISALY SAMUEL D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2017-12-20T22:12:52.000Z","date":"2017-12-18","kind":"exercise","acquired":false,"shares":27241,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The stock options were included in an award to Chau Khuong, an employee of the Reporting Persons, made on December 17, 2014 for services as a director of the Issuer. The award included stock options relating to a total of 30,000 shares of the Issuer's Common Stock and was scheduled to vest quarterly over three years beginning March 31, 2015, with 100% of the total shares vested and exercisable on March 31, 2018, subject to the director's provision of service to the issuer on each vesting date. Mr. Khuong is no longer a director of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"These Shares are held of record by OrbiMed Private Investments III, LP (\"OPI III\"). OrbiMed Capital GP III LLC (\"GP III\") is the general partner of OPI III, and OrbiMed Advisors LLC (\"Advisors\") is the managing member of GP III. Samuel D. Isaly (\"Isaly\"), a natural person, is the managing member of and owner of a controlling interest in Advisors. By virtue of such relationships, GP III, Advisors and Isaly may be deemed to have voting and investment power over the securities held by OPI III and as a result may be deemed to have beneficial ownership over such securities."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F16","text":"This report on Form 4 is jointly filed by GP III, Advisors, and Isaly. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the \"Exchange Act\"), except to the extent of its or his pecuniary interest therein, if any. This report shall not be deemed an admission that any of the Reporting Persons is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose."}],"balance_after":0,"derivative":{"exercise_price":2,"expiration_date":"2018-02-15","underlying":"Common Stock","underlying_shares":27241},"source":{"system":"sec-edgar","filing":"0000947871-17-001023","document":"ss72777_4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":29,"url":"https://www.sec.gov/Archives/edgar/data/1055951/000094787117001023/ss72777_4.xml","form_type":"4"}}],"next_cursor":"2017-12-20T22:12:52.000000Z,4125266"}