{"transactions":[{"id":4639723,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-10-13T21:45:03.000Z","date":"2026-10-12","kind":"purchase","planned":false,"acquired":true,"shares":7215,"price":2.02,"value":14574.3,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2873289,"source":{"system":"sec-edgar","filing":"0001493152-26-046899","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226046899/ownership.xml","form_type":"4"}},{"id":4639722,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-10-13T21:45:03.000Z","date":"2026-10-09","kind":"purchase","planned":false,"acquired":true,"shares":5340,"price":2.0446,"value":10918.164,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.03 to $2.05. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2866074,"source":{"system":"sec-edgar","filing":"0001493152-26-046899","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226046899/ownership.xml","form_type":"4"}},{"id":4639721,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-10-13T21:45:03.000Z","date":"2026-10-08","kind":"purchase","planned":false,"acquired":true,"shares":2077,"price":2.0175,"value":4190.3475,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2860734,"source":{"system":"sec-edgar","filing":"0001493152-26-046899","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226046899/ownership.xml","form_type":"4"}},{"id":4631212,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-10-05T22:46:05.000Z","date":"2026-10-05","kind":"purchase","planned":false,"acquired":true,"shares":1694,"price":2.06,"value":3489.64,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2858657,"source":{"system":"sec-edgar","filing":"0001493152-26-045809","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226045809/ownership.xml","form_type":"4"}},{"id":4631211,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-10-05T22:46:05.000Z","date":"2026-10-02","kind":"purchase","planned":false,"acquired":true,"shares":20000,"price":2.0684,"value":41368.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.03 to $2.07. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2856963,"source":{"system":"sec-edgar","filing":"0001493152-26-045809","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226045809/ownership.xml","form_type":"4"}},{"id":4631210,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-10-05T22:46:05.000Z","date":"2026-10-01","kind":"purchase","planned":false,"acquired":true,"shares":38796,"price":2.0353,"value":78961.4988,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.00 to $2.04. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2836963,"source":{"system":"sec-edgar","filing":"0001493152-26-045809","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226045809/ownership.xml","form_type":"4"}},{"id":4635394,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-10-03T00:05:22.000Z","date":"2026-10-01","kind":"purchase","planned":false,"acquired":true,"shares":19050,"price":8.6947,"value":165634.035,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.645 to $8.70. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":3222954,"source":{"system":"sec-edgar","filing":"0001493152-26-045511","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226045511/ownership.xml","form_type":"4"}},{"id":4634866,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-10-02T00:30:30.000Z","date":"2026-09-29","kind":"purchase","planned":false,"acquired":true,"shares":7849,"price":2.09,"value":16404.41,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. 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As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2798167,"source":{"system":"sec-edgar","filing":"0001493152-26-045358","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1444192/000149315226045358/ownership.xml","form_type":"4"}},{"id":4634863,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-10-02T00:05:26.000Z","date":"2026-09-23","kind":"purchase","planned":false,"acquired":true,"shares":5318,"price":2.1,"value":11167.8,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. 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As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2790318,"source":{"system":"sec-edgar","filing":"0001493152-26-045347","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1444192/000149315226045347/ownership.xml","form_type":"4/A","original_submission_date":"2026-09-23"}},{"id":4634862,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-10-02T00:05:26.000Z","date":"2026-09-21","kind":"purchase","planned":false,"acquired":true,"shares":9771,"price":2.1,"value":20519.1,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2785000,"source":{"system":"sec-edgar","filing":"0001493152-26-045347","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1444192/000149315226045347/ownership.xml","form_type":"4/A","original_submission_date":"2026-09-23"}},{"id":4627915,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-09-28T23:57:34.000Z","date":"2026-09-25","kind":"purchase","planned":false,"acquired":true,"shares":13426,"price":8.47,"value":113718.22,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":3203904,"source":{"system":"sec-edgar","filing":"0001493152-26-044690","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1655923/000149315226044690/ownership.xml","form_type":"4"}},{"id":4627914,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-09-28T23:57:34.000Z","date":"2026-09-24","kind":"purchase","planned":false,"acquired":true,"shares":18337,"price":8.5664,"value":157082.0768,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.52 to $8.57. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":3190478,"source":{"system":"sec-edgar","filing":"0001493152-26-044690","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1655923/000149315226044690/ownership.xml","form_type":"4"}},{"id":4625715,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-09-23T22:19:25.000Z","date":"2026-09-23","kind":"purchase","planned":false,"acquired":true,"shares":5318,"price":2.1,"value":11167.8,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. 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As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2855318,"source":{"system":"sec-edgar","filing":"0001493152-26-043996","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226043996/ownership.xml","form_type":"4"}},{"id":4625714,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-09-23T22:19:25.000Z","date":"2026-09-21","kind":"purchase","planned":false,"acquired":true,"shares":9771,"price":2.1,"value":20519.1,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2850000,"source":{"system":"sec-edgar","filing":"0001493152-26-043996","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226043996/ownership.xml","form_type":"4"}},{"id":4619921,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-09-16T21:57:41.000Z","date":"2026-09-16","kind":"purchase","planned":false,"acquired":true,"shares":27141,"price":8.4,"value":227984.4,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":3172141,"source":{"system":"sec-edgar","filing":"0001493152-26-042969","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1655923/000149315226042969/ownership.xml","form_type":"4"}},{"id":4619920,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-09-16T21:57:41.000Z","date":"2026-09-16","kind":"purchase","planned":false,"acquired":true,"shares":53029,"price":8.5728,"value":454607.0112,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.46 to $8.70. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":3145000,"source":{"system":"sec-edgar","filing":"0001493152-26-042969","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1655923/000149315226042969/ownership.xml","form_type":"4"}},{"id":4619919,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-09-16T21:57:41.000Z","date":"2026-09-15","kind":"purchase","planned":false,"acquired":true,"shares":3375,"price":8.5424,"value":28830.6,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.53 to $8.57. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":3091971,"source":{"system":"sec-edgar","filing":"0001493152-26-042969","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1655923/000149315226042969/ownership.xml","form_type":"4"}},{"id":4619918,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-09-16T21:57:41.000Z","date":"2026-09-14","kind":"purchase","planned":false,"acquired":true,"shares":40373,"price":8.696,"value":351083.608,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.664 to $8.72. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":3088596,"source":{"system":"sec-edgar","filing":"0001493152-26-042969","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1655923/000149315226042969/ownership.xml","form_type":"4"}},{"id":4617258,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-09-14T21:23:17.000Z","date":"2026-09-11","kind":"purchase","planned":false,"acquired":true,"shares":1493,"price":65.945,"value":98455.885,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":540000,"source":{"system":"sec-edgar","filing":"0001493152-26-042615","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226042615/ownership.xml","form_type":"4"}},{"id":4617257,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-09-14T21:23:17.000Z","date":"2026-09-10","kind":"purchase","planned":false,"acquired":true,"shares":1631,"price":66.795,"value":108942.645,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":538507,"source":{"system":"sec-edgar","filing":"0001493152-26-042615","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226042615/ownership.xml","form_type":"4"}},{"id":4614515,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-09-10T20:05:18.000Z","date":"2026-09-09","kind":"purchase","planned":false,"acquired":true,"shares":5836,"price":2.0899,"value":12196.6564,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.085 to $2.09. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2775229,"source":{"system":"sec-edgar","filing":"0001493152-26-042152","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226042152/ownership.xml","form_type":"4"}},{"id":4614514,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-09-10T20:05:18.000Z","date":"2026-09-08","kind":"purchase","planned":false,"acquired":true,"shares":9393,"price":2.0972,"value":19698.9996,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.095 to $2.10. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2769393,"source":{"system":"sec-edgar","filing":"0001493152-26-042152","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226042152/ownership.xml","form_type":"4"}},{"id":4613959,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-09-09T23:18:23.000Z","date":"2026-09-09","kind":"purchase","planned":false,"acquired":true,"shares":3097,"price":68.705,"value":212779.385,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":536876,"source":{"system":"sec-edgar","filing":"0001493152-26-042023","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226042023/ownership.xml","form_type":"4"}},{"id":4613958,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-09-09T23:18:23.000Z","date":"2026-09-08","kind":"purchase","planned":false,"acquired":true,"shares":471,"price":69.37,"value":32673.27,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":533779,"source":{"system":"sec-edgar","filing":"0001493152-26-042023","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226042023/ownership.xml","form_type":"4"}},{"id":4613957,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-09-09T23:18:23.000Z","date":"2026-09-08","kind":"purchase","planned":false,"acquired":true,"shares":3390,"price":68.7403,"value":233029.617,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $68.50-$68.99 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":533308,"source":{"system":"sec-edgar","filing":"0001493152-26-042023","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226042023/ownership.xml","form_type":"4"}},{"id":4613956,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-09-09T23:18:23.000Z","date":"2026-09-04","kind":"purchase","planned":false,"acquired":true,"shares":2100,"price":68.98,"value":144858.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":529918,"source":{"system":"sec-edgar","filing":"0001493152-26-042023","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226042023/ownership.xml","form_type":"4"}},{"id":4613955,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-09-09T23:18:23.000Z","date":"2026-09-04","kind":"purchase","planned":false,"acquired":true,"shares":918,"price":69.52,"value":63819.36,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $68.42-$68.75 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."}],"balance_after":527818,"source":{"system":"sec-edgar","filing":"0001493152-26-042023","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226042023/ownership.xml","form_type":"4"}},{"id":1899,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-09-03T20:05:22.000Z","date":"2026-09-02","kind":"purchase","planned":false,"acquired":true,"shares":900,"price":68.9489,"value":62054.01,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $68.94-$68.95 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":526900,"source":{"system":"sec-edgar","filing":"0001493152-26-041363","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226041363/ownership.xml","form_type":"4"}},{"id":1898,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-09-03T20:05:22.000Z","date":"2026-09-01","kind":"purchase","planned":false,"acquired":true,"shares":783,"price":69.52,"value":54434.16,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":526000,"source":{"system":"sec-edgar","filing":"0001493152-26-041363","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226041363/ownership.xml","form_type":"4"}},{"id":671983,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-08-31T22:24:01.000Z","date":"2026-08-31","kind":"purchase","planned":false,"acquired":true,"shares":217,"price":69.1,"value":14994.7,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":525217,"source":{"system":"sec-edgar","filing":"0001493152-26-040895","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226040895/ownership.xml","form_type":"4"}},{"id":671982,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-08-31T22:24:01.000Z","date":"2026-08-31","kind":"purchase","planned":false,"acquired":true,"shares":5000,"price":68.235,"value":341175.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":525000,"source":{"system":"sec-edgar","filing":"0001493152-26-040895","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226040895/ownership.xml","form_type":"4"}},{"id":671981,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-08-31T22:24:01.000Z","date":"2026-08-28","kind":"purchase","planned":false,"acquired":true,"shares":5000,"price":68.81,"value":344050.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":520000,"source":{"system":"sec-edgar","filing":"0001493152-26-040895","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226040895/ownership.xml","form_type":"4"}},{"id":671980,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-08-31T22:24:01.000Z","date":"2026-08-28","kind":"purchase","planned":false,"acquired":true,"shares":20113,"price":68.4203,"value":1376137.4939,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $66.15-$69.77 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":515000,"source":{"system":"sec-edgar","filing":"0001493152-26-040895","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226040895/ownership.xml","form_type":"4"}},{"id":671979,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-08-31T22:24:01.000Z","date":"2026-08-28","kind":"purchase","planned":false,"acquired":true,"shares":10000,"price":71.3969,"value":713969.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $69.145-$74.77 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":494887,"source":{"system":"sec-edgar","filing":"0001493152-26-040895","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226040895/ownership.xml","form_type":"4"}},{"id":681265,"issuer":{"id":7266,"kind":"organization","name":"Grace Therapeutics, Inc.","symbol":"GRCE"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.0001 per share","published_at":"2026-08-19T11:44:39.000Z","date":"2026-08-14","kind":"purchase","planned":false,"acquired":true,"shares":11608,"price":2.0853,"value":24206.1624,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.05 to $2.09. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2760000,"source":{"system":"sec-edgar","filing":"0001493152-26-039124","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1444192/000149315226039124/ownership.xml","form_type":"4"}},{"id":686911,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-08-14T20:05:22.000Z","date":"2026-08-12","kind":"purchase","planned":false,"acquired":true,"shares":951,"price":71.5,"value":67996.5,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":494887,"source":{"system":"sec-edgar","filing":"0001493152-26-038304","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226038304/ownership.xml","form_type":"4"}},{"id":696833,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-08-04T20:50:08.000Z","date":"2026-08-03","kind":"purchase","planned":false,"acquired":true,"shares":50000,"price":8,"value":400000.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":3048223,"source":{"system":"sec-edgar","filing":"0001493152-26-036015","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226036015/ownership.xml","form_type":"4"}},{"id":696832,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-08-04T20:50:08.000Z","date":"2026-07-31","kind":"purchase","planned":false,"acquired":true,"shares":2900,"price":7.9226,"value":22975.54,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.855 to $7.95. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2998223,"source":{"system":"sec-edgar","filing":"0001493152-26-036015","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226036015/ownership.xml","form_type":"4"}},{"id":702052,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-07-28T20:05:29.000Z","date":"2026-07-24","kind":"purchase","planned":false,"acquired":true,"shares":130,"price":7.9,"value":1027.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2995323,"source":{"system":"sec-edgar","filing":"0001493152-26-035000","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226035000/ownership.xml","form_type":"4"}},{"id":703363,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-07-24T20:05:18.000Z","date":"2026-07-23","kind":"purchase","planned":false,"acquired":true,"shares":49849,"price":7.7953,"value":388587.9097,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.655 to $7.8667. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2995193,"source":{"system":"sec-edgar","filing":"0001493152-26-034560","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226034560/ownership.xml","form_type":"4"}},{"id":703362,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-07-24T20:05:18.000Z","date":"2026-07-22","kind":"purchase","planned":false,"acquired":true,"shares":10000,"price":7.8337,"value":78337.0,"ownership":{"direct":false,"nature":"By Managed Account"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.75 to $7.90. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":100000,"source":{"system":"sec-edgar","filing":"0001493152-26-034560","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226034560/ownership.xml","form_type":"4"}},{"id":703361,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-07-24T20:05:18.000Z","date":"2026-07-22","kind":"purchase","planned":false,"acquired":true,"shares":140237,"price":7.8337,"value":1098574.5869,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.75 to $7.90. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2945344,"source":{"system":"sec-edgar","filing":"0001493152-26-034560","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226034560/ownership.xml","form_type":"4"}},{"id":706882,"issuer":{"id":4598,"kind":"organization","name":"Eton Pharmaceuticals, Inc.","symbol":"ETON"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-07-17T23:12:15.000Z","date":"2026-07-14","kind":"sale","planned":false,"acquired":false,"shares":13315,"price":37.5431,"value":499886.3765,"ownership":{"direct":false,"nature":"By Managed Account"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":40000,"source":{"system":"sec-edgar","filing":"0001493152-26-033818","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1710340/000149315226033818/ownership.xml","form_type":"4/A","original_submission_date":"2026-07-16"}},{"id":706881,"issuer":{"id":4598,"kind":"organization","name":"Eton Pharmaceuticals, Inc.","symbol":"ETON"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-07-17T23:12:15.000Z","date":"2026-07-14","kind":"sale","planned":false,"acquired":false,"shares":15000,"price":37.5431,"value":563146.5,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2665000,"source":{"system":"sec-edgar","filing":"0001493152-26-033818","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1710340/000149315226033818/ownership.xml","form_type":"4/A","original_submission_date":"2026-07-16"}},{"id":708064,"issuer":{"id":4598,"kind":"organization","name":"Eton Pharmaceuticals, Inc.","symbol":"ETON"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-07-16T21:14:32.000Z","date":"2026-07-14","kind":"sale","planned":false,"acquired":false,"shares":13315,"price":37.5431,"value":499886.3765,"ownership":{"direct":false,"nature":"By Managed Account"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":40000,"source":{"system":"sec-edgar","filing":"0001493152-26-033577","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1710340/000149315226033577/ownership.xml","form_type":"4"}},{"id":708063,"issuer":{"id":4598,"kind":"organization","name":"Eton Pharmaceuticals, Inc.","symbol":"ETON"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-07-16T21:14:32.000Z","date":"2026-07-14","kind":"sale","planned":false,"acquired":false,"shares":15000,"price":37.5431,"value":563146.5,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.0152 to $37.9148 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2665000,"source":{"system":"sec-edgar","filing":"0001493152-26-033577","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1710340/000149315226033577/ownership.xml","form_type":"4"}},{"id":708981,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-07-15T20:05:26.000Z","date":"2026-07-14","kind":"purchase","planned":false,"acquired":true,"shares":920,"price":73.4304,"value":67555.968,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $73.34-$73.50 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":493936,"source":{"system":"sec-edgar","filing":"0001493152-26-033354","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226033354/ownership.xml","form_type":"4"}},{"id":708980,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-07-15T20:05:26.000Z","date":"2026-07-13","kind":"purchase","planned":false,"acquired":true,"shares":775,"price":73.8873,"value":57262.6575,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $73.75-$73.95 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":493016,"source":{"system":"sec-edgar","filing":"0001493152-26-033354","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226033354/ownership.xml","form_type":"4"}},{"id":711156,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-07-10T20:41:41.000Z","date":"2026-07-10","kind":"purchase","planned":false,"acquired":true,"shares":229,"price":73.95,"value":16934.55,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":492241,"source":{"system":"sec-edgar","filing":"0001493152-26-032859","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226032859/ownership.xml","form_type":"4"}},{"id":711155,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-07-10T20:41:41.000Z","date":"2026-07-08","kind":"purchase","planned":false,"acquired":true,"shares":300,"price":73.69,"value":22107.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $73.475-$73.845 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":492012,"source":{"system":"sec-edgar","filing":"0001493152-26-032859","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226032859/ownership.xml","form_type":"4"}},{"id":713633,"issuer":{"id":4598,"kind":"organization","name":"Eton Pharmaceuticals, Inc.","symbol":"ETON"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-07-07T22:29:38.000Z","date":"2026-07-07","kind":"sale","planned":false,"acquired":false,"shares":6685,"price":38.3728,"value":256522.168,"ownership":{"direct":false,"nature":"By Managed Account"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $38.00 to $38.565 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":53315,"source":{"system":"sec-edgar","filing":"0001493152-26-032394","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1710340/000149315226032394/ownership.xml","form_type":"4"}},{"id":713632,"issuer":{"id":4598,"kind":"organization","name":"Eton Pharmaceuticals, Inc.","symbol":"ETON"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-07-07T22:29:38.000Z","date":"2026-07-07","kind":"sale","planned":false,"acquired":false,"shares":20000,"price":38.3728,"value":767456.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $38.00 to $38.565 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2680000,"source":{"system":"sec-edgar","filing":"0001493152-26-032394","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1710340/000149315226032394/ownership.xml","form_type":"4"}},{"id":713631,"issuer":{"id":4598,"kind":"organization","name":"Eton Pharmaceuticals, Inc.","symbol":"ETON"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-07-07T22:29:38.000Z","date":"2026-07-06","kind":"sale","planned":false,"acquired":false,"shares":10000,"price":38,"value":380000.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2700000,"source":{"system":"sec-edgar","filing":"0001493152-26-032394","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1710340/000149315226032394/ownership.xml","form_type":"4"}},{"id":713630,"issuer":{"id":4598,"kind":"organization","name":"Eton Pharmaceuticals, Inc.","symbol":"ETON"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-07-07T22:29:38.000Z","date":"2026-07-02","kind":"sale","planned":false,"acquired":false,"shares":25000,"price":37.3851,"value":934627.5,"ownership":{"direct":false,"nature":"By Managed Account"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.05 to $37.85 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":60000,"source":{"system":"sec-edgar","filing":"0001493152-26-032394","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1710340/000149315226032394/ownership.xml","form_type":"4"}},{"id":713629,"issuer":{"id":4598,"kind":"organization","name":"Eton Pharmaceuticals, Inc.","symbol":"ETON"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-07-07T22:29:38.000Z","date":"2026-07-02","kind":"sale","planned":false,"acquired":false,"shares":65000,"price":37.3851,"value":2430031.5,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.05 to $37.85 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2710000,"source":{"system":"sec-edgar","filing":"0001493152-26-032394","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1710340/000149315226032394/ownership.xml","form_type":"4"}},{"id":717995,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-07-02T22:11:30.000Z","date":"2026-07-02","kind":"purchase","planned":false,"acquired":true,"shares":1400,"price":71.9707,"value":100758.98,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $71.96-$71.99 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":491712,"source":{"system":"sec-edgar","filing":"0001493152-26-031991","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226031991/ownership.xml","form_type":"4"}},{"id":717994,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share","published_at":"2026-07-02T22:11:30.000Z","date":"2026-07-01","kind":"purchase","planned":false,"acquired":true,"shares":312,"price":71.99,"value":22460.88,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":490312,"source":{"system":"sec-edgar","filing":"0001493152-26-031991","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226031991/ownership.xml","form_type":"4"}},{"id":723713,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-06-29T20:05:05.000Z","date":"2026-06-26","kind":"purchase","planned":false,"acquired":true,"shares":152336,"price":6.4017,"value":975209.3712,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.335 to $6.50. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2805107,"source":{"system":"sec-edgar","filing":"0001493152-26-031063","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226031063/ownership.xml","form_type":"4"}},{"id":723712,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-06-29T20:05:05.000Z","date":"2026-06-25","kind":"purchase","planned":false,"acquired":true,"shares":197,"price":6.5,"value":1280.5,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2652771,"source":{"system":"sec-edgar","filing":"0001493152-26-031063","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226031063/ownership.xml","form_type":"4"}},{"id":737429,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-06-16T00:10:31.000Z","date":"2026-06-15","kind":"purchase","planned":false,"acquired":true,"shares":4550,"price":5.9896,"value":27252.68,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.97 to $5.9896. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2652574,"source":{"system":"sec-edgar","filing":"0001493152-26-028783","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226028783/ownership.xml","form_type":"4"}},{"id":737428,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-06-16T00:10:31.000Z","date":"2026-06-12","kind":"purchase","planned":false,"acquired":true,"shares":273,"price":5.9321,"value":1619.4633,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.9275 to $5.94. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2648024,"source":{"system":"sec-edgar","filing":"0001493152-26-028783","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226028783/ownership.xml","form_type":"4"}},{"id":737427,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-06-16T00:10:31.000Z","date":"2026-06-11","kind":"purchase","planned":false,"acquired":true,"shares":2862,"price":5.9053,"value":16900.9686,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.87 to $5.91. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2647751,"source":{"system":"sec-edgar","filing":"0001493152-26-028783","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226028783/ownership.xml","form_type":"4"}},{"id":741223,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-06-11T20:05:15.000Z","date":"2026-06-10","kind":"purchase","planned":false,"acquired":true,"shares":5872,"price":5.9873,"value":35157.4256,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.925 to $5.99. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2644889,"source":{"system":"sec-edgar","filing":"0001493152-26-028276","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226028276/ownership.xml","form_type":"4"}},{"id":741222,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-06-11T20:05:15.000Z","date":"2026-06-09","kind":"purchase","planned":false,"acquired":true,"shares":24856,"price":5.9758,"value":148534.4848,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.9465 to $5.99. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2639017,"source":{"system":"sec-edgar","filing":"0001493152-26-028276","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226028276/ownership.xml","form_type":"4"}},{"id":744237,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-06-09T20:05:28.000Z","date":"2026-06-05","kind":"purchase","planned":false,"acquired":true,"shares":10054,"price":5.8281,"value":58595.7174,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.82 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2614161,"source":{"system":"sec-edgar","filing":"0001493152-26-027927","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226027927/ownership.xml","form_type":"4"}},{"id":758414,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-05-29T23:21:38.000Z","date":"2026-05-29","kind":"purchase","planned":false,"acquired":true,"shares":70577,"price":5.8999,"value":416397.2423,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.88 to $5.90. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2604107,"source":{"system":"sec-edgar","filing":"0001493152-26-026472","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226026472/ownership.xml","form_type":"4"}},{"id":758413,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-05-29T23:21:38.000Z","date":"2026-05-28","kind":"purchase","planned":false,"acquired":true,"shares":2000,"price":5.832,"value":11664.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.82 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2533530,"source":{"system":"sec-edgar","filing":"0001493152-26-026472","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226026472/ownership.xml","form_type":"4"}},{"id":758412,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-05-29T23:21:38.000Z","date":"2026-05-27","kind":"purchase","planned":false,"acquired":true,"shares":1161,"price":5.73,"value":6652.53,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2531530,"source":{"system":"sec-edgar","filing":"0001493152-26-026472","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226026472/ownership.xml","form_type":"4"}},{"id":765395,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-05-22T20:05:27.000Z","date":"2026-05-21","kind":"purchase","planned":false,"acquired":true,"shares":15945,"price":5.7,"value":90886.5,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2530369,"source":{"system":"sec-edgar","filing":"0001493152-26-025011","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226025011/ownership.xml","form_type":"4"}},{"id":765394,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-05-22T20:05:27.000Z","date":"2026-05-20","kind":"purchase","planned":false,"acquired":true,"shares":8431,"price":5.89,"value":49658.59,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2514424,"source":{"system":"sec-edgar","filing":"0001493152-26-025011","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226025011/ownership.xml","form_type":"4"}},{"id":765970,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share.","published_at":"2026-05-22T20:05:21.000Z","date":"2026-05-20","kind":"purchase","planned":false,"acquired":true,"shares":1563,"price":64.4349,"value":100711.7487,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $63.97-$64.50 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":490000,"source":{"system":"sec-edgar","filing":"0001493152-26-025013","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226025013/ownership.xml","form_type":"4"}},{"id":771278,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-05-19T20:05:10.000Z","date":"2026-05-18","kind":"purchase","planned":false,"acquired":true,"shares":17395,"price":5.6926,"value":99022.777,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.60 to $5.87. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2505993,"source":{"system":"sec-edgar","filing":"0001493152-26-024411","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226024411/ownership.xml","form_type":"4"}},{"id":771277,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-05-19T20:05:10.000Z","date":"2026-05-15","kind":"purchase","planned":false,"acquired":true,"shares":16648,"price":5.8257,"value":96986.2536,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.75 to $5.83. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2488598,"source":{"system":"sec-edgar","filing":"0001493152-26-024411","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226024411/ownership.xml","form_type":"4"}},{"id":779186,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share.","published_at":"2026-05-14T20:05:04.000Z","date":"2026-05-13","kind":"purchase","planned":false,"acquired":true,"shares":1937,"price":66.8701,"value":129527.3837,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $66.00-$67.3820 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":488437,"source":{"system":"sec-edgar","filing":"0001493152-26-023056","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226023056/ownership.xml","form_type":"4"}},{"id":779185,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share.","published_at":"2026-05-14T20:05:04.000Z","date":"2026-05-12","kind":"purchase","planned":false,"acquired":true,"shares":1500,"price":67.9833,"value":101974.95,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $67.95-$68.00 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":486500,"source":{"system":"sec-edgar","filing":"0001493152-26-023056","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226023056/ownership.xml","form_type":"4"}},{"id":793706,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-05-04T20:05:14.000Z","date":"2026-05-01","kind":"sale","planned":false,"acquired":false,"shares":500,"price":16.1105,"value":8055.25,"ownership":{"direct":false,"nature":"By Managed account"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00-$16.28 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":5000,"source":{"system":"sec-edgar","filing":"0001493152-26-021104","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226021104/ownership.xml","form_type":"4"}},{"id":793705,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-05-04T20:05:14.000Z","date":"2026-05-01","kind":"sale","planned":false,"acquired":false,"shares":10081,"price":16.1105,"value":162409.9505,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.00-$16.28 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":853569,"source":{"system":"sec-edgar","filing":"0001493152-26-021104","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226021104/ownership.xml","form_type":"4"}},{"id":793704,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-05-04T20:05:14.000Z","date":"2026-04-30","kind":"sale","planned":false,"acquired":false,"shares":1000,"price":16.151,"value":16151.0,"ownership":{"direct":false,"nature":"By Managed account"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.10-$16.775 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":5500,"source":{"system":"sec-edgar","filing":"0001493152-26-021104","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226021104/ownership.xml","form_type":"4"}},{"id":793703,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-05-04T20:05:14.000Z","date":"2026-04-30","kind":"sale","planned":false,"acquired":false,"shares":24000,"price":16.151,"value":387624.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.10-$16.775 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":863650,"source":{"system":"sec-edgar","filing":"0001493152-26-021104","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226021104/ownership.xml","form_type":"4"}},{"id":796766,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-04-30T20:10:03.000Z","date":"2026-04-29","kind":"sale","planned":false,"acquired":false,"shares":1000,"price":17.2476,"value":17247.6,"ownership":{"direct":false,"nature":"By Managed account"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.58-$17.51 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":6500,"source":{"system":"sec-edgar","filing":"0001493152-26-020494","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226020494/ownership.xml","form_type":"4"}},{"id":796765,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-04-30T20:10:03.000Z","date":"2026-04-29","kind":"sale","planned":false,"acquired":false,"shares":23360,"price":17.2476,"value":402903.936,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.58-$17.51 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":887650,"source":{"system":"sec-edgar","filing":"0001493152-26-020494","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226020494/ownership.xml","form_type":"4"}},{"id":796764,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-04-30T20:10:03.000Z","date":"2026-04-28","kind":"sale","planned":false,"acquired":false,"shares":2500,"price":18.4674,"value":46168.5,"ownership":{"direct":false,"nature":"By Managed account"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.41-$18.6615 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":7500,"source":{"system":"sec-edgar","filing":"0001493152-26-020494","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226020494/ownership.xml","form_type":"4"}},{"id":796763,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-04-30T20:10:03.000Z","date":"2026-04-28","kind":"sale","planned":false,"acquired":false,"shares":43788,"price":18.4674,"value":808650.5112,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.41-$18.6615 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":911010,"source":{"system":"sec-edgar","filing":"0001493152-26-020494","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226020494/ownership.xml","form_type":"4"}},{"id":803601,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-04-21T22:17:43.000Z","date":"2026-04-21","kind":"sale","planned":false,"acquired":false,"shares":202,"price":20.5025,"value":4141.505,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":954798,"source":{"system":"sec-edgar","filing":"0001493152-26-018387","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226018387/ownership.xml","form_type":"4"}},{"id":803600,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-04-21T22:17:43.000Z","date":"2026-04-17","kind":"sale","planned":false,"acquired":false,"shares":5000,"price":20.4611,"value":102305.5,"ownership":{"direct":false,"nature":"By Managed account"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $20.17-$21.00 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":10000,"source":{"system":"sec-edgar","filing":"0001493152-26-018387","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226018387/ownership.xml","form_type":"4"}},{"id":803599,"issuer":{"id":7321,"kind":"organization","name":"SANUWAVE Health, Inc."},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, par value $0.001 per share","published_at":"2026-04-21T22:17:43.000Z","date":"2026-04-17","kind":"sale","planned":false,"acquired":false,"shares":11267,"price":20.4611,"value":230535.2137,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $20.17-$21.00 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":955000,"source":{"system":"sec-edgar","filing":"0001493152-26-018387","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1417663/000149315226018387/ownership.xml","form_type":"4"}},{"id":823932,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-31T20:05:19.000Z","date":"2026-03-30","kind":"purchase","planned":false,"acquired":true,"shares":1850,"price":4.9873,"value":9226.505,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2471850,"source":{"system":"sec-edgar","filing":"0001493152-26-014123","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226014123/ownership.xml","form_type":"4"}},{"id":823931,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-31T20:05:19.000Z","date":"2026-03-27","kind":"purchase","planned":false,"acquired":true,"shares":10000,"price":5.0792,"value":50792.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.0674 to $5.0909. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2470000,"source":{"system":"sec-edgar","filing":"0001493152-26-014123","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226014123/ownership.xml","form_type":"4"}},{"id":827162,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-26T22:57:51.000Z","date":"2026-03-26","kind":"purchase","planned":false,"acquired":true,"shares":7319,"price":5.2842,"value":38675.0598,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.159 to $5.3243. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2460000,"source":{"system":"sec-edgar","filing":"0001493152-26-013022","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226013022/ownership.xml","form_type":"4"}},{"id":827161,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-26T22:57:51.000Z","date":"2026-03-25","kind":"purchase","planned":false,"acquired":true,"shares":8581,"price":5.4281,"value":46578.5261,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.39 to $5.50. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2452681,"source":{"system":"sec-edgar","filing":"0001493152-26-013022","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226013022/ownership.xml","form_type":"4"}},{"id":827160,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-26T22:57:51.000Z","date":"2026-03-24","kind":"purchase","planned":false,"acquired":true,"shares":4182,"price":5.59,"value":23377.38,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2444100,"source":{"system":"sec-edgar","filing":"0001493152-26-013022","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226013022/ownership.xml","form_type":"4"}},{"id":829347,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share.","published_at":"2026-03-24T20:05:20.000Z","date":"2026-03-24","kind":"purchase","planned":false,"acquired":true,"shares":5000,"price":72,"value":360000.0,"ownership":{"direct":false,"nature":"By Managed Account"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"Securities owned by a separately managed account (the \"Managed Account\"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":15000,"source":{"system":"sec-edgar","filing":"0001493152-26-012354","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226012354/ownership.xml","form_type":"4"}},{"id":829346,"issuer":{"id":1558,"kind":"organization","name":"Sol-Gel Technologies Ltd.","symbol":"SLGL"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value NIS 1.00 per share.","published_at":"2026-03-24T20:05:20.000Z","date":"2026-03-24","kind":"purchase","planned":false,"acquired":true,"shares":34665,"price":72,"value":2495880.0,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":485000,"source":{"system":"sec-edgar","filing":"0001493152-26-012354","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1684693/000149315226012354/ownership.xml","form_type":"4"}},{"id":831999,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-20T20:54:32.000Z","date":"2026-03-19","kind":"purchase","planned":false,"acquired":true,"shares":2094,"price":5.707,"value":11950.458,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.699 to $5.75. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2439918,"source":{"system":"sec-edgar","filing":"0001493152-26-011902","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226011902/ownership.xml","form_type":"4"}},{"id":831998,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-20T20:54:32.000Z","date":"2026-03-18","kind":"purchase","planned":false,"acquired":true,"shares":2481,"price":5.749,"value":14263.269,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.749 to $5.75. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2437824,"source":{"system":"sec-edgar","filing":"0001493152-26-011902","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226011902/ownership.xml","form_type":"4"}},{"id":834511,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-18T22:55:08.000Z","date":"2026-03-16","kind":"purchase","planned":false,"acquired":true,"shares":1331,"price":5.782,"value":7695.842,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.76 to $5.79. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2435343,"source":{"system":"sec-edgar","filing":"0001493152-26-011391","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226011391/ownership.xml","form_type":"4"}},{"id":843538,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-13T22:43:57.000Z","date":"2026-03-13","kind":"purchase","planned":false,"acquired":true,"shares":7358,"price":5.747,"value":42286.426,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.696 to $5.75. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2434012,"source":{"system":"sec-edgar","filing":"0001493152-26-010130","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226010130/ownership.xml","form_type":"4"}},{"id":843537,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-13T22:43:57.000Z","date":"2026-03-12","kind":"purchase","planned":false,"acquired":true,"shares":5708,"price":5.8543,"value":33416.3444,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.84 to $5.859. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2426654,"source":{"system":"sec-edgar","filing":"0001493152-26-010130","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226010130/ownership.xml","form_type":"4"}},{"id":850306,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-10T22:47:04.000Z","date":"2026-03-09","kind":"purchase","planned":false,"acquired":true,"shares":2179,"price":5.8477,"value":12742.1383,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.785 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2420946,"source":{"system":"sec-edgar","filing":"0001493152-26-009591","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226009591/ownership.xml","form_type":"4"}},{"id":850305,"issuer":{"id":6339,"kind":"organization","name":"Alpha Cognition Inc.","symbol":"ACOG"},"owners":[{"id":1559,"kind":"organization","name":"Opaleye Management Inc.","position":1,"cik":"0001595855","reported_name":"Opaleye Management Inc.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock, no par value","published_at":"2026-03-10T22:47:04.000Z","date":"2026-03-06","kind":"purchase","planned":false,"acquired":true,"shares":1900,"price":5.7989,"value":11017.91,"ownership":{"direct":false,"nature":"By Opaleye, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.70 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Represents securities owned directly by Opaleye, L.P. (the \"Fund\"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose."}],"balance_after":2418767,"source":{"system":"sec-edgar","filing":"0001493152-26-009591","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1595855/000149315226009591/ownership.xml","form_type":"4"}}],"next_cursor":"2026-03-10T22:47:04.000000Z,850305"}