{"transactions":[{"id":2892704,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2021-01-29T00:22:03.000Z","date":"2021-01-26","kind":"sale","acquired":false,"shares":28333,"price":63.7353,"value":1805812.2549,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.00 to $64.00, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) of this Form 4."}],"balance_after":2021,"source":{"system":"sec-edgar","filing":"0000874015-21-000051","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000051/edgar.xml","form_type":"4"}},{"id":2898285,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2021-01-26T01:24:13.000Z","date":"2021-01-22","kind":"sale","acquired":false,"shares":40000,"price":61.675,"value":2467000.0,"ownership":{"direct":false,"nature":"By trust"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.00 to $62.00, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) of this Form 4."}],"balance_after":494391,"source":{"system":"sec-edgar","filing":"0000874015-21-000047","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000047/edgar.xml","form_type":"4"}},{"id":2898284,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2021-01-26T01:24:13.000Z","date":"2021-01-21","kind":"sale","acquired":false,"shares":21042,"price":61.65,"value":1297239.3,"ownership":{"direct":false,"nature":"By trust"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.25 to $62.15, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) of this Form 4."}],"balance_after":534391,"source":{"system":"sec-edgar","filing":"0000874015-21-000047","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000047/edgar.xml","form_type":"4"}},{"id":2898283,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2021-01-26T01:24:13.000Z","date":"2021-01-21","kind":"sale","acquired":false,"shares":13958,"price":60.53,"value":844877.74,"ownership":{"direct":false,"nature":"By trust"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.20 to $61.00, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) of this Form 4."}],"balance_after":555433,"source":{"system":"sec-edgar","filing":"0000874015-21-000047","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000047/edgar.xml","form_type":"4"}},{"id":2903412,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Restricted Stock Units","published_at":"2021-01-21T00:12:13.000Z","date":"2021-01-15","kind":"exercise","acquired":false,"shares":4371,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."}],"balance_after":7801,"derivative":{"underlying":"Common Stock","underlying_shares":4371},"source":{"system":"sec-edgar","filing":"0000874015-21-000045","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000045/edgar.xml","form_type":"4"}},{"id":2903411,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Restricted Stock Units","published_at":"2021-01-21T00:12:13.000Z","date":"2021-01-15","kind":"exercise","acquired":false,"shares":47257,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."}],"balance_after":87885,"derivative":{"underlying":"Common Stock","underlying_shares":47257},"source":{"system":"sec-edgar","filing":"0000874015-21-000045","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000045/edgar.xml","form_type":"4"}},{"id":2903410,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Restricted Stock Units","published_at":"2021-01-21T00:12:13.000Z","date":"2021-01-15","kind":"grant","acquired":true,"shares":5333,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F3","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."}],"balance_after":5333,"derivative":{"underlying":"Common Stock","underlying_shares":5333},"source":{"system":"sec-edgar","filing":"0000874015-21-000045","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000045/edgar.xml","form_type":"4"}},{"id":2903409,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2021-01-21T00:12:13.000Z","date":"2021-01-15","kind":"tax_withholding","acquired":false,"shares":1434,"price":61.28,"value":87875.52,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Shares withheld to cover the required tax withholding obligations pursuant to the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"shares","element":"transactionShares","label":"F2","text":"Shares withheld to cover the required tax withholding obligations pursuant to the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."}],"balance_after":3111,"source":{"system":"sec-edgar","filing":"0000874015-21-000045","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000045/edgar.xml","form_type":"4"}},{"id":2903408,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2021-01-21T00:12:13.000Z","date":"2021-01-15","kind":"exercise","acquired":true,"shares":4371,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":4545,"source":{"system":"sec-edgar","filing":"0000874015-21-000045","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000045/edgar.xml","form_type":"4"}},{"id":2903407,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2021-01-21T00:12:13.000Z","date":"2021-01-15","kind":"tax_withholding","acquired":false,"shares":18924,"price":61.28,"value":1159662.72,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Shares withheld to cover the required tax withholding obligations pursuant to the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"shares","element":"transactionShares","label":"F2","text":"Shares withheld to cover the required tax withholding obligations pursuant to the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."}],"balance_after":30354,"source":{"system":"sec-edgar","filing":"0000874015-21-000045","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000045/edgar.xml","form_type":"4"}},{"id":2903406,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2021-01-21T00:12:13.000Z","date":"2021-01-15","kind":"exercise","acquired":true,"shares":47257,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":49278,"source":{"system":"sec-edgar","filing":"0000874015-21-000045","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000045/edgar.xml","form_type":"4"}},{"id":2917370,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Employee Stock Option (right to buy)","published_at":"2021-01-07T02:20:16.000Z","date":"2021-01-04","kind":"grant","acquired":true,"shares":12000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/04/2021 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on 01/04/2021. 25% of the shares subject to the option will vest and become exercisable on 01/04/2022.  Thereafter, the remaining shares subject to the option will vest and become exercisable in 36 equal monthly installments over the next 3 years."}],"balance_after":12000,"derivative":{"exercise_price":56.78,"exercise_date":"2022-01-04","expiration_date":"2028-01-03","underlying":"Common Stock","underlying_shares":12000},"source":{"system":"sec-edgar","filing":"0000874015-21-000017","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000017/edgar.xml","form_type":"4"}},{"id":2917369,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Common Stock","published_at":"2021-01-07T02:17:40.000Z","date":"2020-11-19","kind":"gift","acquired":false,"shares":31000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By trust"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents a bona fide gift to a charitable organization."}],"balance_after":569391,"source":{"system":"sec-edgar","filing":"0000874015-21-000015","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401521000015/edgar.xml","form_type":"5"}},{"id":2941093,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-12-18T00:42:41.000Z","date":"2020-12-17","kind":"sale","acquired":false,"shares":1407,"price":50.5,"value":71053.5,"ownership":{"direct":false,"nature":"by wife"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person's wife on January 2, 2020."}],"balance_after":174,"source":{"system":"sec-edgar","filing":"0000874015-20-000172","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000172/edgar.xml","form_type":"4"}},{"id":2941092,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-12-18T00:42:41.000Z","date":"2020-12-15","kind":"sale","acquired":false,"shares":39000,"price":49.775,"value":1941225.0,"ownership":{"direct":false,"nature":"by trust"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.50 to $50.00, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) of this Form 4."}],"balance_after":600391,"source":{"system":"sec-edgar","filing":"0000874015-20-000172","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000172/edgar.xml","form_type":"4"}},{"id":2952557,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-12-10T01:14:17.000Z","date":"2020-12-07","kind":"sale","acquired":false,"shares":6000,"price":51.5,"value":309000.0,"ownership":{"direct":false,"nature":"by trust"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."}],"balance_after":639391,"source":{"system":"sec-edgar","filing":"0000874015-20-000170","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000170/edgar.xml","form_type":"4"}},{"id":2952556,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-12-10T01:14:17.000Z","date":"2020-12-07","kind":"sale","acquired":false,"shares":5000,"price":51.8701,"value":259350.5,"ownership":{"direct":false,"nature":"by trust"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."}],"balance_after":645391,"source":{"system":"sec-edgar","filing":"0000874015-20-000170","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000170/edgar.xml","form_type":"4"}},{"id":2964817,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2020-11-30T23:48:21.000Z","date":"2020-11-25","kind":"exercise","acquired":false,"shares":12990,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":39.87,"exercise_date":"2015-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":0},"source":{"system":"sec-edgar","filing":"0000874015-20-000158","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000158/edgar.xml","form_type":"4"}},{"id":2964816,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-11-30T23:48:21.000Z","date":"2020-11-25","kind":"sale","acquired":false,"shares":12990,"price":50.05,"value":650149.5,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on March 13, 2019."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.85 to $50.25, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) of this Form 4."}],"balance_after":2021,"source":{"system":"sec-edgar","filing":"0000874015-20-000158","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000158/edgar.xml","form_type":"4"}},{"id":2964815,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-11-30T23:48:21.000Z","date":"2020-11-25","kind":"exercise","acquired":true,"shares":12990,"price":39.87,"value":517911.3,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option that was scheduled to expire on 1/1/21.  The purchase reported on this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on March 13, 2019."}],"balance_after":15011,"source":{"system":"sec-edgar","filing":"0000874015-20-000158","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000158/edgar.xml","form_type":"4"}},{"id":2966918,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2020-11-26T00:04:19.000Z","date":"2020-11-24","kind":"exercise","acquired":false,"shares":2590,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":12990,"derivative":{"exercise_price":39.87,"exercise_date":"2015-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":0},"source":{"system":"sec-edgar","filing":"0000874015-20-000152","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000152/edgar.xml","form_type":"4"}},{"id":2966917,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2020-11-26T00:04:19.000Z","date":"2020-11-23","kind":"exercise","acquired":false,"shares":11600,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":15580,"derivative":{"exercise_price":39.87,"exercise_date":"2015-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":0},"source":{"system":"sec-edgar","filing":"0000874015-20-000152","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000152/edgar.xml","form_type":"4"}},{"id":2966916,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2020-11-26T00:04:19.000Z","date":"2020-11-23","kind":"exercise","acquired":false,"shares":500,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"by wife"},"balance_after":0,"derivative":{"exercise_price":39.87,"exercise_date":"2015-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":0},"source":{"system":"sec-edgar","filing":"0000874015-20-000152","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000152/edgar.xml","form_type":"4"}},{"id":2966915,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-11-26T00:04:19.000Z","date":"2020-11-24","kind":"sale","acquired":false,"shares":2590,"price":50.83,"value":131649.7,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on March 13, 2019."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.50 to $51.00, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (6) of this Form 4."}],"balance_after":2021,"source":{"system":"sec-edgar","filing":"0000874015-20-000152","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000152/edgar.xml","form_type":"4"}},{"id":2966914,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-11-26T00:04:19.000Z","date":"2020-11-24","kind":"exercise","acquired":true,"shares":2590,"price":39.87,"value":103263.3,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"Acquired as a result of exercising a stock option that was scheduled to expire on 1/1/21.  The purchase reported on this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on March 13, 2019."}],"balance_after":4611,"source":{"system":"sec-edgar","filing":"0000874015-20-000152","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000152/edgar.xml","form_type":"4"}},{"id":2966913,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-11-26T00:04:19.000Z","date":"2020-11-23","kind":"sale","acquired":false,"shares":11600,"price":50.11,"value":581276.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on March 13, 2019."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.00 to $50.25, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (5) of this Form 4."}],"balance_after":2021,"source":{"system":"sec-edgar","filing":"0000874015-20-000152","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000152/edgar.xml","form_type":"4"}},{"id":2966912,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-11-26T00:04:19.000Z","date":"2020-11-23","kind":"exercise","acquired":true,"shares":11600,"price":39.87,"value":462492.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"Acquired as a result of exercising a stock option that was scheduled to expire on 1/1/21.  The purchase reported on this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on March 13, 2019."}],"balance_after":13621,"source":{"system":"sec-edgar","filing":"0000874015-20-000152","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000152/edgar.xml","form_type":"4"}},{"id":2966911,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-11-26T00:04:19.000Z","date":"2020-11-23","kind":"sale","acquired":false,"shares":500,"price":50,"value":25000.0,"ownership":{"direct":false,"nature":"by wife"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person's wife on March 13, 2019."}],"balance_after":1581,"source":{"system":"sec-edgar","filing":"0000874015-20-000152","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000152/edgar.xml","form_type":"4"}},{"id":2966910,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-11-26T00:04:19.000Z","date":"2020-11-23","kind":"exercise","acquired":true,"shares":500,"price":39.87,"value":19935.0,"ownership":{"direct":false,"nature":"by wife"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option that was scheduled to expire on 1/1/21.  The purchase reported on this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person's wife on March 13, 2019."}],"balance_after":2081,"source":{"system":"sec-edgar","filing":"0000874015-20-000152","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000152/edgar.xml","form_type":"4"}},{"id":3024175,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-09-23T22:44:03.000Z","date":"2020-09-22","kind":"sale","acquired":false,"shares":50000,"price":50.4092,"value":2520460.0,"ownership":{"direct":false,"nature":"By trust"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020"},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.02 to $50.70, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) of this Form 4"}],"balance_after":650391,"source":{"system":"sec-edgar","filing":"0000874015-20-000131","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000131/edgar.xml","form_type":"4"}},{"id":3024174,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-09-23T22:44:03.000Z","date":"2020-09-21","kind":"sale","acquired":false,"shares":2000,"price":50.18,"value":100360.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person's wife on January 2, 2020."}],"balance_after":1581,"source":{"system":"sec-edgar","filing":"0000874015-20-000131","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000131/edgar.xml","form_type":"4"}},{"id":3099385,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-06-26T23:47:17.000Z","date":"2020-06-25","kind":"sale","acquired":false,"shares":9914,"price":60.1076,"value":595906.7464,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.10 to $60.15, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) of this Form 4"}],"balance_after":2021,"source":{"system":"sec-edgar","filing":"0000874015-20-000076","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000076/edgar.xml","form_type":"4"}},{"id":3099384,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-06-26T23:47:17.000Z","date":"2020-06-24","kind":"sale","acquired":false,"shares":5000,"price":58.8,"value":294000.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."}],"balance_after":11935,"source":{"system":"sec-edgar","filing":"0000874015-20-000076","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000076/edgar.xml","form_type":"4"}},{"id":3104748,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-06-19T23:03:05.000Z","date":"2020-06-19","kind":"sale","acquired":false,"shares":10000,"price":58.325,"value":583250.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.25 to $58.40, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) of this Form 4"}],"balance_after":16935,"source":{"system":"sec-edgar","filing":"0000874015-20-000072","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000072/edgar.xml","form_type":"4"}},{"id":3104747,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-06-19T23:03:05.000Z","date":"2020-06-17","kind":"sale","acquired":false,"shares":2000,"price":58.25,"value":116500.0,"ownership":{"direct":false,"nature":"By Wife"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person's wife on January 2, 2020."}],"balance_after":3581,"source":{"system":"sec-edgar","filing":"0000874015-20-000072","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000072/edgar.xml","form_type":"4"}},{"id":3104746,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-06-19T23:03:05.000Z","date":"2020-06-17","kind":"sale","acquired":false,"shares":15000,"price":57.9014,"value":868521.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.59 to $58.36, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) of this Form 4"}],"balance_after":26935,"source":{"system":"sec-edgar","filing":"0000874015-20-000072","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000072/edgar.xml","form_type":"4"}},{"id":3193583,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-03-27T23:05:30.000Z","date":"2020-03-25","kind":"sale","acquired":false,"shares":1000,"price":47,"value":47000.0,"ownership":{"direct":false,"nature":"By Wife"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person's wife on January 2, 2020."}],"balance_after":5581,"source":{"system":"sec-edgar","filing":"0000874015-20-000066","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000066/edgar.xml","form_type":"4"}},{"id":3193582,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-03-27T23:05:30.000Z","date":"2020-03-25","kind":"sale","acquired":false,"shares":15000,"price":47,"value":705000.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."}],"balance_after":41935,"source":{"system":"sec-edgar","filing":"0000874015-20-000066","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000066/edgar.xml","form_type":"4"}},{"id":3193587,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-03-27T23:01:37.000Z","date":"2020-03-17","kind":"sale","acquired":false,"shares":4349,"price":45,"value":195705.0,"ownership":{"direct":true},"footnotes":[{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"The original Form 4 filed on March 19, 2020 reported 4,969 restricted stock units sold by the reporting person which has been revised by this amendment to reflect the actual amount of shares sold and beneficially owned by Mr. Crooke."}],"balance_after":71935,"source":{"system":"sec-edgar","filing":"0000874015-20-000064","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000064/edgar.xml","form_type":"4/A","original_submission_date":"2020-03-19"}},{"id":3193586,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-03-27T23:01:37.000Z","date":"2020-03-17","kind":"sale","acquired":false,"shares":5651,"price":45,"value":254295.0,"ownership":{"direct":true},"footnotes":[{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"The original Form 4 filed on March 19, 2020 reported 4,969 restricted stock units sold by the reporting person which has been revised by this amendment to reflect the actual amount of shares sold and beneficially owned by Mr. Crooke."}],"balance_after":76284,"source":{"system":"sec-edgar","filing":"0000874015-20-000064","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000064/edgar.xml","form_type":"4/A","original_submission_date":"2020-03-19"}},{"id":3193585,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-03-27T23:01:37.000Z","date":"2020-03-17","kind":"sale","acquired":false,"shares":5421,"price":44.5,"value":241234.5,"ownership":{"direct":true},"footnotes":[{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"The original Form 4 filed on March 19, 2020 reported 4,969 restricted stock units sold by the reporting person which has been revised by this amendment to reflect the actual amount of shares sold and beneficially owned by Mr. Crooke."}],"balance_after":81935,"source":{"system":"sec-edgar","filing":"0000874015-20-000064","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000064/edgar.xml","form_type":"4/A","original_submission_date":"2020-03-19"}},{"id":3193584,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-03-27T23:01:37.000Z","date":"2020-03-17","kind":"sale","acquired":false,"shares":4579,"price":44.5,"value":203765.5,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The original Form 4 filed on March 19, 2020 reported 4,969 restricted stock units sold by the reporting person which has been revised by this amendment to reflect the actual amount of shares sold and beneficially owned by Mr. Crooke."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"The original Form 4 filed on March 19, 2020 reported 4,969 restricted stock units sold by the reporting person which has been revised by this amendment to reflect the actual amount of shares sold and beneficially owned by Mr. Crooke."}],"balance_after":87356,"source":{"system":"sec-edgar","filing":"0000874015-20-000064","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000064/edgar.xml","form_type":"4/A","original_submission_date":"2020-03-19"}},{"id":3198605,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-03-23T22:17:08.000Z","date":"2020-03-19","kind":"sale","acquired":false,"shares":1000,"price":45,"value":45000.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person's wife on January 2, 2020."}],"balance_after":6581,"source":{"system":"sec-edgar","filing":"0000874015-20-000062","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000062/edgar.xml","form_type":"4"}},{"id":3198604,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-03-23T22:17:08.000Z","date":"2020-03-19","kind":"sale","acquired":false,"shares":5000,"price":46,"value":230000.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."}],"balance_after":56545,"source":{"system":"sec-edgar","filing":"0000874015-20-000062","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000062/edgar.xml","form_type":"4"}},{"id":3198603,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"Common Stock","published_at":"2020-03-23T22:17:08.000Z","date":"2020-03-19","kind":"sale","acquired":false,"shares":10000,"price":44.7546,"value":447546.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in column 4 is a weighted average price.  These shares were sold in multiple transactions at prices ranging from $44.50 to $45.07, inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) of this Form 4."}],"balance_after":61545,"source":{"system":"sec-edgar","filing":"0000874015-20-000062","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000062/edgar.xml","form_type":"4"}},{"id":3201278,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"COMMON STOCK","published_at":"2020-03-19T17:55:10.000Z","date":"2020-03-17","kind":"sale","acquired":false,"shares":4349,"price":45,"value":195705.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a  Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."}],"balance_after":71545,"source":{"system":"sec-edgar","filing":"0000874015-20-000060","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000060/edgar.xml","form_type":"4"}},{"id":3201277,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"COMMON STOCK","published_at":"2020-03-19T17:55:10.000Z","date":"2020-03-17","kind":"sale","acquired":false,"shares":5651,"price":45,"value":254295.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a  Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."}],"balance_after":75894,"source":{"system":"sec-edgar","filing":"0000874015-20-000060","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000060/edgar.xml","form_type":"4"}},{"id":3201276,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"COMMON STOCK","published_at":"2020-03-19T17:55:10.000Z","date":"2020-03-17","kind":"sale","acquired":false,"shares":5421,"price":44.5,"value":241234.5,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a  Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."}],"balance_after":81545,"source":{"system":"sec-edgar","filing":"0000874015-20-000060","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000060/edgar.xml","form_type":"4"}},{"id":3201275,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Exec Chairman of the Board"}}],"security":"COMMON STOCK","published_at":"2020-03-19T17:55:10.000Z","date":"2020-03-17","kind":"sale","acquired":false,"shares":4969,"price":44.5,"value":221120.5,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a  Rule 10b5-1 Trading Plan adopted by the reporting person on January 2, 2020."}],"balance_after":86966,"source":{"system":"sec-edgar","filing":"0000874015-20-000060","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000060/edgar.xml","form_type":"4"}},{"id":3308791,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Restricted Stock Units","published_at":"2020-01-17T23:28:00.000Z","date":"2020-01-15","kind":"exercise","acquired":false,"shares":3317,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."}],"balance_after":6627,"derivative":{"underlying":"Common Stock","underlying_shares":3317},"source":{"system":"sec-edgar","filing":"0000874015-20-000029","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000029/edgar.xml","form_type":"4"}},{"id":3308790,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Restricted Stock Units","published_at":"2020-01-17T23:28:00.000Z","date":"2020-01-15","kind":"exercise","acquired":false,"shares":39643,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."}],"balance_after":72160,"derivative":{"underlying":"Common Stock","underlying_shares":39643},"source":{"system":"sec-edgar","filing":"0000874015-20-000029","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000029/edgar.xml","form_type":"4"}},{"id":3308789,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Restricted Stock Units","published_at":"2020-01-17T23:28:00.000Z","date":"2020-01-15","kind":"grant","acquired":true,"shares":5545,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F6","text":"Grant to reporting person's wife of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."}],"balance_after":5545,"derivative":{"underlying":"Common Stock","underlying_shares":5545},"source":{"system":"sec-edgar","filing":"0000874015-20-000029","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000029/edgar.xml","form_type":"4"}},{"id":3308788,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Restricted Stock Units","published_at":"2020-01-17T23:28:00.000Z","date":"2020-01-15","kind":"grant","acquired":true,"shares":62982,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F3","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis."}],"balance_after":62982,"derivative":{"underlying":"Common Stock","underlying_shares":62982},"source":{"system":"sec-edgar","filing":"0000874015-20-000029","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000029/edgar.xml","form_type":"4"}},{"id":3308787,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Common Stock","published_at":"2020-01-17T23:28:00.000Z","date":"2020-01-15","kind":"tax_withholding","acquired":false,"shares":1268,"price":62.06,"value":78692.08,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Shares withheld to cover the required tax withholding obligations pursuant to the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"shares","element":"transactionShares","label":"F2","text":"Shares withheld to cover the required tax withholding obligations pursuant to the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."}],"balance_after":7581,"source":{"system":"sec-edgar","filing":"0000874015-20-000029","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000029/edgar.xml","form_type":"4"}},{"id":3308786,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Common Stock","published_at":"2020-01-17T23:28:00.000Z","date":"2020-01-15","kind":"exercise","acquired":true,"shares":3317,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":8849,"source":{"system":"sec-edgar","filing":"0000874015-20-000029","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000029/edgar.xml","form_type":"4"}},{"id":3308785,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Common Stock","published_at":"2020-01-17T23:28:00.000Z","date":"2020-01-15","kind":"tax_withholding","acquired":false,"shares":17342,"price":62.06,"value":1076244.52,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Shares withheld to cover the required tax withholding obligations pursuant to the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"shares","element":"transactionShares","label":"F2","text":"Shares withheld to cover the required tax withholding obligations pursuant to the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."}],"balance_after":91935,"source":{"system":"sec-edgar","filing":"0000874015-20-000029","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000029/edgar.xml","form_type":"4"}},{"id":3308784,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Common Stock","published_at":"2020-01-17T23:28:00.000Z","date":"2020-01-15","kind":"exercise","acquired":true,"shares":39643,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":109277,"source":{"system":"sec-edgar","filing":"0000874015-20-000029","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000029/edgar.xml","form_type":"4"}},{"id":3324952,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Employee Stock Option (right to buy)","published_at":"2020-01-03T23:56:18.000Z","date":"2020-01-02","kind":"grant","acquired":true,"shares":12477,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2020 to reporting person or reporting person's wife (as indicated) of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on 01/02/2020. 25% of the shares subject to the option will vest and become exercisable on 01/02/2021.  Thereafter, the remaining shares subject to the option will vest and become exercisable in 36 equal monthly installments over the next 3 years."}],"balance_after":12477,"derivative":{"exercise_price":60.89,"exercise_date":"2021-01-02","expiration_date":"2027-01-01","underlying":"Common Stock","underlying_shares":12477},"source":{"system":"sec-edgar","filing":"0000874015-20-000008","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000008/edgar.xml","form_type":"4"}},{"id":3324951,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Employee Stock Option (right to buy)","published_at":"2020-01-03T23:56:18.000Z","date":"2020-01-02","kind":"grant","acquired":true,"shares":141709,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2020 to reporting person or reporting person's wife (as indicated) of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on 01/02/2020. 25% of the shares subject to the option will vest and become exercisable on 01/02/2021.  Thereafter, the remaining shares subject to the option will vest and become exercisable in 36 equal monthly installments over the next 3 years."}],"balance_after":141709,"derivative":{"exercise_price":60.89,"exercise_date":"2021-01-02","expiration_date":"2027-01-01","underlying":"Common Stock","underlying_shares":141709},"source":{"system":"sec-edgar","filing":"0000874015-20-000008","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000008/edgar.xml","form_type":"4"}},{"id":3324953,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive Chairman of Board"}}],"security":"Common Stock","published_at":"2020-01-03T23:50:04.000Z","date":"2019-12-06","kind":"gift","acquired":false,"shares":25000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By trust"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents a bona fide gift to a charitable organization."}],"balance_after":700391,"source":{"system":"sec-edgar","filing":"0000874015-20-000004","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000004/edgar.xml","form_type":"5"}},{"id":3431534,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-08-22T22:41:29.000Z","date":"2019-08-21","kind":"exercise","acquired":false,"shares":10000,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":27180,"derivative":{"exercise_price":39.87,"exercise_date":"2018-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":10000},"source":{"system":"sec-edgar","filing":"0000874015-19-000118","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000118/edgar.xml","form_type":"4"}},{"id":3431533,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-08-22T22:41:29.000Z","date":"2019-08-20","kind":"exercise","acquired":false,"shares":2000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"balance_after":500,"derivative":{"exercise_price":39.87,"exercise_date":"2018-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":2000},"source":{"system":"sec-edgar","filing":"0000874015-19-000118","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000118/edgar.xml","form_type":"4"}},{"id":3431532,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-08-22T22:41:29.000Z","date":"2019-08-20","kind":"exercise","acquired":false,"shares":10000,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":37180,"derivative":{"exercise_price":39.87,"exercise_date":"2018-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":10000},"source":{"system":"sec-edgar","filing":"0000874015-19-000118","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000118/edgar.xml","form_type":"4"}},{"id":3431531,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-08-22T22:41:29.000Z","date":"2019-08-21","kind":"sale","acquired":false,"shares":10000,"price":72.15,"value":721500.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $72.10 to $72.20, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":69634,"source":{"system":"sec-edgar","filing":"0000874015-19-000118","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000118/edgar.xml","form_type":"4"}},{"id":3431530,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-08-22T22:41:29.000Z","date":"2019-08-21","kind":"exercise","acquired":true,"shares":10000,"price":39.87,"value":398700.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."}],"balance_after":79634,"source":{"system":"sec-edgar","filing":"0000874015-19-000118","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000118/edgar.xml","form_type":"4"}},{"id":3431529,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-08-22T22:41:29.000Z","date":"2019-08-20","kind":"sale","acquired":false,"shares":2000,"price":71,"value":142000.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."}],"balance_after":5532,"source":{"system":"sec-edgar","filing":"0000874015-19-000118","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000118/edgar.xml","form_type":"4"}},{"id":3431528,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-08-22T22:41:29.000Z","date":"2019-08-20","kind":"exercise","acquired":true,"shares":2000,"price":39.87,"value":79740.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."}],"balance_after":7532,"source":{"system":"sec-edgar","filing":"0000874015-19-000118","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000118/edgar.xml","form_type":"4"}},{"id":3431527,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-08-22T22:41:29.000Z","date":"2019-08-20","kind":"sale","acquired":false,"shares":10000,"price":71,"value":710000.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."}],"balance_after":69634,"source":{"system":"sec-edgar","filing":"0000874015-19-000118","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000118/edgar.xml","form_type":"4"}},{"id":3431526,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-08-22T22:41:29.000Z","date":"2019-08-20","kind":"exercise","acquired":true,"shares":10000,"price":39.87,"value":398700.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."}],"balance_after":79634,"source":{"system":"sec-edgar","filing":"0000874015-19-000118","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000118/edgar.xml","form_type":"4"}},{"id":3458135,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman & CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-07-22T21:34:10.000Z","date":"2019-07-18","kind":"exercise","acquired":false,"shares":10000,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":47180,"derivative":{"exercise_price":39.87,"exercise_date":"2018-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":10000},"source":{"system":"sec-edgar","filing":"0000874015-19-000116","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000116/edgar.xml","form_type":"4"}},{"id":3458134,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman & CEO"}}],"security":"Common Stock","published_at":"2019-07-22T21:34:10.000Z","date":"2019-07-18","kind":"sale","acquired":false,"shares":10000,"price":70.2506,"value":702506.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan.  The purchase and sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan.  The purchase and sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price.  These shares were sold in multiple transactions at prices ranging from $70.25 to $70.26, inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":69634,"source":{"system":"sec-edgar","filing":"0000874015-19-000116","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000116/edgar.xml","form_type":"4"}},{"id":3458133,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman & CEO"}}],"security":"Common Stock","published_at":"2019-07-22T21:34:10.000Z","date":"2019-07-18","kind":"exercise","acquired":true,"shares":10000,"price":39.87,"value":398700.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan.  The purchase and sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan.  The purchase and sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."}],"balance_after":79634,"source":{"system":"sec-edgar","filing":"0000874015-19-000116","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000116/edgar.xml","form_type":"4"}},{"id":3554530,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"exercise","acquired":false,"shares":700,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"balance_after":2500,"derivative":{"exercise_price":39.87,"exercise_date":"2018-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":700},"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":19,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554529,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"exercise","acquired":false,"shares":300,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"balance_after":0,"derivative":{"exercise_price":10.82,"exercise_date":"2017-01-02","expiration_date":"2020-01-01","underlying":"Common Stock","underlying_shares":300},"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":18,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554528,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"exercise","acquired":false,"shares":13320,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":57180,"derivative":{"exercise_price":39.87,"exercise_date":"2018-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":13320},"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":17,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554527,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"exercise","acquired":false,"shares":6680,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":14.69,"exercise_date":"2017-01-02","expiration_date":"2020-01-29","underlying":"Common Stock","underlying_shares":6680},"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":16,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554526,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-15","kind":"exercise","acquired":false,"shares":1000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"balance_after":300,"derivative":{"exercise_price":10.82,"exercise_date":"2017-01-02","expiration_date":"2020-01-01","underlying":"Common Stock","underlying_shares":1000},"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":15,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554525,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-15","kind":"exercise","acquired":false,"shares":10000,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":6680,"derivative":{"exercise_price":14.69,"exercise_date":"2017-01-02","expiration_date":"2020-01-29","underlying":"Common Stock","underlying_shares":10000},"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":14,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554524,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"sale","acquired":false,"shares":700,"price":84.75,"value":59325.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."}],"balance_after":5532,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554523,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"exercise","acquired":true,"shares":700,"price":39.87,"value":27909.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."}],"balance_after":6232,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554522,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"sale","acquired":false,"shares":300,"price":84.75,"value":25425.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."}],"balance_after":5532,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554521,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"exercise","acquired":true,"shares":300,"price":10.82,"value":3246.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."}],"balance_after":5832,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554520,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"sale","acquired":false,"shares":13320,"price":84.5623,"value":1126369.836,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $84.50 to $84.75, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":69634,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554519,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"exercise","acquired":true,"shares":13320,"price":39.87,"value":531068.4,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."}],"balance_after":82954,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554518,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"sale","acquired":false,"shares":6680,"price":84.75,"value":566130.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."}],"balance_after":69634,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554517,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-16","kind":"exercise","acquired":true,"shares":6680,"price":14.69,"value":98129.2,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."}],"balance_after":76314,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554516,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-15","kind":"sale","acquired":false,"shares":1000,"price":85.25,"value":85250.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."}],"balance_after":5532,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554515,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-15","kind":"exercise","acquired":true,"shares":1000,"price":10.82,"value":10820.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 3/13/2019."}],"balance_after":6532,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554514,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-15","kind":"sale","acquired":false,"shares":10000,"price":85.25,"value":852500.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."}],"balance_after":69634,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3554513,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-04-17T23:30:59.000Z","date":"2019-04-15","kind":"exercise","acquired":true,"shares":10000,"price":14.69,"value":146900.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 3/13/2019."}],"balance_after":79634,"source":{"system":"sec-edgar","filing":"0000874015-19-000061","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000061/edgar.xml","form_type":"4"}},{"id":3630106,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-02-28T00:31:09.000Z","date":"2019-02-26","kind":"exercise","acquired":false,"shares":37000,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":70500,"derivative":{"exercise_price":39.87,"exercise_date":"2018-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":37000},"source":{"system":"sec-edgar","filing":"0000874015-19-000042","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000042/edgar.xml","form_type":"4"}},{"id":3630105,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-02-28T00:31:09.000Z","date":"2019-02-25","kind":"exercise","acquired":false,"shares":40000,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":107500,"derivative":{"exercise_price":39.87,"exercise_date":"2018-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":40000},"source":{"system":"sec-edgar","filing":"0000874015-19-000042","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000042/edgar.xml","form_type":"4"}},{"id":3630104,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-02-28T00:31:09.000Z","date":"2019-02-26","kind":"sale","acquired":false,"shares":37000,"price":61.5351,"value":2276798.7,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.45 to $61.68, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":69634,"source":{"system":"sec-edgar","filing":"0000874015-19-000042","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000042/edgar.xml","form_type":"4"}},{"id":3630103,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-02-28T00:31:09.000Z","date":"2019-02-26","kind":"exercise","acquired":true,"shares":37000,"price":39.87,"value":1475190.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016."}],"balance_after":106634,"source":{"system":"sec-edgar","filing":"0000874015-19-000042","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000042/edgar.xml","form_type":"4"}},{"id":3630102,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-02-28T00:31:09.000Z","date":"2019-02-25","kind":"sale","acquired":false,"shares":40000,"price":60.0675,"value":2402700.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.02 to $60.15, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":69634,"source":{"system":"sec-edgar","filing":"0000874015-19-000042","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000042/edgar.xml","form_type":"4"}},{"id":3630101,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-02-28T00:31:09.000Z","date":"2019-02-25","kind":"exercise","acquired":true,"shares":40000,"price":39.87,"value":1594800.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/17/2016."}],"balance_after":109634,"source":{"system":"sec-edgar","filing":"0000874015-19-000042","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000042/edgar.xml","form_type":"4"}},{"id":3658411,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-02-14T22:57:09.000Z","date":"2019-02-13","kind":"exercise","acquired":false,"shares":5300,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"balance_after":3200,"derivative":{"exercise_price":39.87,"exercise_date":"2018-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":5300},"source":{"system":"sec-edgar","filing":"0000874015-19-000038","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000038/edgar.xml","form_type":"4"}},{"id":3658410,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-02-14T22:57:09.000Z","date":"2019-02-13","kind":"exercise","acquired":false,"shares":1604,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By wife"},"balance_after":1300,"derivative":{"exercise_price":10.82,"exercise_date":"2017-01-02","expiration_date":"2020-01-01","underlying":"Common Stock","underlying_shares":1604},"source":{"system":"sec-edgar","filing":"0000874015-19-000038","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000038/edgar.xml","form_type":"4"}},{"id":3658409,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Employee Stock Option (right to buy)","published_at":"2019-02-14T22:57:09.000Z","date":"2019-02-13","kind":"exercise","acquired":false,"shares":40000,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":147500,"derivative":{"exercise_price":39.87,"exercise_date":"2018-01-02","expiration_date":"2021-01-01","underlying":"Common Stock","underlying_shares":40000},"source":{"system":"sec-edgar","filing":"0000874015-19-000038","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000038/edgar.xml","form_type":"4"}},{"id":3658408,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":143377,"kind":"person","name":"CROOKE STANLEY T","position":1,"cik":"0000897667","reported_name":"CROOKE STANLEY T","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chairman and CEO"}}],"security":"Common Stock","published_at":"2019-02-14T22:57:09.000Z","date":"2019-02-13","kind":"sale","acquired":false,"shares":5300,"price":60,"value":318000.0,"ownership":{"direct":false,"nature":"By wife"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 6/17/2016."},{"field":"shares","element":"transactionShares","label":"F2","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 6/17/2016."}],"balance_after":5532,"source":{"system":"sec-edgar","filing":"0000874015-19-000038","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000038/edgar.xml","form_type":"4"}}],"next_cursor":"2019-02-14T22:57:09.000000Z,3658408"}