{"transactions":[{"id":2635343,"issuer":{"id":2416,"kind":"organization","name":"Mirum Pharmaceuticals, Inc.","symbol":"MIRM"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29895,"kind":"person","name":"Deerfield Mgmt HIF, L.P.","position":2,"cik":"0001665736","reported_name":"Deerfield Mgmt HIF, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":3,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":4,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":5,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29896,"kind":"person","name":"Deerfield Healthcare Innovations Fund, L.P.","position":6,"cik":"0001646981","reported_name":"Deerfield Healthcare Innovations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":7,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":8,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2021-07-13T16:06:20.000Z","date":"2021-07-09","kind":"sale","acquired":false,"shares":99325,"price":15.81,"value":1570328.25,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $15.81 to $15.91, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (\"Deerfield Special Situations\"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Fund IV and Deerfield Special Situations, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0001193805-21-001014","document":"e620792_4-mirum.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380521001014/e620792_4-mirum.xml","form_type":"4"}},{"id":2639990,"issuer":{"id":2416,"kind":"organization","name":"Mirum Pharmaceuticals, Inc.","symbol":"MIRM"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29895,"kind":"person","name":"Deerfield Mgmt HIF, L.P.","position":2,"cik":"0001665736","reported_name":"Deerfield Mgmt HIF, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":3,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":4,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":5,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29896,"kind":"person","name":"Deerfield Healthcare Innovations Fund, L.P.","position":6,"cik":"0001646981","reported_name":"Deerfield Healthcare Innovations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":7,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":8,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2021-07-07T22:48:32.000Z","date":"2021-07-07","kind":"sale","acquired":false,"shares":6837,"price":15.869,"value":108496.353,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $15.84 to $15.955, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (\"Deerfield Special Situations\"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Fund IV and Deerfield Special Situations, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":99325,"source":{"system":"sec-edgar","filing":"0001193805-21-000999","document":"e620783_4-mirum.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380521000999/e620783_4-mirum.xml","form_type":"4"}},{"id":2639989,"issuer":{"id":2416,"kind":"organization","name":"Mirum Pharmaceuticals, Inc.","symbol":"MIRM"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29895,"kind":"person","name":"Deerfield Mgmt HIF, L.P.","position":2,"cik":"0001665736","reported_name":"Deerfield Mgmt HIF, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":3,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":4,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":5,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29896,"kind":"person","name":"Deerfield Healthcare Innovations Fund, L.P.","position":6,"cik":"0001646981","reported_name":"Deerfield Healthcare Innovations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":7,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":8,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2021-07-07T22:48:32.000Z","date":"2021-07-06","kind":"sale","acquired":false,"shares":49239,"price":16.195,"value":797425.605,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $16.185 to $16.345, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (\"Deerfield Special Situations\"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Fund IV and Deerfield Special Situations, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":106162,"source":{"system":"sec-edgar","filing":"0001193805-21-000999","document":"e620783_4-mirum.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380521000999/e620783_4-mirum.xml","form_type":"4"}},{"id":2639988,"issuer":{"id":2416,"kind":"organization","name":"Mirum Pharmaceuticals, Inc.","symbol":"MIRM"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29895,"kind":"person","name":"Deerfield Mgmt HIF, L.P.","position":2,"cik":"0001665736","reported_name":"Deerfield Mgmt HIF, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":3,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":4,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":5,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29896,"kind":"person","name":"Deerfield Healthcare Innovations Fund, L.P.","position":6,"cik":"0001646981","reported_name":"Deerfield Healthcare Innovations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":7,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":8,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"* Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2021-07-07T22:48:32.000Z","date":"2021-07-02","kind":"sale","acquired":false,"shares":10599,"price":17.011,"value":180299.589,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $16.85 to $17.55, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes 1 and 2 of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (\"Deerfield Special Situations\"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Fund IV and Deerfield Special Situations, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":155401,"source":{"system":"sec-edgar","filing":"0001193805-21-000999","document":"e620783_4-mirum.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380521000999/e620783_4-mirum.xml","form_type":"4"}},{"id":3385591,"issuer":{"id":5418,"kind":"organization","name":"Cabaletta Bio, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":2,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":4,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":5,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":7,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Series B Preferred Stock","published_at":"2019-10-30T22:04:41.000Z","date":"2019-10-29","kind":"exercise","acquired":false,"shares":696379,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into 0.66666667 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.5 reverse stock split of the Issuer's common stock effected by the Issuer on October 16, 2019)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into 0.66666667 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.5 reverse stock split of the Issuer's common stock effected by the Issuer on October 16, 2019)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into 0.66666667 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.5 reverse stock split of the Issuer's common stock effected by the Issuer on October 16, 2019)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into 0.66666667 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.5 reverse stock split of the Issuer's common stock effected by the Issuer on October 16, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":464253},"source":{"system":"sec-edgar","filing":"0001193805-19-001376","document":"e619146_4-cabaletta.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519001376/e619146_4-cabaletta.xml","form_type":"4"}},{"id":3385590,"issuer":{"id":5418,"kind":"organization","name":"Cabaletta Bio, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":2,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":4,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":5,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":7,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Series B Preferred Stock","published_at":"2019-10-30T22:04:41.000Z","date":"2019-10-29","kind":"exercise","acquired":false,"shares":696379,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund IV, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into 0.66666667 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.5 reverse stock split of the Issuer's common stock effected by the Issuer on October 16, 2019)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into 0.66666667 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.5 reverse stock split of the Issuer's common stock effected by the Issuer on October 16, 2019)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into 0.66666667 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.5 reverse stock split of the Issuer's common stock effected by the Issuer on October 16, 2019)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into 0.66666667 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.5 reverse stock split of the Issuer's common stock effected by the Issuer on October 16, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":464253},"source":{"system":"sec-edgar","filing":"0001193805-19-001376","document":"e619146_4-cabaletta.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519001376/e619146_4-cabaletta.xml","form_type":"4"}},{"id":3385589,"issuer":{"id":5418,"kind":"organization","name":"Cabaletta Bio, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":2,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":4,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":5,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":7,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-10-30T22:04:41.000Z","date":"2019-10-29","kind":"purchase","acquired":true,"shares":700000,"price":11,"value":7700000.0,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":700000,"source":{"system":"sec-edgar","filing":"0001193805-19-001376","document":"e619146_4-cabaletta.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519001376/e619146_4-cabaletta.xml","form_type":"4"}},{"id":3385588,"issuer":{"id":5418,"kind":"organization","name":"Cabaletta Bio, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":2,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":464253,"source":{"system":"sec-edgar","filing":"0001193805-19-001376","document":"e619146_4-cabaletta.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519001376/e619146_4-cabaletta.xml","form_type":"4"}},{"id":3385587,"issuer":{"id":5418,"kind":"organization","name":"Cabaletta Bio, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":2,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":464253,"source":{"system":"sec-edgar","filing":"0001193805-19-001376","document":"e619146_4-cabaletta.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519001376/e619146_4-cabaletta.xml","form_type":"4"}},{"id":3396840,"issuer":{"id":6388,"kind":"organization","name":"Korro Bio, Inc.","symbol":"KRRO"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":5,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":6,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":7,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Series C Preferred Stock","published_at":"2019-10-07T20:43:50.000Z","date":"2019-10-07","kind":"exercise","acquired":false,"shares":3184948,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.148467077 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-6.7355 reverse stock split of the Issuer's common stock effected by the Issuer on September 20, 2019)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.148467077 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-6.7355 reverse stock split of the Issuer's common stock effected by the Issuer on September 20, 2019)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.148467077 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-6.7355 reverse stock split of the Issuer's common stock effected by the Issuer on September 20, 2019)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.148467077 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-6.7355 reverse stock split of the Issuer's common stock effected by the Issuer on September 20, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":472860},"source":{"system":"sec-edgar","filing":"0001193805-19-000911","document":"e619107_4-ft.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000911/e619107_4-ft.xml","form_type":"4"}},{"id":3396839,"issuer":{"id":6388,"kind":"organization","name":"Korro Bio, Inc.","symbol":"KRRO"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":5,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":6,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":7,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Series C Preferred Stock","published_at":"2019-10-07T20:43:50.000Z","date":"2019-10-07","kind":"exercise","acquired":false,"shares":3184948,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund IV, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.148467077 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-6.7355 reverse stock split of the Issuer's common stock effected by the Issuer on September 20, 2019)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.148467077 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-6.7355 reverse stock split of the Issuer's common stock effected by the Issuer on September 20, 2019)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.148467077 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-6.7355 reverse stock split of the Issuer's common stock effected by the Issuer on September 20, 2019)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.148467077 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-6.7355 reverse stock split of the Issuer's common stock effected by the Issuer on September 20, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":472860},"source":{"system":"sec-edgar","filing":"0001193805-19-000911","document":"e619107_4-ft.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000911/e619107_4-ft.xml","form_type":"4"}},{"id":3396838,"issuer":{"id":6388,"kind":"organization","name":"Korro Bio, Inc.","symbol":"KRRO"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":5,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":6,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":7,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-10-07T20:43:50.000Z","date":"2019-10-07","kind":"purchase","acquired":true,"shares":285714,"price":14,"value":3999996.0,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":285714,"source":{"system":"sec-edgar","filing":"0001193805-19-000911","document":"e619107_4-ft.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000911/e619107_4-ft.xml","form_type":"4"}},{"id":3396837,"issuer":{"id":6388,"kind":"organization","name":"Korro Bio, Inc.","symbol":"KRRO"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":5,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":6,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":7,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-10-07T20:43:50.000Z","date":"2019-10-07","kind":"exercise","acquired":true,"shares":472860,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund IV, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.148467077 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-6.7355 reverse stock split of the Issuer's common stock effected by the Issuer on September 20, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":472860,"source":{"system":"sec-edgar","filing":"0001193805-19-000911","document":"e619107_4-ft.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000911/e619107_4-ft.xml","form_type":"4"}},{"id":3396836,"issuer":{"id":6388,"kind":"organization","name":"Korro Bio, Inc.","symbol":"KRRO"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":5,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":6,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":7,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-10-07T20:43:50.000Z","date":"2019-10-07","kind":"exercise","acquired":true,"shares":472860,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.148467077 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-6.7355 reverse stock split of the Issuer's common stock effected by the Issuer on September 20, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":472860,"source":{"system":"sec-edgar","filing":"0001193805-19-000911","document":"e619107_4-ft.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000911/e619107_4-ft.xml","form_type":"4"}},{"id":3457035,"issuer":{"id":2416,"kind":"organization","name":"Mirum Pharmaceuticals, Inc.","symbol":"MIRM"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29895,"kind":"person","name":"Deerfield Mgmt HIF, L.P.","position":2,"cik":"0001665736","reported_name":"Deerfield Mgmt HIF, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":3,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":4,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":5,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29896,"kind":"person","name":"Deerfield Healthcare Innovations Fund, L.P.","position":6,"cik":"0001646981","reported_name":"Deerfield Healthcare Innovations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":7,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":8,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Series A Preferred Stock","published_at":"2019-07-24T18:18:04.000Z","date":"2019-07-22","kind":"exercise","acquired":false,"shares":12467650,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund IV, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series A Preferred Stock automatically converted into 0.125 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-8 reverse stock split of the common stock effected by the Issuer on July 3, 2019)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series A Preferred Stock automatically converted into 0.125 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-8 reverse stock split of the common stock effected by the Issuer on July 3, 2019)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series A Preferred Stock automatically converted into 0.125 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-8 reverse stock split of the common stock effected by the Issuer on July 3, 2019)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series A Preferred Stock automatically converted into 0.125 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-8 reverse stock split of the common stock effected by the Issuer on July 3, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (\"Deerfield Special Situations\"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Fund IV and Deerfield Special Situations, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":1558456},"source":{"system":"sec-edgar","filing":"0001193805-19-000660","document":"e618569_4-mirum.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000660/e618569_4-mirum.xml","form_type":"4"}},{"id":3457034,"issuer":{"id":2416,"kind":"organization","name":"Mirum Pharmaceuticals, Inc.","symbol":"MIRM"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29895,"kind":"person","name":"Deerfield Mgmt HIF, L.P.","position":2,"cik":"0001665736","reported_name":"Deerfield Mgmt HIF, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":3,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":4,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":5,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29896,"kind":"person","name":"Deerfield Healthcare Innovations Fund, L.P.","position":6,"cik":"0001646981","reported_name":"Deerfield Healthcare Innovations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":7,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":8,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Series A Preferred Stock","published_at":"2019-07-24T18:18:04.000Z","date":"2019-07-22","kind":"exercise","acquired":false,"shares":12467650,"ownership":{"direct":false,"nature":"Through Deerfield Healthcare Innovations Fund, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series A Preferred Stock automatically converted into 0.125 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-8 reverse stock split of the common stock effected by the Issuer on July 3, 2019)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series A Preferred Stock automatically converted into 0.125 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-8 reverse stock split of the common stock effected by the Issuer on July 3, 2019)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series A Preferred Stock automatically converted into 0.125 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-8 reverse stock split of the common stock effected by the Issuer on July 3, 2019)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series A Preferred Stock automatically converted into 0.125 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-8 reverse stock split of the common stock effected by the Issuer on July 3, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (\"Deerfield Special Situations\"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Fund IV and Deerfield Special Situations, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":1558456},"source":{"system":"sec-edgar","filing":"0001193805-19-000660","document":"e618569_4-mirum.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000660/e618569_4-mirum.xml","form_type":"4"}},{"id":3457033,"issuer":{"id":2416,"kind":"organization","name":"Mirum Pharmaceuticals, Inc.","symbol":"MIRM"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29895,"kind":"person","name":"Deerfield Mgmt HIF, L.P.","position":2,"cik":"0001665736","reported_name":"Deerfield Mgmt HIF, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":3,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":4,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":5,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29896,"kind":"person","name":"Deerfield Healthcare Innovations Fund, L.P.","position":6,"cik":"0001646981","reported_name":"Deerfield Healthcare Innovations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":7,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":8,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-07-24T18:18:04.000Z","date":"2019-07-22","kind":"purchase","acquired":true,"shares":166000,"price":15,"value":2490000.0,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (\"Deerfield Special Situations\"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Fund IV and Deerfield Special Situations, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":166000,"source":{"system":"sec-edgar","filing":"0001193805-19-000660","document":"e618569_4-mirum.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000660/e618569_4-mirum.xml","form_type":"4"}},{"id":3457032,"issuer":{"id":2416,"kind":"organization","name":"Mirum Pharmaceuticals, Inc.","symbol":"MIRM"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29895,"kind":"person","name":"Deerfield Mgmt HIF, L.P.","position":2,"cik":"0001665736","reported_name":"Deerfield Mgmt HIF, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":3,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":4,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":5,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29896,"kind":"person","name":"Deerfield Healthcare Innovations Fund, L.P.","position":6,"cik":"0001646981","reported_name":"Deerfield Healthcare Innovations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":7,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":8,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-07-24T18:18:04.000Z","date":"2019-07-22","kind":"purchase","acquired":true,"shares":166000,"price":15,"value":2490000.0,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund IV, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (\"Deerfield Special Situations\"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Fund IV and Deerfield Special Situations, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1724456,"source":{"system":"sec-edgar","filing":"0001193805-19-000660","document":"e618569_4-mirum.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000660/e618569_4-mirum.xml","form_type":"4"}},{"id":3457031,"issuer":{"id":2416,"kind":"organization","name":"Mirum Pharmaceuticals, Inc.","symbol":"MIRM"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29895,"kind":"person","name":"Deerfield Mgmt HIF, L.P.","position":2,"cik":"0001665736","reported_name":"Deerfield Mgmt HIF, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":3,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":4,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":5,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29896,"kind":"person","name":"Deerfield Healthcare Innovations Fund, L.P.","position":6,"cik":"0001646981","reported_name":"Deerfield Healthcare Innovations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":7,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":8,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-07-24T18:18:04.000Z","date":"2019-07-22","kind":"exercise","acquired":true,"shares":1558456,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund IV, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series A Preferred Stock automatically converted into 0.125 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-8 reverse stock split of the common stock effected by the Issuer on July 3, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (\"Deerfield Special Situations\"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Fund IV and Deerfield Special Situations, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1558456,"source":{"system":"sec-edgar","filing":"0001193805-19-000660","document":"e618569_4-mirum.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000660/e618569_4-mirum.xml","form_type":"4"}},{"id":3457030,"issuer":{"id":2416,"kind":"organization","name":"Mirum Pharmaceuticals, Inc.","symbol":"MIRM"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29895,"kind":"person","name":"Deerfield Mgmt HIF, L.P.","position":2,"cik":"0001665736","reported_name":"Deerfield Mgmt HIF, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":3,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":4,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (\"Deerfield Special Situations\"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. (collectively with Fund IV and Deerfield Special Situations, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1558456,"source":{"system":"sec-edgar","filing":"0001193805-19-000660","document":"e618569_4-mirum.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000660/e618569_4-mirum.xml","form_type":"4"}},{"id":3475111,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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The shares were sold in multiple transactions at prices ranging from $2.50 to $2.98, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. 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For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":3159165,"source":{"system":"sec-edgar","filing":"0001193805-19-000616","document":"e618541_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000616/e618541_4-aclaris.xml","form_type":"4"}},{"id":3475110,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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The shares were sold in multiple transactions at prices ranging from $2.50 to $2.98, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. 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The shares were sold in multiple transactions at prices ranging from $4.50 to $4.505, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. 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For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1072775,"source":{"system":"sec-edgar","filing":"0001193805-19-000603","document":"e618536_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000603/e618536_4-aclaris.xml","form_type":"4"}},{"id":3479309,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":3751318,"source":{"system":"sec-edgar","filing":"0001193805-19-000599","document":"e618533_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000599/e618533_4-aclaris.xml","form_type":"4"}},{"id":3479308,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1073127,"source":{"system":"sec-edgar","filing":"0001193805-19-000599","document":"e618533_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000599/e618533_4-aclaris.xml","form_type":"4"}},{"id":3479307,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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The shares were sold in multiple transactions at prices ranging from $4.50 to $4.67, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1083761,"source":{"system":"sec-edgar","filing":"0001193805-19-000599","document":"e618533_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000599/e618533_4-aclaris.xml","form_type":"4"}},{"id":3479305,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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The shares were sold in multiple transactions at prices ranging from $4.50 to $4.89, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1), (4) and (5) of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":3842345,"source":{"system":"sec-edgar","filing":"0001193805-19-000599","document":"e618533_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000599/e618533_4-aclaris.xml","form_type":"4"}},{"id":3479304,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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The shares were sold in multiple transactions at prices ranging from $4.50 to $4.89, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1), (4) and (5) of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1096824,"source":{"system":"sec-edgar","filing":"0001193805-19-000599","document":"e618533_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000599/e618533_4-aclaris.xml","form_type":"4"}},{"id":3530346,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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The shares were sold in multiple transactions at prices ranging from $6.00 to $6.12, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1166959,"source":{"system":"sec-edgar","filing":"0001193805-19-000485","document":"e618447_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000485/e618447_4-aclaris.xml","form_type":"4"}},{"id":3530345,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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The shares were sold in multiple transactions at prices ranging from $6.00 to $6.12, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":4111747,"source":{"system":"sec-edgar","filing":"0001193805-19-000485","document":"e618447_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000485/e618447_4-aclaris.xml","form_type":"4"}},{"id":3530344,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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The shares were sold in multiple transactions at prices ranging from $6.00 to $6.61, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1) and (4) of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. 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For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1238828,"source":{"system":"sec-edgar","filing":"0001193805-19-000485","document":"e618447_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000485/e618447_4-aclaris.xml","form_type":"4"}},{"id":3530343,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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The shares were sold in multiple transactions at prices ranging from $6.00 to $6.61, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1) and (4) of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":4220443,"source":{"system":"sec-edgar","filing":"0001193805-19-000485","document":"e618447_4-aclaris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000485/e618447_4-aclaris.xml","form_type":"4"}},{"id":3602893,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":23333},"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3602892,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":132740},"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3602891,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":23333},"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3602890,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":132740},"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3602889,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":10000,"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3602888,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":166073,"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3602887,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-03-11T18:16:52.000Z","date":"2019-03-11","kind":"purchase","acquired":true,"shares":10000,"price":17,"value":170000.0,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund III, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":166073,"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3602886,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-03-11T18:16:52.000Z","date":"2019-03-11","kind":"exercise","acquired":true,"shares":23333,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Each share of Series C Preferred Stock automatically converted into one share of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-12.2 reverse stock split effected by the Issuer on February 22, 2019)."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"Each share of Series C Preferred Stock automatically converted into one share of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-12.2 reverse stock split effected by the Issuer on February 22, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":156073,"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3602885,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-03-11T18:16:52.000Z","date":"2019-03-11","kind":"exercise","acquired":true,"shares":132740,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into one share of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-12.2 reverse stock split effected by the Issuer on February 22, 2019)."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into one share of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-12.2 reverse stock split effected by the Issuer on February 22, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":132740,"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3602884,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-03-11T18:16:52.000Z","date":"2019-03-11","kind":"exercise","acquired":true,"shares":23333,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund III, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Each share of Series C Preferred Stock automatically converted into one share of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-12.2 reverse stock split effected by the Issuer on February 22, 2019)."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"Each share of Series C Preferred Stock automatically converted into one share of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-12.2 reverse stock split effected by the Issuer on February 22, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":156073,"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3602883,"issuer":{"id":90374,"kind":"organization","name":"Shockwave Medical, Inc.","symbol":"SWAV"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-03-11T18:16:52.000Z","date":"2019-03-11","kind":"exercise","acquired":true,"shares":132740,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund III, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into one share of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-12.2 reverse stock split effected by the Issuer on February 22, 2019)."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"Each share of Series B Preferred Stock automatically converted into one share of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-12.2 reverse stock split effected by the Issuer on February 22, 2019)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":132740,"source":{"system":"sec-edgar","filing":"0001193805-19-000271","document":"e618284_4-swav.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000271/e618284_4-swav.xml","form_type":"4"}},{"id":3664040,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-02-12T22:55:08.000Z","date":"2019-02-11","kind":"sale","acquired":false,"shares":1351,"price":15,"value":20265.0,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":856470,"source":{"system":"sec-edgar","filing":"0001193805-19-000209","document":"e618226_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000209/e618226_4-xeris.xml","form_type":"4"}},{"id":3664039,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-02-12T22:55:08.000Z","date":"2019-02-08","kind":"sale","acquired":false,"shares":5890,"price":15.1079,"value":88985.531,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.25, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":857821,"source":{"system":"sec-edgar","filing":"0001193805-19-000209","document":"e618226_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000209/e618226_4-xeris.xml","form_type":"4"}},{"id":3670879,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-02-08T01:13:40.000Z","date":"2019-02-07","kind":"sale","acquired":false,"shares":9409,"price":15,"value":141135.0,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":863711,"source":{"system":"sec-edgar","filing":"0001193805-19-000117","document":"e618211_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000117/e618211_4-xeris.xml","form_type":"4"}},{"id":3670878,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-02-08T01:13:40.000Z","date":"2019-02-06","kind":"sale","acquired":false,"shares":400,"price":15,"value":6000.0,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":873120,"source":{"system":"sec-edgar","filing":"0001193805-19-000117","document":"e618211_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000117/e618211_4-xeris.xml","form_type":"4"}},{"id":3670877,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. 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The shares were sold in multiple transactions at prices ranging from $15.00 to $15.13, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":873520,"source":{"system":"sec-edgar","filing":"0001193805-19-000117","document":"e618211_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000117/e618211_4-xeris.xml","form_type":"4"}},{"id":3682829,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-01-30T22:38:00.000Z","date":"2019-01-29","kind":"sale","acquired":false,"shares":6210,"price":15.1414,"value":94028.094,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.28, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":878518,"source":{"system":"sec-edgar","filing":"0001193805-19-000102","document":"e618172_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000102/e618172_4-xeris.xml","form_type":"4"}},{"id":3682828,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-01-30T22:38:00.000Z","date":"2019-01-28","kind":"sale","acquired":false,"shares":828,"price":15,"value":12420.0,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":884728,"source":{"system":"sec-edgar","filing":"0001193805-19-000102","document":"e618172_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000102/e618172_4-xeris.xml","form_type":"4"}},{"id":3687217,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-01-25T23:24:48.000Z","date":"2019-01-25","kind":"sale","acquired":false,"shares":76820,"price":15.0775,"value":1158253.55,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 2 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.50, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":885556,"source":{"system":"sec-edgar","filing":"0001193805-19-000089","document":"e618167_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000089/e618167_4-xeris.xml","form_type":"4"}},{"id":3687216,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-01-25T23:24:48.000Z","date":"2019-01-24","kind":"sale","acquired":false,"shares":5425,"price":15.0346,"value":81562.705,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 2 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.50, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":962376,"source":{"system":"sec-edgar","filing":"0001193805-19-000089","document":"e618167_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000089/e618167_4-xeris.xml","form_type":"4"}},{"id":3687215,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2019-01-25T23:24:48.000Z","date":"2019-01-23","kind":"sale","acquired":false,"shares":32199,"price":16.3476,"value":526376.3724,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 2 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $16.00 to $16.70, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price  within the ranges set forth in footnotes (1), (4) and (5) of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":967801,"source":{"system":"sec-edgar","filing":"0001193805-19-000089","document":"e618167_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000089/e618167_4-xeris.xml","form_type":"4"}},{"id":3692103,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Cash-Settled Total Return Swap","published_at":"2019-01-18T19:55:26.000Z","date":"2019-01-15","kind":"other","acquired":true,"shares":1,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F6","text":"On January 15, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 48,254 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F7","text":"The price reported in Column 2 represents a weighted average reference price associated with the swap agreement. The reference prices applicable to the 48,254 notional shares subject to the swap agreement reported herein range from $6.79 to $7.00, inclusive."},{"field":"shares","element":"transactionShares","label":"F6","text":"On January 15, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 48,254 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"On January 15, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 48,254 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"On January 15, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 48,254 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1,"derivative":{"exercise_price":6.931,"expiration_date":"2022-01-19","underlying":"Common Stock","underlying_shares":48254},"source":{"system":"sec-edgar","filing":"0001193805-19-000067","document":"e618155_4-aclaris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000067/e618155_4-aclaris.xml","form_type":"4"}},{"id":3692102,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Cash-Settled Total Return Swap","published_at":"2019-01-18T19:55:26.000Z","date":"2019-01-14","kind":"other","acquired":true,"shares":1,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F4","text":"On January 14, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 61,789 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"The price reported in Column 2 represents a weighted average reference price associated with the swap agreement. The reference prices applicable to the 61,789 notional shares subject to the swap agreement reported herein range from $6.85 to $7.00, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of notional shares subject to each separate reference price within the ranges set forth in footnotes (5) and (7) of this Form 4."},{"field":"shares","element":"transactionShares","label":"F4","text":"On January 14, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 61,789 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"On January 14, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 61,789 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"On January 14, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 61,789 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1,"derivative":{"exercise_price":6.969,"expiration_date":"2022-01-19","underlying":"Common Stock","underlying_shares":61789},"source":{"system":"sec-edgar","filing":"0001193805-19-000067","document":"e618155_4-aclaris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000067/e618155_4-aclaris.xml","form_type":"4"}},{"id":3692101,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Cash-Settled Total Return Swap","published_at":"2019-01-18T19:55:26.000Z","date":"2019-01-11","kind":"other","acquired":true,"shares":1,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"On January 11, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 1,851 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference price, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"shares","element":"transactionShares","label":"F3","text":"On January 11, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 1,851 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference price, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"On January 11, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 1,851 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference price, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"On January 11, 2019, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 1,851 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference price, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1,"derivative":{"exercise_price":7,"expiration_date":"2022-01-19","underlying":"Common Stock","underlying_shares":1851},"source":{"system":"sec-edgar","filing":"0001193805-19-000067","document":"e618155_4-aclaris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000067/e618155_4-aclaris.xml","form_type":"4"}},{"id":3714710,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Cash-Settled Total Return Swap","published_at":"2019-01-02T22:33:03.000Z","date":"2018-12-28","kind":"other","acquired":true,"shares":1,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"On December 28, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 14,200 notional shares.  The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"The price reported in Column 2 represents a weighted average reference price associated with the swap agreement. The reference prices applicable to the 14,200 notional shares subject to the swap agreement reported herein range from $6.98 to $7.00, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of notional shares subject to each separate reference price within the range set forth in this footnote (4)."},{"field":"shares","element":"transactionShares","label":"F3","text":"On December 28, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 14,200 notional shares.  The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"On December 28, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 14,200 notional shares.  The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"On December 28, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 14,200 notional shares.  The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1,"derivative":{"exercise_price":6.999,"expiration_date":"2022-01-19","underlying":"Common Stock","underlying_shares":14200},"source":{"system":"sec-edgar","filing":"0001193805-19-000014","document":"e618134_4-aclaris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380519000014/e618134_4-aclaris.xml","form_type":"4"}},{"id":3718329,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Cash-Settled Total Return Swap","published_at":"2018-12-28T00:07:27.000Z","date":"2018-12-27","kind":"other","acquired":true,"shares":1,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F7","text":"On December 27, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 216,159 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F8","text":"The price reported in Column 2 represents a weighted average reference price associated with the applicable swap agreement. The reference prices applicable to 216,159 notional shares subject to the swap agreement range from $6.73 to $7.00, inclusive."},{"field":"shares","element":"transactionShares","label":"F7","text":"On December 27, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 216,159 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"On December 27, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 216,159 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"On December 27, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 216,159 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1,"derivative":{"exercise_price":6.889,"expiration_date":"2022-01-19","underlying":"Common Stock","underlying_shares":216159},"source":{"system":"sec-edgar","filing":"0001193805-18-001441","document":"e618118_4-aclaris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001441/e618118_4-aclaris.xml","form_type":"4"}},{"id":3718328,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Cash-Settled Total Return Swap","published_at":"2018-12-28T00:07:27.000Z","date":"2018-12-26","kind":"other","acquired":true,"shares":1,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F5","text":"On December 26, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 27,128 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F6","text":"The price reported in Column 2 represents a weighted average reference price associated with the applicable swap agreement. The reference prices applicable to 27,128 notional shares subject to the swap agreement range from $6.83 to $7.00, inclusive."},{"field":"shares","element":"transactionShares","label":"F5","text":"On December 26, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 27,128 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"On December 26, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 27,128 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"On December 26, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 27,128 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1,"derivative":{"exercise_price":6.855,"expiration_date":"2022-01-19","underlying":"Common Stock","underlying_shares":27128},"source":{"system":"sec-edgar","filing":"0001193805-18-001441","document":"e618118_4-aclaris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001441/e618118_4-aclaris.xml","form_type":"4"}},{"id":3718327,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Cash-Settled Total Return Swap","published_at":"2018-12-28T00:07:27.000Z","date":"2018-12-24","kind":"other","acquired":true,"shares":1,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"On December 24, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 260,661 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"The price reported in Column 2 represents a weighted average reference price associated with the applicable swap agreement. The reference prices applicable to 260,661 notional shares subject to the swap agreement range from $6.80 to $6.95, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of notional shares subject to each separate reference price within the ranges set forth in footnotes (4), (6) and (8) of this Form 4."},{"field":"shares","element":"transactionShares","label":"F3","text":"On December 24, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 260,661 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"On December 24, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 260,661 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"On December 24, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 260,661 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1,"derivative":{"exercise_price":6.919,"expiration_date":"2022-01-19","underlying":"Common Stock","underlying_shares":260661},"source":{"system":"sec-edgar","filing":"0001193805-18-001441","document":"e618118_4-aclaris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001441/e618118_4-aclaris.xml","form_type":"4"}},{"id":3722399,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Cash-Settled Total Return Swap","published_at":"2018-12-22T00:16:49.000Z","date":"2018-12-21","kind":"other","acquired":true,"shares":1,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F7","text":"On December 21, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 410,511 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F8","text":"The price reported in Column 2 represents a weighted average reference price associated with the applicable swap agreement. The reference prices applicable to 410,511 notional shares subject to the swap agreement range from $6.765 to 7.00, inclusive."},{"field":"shares","element":"transactionShares","label":"F7","text":"On December 21, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 410,511 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"On December 21, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 410,511 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"On December 21, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 410,511 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1,"derivative":{"exercise_price":6.945,"expiration_date":"2022-01-19","underlying":"Common Stock","underlying_shares":410511},"source":{"system":"sec-edgar","filing":"0001193805-18-001435","document":"e618114_4-aclaris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001435/e618114_4-aclaris.xml","form_type":"4"}},{"id":3722398,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Cash-Settled Total Return Swap","published_at":"2018-12-22T00:16:49.000Z","date":"2018-12-20","kind":"other","acquired":true,"shares":1,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F5","text":"On December 20, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 190,502 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F6","text":"The price reported in Column 2 represents a weighted average reference price associated with the applicable swap agreement. The reference prices applicable to 190,502 notional shares subject to the swap agreement range from $6.72 to $6.90, inclusive."},{"field":"shares","element":"transactionShares","label":"F5","text":"On December 20, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 190,502 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"On December 20, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 190,502 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"On December 20, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 190,502 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1,"derivative":{"exercise_price":6.842,"expiration_date":"2022-01-19","underlying":"Common Stock","underlying_shares":190502},"source":{"system":"sec-edgar","filing":"0001193805-18-001435","document":"e618114_4-aclaris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001435/e618114_4-aclaris.xml","form_type":"4"}},{"id":3722397,"issuer":{"id":5041,"kind":"organization","name":"Aclaris Therapeutics, Inc."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Cash-Settled Total Return Swap","published_at":"2018-12-22T00:16:49.000Z","date":"2018-12-19","kind":"other","acquired":true,"shares":1,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"On December 19, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 194,207 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"The price reported in Column 2 represents a weighted average reference price associated with the applicable swap agreement. The reference prices applicable to 194,207 notional shares subject to the swap agreement range from $6.45 to $7.00, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of notional shares subject to each separate reference price within the ranges set forth in footnotes (4), (6) and (8) of this Form 4."},{"field":"shares","element":"transactionShares","label":"F3","text":"On December 19, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 194,207 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"On December 19, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 194,207 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"On December 19, 2018, Deerfield Partners entered into a cash-settled total return swap agreement with an unaffiliated third party financial institution, which provides Deerfield Partners with economic exposure to an aggregate of 194,207 notional shares. The swap agreement provides Deerfield Partners with economic results that are comparable to the economic results of ownership of, based on the applicable reference prices, but does not provide Deerfield Partners with the power to vote or direct the voting of, or dispose of or direct the disposition of, the shares of common stock that are the subject of such swap agreement."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. (\"Deerfield Partners\") and Deerfield Special Situations Fund, L.P. (collectively with Deerfield Partners, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1,"derivative":{"exercise_price":6.914,"expiration_date":"2022-01-19","underlying":"Common Stock","underlying_shares":194207},"source":{"system":"sec-edgar","filing":"0001193805-18-001435","document":"e618114_4-aclaris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001435/e618114_4-aclaris.xml","form_type":"4"}},{"id":3804685,"issuer":{"id":5355,"kind":"organization","name":"ARVINAS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":3,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":4,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":5,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":7,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":8,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}}],"security":"Series C Preferred Stock","published_at":"2018-10-01T17:47:03.000Z","date":"2018-10-01","kind":"exercise","acquired":false,"shares":998004,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III and Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":307078},"source":{"system":"sec-edgar","filing":"0001193805-18-001183","document":"e617963_4-arvinas.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001183/e617963_4-arvinas.xml","form_type":"4"}},{"id":3804684,"issuer":{"id":5355,"kind":"organization","name":"ARVINAS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":3,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":4,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":5,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":7,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":8,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}}],"security":"Series C Preferred Stock","published_at":"2018-10-01T17:47:03.000Z","date":"2018-10-01","kind":"exercise","acquired":false,"shares":998004,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund IV, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III and Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":307078},"source":{"system":"sec-edgar","filing":"0001193805-18-001183","document":"e617963_4-arvinas.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001183/e617963_4-arvinas.xml","form_type":"4"}},{"id":3804683,"issuer":{"id":5355,"kind":"organization","name":"ARVINAS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":3,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":4,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":5,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":7,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":8,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}}],"security":"Series C Preferred Stock","published_at":"2018-10-01T17:47:03.000Z","date":"2018-10-01","kind":"exercise","acquired":false,"shares":998004,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund III, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III and Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":307078},"source":{"system":"sec-edgar","filing":"0001193805-18-001183","document":"e617963_4-arvinas.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001183/e617963_4-arvinas.xml","form_type":"4"}},{"id":3804682,"issuer":{"id":5355,"kind":"organization","name":"ARVINAS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":3,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":4,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":5,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":7,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":8,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}}],"security":"Common Stock","published_at":"2018-10-01T17:47:03.000Z","date":"2018-10-01","kind":"purchase","acquired":true,"shares":104166,"price":16,"value":1666656.0,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund IV, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III and Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":411244,"source":{"system":"sec-edgar","filing":"0001193805-18-001183","document":"e617963_4-arvinas.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001183/e617963_4-arvinas.xml","form_type":"4"}},{"id":3804681,"issuer":{"id":5355,"kind":"organization","name":"ARVINAS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":3,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":4,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":5,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":7,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":8,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}}],"security":"Common Stock","published_at":"2018-10-01T17:47:03.000Z","date":"2018-10-01","kind":"purchase","acquired":true,"shares":104167,"price":16,"value":1666672.0,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund III, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III and Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":411245,"source":{"system":"sec-edgar","filing":"0001193805-18-001183","document":"e617963_4-arvinas.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001183/e617963_4-arvinas.xml","form_type":"4"}},{"id":3804680,"issuer":{"id":5355,"kind":"organization","name":"ARVINAS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":3,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":4,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":5,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":7,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":8,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}}],"security":"Common Stock","published_at":"2018-10-01T17:47:03.000Z","date":"2018-10-01","kind":"purchase","acquired":true,"shares":104167,"price":16,"value":1666672.0,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III and Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":411245,"source":{"system":"sec-edgar","filing":"0001193805-18-001183","document":"e617963_4-arvinas.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001183/e617963_4-arvinas.xml","form_type":"4"}},{"id":3804679,"issuer":{"id":5355,"kind":"organization","name":"ARVINAS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":3,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":4,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":5,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":7,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":8,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}}],"security":"Common Stock","published_at":"2018-10-01T17:47:03.000Z","date":"2018-10-01","kind":"exercise","acquired":true,"shares":307078,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund IV, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III and Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":307078,"source":{"system":"sec-edgar","filing":"0001193805-18-001183","document":"e617963_4-arvinas.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001183/e617963_4-arvinas.xml","form_type":"4"}},{"id":3804678,"issuer":{"id":5355,"kind":"organization","name":"ARVINAS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":3,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":4,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":5,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":7,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":8,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}}],"security":"Common Stock","published_at":"2018-10-01T17:47:03.000Z","date":"2018-10-01","kind":"exercise","acquired":true,"shares":307078,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund III, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III and Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":307078,"source":{"system":"sec-edgar","filing":"0001193805-18-001183","document":"e617963_4-arvinas.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001183/e617963_4-arvinas.xml","form_type":"4"}},{"id":3804677,"issuer":{"id":5355,"kind":"organization","name":"ARVINAS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":3,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29899,"kind":"person","name":"Deerfield Mgmt IV, L.P.","position":4,"cik":"0001713467","reported_name":"Deerfield Mgmt IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":5,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":6,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":7,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}},{"id":29900,"kind":"person","name":"Deerfield Private Design Fund IV, L.P.","position":8,"cik":"0001680307","reported_name":"Deerfield Private Design Fund IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of a 10% Group"}}],"security":"Common Stock","published_at":"2018-10-01T17:47:03.000Z","date":"2018-10-01","kind":"exercise","acquired":true,"shares":307078,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.3076923 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-3.25 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (\"Fund IV\"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III and Fund IV, the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":307078,"source":{"system":"sec-edgar","filing":"0001193805-18-001183","document":"e617963_4-arvinas.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001183/e617963_4-arvinas.xml","form_type":"4"}},{"id":3863094,"issuer":{"id":137050,"kind":"organization","name":"CONSTELLATION PHARMACEUTICALS INC","symbol":"CNST"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}}],"security":"Series F Preferred Stock","published_at":"2018-07-23T17:00:30.000Z","date":"2018-07-23","kind":"exercise","acquired":false,"shares":7000000,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series F Preferred Stock automatically converted into 0.090834772 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-11.009 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series F Preferred Stock automatically converted into 0.090834772 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-11.009 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series F Preferred Stock automatically converted into 0.090834772 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-11.009 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series F Preferred Stock automatically converted into 0.090834772 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-11.009 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (the \"Fund\").  Deerfield Management Company, L.P. is the investment manager of the Fund. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Fund is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":635843},"source":{"system":"sec-edgar","filing":"0001193805-18-001002","document":"e618183_4-cpi.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001002/e618183_4-cpi.xml","form_type":"4"}},{"id":3863093,"issuer":{"id":137050,"kind":"organization","name":"CONSTELLATION PHARMACEUTICALS INC","symbol":"CNST"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}}],"security":"Common Stock","published_at":"2018-07-23T17:00:30.000Z","date":"2018-07-23","kind":"purchase","acquired":true,"shares":200000,"price":15,"value":3000000.0,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (the \"Fund\").  Deerfield Management Company, L.P. is the investment manager of the Fund. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Fund is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":835843,"source":{"system":"sec-edgar","filing":"0001193805-18-001002","document":"e618183_4-cpi.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001002/e618183_4-cpi.xml","form_type":"4"}},{"id":3863092,"issuer":{"id":137050,"kind":"organization","name":"CONSTELLATION PHARMACEUTICALS INC","symbol":"CNST"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible member of 10% group"}}],"security":"Common Stock","published_at":"2018-07-23T17:00:30.000Z","date":"2018-07-23","kind":"exercise","acquired":true,"shares":635843,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series F Preferred Stock automatically converted into 0.090834772 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-11.009 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (the \"Fund\").  Deerfield Management Company, L.P. is the investment manager of the Fund. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Fund is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":635843,"source":{"system":"sec-edgar","filing":"0001193805-18-001002","document":"e618183_4-cpi.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518001002/e618183_4-cpi.xml","form_type":"4"}},{"id":3882566,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Series C Preferred Stock","published_at":"2018-06-27T20:58:59.000Z","date":"2018-06-25","kind":"exercise","acquired":false,"shares":1557292,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.5614445 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.78112 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.5614445 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.78112 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.5614445 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.78112 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.5614445 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.78112 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":874333},"source":{"system":"sec-edgar","filing":"0001193805-18-000920","document":"e618139_4-xeris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000920/e618139_4-xeris.xml","form_type":"4"}},{"id":3882565,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Series C Preferred Stock","published_at":"2018-06-27T20:58:59.000Z","date":"2018-06-25","kind":"exercise","acquired":false,"shares":1557292,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund III, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.5614445 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.78112 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.5614445 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.78112 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.5614445 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.78112 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.5614445 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.78112 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":874333},"source":{"system":"sec-edgar","filing":"0001193805-18-000920","document":"e618139_4-xeris.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000920/e618139_4-xeris.xml","form_type":"4"}},{"id":3882564,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-06-27T20:58:59.000Z","date":"2018-06-25","kind":"purchase","acquired":true,"shares":624333,"price":15,"value":9364995.0,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund III, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1498666,"source":{"system":"sec-edgar","filing":"0001193805-18-000920","document":"e618139_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000920/e618139_4-xeris.xml","form_type":"4"}},{"id":3882563,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-06-27T20:58:59.000Z","date":"2018-06-25","kind":"purchase","acquired":true,"shares":125667,"price":15,"value":1885005.0,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":1000000,"source":{"system":"sec-edgar","filing":"0001193805-18-000920","document":"e618139_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000920/e618139_4-xeris.xml","form_type":"4"}},{"id":3882562,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-06-27T20:58:59.000Z","date":"2018-06-25","kind":"exercise","acquired":true,"shares":874333,"ownership":{"direct":false,"nature":"Through Deerfield Private Design Fund III, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.5614445 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.78112 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":874333,"source":{"system":"sec-edgar","filing":"0001193805-18-000920","document":"e618139_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000920/e618139_4-xeris.xml","form_type":"4"}},{"id":3882561,"issuer":{"id":134906,"kind":"organization","name":"XERIS PHARMACEUTICALS INC","symbol":"XERS"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39427,"kind":"organization","name":"Deerfield Mgmt III, L.P.","position":5,"cik":"0001610540","reported_name":"Deerfield Mgmt III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":39428,"kind":"organization","name":"Deerfield Private Design Fund III, L.P.","position":6,"cik":"0001603333","reported_name":"Deerfield Private Design Fund III, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-06-27T20:58:59.000Z","date":"2018-06-25","kind":"exercise","acquired":true,"shares":874333,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock automatically converted into 0.5614445 shares of the Issuer's common stock upon the closing of the Issuer's initial public offering (on an adjusted basis, after giving effect to the 1-for-1.78112 reverse stock split effected by the Issuer in connection with its initial public offering)."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. (\"Fund III\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. (collectively with Fund III, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":874333,"source":{"system":"sec-edgar","filing":"0001193805-18-000920","document":"e618139_4-xeris.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000920/e618139_4-xeris.xml","form_type":"4"}},{"id":3884353,"issuer":{"id":65991,"kind":"organization","name":"AVADEL PHARMACEUTICALS PLC","symbol":"AVDL"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":2,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":165494,"kind":"organization","name":"Deerfield Private Design Fund II, L.P.","position":3,"cik":"0001483687","reported_name":"Deerfield Private Design Fund II, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"*Possible member of 10% group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":5,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":165495,"kind":"organization","name":"Deerfield Private Design International II, L.P.","position":6,"cik":"0001483686","reported_name":"Deerfield Private Design International II, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"*Possible member of 10% group"}},{"id":165496,"kind":"organization","name":"Breaking Stick Holdings, LLC","position":7,"cik":"0001670085","reported_name":"Breaking Stick Holdings, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":false,"other":true,"other_text":"*Possible member of 10% group"}}],"security":"American Depositary Shares","published_at":"2018-06-25T21:59:10.000Z","date":"2018-06-25","kind":"sale","acquired":false,"shares":114034,"price":5.9922,"value":683314.5348,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"Each American Depositary Share (\"ADS\") represents one Ordinary Share of the Issuer."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price.  The shares were sold in multiple transactions at prices ranging from $5.635 to $6.12, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote (2) of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P., Deerfield Private Design Fund II, L.P. and Deerfield Private Design International II, L.P.  (collectively, the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds and is the manager of Breaking Stick Holdings, LLC.  Deerfield Private Design Fund II, L.P. and Deerfield Private Design International II, L.P. are members of Breaking Stick Holdings, LLC.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":952265,"source":{"system":"sec-edgar","filing":"0001193805-18-000909","document":"e618134_4-avadel.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000909/e618134_4-avadel.xml","form_type":"4"}},{"id":3913072,"issuer":{"id":1954,"kind":"organization","name":"Kiniksa Pharmaceuticals International, plc","symbol":"KNSA"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}}],"security":"Series C Preferred Stock","published_at":"2018-05-31T20:19:52.000Z","date":"2018-05-29","kind":"exercise","acquired":false,"shares":383538,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each share of Series C Preferred Stock converted into one share of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering. The number of shares reported herein gives effect to the 1-for-2.73235 reverse stock split of the Issuer's common stock and preferred stock effected by the Issuer in connection with its initial public offering."},{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock converted into one share of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering. The number of shares reported herein gives effect to the 1-for-2.73235 reverse stock split of the Issuer's common stock and preferred stock effected by the Issuer in connection with its initial public offering."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each share of Series C Preferred Stock converted into one share of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering. The number of shares reported herein gives effect to the 1-for-2.73235 reverse stock split of the Issuer's common stock and preferred stock effected by the Issuer in connection with its initial public offering."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each share of Series C Preferred Stock converted into one share of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering. The number of shares reported herein gives effect to the 1-for-2.73235 reverse stock split of the Issuer's common stock and preferred stock effected by the Issuer in connection with its initial public offering."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of each of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":0,"derivative":{"underlying":"Class A Common Stock","underlying_shares":383538},"source":{"system":"sec-edgar","filing":"0001193805-18-000778","document":"e618063_4-kiniksa.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000778/e618063_4-kiniksa.xml","form_type":"4"}},{"id":3913071,"issuer":{"id":1954,"kind":"organization","name":"Kiniksa Pharmaceuticals International, plc","symbol":"KNSA"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}}],"security":"Class A Common Stock","published_at":"2018-05-31T20:19:52.000Z","date":"2018-05-29","kind":"purchase","acquired":true,"shares":235019,"price":19.2365,"value":4520942.9935,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $19.00 to $19.255, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of each of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":843352,"source":{"system":"sec-edgar","filing":"0001193805-18-000778","document":"e618063_4-kiniksa.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000778/e618063_4-kiniksa.xml","form_type":"4"}},{"id":3913070,"issuer":{"id":1954,"kind":"organization","name":"Kiniksa Pharmaceuticals International, plc","symbol":"KNSA"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}}],"security":"Class A Common Stock","published_at":"2018-05-31T20:19:52.000Z","date":"2018-05-29","kind":"purchase","acquired":true,"shares":25000,"price":20.9099,"value":522747.5,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $20.78 to $21.00, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of each of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":608333,"source":{"system":"sec-edgar","filing":"0001193805-18-000778","document":"e618063_4-kiniksa.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000778/e618063_4-kiniksa.xml","form_type":"4"}},{"id":3913069,"issuer":{"id":1954,"kind":"organization","name":"Kiniksa Pharmaceuticals International, plc","symbol":"KNSA"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}}],"security":"Class A Common Stock","published_at":"2018-05-31T20:19:52.000Z","date":"2018-05-29","kind":"purchase","acquired":true,"shares":250000,"price":19.8126,"value":4953150.0,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $19.30 to $20.00, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes (2), (3) and (4) of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of each of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":583333,"source":{"system":"sec-edgar","filing":"0001193805-18-000778","document":"e618063_4-kiniksa.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000778/e618063_4-kiniksa.xml","form_type":"4"}},{"id":3913068,"issuer":{"id":1954,"kind":"organization","name":"Kiniksa Pharmaceuticals International, plc","symbol":"KNSA"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}}],"security":"Class A Common Stock","published_at":"2018-05-31T20:19:52.000Z","date":"2018-05-29","kind":"purchase","acquired":true,"shares":333333,"price":18,"value":5999994.0,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of each of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":333333,"source":{"system":"sec-edgar","filing":"0001193805-18-000778","document":"e618063_4-kiniksa.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000778/e618063_4-kiniksa.xml","form_type":"4"}},{"id":3913067,"issuer":{"id":1954,"kind":"organization","name":"Kiniksa Pharmaceuticals International, plc","symbol":"KNSA"},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"*Possible member of 10% group"}}],"security":"Class A Common Stock","published_at":"2018-05-31T20:19:52.000Z","date":"2018-05-29","kind":"exercise","acquired":true,"shares":383538,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each share of Series C Preferred Stock converted into one share of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering. The number of shares reported herein gives effect to the 1-for-2.73235 reverse stock split of the Issuer's common stock and preferred stock effected by the Issuer in connection with its initial public offering."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\"). Deerfield Mgmt, L.P. is the general partner of each of Deerfield Partners, L.P. and Deerfield Special Situations Fund, L.P. (the \"Funds\"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"In accordance with Instruction 4(b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."}],"balance_after":383538,"source":{"system":"sec-edgar","filing":"0001193805-18-000778","document":"e618063_4-kiniksa.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000778/e618063_4-kiniksa.xml","form_type":"4"}},{"id":3986720,"issuer":{"id":5247,"kind":"organization","name":"GYRE THERAPEUTICS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-03-21T20:12:21.000Z","date":"2018-03-08","kind":"sale","acquired":false,"shares":2233,"price":29.03,"value":64823.99,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price.  The shares were sold in multiple transactions at prices ranging from $29.00 to $29.75, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the \"Original Filing\") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged."}],"balance_after":305965,"source":{"system":"sec-edgar","filing":"0001193805-18-000436","document":"e617828_4a-catalyst.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000436/e617828_4a-catalyst.xml","form_type":"4/A","original_submission_date":"2018-03-08"}},{"id":3986719,"issuer":{"id":5247,"kind":"organization","name":"GYRE THERAPEUTICS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-03-21T20:12:21.000Z","date":"2018-03-08","kind":"sale","acquired":false,"shares":5890,"price":29.03,"value":170986.7,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price.  The shares were sold in multiple transactions at prices ranging from $29.00 to $29.75, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the \"Original Filing\") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged."}],"balance_after":807257,"source":{"system":"sec-edgar","filing":"0001193805-18-000436","document":"e617828_4a-catalyst.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000436/e617828_4a-catalyst.xml","form_type":"4/A","original_submission_date":"2018-03-08"}},{"id":3986718,"issuer":{"id":5247,"kind":"organization","name":"GYRE THERAPEUTICS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-03-21T20:12:21.000Z","date":"2018-03-08","kind":"sale","acquired":false,"shares":328,"price":30,"value":9840.0,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the \"Original Filing\") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged."}],"balance_after":308198,"source":{"system":"sec-edgar","filing":"0001193805-18-000436","document":"e617828_4a-catalyst.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000436/e617828_4a-catalyst.xml","form_type":"4/A","original_submission_date":"2018-03-08"}},{"id":3986717,"issuer":{"id":5247,"kind":"organization","name":"GYRE THERAPEUTICS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-03-21T20:12:21.000Z","date":"2018-03-08","kind":"sale","acquired":false,"shares":866,"price":30,"value":25980.0,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the \"Original Filing\") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged."}],"balance_after":813147,"source":{"system":"sec-edgar","filing":"0001193805-18-000436","document":"e617828_4a-catalyst.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000436/e617828_4a-catalyst.xml","form_type":"4/A","original_submission_date":"2018-03-08"}},{"id":3986716,"issuer":{"id":5247,"kind":"organization","name":"GYRE THERAPEUTICS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-03-21T20:12:21.000Z","date":"2018-03-07","kind":"sale","acquired":false,"shares":2748,"price":30,"value":82440.0,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the \"Original Filing\") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged."}],"balance_after":308526,"source":{"system":"sec-edgar","filing":"0001193805-18-000436","document":"e617828_4a-catalyst.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000436/e617828_4a-catalyst.xml","form_type":"4/A","original_submission_date":"2018-03-08"}},{"id":3986715,"issuer":{"id":5247,"kind":"organization","name":"GYRE THERAPEUTICS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-03-21T20:12:21.000Z","date":"2018-03-07","kind":"sale","acquired":false,"shares":7252,"price":30,"value":217560.0,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the \"Original Filing\") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged."}],"balance_after":814013,"source":{"system":"sec-edgar","filing":"0001193805-18-000436","document":"e617828_4a-catalyst.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000436/e617828_4a-catalyst.xml","form_type":"4/A","original_submission_date":"2018-03-08"}},{"id":3986714,"issuer":{"id":5247,"kind":"organization","name":"GYRE THERAPEUTICS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-03-21T20:12:21.000Z","date":"2018-03-06","kind":"sale","acquired":false,"shares":10802,"price":31.18,"value":336806.36,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price.  The shares were sold in multiple transactions at prices ranging from $31.00 to $31.21, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the \"Original Filing\") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged."}],"balance_after":311274,"source":{"system":"sec-edgar","filing":"0001193805-18-000436","document":"e617828_4a-catalyst.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000436/e617828_4a-catalyst.xml","form_type":"4/A","original_submission_date":"2018-03-08"}},{"id":3986713,"issuer":{"id":5247,"kind":"organization","name":"GYRE THERAPEUTICS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-03-21T20:12:21.000Z","date":"2018-03-06","kind":"sale","acquired":false,"shares":28498,"price":31.18,"value":888567.64,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price.  The shares were sold in multiple transactions at prices ranging from $31.00 to $31.21, inclusive."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the \"Original Filing\") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged."}],"balance_after":821265,"source":{"system":"sec-edgar","filing":"0001193805-18-000436","document":"e617828_4a-catalyst.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000436/e617828_4a-catalyst.xml","form_type":"4/A","original_submission_date":"2018-03-08"}},{"id":3986712,"issuer":{"id":5247,"kind":"organization","name":"GYRE THERAPEUTICS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-03-21T20:12:21.000Z","date":"2018-03-06","kind":"sale","acquired":false,"shares":3617,"price":29.94,"value":108292.98,"ownership":{"direct":false,"nature":"Through Deerfield Special Situations Fund, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price.  The shares were sold in multiple transactions at prices ranging from $29.75 to $30.50, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission (the \"Commission\"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1), (2) and (3) of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the \"Original Filing\") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged."}],"balance_after":322076,"source":{"system":"sec-edgar","filing":"0001193805-18-000436","document":"e617828_4a-catalyst.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000436/e617828_4a-catalyst.xml","form_type":"4/A","original_submission_date":"2018-03-08"}},{"id":3986711,"issuer":{"id":5247,"kind":"organization","name":"GYRE THERAPEUTICS, INC."},"owners":[{"id":29893,"kind":"person","name":"Flynn James E","position":1,"cik":"0001352546","reported_name":"Flynn James E","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29898,"kind":"person","name":"Deerfield Mgmt L.P.","position":2,"cik":"0001010823","reported_name":"Deerfield Mgmt L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29894,"kind":"person","name":"DEERFIELD MANAGEMENT COMPANY, L.P.","position":3,"cik":"0001009258","reported_name":"DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":137394,"kind":"organization","name":"Deerfield Special Situations Fund, L.P.","position":4,"cik":"0001354395","reported_name":"Deerfield Special Situations Fund, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}},{"id":29897,"kind":"person","name":"DEERFIELD PARTNERS, L.P.","position":5,"cik":"0001301041","reported_name":"DEERFIELD PARTNERS, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":true,"other_text":"Possible Member of 10% Group"}}],"security":"Common Stock","published_at":"2018-03-21T20:12:21.000Z","date":"2018-03-06","kind":"sale","acquired":false,"shares":9544,"price":29.94,"value":285747.36,"ownership":{"direct":false,"nature":"Through Deerfield Partners, L.P."},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price.  The shares were sold in multiple transactions at prices ranging from $29.75 to $30.50, inclusive.  The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission (the \"Commission\"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1), (2) and (3) of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the \"Reporting Persons\").  Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Partners, L.P. (the \"Funds\").  Deerfield Management Company, L.P. is the investment manager of the Funds.  James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt, L.P. and Deerfield Management Company, L.P."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"This Amendment to the Form 4 filed with the Commission on March 8, 2018 (the \"Original Filing\") is being filed to correctly report the identity of the direct beneficial owners of shares sold on March 6, 2018, March 7, 2018 and March 8, 2018 (as well as the direct holder of shares beneficially owned by the applicable Reporting Persons following such sales) which were incorrectly reported on the March 8, 2018 Form 4 report. The aggregate number of shares sold by the Funds and the aggregate number of shares beneficially owned by the Reporting Persons, as reported in the Original Filing, remains unchanged."}],"balance_after":849763,"source":{"system":"sec-edgar","filing":"0001193805-18-000436","document":"e617828_4a-catalyst.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1009258/000119380518000436/e617828_4a-catalyst.xml","form_type":"4/A","original_submission_date":"2018-03-08"}}],"next_cursor":"2018-03-21T20:12:21.000000Z,3986711"}