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The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 4/4/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 4/4/2019."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $72.60 to $72.92, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":9794,"source":{"system":"sec-edgar","filing":"0000874015-19-000065","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401519000065/edgar.xml","form_type":"4"}},{"id":3535829,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":125326,"kind":"person","name":"MUTO FREDERICK T","position":1,"cik":"0001181560","reported_name":"MUTO FREDERICK T","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2019-05-08T22:16:11.000Z","date":"2019-05-06","kind":"exercise","acquired":true,"shares":8000,"price":24.42,"value":195360.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 4/4/2019."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. 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The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 2, 2019. The option shall be fully vested and exercisable on July 2, 2022. The option is exercisable to 0 shares on July 2, 2018."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Grant of July 2, 2018 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 2, 2019. The option shall be fully vested and exercisable on July 2, 2022. 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Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"Restricted Stock Units vest in four equal annual installments. 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The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/26/2015."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/26/2015."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $46.25 to $46.60, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":7127,"source":{"system":"sec-edgar","filing":"0000874015-18-000067","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401518000067/edgar.xml","form_type":"4"}},{"id":3913280,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":125326,"kind":"person","name":"MUTO FREDERICK T","position":1,"cik":"0001181560","reported_name":"MUTO FREDERICK T","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2018-06-01T00:02:44.000Z","date":"2018-05-31","kind":"exercise","acquired":true,"shares":15000,"price":13.88,"value":208200.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/26/2015."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/26/2015."}],"balance_after":22127,"source":{"system":"sec-edgar","filing":"0000874015-18-000067","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401518000067/edgar.xml","form_type":"4"}},{"id":4268104,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":125326,"kind":"person","name":"MUTO FREDERICK T","position":1,"cik":"0001181560","reported_name":"MUTO FREDERICK T","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Director Stock Option (right to buy)","published_at":"2017-07-03T21:33:04.000Z","date":"2017-07-03","kind":"grant","acquired":true,"shares":16000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Grant of July 3, 2017 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 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The RSU is vested as to 0 shares on July 3, 2017."}],"balance_after":2667,"derivative":{"underlying":"Common Stock","underlying_shares":2667},"source":{"system":"sec-edgar","filing":"0000874015-17-000040","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401517000040/edgar.xml","form_type":"4"}},{"id":4268102,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":125326,"kind":"person","name":"MUTO FREDERICK T","position":1,"cik":"0001181560","reported_name":"MUTO FREDERICK T","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Restricted Stock Units","published_at":"2017-07-03T21:33:04.000Z","date":"2017-07-01","kind":"exercise","acquired":false,"shares":2469,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"Restricted Stock Units vest in four equal annual installments.  Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"Restricted Stock Units vest in four equal annual installments.  Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":3999,"derivative":{"underlying":"Common Stock","underlying_shares":2469},"source":{"system":"sec-edgar","filing":"0000874015-17-000040","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401517000040/edgar.xml","form_type":"4"}},{"id":4268101,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":125326,"kind":"person","name":"MUTO FREDERICK T","position":1,"cik":"0001181560","reported_name":"MUTO FREDERICK T","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2017-07-03T21:33:04.000Z","date":"2017-07-01","kind":"exercise","acquired":true,"shares":2469,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards."}],"balance_after":7127,"source":{"system":"sec-edgar","filing":"0000874015-17-000040","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401517000040/edgar.xml","form_type":"4"}},{"id":4296903,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":125326,"kind":"person","name":"MUTO FREDERICK T","position":1,"cik":"0001181560","reported_name":"MUTO FREDERICK T","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Non-Employee Director Stock Option","published_at":"2017-06-02T22:16:30.000Z","date":"2017-05-31","kind":"exercise","acquired":false,"shares":12500,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":9.77,"exercise_date":"2011-07-02","expiration_date":"2017-07-01","underlying":"Common Stock","underlying_shares":12500},"source":{"system":"sec-edgar","filing":"0000874015-17-000035","document":"edgar.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401517000035/edgar.xml","form_type":"4"}},{"id":4296902,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":125326,"kind":"person","name":"MUTO FREDERICK T","position":1,"cik":"0001181560","reported_name":"MUTO FREDERICK T","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2017-06-02T22:16:30.000Z","date":"2017-05-31","kind":"sale","acquired":false,"shares":12500,"price":45.22,"value":565250.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option that was scheduled to expire on 7/1/2017. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 6/26/2015."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option that was scheduled to expire on 7/1/2017. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 6/26/2015."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.00 to $45.40, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":4658,"source":{"system":"sec-edgar","filing":"0000874015-17-000035","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401517000035/edgar.xml","form_type":"4"}},{"id":4296901,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":125326,"kind":"person","name":"MUTO FREDERICK T","position":1,"cik":"0001181560","reported_name":"MUTO FREDERICK T","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2017-06-02T22:16:30.000Z","date":"2017-05-31","kind":"exercise","acquired":true,"shares":12500,"price":9.77,"value":122125.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired as a result of exercising a stock option that was scheduled to expire on 7/1/2017. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 6/26/2015."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option that was scheduled to expire on 7/1/2017. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 6/26/2015."}],"balance_after":17158,"source":{"system":"sec-edgar","filing":"0000874015-17-000035","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401517000035/edgar.xml","form_type":"4"}}]}