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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) on this Form 4."}],"balance_after":80554,"source":{"system":"sec-edgar","filing":"0000874015-26-000134","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000134/edgardoc.xml","form_type":"4"}},{"id":859779,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2026-03-05T23:13:59.000Z","date":"2026-03-03","kind":"sale","planned":true,"acquired":false,"shares":12687,"price":79.8778,"value":1013409.6486,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on November 19, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":94043,"source":{"system":"sec-edgar","filing":"0000874015-26-000134","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000134/edgardoc.xml","form_type":"4"}},{"id":859777,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2026-03-05T23:13:59.000Z","date":"2026-03-03","kind":"exercise","planned":true,"acquired":true,"shares":48626,"price":60.89,"value":2960837.14,"ownership":{"direct":true},"balance_after":165643,"source":{"system":"sec-edgar","filing":"0000874015-26-000134","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000134/edgardoc.xml","form_type":"4"}},{"id":859776,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2026-03-05T23:13:59.000Z","date":"2026-03-03","kind":"exercise","planned":true,"acquired":true,"shares":16463,"price":32.6,"value":536693.8,"ownership":{"direct":true},"balance_after":117017,"source":{"system":"sec-edgar","filing":"0000874015-26-000134","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000134/edgardoc.xml","form_type":"4"}},{"id":871249,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2026-03-03T22:28:34.000Z","date":"2026-02-27","kind":"other","planned":false,"acquired":true,"shares":261,"price":48.8665,"value":12754.1565,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. 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These shares were sold in multiple transactions at prices ranging from $81.92 to $82.775 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":80293,"source":{"system":"sec-edgar","filing":"0000874015-26-000104","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000104/edgardoc.xml","form_type":"4"}},{"id":926037,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2026-02-03T01:51:27.000Z","date":"2026-01-30","kind":"sale","planned":false,"acquired":false,"shares":5885,"price":82.9466,"value":488140.741,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.94 to $82.95 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":100293,"source":{"system":"sec-edgar","filing":"0000874015-26-000096","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000096/edgardoc.xml","form_type":"4"}},{"id":926036,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2026-02-03T01:51:27.000Z","date":"2026-01-29","kind":"grant","planned":false,"acquired":true,"shares":11421,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the performance period of the grant to the reporting person reported on January 18, 2023. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 167.27% of target shares. As reported at grant, the PRSUs could result in a payout of 0% to 200% based on actual achievement of the goal."}],"balance_after":106178,"source":{"system":"sec-edgar","filing":"0000874015-26-000096","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000096/edgardoc.xml","form_type":"4"}},{"id":936196,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Restricted Stock Unit","published_at":"2026-01-21T01:18:10.000Z","date":"2026-01-15","kind":"grant","planned":false,"acquired":true,"shares":9675,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F8","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 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Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":27109,"derivative":{"exercise_price":0,"exercise_date":"2027-01-15","underlying":"Common Stock","underlying_shares":9675},"source":{"system":"sec-edgar","filing":"0000874015-26-000062","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000062/edgardoc.xml","form_type":"4"}},{"id":936195,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Restricted Stock Unit","published_at":"2026-01-21T01:18:10.000Z","date":"2026-01-15","kind":"exercise","planned":false,"acquired":false,"shares":21055,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F6","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"Restricted Stock Units vest in four equal annual installments. 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These shares were sold in multiple transactions at prices ranging from $75.14 to $75.18  inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":94757,"source":{"system":"sec-edgar","filing":"0000874015-26-000062","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000062/edgardoc.xml","form_type":"4"}},{"id":936192,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2026-01-21T01:18:10.000Z","date":"2026-01-15","kind":"exercise","planned":false,"acquired":true,"shares":21055,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":103734,"source":{"system":"sec-edgar","filing":"0000874015-26-000062","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000062/edgardoc.xml","form_type":"4"}},{"id":948706,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-01-06T22:34:16.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":19350,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2026 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 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These shares were sold in multiple transactions at prices ranging from $59.25 to $59.86 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":82679,"source":{"system":"sec-edgar","filing":"0000874015-25-000227","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000227/edgardoc.xml","form_type":"4"}},{"id":1048735,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-09-05T00:29:05.000Z","date":"2025-09-03","kind":"exercise","planned":true,"acquired":false,"shares":46800,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":53.77,"exercise_date":"2020-01-02","expiration_date":"2026-01-01","underlying":"Common Stock","underlying_shares":46800},"source":{"system":"sec-edgar","filing":"0000874015-25-000213","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000213/edgardoc.xml","form_type":"4"}},{"id":1048734,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:29:05.000Z","date":"2025-09-03","kind":"exercise","planned":true,"acquired":false,"shares":12891,"price":61.5,"value":792796.5,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on May 13, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.26 to $61.995 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (e) on this Form 4."}],"balance_after":88679,"source":{"system":"sec-edgar","filing":"0000874015-25-000213","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000213/edgardoc.xml","form_type":"4"}},{"id":1048733,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:29:05.000Z","date":"2025-09-03","kind":"sale","planned":true,"acquired":false,"shares":33909,"price":60.62,"value":2055563.58,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on May 13, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":101570,"source":{"system":"sec-edgar","filing":"0000874015-25-000213","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000213/edgardoc.xml","form_type":"4"}},{"id":1048732,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:29:05.000Z","date":"2025-09-03","kind":"exercise","planned":true,"acquired":true,"shares":46800,"price":53.77,"value":2516436.0,"ownership":{"direct":true},"balance_after":135479,"source":{"system":"sec-edgar","filing":"0000874015-25-000213","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000213/edgardoc.xml","form_type":"4"}},{"id":1048731,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:29:05.000Z","date":"2025-09-02","kind":"sale","planned":true,"acquired":false,"shares":5000,"price":49.14,"value":245700.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on May 13, 2025."}],"balance_after":88679,"source":{"system":"sec-edgar","filing":"0000874015-25-000213","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000213/edgardoc.xml","form_type":"4"}},{"id":1050677,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2025-09-03T22:29:50.000Z","date":"2025-08-29","kind":"other","planned":false,"acquired":true,"shares":213,"price":27.71,"value":5902.23,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. 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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":93466,"source":{"system":"sec-edgar","filing":"0000874015-25-000178","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000178/edgardoc.xml","form_type":"4"}},{"id":1060831,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2025-08-20T22:14:40.000Z","date":"2025-08-18","kind":"exercise","planned":true,"acquired":true,"shares":10000,"price":32.6,"value":326000.0,"ownership":{"direct":true},"balance_after":103466,"source":{"system":"sec-edgar","filing":"0000874015-25-000178","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000178/edgardoc.xml","form_type":"4"}},{"id":1232373,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2025-03-04T22:16:26.000Z","date":"2025-02-28","kind":"other","planned":false,"acquired":true,"shares":320,"price":28.2115,"value":9027.68,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. 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These shares were sold in multiple transactions at prices ranging from $32.21 to $32.86 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":93146,"source":{"system":"sec-edgar","filing":"0000874015-25-000075","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000075/edgardoc.xml","form_type":"4"}},{"id":1288298,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2025-02-04T00:26:31.000Z","date":"2025-01-30","kind":"grant","planned":false,"acquired":true,"shares":3607,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the final performance period of the grant to the reporting person reported on January 19, 2022. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 150% of target shares. 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These shares were sold in multiple transactions at prices ranging from $32.88 to $32.92 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":90866,"source":{"system":"sec-edgar","filing":"0000874015-25-000056","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000056/edgardoc.xml","form_type":"4"}},{"id":1300949,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2025-01-18T00:40:07.000Z","date":"2025-01-15","kind":"exercise","planned":false,"acquired":true,"shares":18011,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":97618,"source":{"system":"sec-edgar","filing":"0000874015-25-000056","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000056/edgardoc.xml","form_type":"4"}},{"id":1312091,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-01-06T21:52:06.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":22000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2025 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 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These shares were sold in multiple transactions at prices ranging from $49.51 to $49.53 inclusive. The\nreporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange\nCommission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"The original Form 4 filed on February 2, 2024 reported 1,853 restricted stock units sold by the reporting person which has been revised by this amendment to reflect\nthe actual amount of shares sold and beneficially owned by Mr. Bennett."}],"balance_after":79047,"source":{"system":"sec-edgar","filing":"0000874015-24-000193","document":"primary_doc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000193/primary_doc.xml","form_type":"4/A","original_submission_date":"2024-02-02"}},{"id":1604778,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Officer Level 14"}}],"security":"Common Stock","published_at":"2024-03-05T00:13:13.000Z","date":"2024-02-29","kind":"other","planned":false,"acquired":true,"shares":383,"price":34.425,"value":13184.775,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. 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These shares were sold in multiple transactions at prices ranging from $49.51 to $49.53 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":79079,"source":{"system":"sec-edgar","filing":"0000874015-24-000103","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000103/edgardoc.xml","form_type":"4"}},{"id":1662905,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2024-02-03T00:54:45.000Z","date":"2024-02-01","kind":"grant","planned":false,"acquired":true,"shares":3609,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the second performance period of the grant to the reporting person reported on January 19, 2022. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 150% of target shares. As reported at grant, the PRSUs could result in a payout of 0% to 150% based on actual achievement of the goal."}],"balance_after":80932,"source":{"system":"sec-edgar","filing":"0000874015-24-000103","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000103/edgardoc.xml","form_type":"4"}},{"id":1677151,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Restricted Stock Unit","published_at":"2024-01-18T22:44:19.000Z","date":"2024-01-16","kind":"exercise","planned":false,"acquired":false,"shares":18314,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":23500,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":18314},"source":{"system":"sec-edgar","filing":"0000874015-24-000073","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000073/edgardoc.xml","form_type":"4"}},{"id":1677150,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2024-01-18T22:44:19.000Z","date":"2024-01-17","kind":"sale","planned":false,"acquired":false,"shares":6745,"price":50.417,"value":340062.665,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.35 to $50.43, inclusive. The reporting person undertakes to provide to Ionis\nPharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) of this Form 4."}],"balance_after":77323,"source":{"system":"sec-edgar","filing":"0000874015-24-000073","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000073/edgardoc.xml","form_type":"4"}},{"id":1677149,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2024-01-18T22:44:19.000Z","date":"2024-01-16","kind":"exercise","planned":false,"acquired":true,"shares":18314,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":84068,"source":{"system":"sec-edgar","filing":"0000874015-24-000073","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000073/edgardoc.xml","form_type":"4"}},{"id":1678503,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Restricted Stock Unit","published_at":"2024-01-18T01:49:28.000Z","date":"2024-01-15","kind":"grant","planned":false,"acquired":true,"shares":20400,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 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Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. 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Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on\n01/02/2024. 25% of the shares subject to the option will vest and become exercisable on 01/02/2025. 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These shares were sold in multiple transactions at prices ranging from $49.11 to $49.50 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":65754,"source":{"system":"sec-edgar","filing":"0000874015-23-000236","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000236/edgardoc.xml","form_type":"4"}},{"id":1701573,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2023-12-23T00:11:38.000Z","date":"2023-12-21","kind":"exercise","planned":true,"acquired":true,"shares":16113,"price":47.34,"value":762789.42,"ownership":{"direct":true},"balance_after":81867,"source":{"system":"sec-edgar","filing":"0000874015-23-000236","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000236/edgardoc.xml","form_type":"4"}},{"id":1701572,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2023-12-23T00:11:38.000Z","date":"2023-12-20","kind":"sale","planned":true,"acquired":false,"shares":6500,"price":49.6374,"value":322643.1,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.40 to $49.90 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) on this Form 4."}],"balance_after":65754,"source":{"system":"sec-edgar","filing":"0000874015-23-000236","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000236/edgardoc.xml","form_type":"4"}},{"id":1701571,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2023-12-23T00:11:38.000Z","date":"2023-12-20","kind":"exercise","planned":true,"acquired":true,"shares":6500,"price":47.34,"value":307710.0,"ownership":{"direct":true},"balance_after":72254,"source":{"system":"sec-edgar","filing":"0000874015-23-000236","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000236/edgardoc.xml","form_type":"4"}},{"id":1708149,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2023-12-18T21:55:42.000Z","date":"2023-12-14","kind":"exercise","planned":true,"acquired":false,"shares":8610,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":22613,"derivative":{"exercise_price":47.34,"exercise_date":"2018-01-03","expiration_date":"2024-01-02","underlying":"Common Stock","underlying_shares":8610},"source":{"system":"sec-edgar","filing":"0000874015-23-000226","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000226/edgardoc.xml","form_type":"4"}},{"id":1708148,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2023-12-18T21:55:42.000Z","date":"2023-12-14","kind":"exercise","planned":true,"acquired":false,"shares":14002,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":31223,"derivative":{"exercise_price":47.34,"exercise_date":"2018-01-03","expiration_date":"2024-01-02","underlying":"Common Stock","underlying_shares":14002},"source":{"system":"sec-edgar","filing":"0000874015-23-000226","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000226/edgardoc.xml","form_type":"4"}},{"id":1708147,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2023-12-18T21:55:42.000Z","date":"2023-12-14","kind":"sale","planned":true,"acquired":false,"shares":8610,"price":50.187,"value":432110.07,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.00 to $50.50 inclusive.  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The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":69651,"source":{"system":"sec-edgar","filing":"0000874015-23-000089","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000089/edgardoc.xml","form_type":"4"}},{"id":2029448,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2023-02-07T22:36:04.000Z","date":"2023-02-03","kind":"grant","acquired":true,"shares":3609,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the first performance period of the grant to the reporting person reported on January 19, 2022. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 150% of target shares. 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These shares were sold in multiple transactions at prices ranging from $38.65 to $39.36 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":67855,"source":{"system":"sec-edgar","filing":"0000874015-23-000062","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000062/edgardoc.xml","form_type":"4"}},{"id":2051579,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2023-01-20T01:19:15.000Z","date":"2023-01-17","kind":"exercise","acquired":true,"shares":19417,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":74833,"source":{"system":"sec-edgar","filing":"0000874015-23-000062","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000062/edgardoc.xml","form_type":"4"}},{"id":2053168,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Scientific Officer"}}],"security":"Restricted Stock Unit","published_at":"2023-01-19T01:23:39.000Z","date":"2023-01-15","kind":"grant","acquired":true,"shares":16387,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 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These shares were sold in multiple transactions at prices ranging from $51.00-$51.10, inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc.,  any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) of this Form 4."}],"balance_after":32476,"source":{"system":"sec-edgar","filing":"0000874015-20-000166","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000166/edgar.xml","form_type":"4"}},{"id":2954286,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1188,"kind":"person","name":"BENNETT C FRANK","position":1,"cik":"0001073387","reported_name":"BENNETT C FRANK","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2020-12-09T01:49:59.000Z","date":"2020-12-04","kind":"exercise","acquired":true,"shares":7947,"price":39.87,"value":316846.89,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired as a result of exercising a stock option that was scheduled to expire on 1/1/21.  The purchase reported on this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on May 14, 2020."}],"balance_after":40423,"source":{"system":"sec-edgar","filing":"0000874015-20-000166","document":"edgar.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401520000166/edgar.xml","form_type":"4"}}],"next_cursor":"2020-12-09T01:49:59.000000Z,2954286"}