{"transactions":[{"id":1516,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-09-03T00:22:24.000Z","date":"2026-08-31","kind":"other","planned":false,"acquired":true,"shares":98,"price":51.306,"value":5027.988,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on August 31, 2026. These shares may not be sold until February 28, 2027."}],"balance_after":242760,"source":{"system":"sec-edgar","filing":"0000874015-26-000260","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1537529/000087401526000260/edgardoc.xml","form_type":"4"}},{"id":725952,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-06-26T23:09:50.000Z","date":"2026-06-26","kind":"exercise","planned":true,"acquired":false,"shares":50000,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":99872,"derivative":{"exercise_price":56.78,"exercise_date":"2022-01-04","expiration_date":"2028-01-03","underlying":"Common Stock","underlying_shares":50000},"source":{"system":"sec-edgar","filing":"0000874015-26-000212","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000212/edgardoc.xml","form_type":"4"}},{"id":725951,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-06-26T23:09:50.000Z","date":"2026-06-25","kind":"exercise","planned":true,"acquired":false,"shares":21072,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":32.6,"exercise_date":"2023-01-03","expiration_date":"2032-01-02","underlying":"Common Stock","underlying_shares":21072},"source":{"system":"sec-edgar","filing":"0000874015-26-000212","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000212/edgardoc.xml","form_type":"4"}},{"id":725950,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-06-26T23:09:50.000Z","date":"2026-06-24","kind":"exercise","planned":true,"acquired":false,"shares":14565,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":21072,"derivative":{"exercise_price":32.6,"exercise_date":"2023-01-03","expiration_date":"2032-01-02","underlying":"Common Stock","underlying_shares":14565},"source":{"system":"sec-edgar","filing":"0000874015-26-000212","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000212/edgardoc.xml","form_type":"4"}},{"id":725949,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-06-26T23:09:50.000Z","date":"2026-06-26","kind":"sale","planned":true,"acquired":false,"shares":50000,"price":80.59,"value":4029500.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on December 8, 2025"},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80 to $81 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) on this Form 4."}],"balance_after":245571,"source":{"system":"sec-edgar","filing":"0000874015-26-000212","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000212/edgardoc.xml","form_type":"4"}},{"id":725948,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-06-26T23:09:50.000Z","date":"2026-06-26","kind":"exercise","planned":true,"acquired":true,"shares":50000,"price":56.78,"value":2839000.0,"ownership":{"direct":true},"balance_after":295571,"source":{"system":"sec-edgar","filing":"0000874015-26-000212","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000212/edgardoc.xml","form_type":"4"}},{"id":725947,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-06-26T23:09:50.000Z","date":"2026-06-25","kind":"sale","planned":true,"acquired":false,"shares":21072,"price":78.49,"value":1653941.28,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on December 8, 2025"},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.005 to $78.78 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":245571,"source":{"system":"sec-edgar","filing":"0000874015-26-000212","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000212/edgardoc.xml","form_type":"4"}},{"id":725946,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-06-26T23:09:50.000Z","date":"2026-06-25","kind":"exercise","planned":true,"acquired":true,"shares":21072,"price":32.6,"value":686947.2,"ownership":{"direct":true},"balance_after":266643,"source":{"system":"sec-edgar","filing":"0000874015-26-000212","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000212/edgardoc.xml","form_type":"4"}},{"id":725945,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-06-26T23:09:50.000Z","date":"2026-06-24","kind":"sale","planned":true,"acquired":false,"shares":14565,"price":78.4128,"value":1142082.432,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on December 8, 2025"},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.00 to $78.87 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":245571,"source":{"system":"sec-edgar","filing":"0000874015-26-000212","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000212/edgardoc.xml","form_type":"4"}},{"id":725944,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-06-26T23:09:50.000Z","date":"2026-06-24","kind":"exercise","planned":true,"acquired":true,"shares":14565,"price":32.6,"value":474819.0,"ownership":{"direct":true},"balance_after":260136,"source":{"system":"sec-edgar","filing":"0000874015-26-000212","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000212/edgardoc.xml","form_type":"4"}},{"id":730436,"issuer":{"id":6792,"kind":"organization","name":"COGNITION THERAPEUTICS INC"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-06-22T21:16:44.000Z","date":"2026-06-17","kind":"grant","planned":false,"acquired":true,"shares":25000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Each share is represented by a restricted stock unit (\"RSU\"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 17, 2027 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date."}],"balance_after":73500,"source":{"system":"sec-edgar","filing":"0001104659-26-076475","document":"tm2618497-3_4seq1.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1455365/000110465926076475/tm2618497-3_4seq1.xml","form_type":"4"}},{"id":777956,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-05-15T22:15:03.000Z","date":"2026-05-14","kind":"exercise","planned":true,"acquired":false,"shares":3220,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":35637,"derivative":{"exercise_price":32.6,"exercise_date":"2023-01-03","expiration_date":"2032-01-02","underlying":"Common Stock","underlying_shares":3220},"source":{"system":"sec-edgar","filing":"0000874015-26-000185","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000185/edgardoc.xml","form_type":"4"}},{"id":777955,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-05-15T22:15:03.000Z","date":"2026-05-13","kind":"exercise","planned":true,"acquired":false,"shares":1316,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":38857,"derivative":{"exercise_price":32.6,"exercise_date":"2023-01-03","expiration_date":"2032-01-02","underlying":"Common Stock","underlying_shares":1316},"source":{"system":"sec-edgar","filing":"0000874015-26-000185","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000185/edgardoc.xml","form_type":"4"}},{"id":777954,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-05-15T22:15:03.000Z","date":"2026-05-14","kind":"sale","planned":true,"acquired":false,"shares":3220,"price":78.6793,"value":253347.346,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on December 8, 2025"},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.075 to $79.01 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":242662,"source":{"system":"sec-edgar","filing":"0000874015-26-000185","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000185/edgardoc.xml","form_type":"4"}},{"id":777953,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-05-15T22:15:03.000Z","date":"2026-05-14","kind":"exercise","planned":true,"acquired":true,"shares":3220,"price":32.6,"value":104972.0,"ownership":{"direct":true},"balance_after":245882,"source":{"system":"sec-edgar","filing":"0000874015-26-000185","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000185/edgardoc.xml","form_type":"4"}},{"id":777952,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-05-15T22:15:03.000Z","date":"2026-05-13","kind":"sale","planned":true,"acquired":false,"shares":1316,"price":78.013,"value":102665.108,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on December 8, 2025"},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.00 to $78.025 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":242662,"source":{"system":"sec-edgar","filing":"0000874015-26-000185","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000185/edgardoc.xml","form_type":"4"}},{"id":777951,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-05-15T22:15:03.000Z","date":"2026-05-13","kind":"exercise","planned":true,"acquired":true,"shares":1316,"price":32.6,"value":42901.6,"ownership":{"direct":true},"balance_after":243978,"source":{"system":"sec-edgar","filing":"0000874015-26-000185","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000185/edgardoc.xml","form_type":"4"}},{"id":849640,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-10","kind":"exercise","planned":true,"acquired":false,"shares":34103,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":60.89,"exercise_date":"2021-01-02","expiration_date":"2027-01-01","underlying":"Common Stock","underlying_shares":34103},"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":849639,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-09","kind":"exercise","planned":true,"acquired":false,"shares":73529,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":34103,"derivative":{"exercise_price":60.89,"exercise_date":"2021-01-02","expiration_date":"2027-01-01","underlying":"Common Stock","underlying_shares":73529},"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":849638,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-09","kind":"exercise","planned":true,"acquired":false,"shares":40822,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":107632,"derivative":{"exercise_price":60.89,"exercise_date":"2021-01-02","expiration_date":"2027-01-01","underlying":"Common Stock","underlying_shares":40822},"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":849637,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-10","kind":"sale","planned":true,"acquired":false,"shares":17591,"price":76.3407,"value":1342909.2537,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on December 8, 2025"},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $76.02 to $76.70 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (6) on this Form 4."}],"balance_after":242662,"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":849636,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-10","kind":"sale","planned":true,"acquired":false,"shares":16512,"price":75.4745,"value":1246234.944,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on December 8, 2025"},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.005 to $76.00 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (5) on this Form 4."}],"balance_after":260253,"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":849635,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-10","kind":"exercise","planned":true,"acquired":true,"shares":34103,"price":60.89,"value":2076531.67,"ownership":{"direct":true},"balance_after":276765,"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":849634,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-09","kind":"sale","planned":true,"acquired":false,"shares":1684,"price":75.583,"value":127281.772,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on December 8, 2025"},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.55 to $75.63 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) on this Form 4."}],"balance_after":242662,"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":849633,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-09","kind":"sale","planned":true,"acquired":false,"shares":117604,"price":75.258,"value":8850641.832,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on December 8, 2025"},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $74.54 to $75.54 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":244346,"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":849632,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-09","kind":"sale","planned":true,"acquired":false,"shares":7382,"price":74.111,"value":547087.402,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on December 8, 2025"},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $73.44 to $74.42 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":361950,"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":849631,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-09","kind":"exercise","planned":true,"acquired":true,"shares":73529,"price":60.89,"value":4477180.81,"ownership":{"direct":true},"balance_after":369332,"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":849630,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-03-11T20:19:03.000Z","date":"2026-03-09","kind":"exercise","planned":true,"acquired":true,"shares":40822,"price":60.89,"value":2485651.58,"ownership":{"direct":true},"balance_after":295803,"source":{"system":"sec-edgar","filing":"0000874015-26-000143","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000143/edgardoc.xml","form_type":"4"}},{"id":871252,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-03-03T22:28:55.000Z","date":"2026-02-27","kind":"other","planned":false,"acquired":true,"shares":484,"price":48.8665,"value":23651.386,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on February 27, 2026. These shares may not be sold until August 27, 2026."}],"balance_after":254981,"source":{"system":"sec-edgar","filing":"0000874015-26-000123","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000123/edgardoc.xml","form_type":"4"}},{"id":913204,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-02-10T22:04:29.000Z","date":"2026-02-06","kind":"sale","planned":true,"acquired":false,"shares":29430,"price":85.7907,"value":2524820.301,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $85.22 to $86.055 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":254497,"source":{"system":"sec-edgar","filing":"0000874015-26-000106","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000106/edgardoc.xml","form_type":"4"}},{"id":926045,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-02-03T01:51:49.000Z","date":"2026-01-30","kind":"sale","planned":false,"acquired":false,"shares":62970,"price":82.7216,"value":5208979.152,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.26 to $82.925 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":283927,"source":{"system":"sec-edgar","filing":"0000874015-26-000099","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000099/edgardoc.xml","form_type":"4"}},{"id":926044,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-02-03T01:51:49.000Z","date":"2026-01-29","kind":"grant","planned":false,"acquired":true,"shares":122214,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the performance period of the grant to the reporting person reported on January 18, 2023. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 167.27% of target shares. As reported at grant, the PRSUs could result in a payout of 0% to 200% based on actual achievement of the goal."}],"balance_after":346897,"source":{"system":"sec-edgar","filing":"0000874015-26-000099","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000099/edgardoc.xml","form_type":"4"}},{"id":936227,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Restricted Stock Unit","published_at":"2026-01-21T01:20:23.000Z","date":"2026-01-15","kind":"grant","planned":false,"acquired":true,"shares":42705,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F8","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F6","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F7","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":205719,"derivative":{"exercise_price":0,"exercise_date":"2027-01-15","underlying":"Common Stock","underlying_shares":42705},"source":{"system":"sec-edgar","filing":"0000874015-26-000069","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000069/edgardoc.xml","form_type":"4"}},{"id":936226,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Restricted Stock Unit","published_at":"2026-01-21T01:20:23.000Z","date":"2026-01-15","kind":"exercise","planned":false,"acquired":false,"shares":89145,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F6","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F7","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":163014,"derivative":{"exercise_price":0,"exercise_date":"2026-01-15","underlying":"Common Stock","underlying_shares":89145},"source":{"system":"sec-edgar","filing":"0000874015-26-000069","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000069/edgardoc.xml","form_type":"4"}},{"id":936225,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Performance Restricted Stock Units","published_at":"2026-01-21T01:20:23.000Z","date":"2026-01-15","kind":"grant","planned":false,"acquired":true,"shares":113880,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F4","text":"Grant to reporting person of Performance Restricted Stock Units (PRSUs) under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."}],"balance_after":744081,"derivative":{"exercise_price":0,"exercise_date":"2027-01-15","underlying":"Common Stock","underlying_shares":113880},"source":{"system":"sec-edgar","filing":"0000874015-26-000069","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000069/edgardoc.xml","form_type":"4"}},{"id":936224,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-01-21T01:20:23.000Z","date":"2026-01-16","kind":"sale","planned":false,"acquired":false,"shares":44034,"price":74.82,"value":3294623.88,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $74.57 to $75.07 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":224683,"source":{"system":"sec-edgar","filing":"0000874015-26-000069","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000069/edgardoc.xml","form_type":"4"}},{"id":936223,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2026-01-21T01:20:23.000Z","date":"2026-01-15","kind":"exercise","planned":false,"acquired":true,"shares":89145,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":268717,"source":{"system":"sec-edgar","filing":"0000874015-26-000069","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000069/edgardoc.xml","form_type":"4"}},{"id":948711,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-01-06T22:35:06.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":85410,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2026 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on\n01/02/2026. 25% of the shares subject to the option will vest and become exercisable on 01/02/2027. Thereafter, the remaining shares subject to the option will vest and become exercisable in 36 equal monthly installments over the next 3 years."}],"balance_after":85410,"derivative":{"exercise_price":79.67,"exercise_date":"2027-01-02","expiration_date":"2036-01-01","underlying":"Common Stock","underlying_shares":85410},"source":{"system":"sec-edgar","filing":"0000874015-26-000023","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000023/edgardoc.xml","form_type":"4"}},{"id":1021835,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-10-08T22:36:54.000Z","date":"2025-10-06","kind":"sale","planned":true,"acquired":false,"shares":437,"price":69.2637,"value":30268.2369,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."}],"balance_after":179572,"source":{"system":"sec-edgar","filing":"0000874015-25-000252","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000252/edgardoc.xml","form_type":"4"}},{"id":1048779,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"exercise","planned":false,"acquired":false,"shares":102900,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":53.77,"exercise_date":"2020-01-02","expiration_date":"2026-01-01","underlying":"Common Stock","underlying_shares":102900},"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1048778,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"exercise","planned":false,"acquired":false,"shares":42030,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":76643,"derivative":{"exercise_price":37.58,"exercise_date":"2024-01-03","expiration_date":"2033-01-02","underlying":"Common Stock","underlying_shares":42030},"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1048777,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"exercise","planned":false,"acquired":false,"shares":27568,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":40173,"derivative":{"exercise_price":32.6,"exercise_date":"2023-01-03","expiration_date":"2032-01-02","underlying":"Common Stock","underlying_shares":27568},"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1048776,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"exercise","planned":false,"acquired":false,"shares":31316,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":67741,"derivative":{"exercise_price":32.6,"exercise_date":"2023-01-03","expiration_date":"2032-01-02","underlying":"Common Stock","underlying_shares":31316},"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1048775,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"sale","planned":false,"acquired":false,"shares":59699,"price":61.0629,"value":3645394.0671,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.61 to $61.48 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) on this Form 4."}],"balance_after":180009,"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1048774,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"exercise","planned":false,"acquired":true,"shares":27568,"price":32.6,"value":898716.8,"ownership":{"direct":true},"balance_after":239708,"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1048773,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"exercise","planned":false,"acquired":true,"shares":31316,"price":32.6,"value":1020901.6,"ownership":{"direct":true},"balance_after":212140,"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1048772,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"sale","planned":false,"acquired":false,"shares":127500,"price":60.1337,"value":7667046.75,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $59.60 to $60.57 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":180824,"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1048771,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"exercise","planned":false,"acquired":true,"shares":42030,"price":37.58,"value":1579487.4,"ownership":{"direct":true},"balance_after":308324,"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1048770,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"sale","planned":false,"acquired":false,"shares":16615,"price":59.119,"value":982262.185,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.57 to $59.55 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":266294,"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1048769,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-09-05T00:38:20.000Z","date":"2025-09-03","kind":"exercise","planned":false,"acquired":true,"shares":102900,"price":53.77,"value":5532933.0,"ownership":{"direct":true},"balance_after":282909,"source":{"system":"sec-edgar","filing":"0000874015-25-000221","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000221/edgardoc.xml","form_type":"4"}},{"id":1050679,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-09-03T22:30:26.000Z","date":"2025-08-29","kind":"other","planned":false,"acquired":true,"shares":189,"price":27.71,"value":5237.19,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on August 29, 2025. These shares may not be sold until March 2, 2026."}],"balance_after":180009,"source":{"system":"sec-edgar","filing":"0000874015-25-000191","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000191/edgardoc.xml","form_type":"4"}},{"id":1077928,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-08-01T20:06:41.000Z","date":"2025-07-30","kind":"exercise","planned":true,"acquired":false,"shares":2432,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":99057,"derivative":{"exercise_price":32.6,"exercise_date":"2023-01-03","expiration_date":"2032-01-02","underlying":"Common Stock","underlying_shares":2432},"source":{"system":"sec-edgar","filing":"0000874015-25-000170","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000170/edgardoc.xml","form_type":"4"}},{"id":1077927,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-08-01T20:06:41.000Z","date":"2025-07-30","kind":"sale","planned":true,"acquired":false,"shares":2432,"price":45,"value":109440.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."}],"balance_after":179820,"source":{"system":"sec-edgar","filing":"0000874015-25-000170","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000170/edgardoc.xml","form_type":"4"}},{"id":1077926,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-08-01T20:06:41.000Z","date":"2025-07-30","kind":"exercise","planned":true,"acquired":true,"shares":2432,"price":32.6,"value":79283.2,"ownership":{"direct":true},"balance_after":182252,"source":{"system":"sec-edgar","filing":"0000874015-25-000170","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000170/edgardoc.xml","form_type":"4"}},{"id":1087713,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-07-16T00:54:09.000Z","date":"2025-07-11","kind":"sale","planned":true,"acquired":false,"shares":1160,"price":41.7381,"value":48416.196,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $41.67 to $41.79 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":179820,"source":{"system":"sec-edgar","filing":"0000874015-25-000146","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000146/edgardoc.xml","form_type":"4"}},{"id":1103680,"issuer":{"id":6792,"kind":"organization","name":"COGNITION THERAPEUTICS INC"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2025-06-23T23:20:50.000Z","date":"2025-06-18","kind":"grant","planned":false,"acquired":true,"shares":34000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Each share is represented by a restricted stock unit (\"RSU\"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 18, 2026 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date."}],"balance_after":48500,"source":{"system":"sec-edgar","filing":"0001062993-25-012078","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1455365/000106299325012078/form4.xml","form_type":"4"}},{"id":1208478,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-03-13T20:45:26.000Z","date":"2025-03-11","kind":"sale","planned":true,"acquired":false,"shares":140,"price":32.32,"value":4524.8,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."}],"balance_after":180980,"source":{"system":"sec-edgar","filing":"0000874015-25-000105","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000105/edgardoc.xml","form_type":"4"}},{"id":1232376,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-03-04T22:16:51.000Z","date":"2025-02-28","kind":"other","planned":false,"acquired":true,"shares":437,"price":28.2115,"value":12328.4255,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on February 28,2025. These shares may not be sold until August 28, 2025."}],"balance_after":181120,"source":{"system":"sec-edgar","filing":"0000874015-25-000101","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000101/edgardoc.xml","form_type":"4"}},{"id":1280790,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-02-06T23:26:58.000Z","date":"2025-02-04","kind":"sale","planned":true,"acquired":false,"shares":38843,"price":31.6521,"value":1229462.5203,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $31.555 to $31.755 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":180683,"source":{"system":"sec-edgar","filing":"0000874015-25-000084","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000084/edgardoc.xml","form_type":"4"}},{"id":1288305,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-02-04T00:26:55.000Z","date":"2025-01-31","kind":"sale","planned":false,"acquired":false,"shares":13242,"price":32.4464,"value":429655.2288,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.04 to $32.81 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":219526,"source":{"system":"sec-edgar","filing":"0000874015-25-000078","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000078/edgardoc.xml","form_type":"4"}},{"id":1288304,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-02-04T00:26:55.000Z","date":"2025-01-30","kind":"grant","planned":false,"acquired":true,"shares":25372,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the final performance period of the grant to the reporting person reported on January 19, 2022. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 150% of target shares. As reported at grant, the PRSUs could result in a payout of 0% to 150% based on actual achievement of the goal."}],"balance_after":232768,"source":{"system":"sec-edgar","filing":"0000874015-25-000078","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000078/edgardoc.xml","form_type":"4"}},{"id":1300994,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Restricted Stock Unit","published_at":"2025-01-18T00:41:07.000Z","date":"2025-01-15","kind":"exercise","planned":false,"acquired":false,"shares":73448,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F7","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F8","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":252159,"derivative":{"exercise_price":0,"exercise_date":"2025-01-15","underlying":"Common Stock","underlying_shares":73448},"source":{"system":"sec-edgar","filing":"0000874015-25-000062","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000062/edgardoc.xml","form_type":"4"}},{"id":1300993,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Restricted Stock Unit","published_at":"2025-01-18T00:41:07.000Z","date":"2025-01-15","kind":"grant","planned":false,"acquired":true,"shares":129395,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F6","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F7","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F8","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":325607,"derivative":{"exercise_price":0,"exercise_date":"2026-01-15","underlying":"Common Stock","underlying_shares":129395},"source":{"system":"sec-edgar","filing":"0000874015-25-000062","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000062/edgardoc.xml","form_type":"4"}},{"id":1300992,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Performance Restricted Stock Units","published_at":"2025-01-18T00:41:07.000Z","date":"2025-01-15","kind":"grant","planned":false,"acquired":true,"shares":169950,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F4","text":"Grant to reporting person of Performance Restricted Stock Units (PRSUs) under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."}],"balance_after":630201,"derivative":{"exercise_price":0,"exercise_date":"2028-01-15","underlying":"Common Stock","underlying_shares":169950},"source":{"system":"sec-edgar","filing":"0000874015-25-000062","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000062/edgardoc.xml","form_type":"4"}},{"id":1300991,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-01-18T00:41:07.000Z","date":"2025-01-16","kind":"sale","planned":false,"acquired":false,"shares":33445,"price":32.634,"value":1091444.13,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.26 to $33.00 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":207396,"source":{"system":"sec-edgar","filing":"0000874015-25-000062","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000062/edgardoc.xml","form_type":"4"}},{"id":1300990,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2025-01-18T00:41:07.000Z","date":"2025-01-15","kind":"exercise","planned":false,"acquired":true,"shares":73448,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":240841,"source":{"system":"sec-edgar","filing":"0000874015-25-000062","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000062/edgardoc.xml","form_type":"4"}},{"id":1312096,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-01-06T21:55:28.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":86263,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2025 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on\n01/02/2025. 25% of the shares subject to the option will vest and become exercisable on 01/02/2026. Thereafter, the remaining shares subject to the option will vest and become exercisable in 36 equal monthly installments over the next 3 years."}],"balance_after":86263,"derivative":{"exercise_price":34.69,"exercise_date":"2026-01-02","expiration_date":"2035-01-01","underlying":"Common Stock","underlying_shares":86263},"source":{"system":"sec-edgar","filing":"0000874015-25-000028","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000028/edgardoc.xml","form_type":"4"}},{"id":1365786,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-11-14T22:30:47.000Z","date":"2024-11-12","kind":"sale","planned":true,"acquired":false,"shares":6630,"price":38.0534,"value":252294.042,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 13, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.73 to $38.655 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":167393,"source":{"system":"sec-edgar","filing":"0000874015-24-000240","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000240/edgardoc.xml","form_type":"4"}},{"id":1416857,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-09-05T01:43:19.000Z","date":"2024-08-30","kind":"other","planned":false,"acquired":true,"shares":140,"price":38.641,"value":5409.74,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on August 30, 2024. These shares may not be sold until February 28, 2025."}],"balance_after":174023,"source":{"system":"sec-edgar","filing":"0000874015-24-000218","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000218/edgardoc.xml","form_type":"4"}},{"id":1416848,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-09-05T00:52:40.000Z","date":"2024-02-02","kind":"sale","planned":false,"acquired":false,"shares":23907,"price":49.3725,"value":1180348.3575,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The original Form 4 filed on February 2, 2024 reported 23,501 restricted stock units sold by the reporting person which has been revised by this amendment to reflect\nthe actual amount of shares sold and beneficially owned by Mr. Monia."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.22 to $49.51 inclusive. The\nreporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange\nCommission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"The original Form 4 filed on February 2, 2024 reported 23,501 restricted stock units sold by the reporting person which has been revised by this amendment to reflect\nthe actual amount of shares sold and beneficially owned by Mr. Monia."}],"balance_after":173732,"source":{"system":"sec-edgar","filing":"0000874015-24-000195","document":"primary_doc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000195/primary_doc.xml","form_type":"4/A","original_submission_date":"2024-02-02"}},{"id":1416847,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-09-05T00:51:59.000Z","date":"2024-02-02","kind":"sale","planned":false,"acquired":false,"shares":23907,"price":49.3725,"value":1180348.3575,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The original Form 4 filed on February 2, 2024 reported 23,501 restricted stock units sold by the reporting person which has been revised by this amendment to reflect\nthe actual amount of shares sold and beneficially owned by Mr. Monia."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.22 to $49.51 inclusive. The\nreporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange\nCommission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F1","text":"The original Form 4 filed on February 2, 2024 reported 23,501 restricted stock units sold by the reporting person which has been revised by this amendment to reflect\nthe actual amount of shares sold and beneficially owned by Mr. Monia."}],"balance_after":173732,"source":{"system":"sec-edgar","filing":"0000874015-24-000192","document":"primary_doc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000192/primary_doc.xml","form_type":"4/A","original_submission_date":"2024-02-02"}},{"id":1483365,"issuer":{"id":6792,"kind":"organization","name":"COGNITION THERAPEUTICS INC"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2024-06-11T22:46:17.000Z","date":"2024-06-07","kind":"grant","planned":false,"acquired":true,"shares":8500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The option vests in full on the earlier of (i) June 7, 2025 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date."}],"balance_after":8500,"derivative":{"exercise_price":1.95,"expiration_date":"2034-06-07","underlying":"Common Stock","underlying_shares":8500},"source":{"system":"sec-edgar","filing":"0001062993-24-012411","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1455365/000106299324012411/form4.xml","form_type":"4"}},{"id":1483364,"issuer":{"id":6792,"kind":"organization","name":"COGNITION THERAPEUTICS INC"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2024-06-11T22:46:17.000Z","date":"2024-06-07","kind":"grant","planned":false,"acquired":true,"shares":8500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Each share is represented by a restricted stock unit (\"RSU\"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The RSUs vest in full on the earlier of (i) June 7, 2025 or (ii) on the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continuous service as a director as of the applicable vesting date."}],"balance_after":14500,"source":{"system":"sec-edgar","filing":"0001062993-24-012411","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1455365/000106299324012411/form4.xml","form_type":"4"}},{"id":1604781,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CEO Level 15"}}],"security":"Common Stock","published_at":"2024-03-05T00:13:40.000Z","date":"2024-02-29","kind":"other","planned":false,"acquired":true,"shares":538,"price":34.425,"value":18520.65,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on February 29, 2024. These shares may not be sold until August 31, 2024."}],"balance_after":174289,"source":{"system":"sec-edgar","filing":"0000874015-24-000125","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000125/edgardoc.xml","form_type":"4"}},{"id":1639666,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-02-17T00:47:19.000Z","date":"2024-02-16","kind":"sale","planned":true,"acquired":false,"shares":387,"price":44.4924,"value":17218.5588,"ownership":{"direct":true},"balance_after":173751,"source":{"system":"sec-edgar","filing":"0000874015-24-000112","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000112/edgardoc.xml","form_type":"4"}},{"id":1662915,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-02-03T00:55:25.000Z","date":"2024-02-02","kind":"sale","planned":false,"acquired":false,"shares":23501,"price":49.3725,"value":1160303.1225,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F3","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Performance restricted Stock Unit Agreement and Grant Notice."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.22 to $49.51 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (4) on this Form 4."}],"balance_after":174138,"source":{"system":"sec-edgar","filing":"0000874015-24-000107","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000107/edgardoc.xml","form_type":"4"}},{"id":1662914,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-02-03T00:55:25.000Z","date":"2024-02-01","kind":"grant","planned":false,"acquired":true,"shares":20416,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the final performance period of the grant to the reporting person reported on January 20, 2021. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 100% of target shares and a true-up of 18.63% of target shares pursuant to the alternative calculation. Since this PRSU award paid out less than 100% of target for tranche 1 of such PRSU award, the alternative calculation applies, resulting in an additional payout of 3,206 shares under tranche 1 yielding in the aggregate a total tranche 3 payout of 20,416 shares, or 118.63% of target"}],"balance_after":197639,"source":{"system":"sec-edgar","filing":"0000874015-24-000107","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000107/edgardoc.xml","form_type":"4"}},{"id":1662913,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-02-03T00:55:25.000Z","date":"2024-02-01","kind":"grant","planned":false,"acquired":true,"shares":25372,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the second performance period of the grant to the reporting person reported on January 19, 2022. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 150% of target shares. As reported at grant, the PRSUs could result in a payout of 0% to 150% based on actual achievement of the goal."}],"balance_after":177223,"source":{"system":"sec-edgar","filing":"0000874015-24-000107","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000107/edgardoc.xml","form_type":"4"}},{"id":1668732,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-01-29T22:34:18.000Z","date":"2024-01-25","kind":"sale","planned":true,"acquired":false,"shares":2285,"price":51.75,"value":118248.75,"ownership":{"direct":true},"balance_after":151851,"source":{"system":"sec-edgar","filing":"0000874015-24-000085","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000085/edgardoc.xml","form_type":"4"}},{"id":1677160,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Restricted Stock Unit","published_at":"2024-01-18T22:48:41.000Z","date":"2024-01-16","kind":"exercise","planned":false,"acquired":false,"shares":68084,"price":10,"value":680840.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":196212,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":68084},"source":{"system":"sec-edgar","filing":"0000874015-24-000076","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000076/edgardoc.xml","form_type":"4"}},{"id":1677159,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-01-18T22:48:41.000Z","date":"2024-01-17","kind":"sale","planned":false,"acquired":false,"shares":32059,"price":50.417,"value":1616318.603,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.35 to $50.43, inclusive. The reporting person undertakes to provide to Ionis\nPharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) of this Form 4."}],"balance_after":154136,"source":{"system":"sec-edgar","filing":"0000874015-24-000076","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000076/edgardoc.xml","form_type":"4"}},{"id":1677158,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2024-01-18T22:48:41.000Z","date":"2024-01-16","kind":"exercise","planned":false,"acquired":true,"shares":68084,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":186195,"source":{"system":"sec-edgar","filing":"0000874015-24-000076","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000076/edgardoc.xml","form_type":"4"}},{"id":1678513,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Restricted Stock Unit","published_at":"2024-01-18T01:50:11.000Z","date":"2024-01-15","kind":"grant","planned":false,"acquired":true,"shares":87435,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."}],"balance_after":264296,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":87435},"source":{"system":"sec-edgar","filing":"0000874015-24-000055","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000055/edgardoc.xml","form_type":"4"}},{"id":1678512,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Performance Restricted Stock Units","published_at":"2024-01-18T01:50:11.000Z","date":"2024-01-15","kind":"grant","planned":false,"acquired":true,"shares":143550,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"Grant to reporting person of Performance Restricted Stock Units (PRSUs) under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F2","text":"The PRSUs may vest at the end of the three-year performance period following the date of grant based on the Issuer's relative total shareholder return as compared to a peer group of companies. The number of PRSUs reported represents the maximum that may be earned, which is 200% of the target number. No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."}],"balance_after":460251,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":143550},"source":{"system":"sec-edgar","filing":"0000874015-24-000055","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000055/edgardoc.xml","form_type":"4"}},{"id":1689431,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2024-01-04T22:23:50.000Z","date":"2024-01-02","kind":"grant","planned":false,"acquired":true,"shares":116580,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2024 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on\n01/02/2024. 25% of the shares subject to the option will vest and become exercisable on 01/02/2025. Thereafter, the remaining shares subject to the option will vest and become exercisable in 36 equal monthly installments over the next 3 years."}],"balance_after":116580,"derivative":{"exercise_price":52.87,"exercise_date":"2025-01-02","expiration_date":"2034-01-01","underlying":"Common Stock","underlying_shares":116580},"source":{"system":"sec-edgar","filing":"0000874015-24-000023","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000023/edgardoc.xml","form_type":"4"}},{"id":1701564,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2023-12-23T00:11:23.000Z","date":"2023-12-21","kind":"exercise","planned":true,"acquired":false,"shares":17500,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":47.34,"exercise_date":"2021-01-03","expiration_date":"2024-01-02","underlying":"Common Stock","underlying_shares":17500},"source":{"system":"sec-edgar","filing":"0000874015-23-000234","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000234/edgardoc.xml","form_type":"4"}},{"id":1701563,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2023-12-23T00:11:23.000Z","date":"2023-12-20","kind":"exercise","planned":true,"acquired":false,"shares":6500,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":17500,"derivative":{"exercise_price":47.34,"exercise_date":"2019-01-03","expiration_date":"2024-01-02","underlying":"Common Stock","underlying_shares":6500},"source":{"system":"sec-edgar","filing":"0000874015-23-000234","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000234/edgardoc.xml","form_type":"4"}},{"id":1701562,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2023-12-23T00:11:23.000Z","date":"2023-12-21","kind":"sale","planned":true,"acquired":false,"shares":17500,"price":49.2901,"value":862576.75,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.11 to $49.50 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":118111,"source":{"system":"sec-edgar","filing":"0000874015-23-000234","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000234/edgardoc.xml","form_type":"4"}},{"id":1701561,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2023-12-23T00:11:23.000Z","date":"2023-12-21","kind":"exercise","planned":true,"acquired":true,"shares":17500,"price":47.34,"value":828450.0,"ownership":{"direct":true},"balance_after":135611,"source":{"system":"sec-edgar","filing":"0000874015-23-000234","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000234/edgardoc.xml","form_type":"4"}},{"id":1701560,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2023-12-23T00:11:23.000Z","date":"2023-12-20","kind":"sale","planned":true,"acquired":false,"shares":6500,"price":49.6374,"value":322643.1,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.40 to $49.90 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) on this Form 4."}],"balance_after":118111,"source":{"system":"sec-edgar","filing":"0000874015-23-000234","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000234/edgardoc.xml","form_type":"4"}},{"id":1701559,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2023-12-23T00:11:23.000Z","date":"2023-12-20","kind":"exercise","planned":true,"acquired":true,"shares":6500,"price":47.34,"value":307710.0,"ownership":{"direct":true},"balance_after":124611,"source":{"system":"sec-edgar","filing":"0000874015-23-000234","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000234/edgardoc.xml","form_type":"4"}},{"id":1708161,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2023-12-18T21:56:04.000Z","date":"2023-12-14","kind":"exercise","planned":true,"acquired":false,"shares":9140,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":24000,"derivative":{"exercise_price":47.34,"exercise_date":"2018-01-03","expiration_date":"2024-01-02","underlying":"Common Stock","underlying_shares":9140},"source":{"system":"sec-edgar","filing":"0000874015-23-000228","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000228/edgardoc.xml","form_type":"4"}},{"id":1708160,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2023-12-18T21:56:04.000Z","date":"2023-12-14","kind":"exercise","planned":true,"acquired":false,"shares":14860,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":33140,"derivative":{"exercise_price":47.34,"exercise_date":"2018-01-03","expiration_date":"2024-01-02","underlying":"Common Stock","underlying_shares":14860},"source":{"system":"sec-edgar","filing":"0000874015-23-000228","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000228/edgardoc.xml","form_type":"4"}},{"id":1708159,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2023-12-18T21:56:04.000Z","date":"2023-12-14","kind":"sale","planned":true,"acquired":false,"shares":9140,"price":50.187,"value":458709.18,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.00 to $50.50 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":118111,"source":{"system":"sec-edgar","filing":"0000874015-23-000228","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000228/edgardoc.xml","form_type":"4"}},{"id":1708158,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2023-12-18T21:56:04.000Z","date":"2023-12-14","kind":"exercise","planned":true,"acquired":true,"shares":9140,"price":47.34,"value":432687.6,"ownership":{"direct":true},"balance_after":127251,"source":{"system":"sec-edgar","filing":"0000874015-23-000228","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000228/edgardoc.xml","form_type":"4"}},{"id":1708157,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2023-12-18T21:56:04.000Z","date":"2023-12-14","kind":"sale","planned":true,"acquired":false,"shares":14860,"price":49.2133,"value":731309.638,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $48.75 to $49.75 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) on this Form 4."}],"balance_after":118111,"source":{"system":"sec-edgar","filing":"0000874015-23-000228","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000228/edgardoc.xml","form_type":"4"}},{"id":1708156,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2023-12-18T21:56:04.000Z","date":"2023-12-14","kind":"exercise","planned":true,"acquired":true,"shares":14860,"price":47.34,"value":703472.4,"ownership":{"direct":true},"balance_after":132971,"source":{"system":"sec-edgar","filing":"0000874015-23-000228","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000228/edgardoc.xml","form_type":"4"}},{"id":1760116,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2023-10-16T20:35:13.000Z","date":"2023-10-12","kind":"sale","planned":true,"acquired":false,"shares":3770,"price":46,"value":173420.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on July 13, 2023"}],"balance_after":118111,"source":{"system":"sec-edgar","filing":"0000874015-23-000201","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000201/edgardoc.xml","form_type":"4"}},{"id":1789930,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CEO Level 15"}}],"security":"Common Stock","published_at":"2023-09-05T20:59:06.000Z","date":"2023-08-31","kind":"other","planned":false,"acquired":true,"shares":157,"price":30.5575,"value":4797.5275,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on August 31, 2023. These shares may not be sold until February 29, 2024."}],"balance_after":121881,"source":{"system":"sec-edgar","filing":"0000874015-23-000190","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000190/edgardoc.xml","form_type":"4"}},{"id":1831759,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1185,"kind":"person","name":"Monia Brett P","position":1,"cik":"0001537529","reported_name":"Monia Brett P","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Executive Officer"}}],"security":"Common Stock","published_at":"2023-07-11T21:07:49.000Z","date":"2023-07-07","kind":"sale","planned":true,"acquired":false,"shares":18650,"price":42.2495,"value":787953.175,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on November 16, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $42.00 to $42.50 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":121724,"source":{"system":"sec-edgar","filing":"0000874015-23-000163","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000163/edgardoc.xml","form_type":"4"}}],"next_cursor":"2023-07-11T21:07:49.000000Z,1831759"}