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Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. 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These shares were sold in multiple transactions at prices ranging from $75.01 to $75.06 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":67500,"source":{"system":"sec-edgar","filing":"0000874015-26-000170","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000170/edgardoc.xml","form_type":"4"}},{"id":806327,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Common Stock","published_at":"2026-04-17T23:19:21.000Z","date":"2026-04-15","kind":"exercise","planned":false,"acquired":true,"shares":1875,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."}],"balance_after":68473,"source":{"system":"sec-edgar","filing":"0000874015-26-000170","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000170/edgardoc.xml","form_type":"4"}},{"id":871248,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Common Stock","published_at":"2026-03-03T22:28:43.000Z","date":"2026-02-27","kind":"other","planned":false,"acquired":true,"shares":351,"price":48.8665,"value":17152.1415,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. 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These shares were sold in multiple transactions at prices ranging from $83.00 to $83.08 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":66247,"source":{"system":"sec-edgar","filing":"0000874015-26-000097","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000097/edgardoc.xml","form_type":"4"}},{"id":926038,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Common Stock","published_at":"2026-02-03T01:51:32.000Z","date":"2026-01-29","kind":"grant","planned":false,"acquired":true,"shares":11991,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents shares earned upon the vesting of performance-based restricted stock units (\"PRSUs\") for the performance period of the grant to the reporting person reported on January 18, 2023. The Compensation Committee certified achievement of the pre-established performance goal based on the Issuer's relative total shareholder return as compared to a peer group of companies at a level resulting in a vest of 167.27% of target shares. 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Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F7","text":"Restricted Stock Units vest in four equal annual installments. 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These shares were sold in multiple transactions at prices ranging from $75.07 to $75.14 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":60435,"source":{"system":"sec-edgar","filing":"0000874015-26-000063","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000063/edgardoc.xml","form_type":"4"}},{"id":936197,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Common Stock","published_at":"2026-01-21T01:18:16.000Z","date":"2026-01-15","kind":"exercise","planned":false,"acquired":true,"shares":20089,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":68915,"source":{"system":"sec-edgar","filing":"0000874015-26-000063","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401526000063/edgardoc.xml","form_type":"4"}},{"id":948707,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2026-01-06T22:34:24.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":19350,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2026 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 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These shares were sold in multiple transactions at prices ranging from $76.00 to $76.32 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":48826,"source":{"system":"sec-edgar","filing":"0000874015-25-000278","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000278/edgardoc.xml","form_type":"4"}},{"id":1017887,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-10-17T00:15:51.000Z","date":"2025-10-15","kind":"exercise","planned":true,"acquired":false,"shares":12425,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":0,"derivative":{"exercise_price":53.77,"exercise_date":"2021-01-02","expiration_date":"2026-01-01","underlying":"Common Stock","underlying_shares":12425},"source":{"system":"sec-edgar","filing":"0000874015-25-000259","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000259/edgardoc.xml","form_type":"4"}},{"id":1017886,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2025-10-17T00:15:51.000Z","date":"2025-10-14","kind":"exercise","planned":true,"acquired":false,"shares":11475,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":12425,"derivative":{"exercise_price":53.77,"exercise_date":"2020-01-02","expiration_date":"2026-01-01","underlying":"Common Stock","underlying_shares":11475},"source":{"system":"sec-edgar","filing":"0000874015-25-000259","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000259/edgardoc.xml","form_type":"4"}},{"id":1017885,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Common Stock","published_at":"2025-10-17T00:15:51.000Z","date":"2025-10-15","kind":"sale","planned":true,"acquired":false,"shares":12425,"price":72.2252,"value":897398.11,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 12, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in column 4 is a weighted average price. 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These shares were sold in multiple transactions at prices ranging from $41.65 to $41.66 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4."}],"balance_after":46156,"source":{"system":"sec-edgar","filing":"0000874015-24-000138","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000138/edgardoc.xml","form_type":"4"}},{"id":1540525,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Common Stock","published_at":"2024-04-17T21:16:37.000Z","date":"2024-04-15","kind":"exercise","planned":false,"acquired":true,"shares":1875,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."}],"balance_after":47061,"source":{"system":"sec-edgar","filing":"0000874015-24-000138","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000138/edgardoc.xml","form_type":"4"}},{"id":1604779,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Vice President Level 14"}}],"security":"Common Stock","published_at":"2024-03-05T00:13:25.000Z","date":"2024-02-29","kind":"other","planned":false,"acquired":true,"shares":604,"price":34.425,"value":20792.7,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Reporting shares purchased under the Ionis Pharmaceuticals, Inc. 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These shares were sold in multiple transactions at prices ranging from $50.35 to $50.43, inclusive. The reporting person undertakes to provide to Ionis\nPharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) of this Form 4."}],"balance_after":44582,"source":{"system":"sec-edgar","filing":"0000874015-24-000079","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000079/edgardoc.xml","form_type":"4"}},{"id":1677170,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Common Stock","published_at":"2024-01-18T22:55:44.000Z","date":"2024-01-16","kind":"exercise","planned":false,"acquired":true,"shares":12080,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards."}],"balance_after":49079,"source":{"system":"sec-edgar","filing":"0000874015-24-000079","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000079/edgardoc.xml","form_type":"4"}},{"id":1678505,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Restricted Stock Unit","published_at":"2024-01-18T01:49:36.000Z","date":"2024-01-15","kind":"grant","planned":false,"acquired":true,"shares":20400,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 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No number of PRSUs is guaranteed to vest and the actual number of PRSUs that will vest at the end of the performance period may be anywhere from zero to the amount stated."}],"balance_after":31338,"derivative":{"exercise_price":0,"underlying":"Common Stock","underlying_shares":17000},"source":{"system":"sec-edgar","filing":"0000874015-24-000051","document":"edgardoc.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000051/edgardoc.xml","form_type":"4"}},{"id":1689427,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Non-Qualified Stock Option (right to buy)","published_at":"2024-01-04T22:23:12.000Z","date":"2024-01-02","kind":"grant","planned":false,"acquired":true,"shares":27200,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Grant on 01/02/2024 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Following this transaction, the option was exercisable as to 0 shares on\n01/02/2024. 25% of the shares subject to the option will vest and become exercisable on 01/02/2025. 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The reporting person received 471 shares of common stock on net exercise of option to purchase 11,500 shares of common stock. Pursuant to the terms of the Company's 2011 Equity Incentive Plan, the Company withheld 11,029 shares of common stock underlying the option for payment of the exercise price and tax withholdings using the closing  stock price on December 28, 2023 of $50.50."}],"balance_after":36999,"source":{"system":"sec-edgar","filing":"0000874015-24-000004","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000004/edgardoc.xml","form_type":"4"}},{"id":1697224,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Common Stock","published_at":"2024-01-02T22:54:26.000Z","date":"2023-12-28","kind":"exercise","planned":false,"acquired":true,"shares":11500,"price":47.34,"value":544410.0,"ownership":{"direct":true},"balance_after":48028,"source":{"system":"sec-edgar","filing":"0000874015-24-000004","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401524000004/edgardoc.xml","form_type":"4"}},{"id":1917568,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Restricted Stock Unit","published_at":"2023-04-20T00:18:56.000Z","date":"2023-04-17","kind":"exercise","planned":false,"acquired":false,"shares":1875,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"Restricted Stock Units vest in four equal annual installments. 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These shares were sold in multiple transactions at prices ranging from $36.19 to $36.50953 inclusive.  The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4."}],"balance_after":36528,"source":{"system":"sec-edgar","filing":"0000874015-23-000132","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000132/edgardoc.xml","form_type":"4"}},{"id":1917566,"issuer":{"id":1182,"kind":"organization","name":"IONIS PHARMACEUTICALS INC","symbol":"IONS"},"owners":[{"id":1183,"kind":"person","name":"Birchler Brian","position":1,"cik":"0001970151","reported_name":"Birchler Brian","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Corp and Development Ops"}}],"security":"Common Stock","published_at":"2023-04-20T00:18:56.000Z","date":"2023-04-17","kind":"exercise","planned":false,"acquired":true,"shares":1875,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."},{"field":"shares","element":"transactionShares","label":"F1","text":"Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award."}],"balance_after":37200,"source":{"system":"sec-edgar","filing":"0000874015-23-000132","document":"edgardoc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/874015/000087401523000132/edgardoc.xml","form_type":"4"}}]}