{"transactions":[{"id":1978795,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Chief Business Officer"}}],"security":"Common Stock","published_at":"2023-03-02T22:36:32.000Z","date":"2023-03-01","kind":"sale","acquired":false,"shares":6357,"price":3.0292,"value":19256.6244,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F3","text":"This transaction was a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units and does not represent a discretionary trade by the reporting person."}],"balance_after":128313,"source":{"system":"sec-edgar","filing":"0001209191-23-014869","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1503802/000120919123014869/doc4.xml","form_type":"4"}},{"id":1978794,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Chief Business Officer"}}],"security":"Common Stock","published_at":"2023-03-02T22:36:32.000Z","date":"2023-02-28","kind":"grant","acquired":true,"shares":60000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents the award of restricted stock units (\"RSUs\") pursuant to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan. RSUs convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis. The RSUs vest in three equal annual installments beginning February 28, 2024."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"Includes 2,147 shares and 1,977 shares acquired under the Karyopharm Therapeutics Inc. 2013 Employee Stock Purchase Plan on April 30, 2022 and October 31, 2022, respectively."}],"balance_after":134670,"source":{"system":"sec-edgar","filing":"0001209191-23-014869","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1503802/000120919123014869/doc4.xml","form_type":"4"}},{"id":2168792,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Chief Business Officer"}}],"security":"Stock Option (right to buy)","published_at":"2022-09-02T01:03:14.000Z","date":"2022-08-31","kind":"grant","acquired":true,"shares":30000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"This option was granted on August 31, 2022 pursuant to the Plan.  The shares underlying this option vest as to 50% of the shares on August 31, 2023, with the remaining 50% vesting on August 31, 2024."}],"balance_after":30000,"derivative":{"exercise_price":5.06,"expiration_date":"2032-08-30","underlying":"Common Stock","underlying_shares":30000},"source":{"system":"sec-edgar","filing":"0001209191-22-048397","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1503802/000120919122048397/doc4.xml","form_type":"4"}},{"id":2168791,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Chief Business Officer"}}],"security":"Common Stock","published_at":"2022-09-02T01:03:14.000Z","date":"2022-08-31","kind":"grant","acquired":true,"shares":20000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents the award of restricted stock units (\"RSUs\") pursuant to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan (the \"Plan\").  RSUs convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis.  The RSUs vest  as to 50% of the shares on August 31, 2023, with the remaining 50% vesting on August 31, 2024."}],"balance_after":70546,"source":{"system":"sec-edgar","filing":"0001209191-22-048397","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1503802/000120919122048397/doc4.xml","form_type":"4"}},{"id":2359660,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Chief Business Officer"}}],"security":"Stock Option (right to buy)","published_at":"2022-03-02T20:15:37.000Z","date":"2022-02-28","kind":"grant","acquired":true,"shares":59400,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"This option was granted on February 28, 2022 pursuant to the Plan.  The shares underlying this option vest as to 25% of the shares on February 28, 2023, with the remaining 75% vesting in 36 equal monthly installments thereafter."}],"balance_after":59400,"derivative":{"exercise_price":10.33,"expiration_date":"2032-02-27","underlying":"Common Stock","underlying_shares":59400},"source":{"system":"sec-edgar","filing":"0001209191-22-014623","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1503802/000120919122014623/doc4.xml","form_type":"4"}},{"id":2359659,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Chief Business Officer"}}],"security":"Common Stock","published_at":"2022-03-02T20:15:37.000Z","date":"2022-02-28","kind":"grant","acquired":true,"shares":47250,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents the award of restricted stock units (\"RSUs\") pursuant to the Karyopharm Therapeutics Inc. 2013 Stock Incentive Plan (the \"Plan\").  RSUs convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis.  The RSUs vest in four equal annual installments beginning February 28, 2023."}],"balance_after":50546,"source":{"system":"sec-edgar","filing":"0001209191-22-014623","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1503802/000120919122014623/doc4.xml","form_type":"4"}},{"id":2485115,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Chief Business Officer"}}],"security":"Common Stock","published_at":"2021-12-03T23:17:28.000Z","date":"2021-12-02","kind":"sale","acquired":false,"shares":499,"price":6.69,"value":3338.31,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units and does not represent a discretionary sale by the reporting person."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"Includes 1,323 shares acquired by the reporting person under the Karyopharm Therapeutics Inc. 2013 Employee Stock Purchase Plan on October 31, 2021."}],"balance_after":3296,"source":{"system":"sec-edgar","filing":"0001209191-21-067954","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1503802/000120919121067954/doc4.xml","form_type":"4"}},{"id":2682553,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Chief Business Officer"}}],"security":"Common Stock","published_at":"2021-06-03T20:06:34.000Z","date":"2021-06-02","kind":"sale","acquired":false,"shares":528,"price":9.29,"value":4905.12,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"This transaction was a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units and does not represent a discretionary trade by the reporting person."}],"balance_after":2472,"source":{"system":"sec-edgar","filing":"0000899243-21-021767","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1503802/000089924321021767/doc4.xml","form_type":"4"}},{"id":2688555,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Chief Business Officer"}}],"security":"Restricted Stock Units","published_at":"2021-06-01T20:05:49.000Z","date":"2021-05-30","kind":"exercise","acquired":false,"shares":1500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Restricted stock units (\"RSUs\") convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"On November 30, 2020, the reporting person was granted 3,000 RSUs, which vested as to 50% of the shares on May 30, 2021, with the remaining 50% vesting on November 30, 2021. 1,500 of the RSUs vested on May 30, 2021. Vested shares will be delivered to the reporting person as soon as practicable following the vesting date, but in any event within 30 days of such date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"On November 30, 2020, the reporting person was granted 3,000 RSUs, which vested as to 50% of the shares on May 30, 2021, with the remaining 50% vesting on November 30, 2021. 1,500 of the RSUs vested on May 30, 2021. Vested shares will be delivered to the reporting person as soon as practicable following the vesting date, but in any event within 30 days of such date."}],"balance_after":1500,"derivative":{"underlying":"Common Stock","underlying_shares":1500},"source":{"system":"sec-edgar","filing":"0000899243-21-021292","document":"doc4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1503802/000089924321021292/doc4.xml","form_type":"4"}},{"id":2688554,"issuer":{"id":781,"kind":"organization","name":"Karyopharm Therapeutics Inc.","symbol":"KPTI"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Chief Business Officer"}}],"security":"Common Stock","published_at":"2021-06-01T20:05:49.000Z","date":"2021-05-30","kind":"exercise","acquired":true,"shares":1500,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Restricted stock units (\"RSUs\") convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"The reporting person has reported a prior award of 3,000 RSUs (described in footnote 3 below) in Table II of Form 4. The total reported in Column 5 includes 1,500 RSUs previously reported in Table II and 1,500 shares of common stock."}],"balance_after":3000,"source":{"system":"sec-edgar","filing":"0000899243-21-021292","document":"doc4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1503802/000089924321021292/doc4.xml","form_type":"4"}},{"id":3333530,"issuer":{"id":116059,"kind":"organization","name":"Axcella Health Inc.","symbol":"AXLA"},"owners":[{"id":116131,"kind":"person","name":"Mitchener Stephen","position":1,"cik":"0001774519","reported_name":"Mitchener Stephen","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP & Chief Business Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2019-12-20T20:04:22.000Z","date":"2019-12-18","kind":"grant","acquired":true,"shares":43000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"25% of this option shall vest and become exercisable on December 18, 2020, with the remainder to vest in 12 equal quarterly installments thereafter."}],"balance_after":43000,"derivative":{"exercise_price":3.4,"expiration_date":"2029-12-18","underlying":"Common Stock","underlying_shares":43000},"source":{"system":"sec-edgar","filing":"0001104659-19-075210","document":"a4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1633070/000110465919075210/a4.xml","form_type":"4"}}]}