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Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":79746},"source":{"system":"sec-edgar","filing":"0001104659-19-053617","document":"a4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1240357/000110465919053617/a4.xml","form_type":"4"}},{"id":3395163,"issuer":{"id":7948,"kind":"organization","name":"Aprea Therapeutics, Inc."},"owners":[{"id":114514,"kind":"organization","name":"5AM Ventures IV, L.P.","position":1,"cik":"0001589315","reported_name":"5AM Ventures IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":114515,"kind":"organization","name":"5AM Co-Investors IV, L.P.","position":2,"cik":"0001593361","reported_name":"5AM Co-Investors IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":114513,"kind":"organization","name":"5AM Partners IV, LLC","position":3,"cik":"0001589314","reported_name":"5AM Partners IV, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":25025,"kind":"organization","name":"5AM Opportunities I, L.P.","position":4,"cik":"0001753000","reported_name":"5AM Opportunities I, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":25026,"kind":"organization","name":"5AM Opportunities I (GP), LLC","position":5,"cik":"0001790778","reported_name":"5AM Opportunities I (GP), LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":21275,"kind":"person","name":"DIEKMAN JOHN D","position":6,"cik":"0001240357","reported_name":"DIEKMAN JOHN D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":18314,"kind":"person","name":"Schwab Andrew J.","position":7,"cik":"0001598549","reported_name":"Schwab Andrew J.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":21276,"kind":"person","name":"PARMAR KUSH","position":8,"cik":"0001664281","reported_name":"PARMAR KUSH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series B Convertible Preferred Stock","published_at":"2019-10-09T22:23:26.000Z","date":"2019-10-07","kind":"exercise","acquired":false,"shares":1913910,"ownership":{"direct":false,"nature":"See footnotes"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"These shares of Series B Convertible Preferred Stock and Series C Convertible Preferred Stock (collectively, \"Preferred Stock\") automatically converted into shares of the Issuer's Common Stock (\"Common Stock\"), on a 1-for-1 basis, immediately prior to the completion of the Issuer's initial public offering for no additional consideration.  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Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":1913910},"source":{"system":"sec-edgar","filing":"0001104659-19-053617","document":"a4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1240357/000110465919053617/a4.xml","form_type":"4"}},{"id":3395162,"issuer":{"id":7948,"kind":"organization","name":"Aprea Therapeutics, Inc."},"owners":[{"id":114514,"kind":"organization","name":"5AM Ventures IV, L.P.","position":1,"cik":"0001589315","reported_name":"5AM Ventures IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":114515,"kind":"organization","name":"5AM Co-Investors IV, L.P.","position":2,"cik":"0001593361","reported_name":"5AM Co-Investors IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":114513,"kind":"organization","name":"5AM Partners IV, LLC","position":3,"cik":"0001589314","reported_name":"5AM Partners IV, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":25025,"kind":"organization","name":"5AM Opportunities I, L.P.","position":4,"cik":"0001753000","reported_name":"5AM Opportunities I, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":25026,"kind":"organization","name":"5AM Opportunities I (GP), LLC","position":5,"cik":"0001790778","reported_name":"5AM Opportunities I (GP), LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":21275,"kind":"person","name":"DIEKMAN JOHN D","position":6,"cik":"0001240357","reported_name":"DIEKMAN JOHN D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":18314,"kind":"person","name":"Schwab Andrew J.","position":7,"cik":"0001598549","reported_name":"Schwab Andrew J.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":21276,"kind":"person","name":"PARMAR KUSH","position":8,"cik":"0001664281","reported_name":"PARMAR KUSH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2019-10-09T22:23:26.000Z","date":"2019-10-07","kind":"purchase","acquired":true,"shares":333333,"price":15,"value":4999995.0,"ownership":{"direct":false,"nature":"See footnotes"},"footnotes":[{"field":"ownership.direct","element":"directOrIndirectOwnership","label":"F5","text":"Shares are held directly by 5AM Opportunities I, L.P. 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The 5AM IV Funds and Opportunities expressly disclaim status as a \"group\" for purposes of this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"5AM Opportunities I (GP), LLC (\"Opportunities GP\") is the sole general partner of Opportunities.  Andrew J. Schwab and Kush Parmar are managing members of Opportunities GP and may be deemed to have shared voting and investment power over the shares beneficially owned by Opportunities.  Each of Opportunities GP, Mr. Schwab and Mr. Parmar disclaims beneficial ownership of the shares of Common Stock held directly by Opportunities, except to the extent of its or his pecuniary interest therein."}],"balance_after":333333,"source":{"system":"sec-edgar","filing":"0001104659-19-053617","document":"a4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1240357/000110465919053617/a4.xml","form_type":"4"}},{"id":3395161,"issuer":{"id":7948,"kind":"organization","name":"Aprea Therapeutics, Inc."},"owners":[{"id":114514,"kind":"organization","name":"5AM Ventures IV, L.P.","position":1,"cik":"0001589315","reported_name":"5AM Ventures IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":114515,"kind":"organization","name":"5AM Co-Investors IV, L.P.","position":2,"cik":"0001593361","reported_name":"5AM Co-Investors IV, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":114513,"kind":"organization","name":"5AM Partners IV, LLC","position":3,"cik":"0001589314","reported_name":"5AM Partners IV, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":25025,"kind":"organization","name":"5AM Opportunities I, L.P.","position":4,"cik":"0001753000","reported_name":"5AM Opportunities I, L.P.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":25026,"kind":"organization","name":"5AM Opportunities I (GP), LLC","position":5,"cik":"0001790778","reported_name":"5AM Opportunities I (GP), LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":21275,"kind":"person","name":"DIEKMAN JOHN D","position":6,"cik":"0001240357","reported_name":"DIEKMAN JOHN D","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":18314,"kind":"person","name":"Schwab Andrew J.","position":7,"cik":"0001598549","reported_name":"Schwab Andrew J.","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}},{"id":21276,"kind":"person","name":"PARMAR KUSH","position":8,"cik":"0001664281","reported_name":"PARMAR KUSH","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2019-10-09T22:23:26.000Z","date":"2019-10-07","kind":"exercise","acquired":true,"shares":20519,"ownership":{"direct":false,"nature":"See footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"These shares of Series B Convertible Preferred Stock and Series C Convertible Preferred Stock (collectively, \"Preferred Stock\") automatically converted into shares of the Issuer's Common Stock (\"Common Stock\"), on a 1-for-1 basis, immediately prior to the completion of the Issuer's initial public offering for no additional consideration.  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