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The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1347543,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":13,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5010,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":847,"price":365.4163,"value":309507.6061,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F14","text":"The transaction was executed in multiple trades ranging from $365.07 to $366.03. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1347948,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5009,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":1358,"price":364.4794,"value":494963.0252,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F13","text":"The transaction was executed in multiple trades ranging from $364.07 to $365.05. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1348795,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5008,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":573,"price":363.3424,"value":208195.1952,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F12","text":"The transaction was executed in multiple trades ranging from $363.05 to $364.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1350153,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5007,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":2010,"price":362.6504,"value":728927.304,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F11","text":"The transaction was executed in multiple trades ranging from $362.02 to $363.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1350726,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5006,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":1214,"price":361.6091,"value":438993.4474,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F10","text":"The transaction was executed in multiple trades ranging from $361.02 to $362.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1352736,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5005,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":2266,"price":360.463,"value":816809.158,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1353950,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5004,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3357,"price":359.3861,"value":1206459.1377,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1356216,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5003,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3143,"price":358.4182,"value":1126508.4026,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1359573,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5002,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3981,"price":357.5738,"value":1423501.2978,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1362716,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5001,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3297,"price":356.3687,"value":1174947.6039,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $355.98 to $356.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1366697,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5000,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":2029,"price":355.5719,"value":721455.3851,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1369994,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":4999,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":520,"price":354.54,"value":184360.8,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1372023,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":748004,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":40,"price":312.23,"value":12489.2,"ownership":{"direct":true},"balance_after":1450253,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":748003,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":964,"price":311.358,"value":300149.112,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F11","text":"The transaction was executed in multiple trades ranging from $311.07 to $311.77. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1450293,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":748002,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":2652,"price":310.429,"value":823257.708,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F10","text":"The transaction was executed in multiple trades ranging from $310.06 to $311.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1451257,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":748001,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":2784,"price":309.4901,"value":861620.4384,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $309.04 to $310.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1453909,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":748000,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":4830,"price":308.4677,"value":1489898.991,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $308.03 to $309.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1456693,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747999,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":11461,"price":307.6776,"value":3526292.9736,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $307.03 to $308.02. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1461523,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747998,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":589,"price":306.3318,"value":180429.4302,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $306.00 to $306.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1472984,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747997,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":544,"price":304.8102,"value":165816.7488,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $304.07 to $304.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1473573,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747996,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":176,"price":303.1689,"value":53357.7264,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $303.05 to $303.82. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1474117,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747995,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":640,"price":302.2367,"value":193431.488,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $302.05 to $303.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1474293,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747994,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":320,"price":300.75,"value":96240.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. 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The Rule 10b5-1 trading plan started on December 4, 2025, and will terminate on December 4, 2026, or earlier in accordance with the terms of the Rule 10b5-1 trading plan, including upon completion of the sale of all of the shares of the Company's common stock subject to the Rule 10b5-1 trading plan."}],"balance_after":1474933,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":855924,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":920,"price":266.555,"value":245230.6,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F12","text":"The transaction was executed in multiple trades ranging from $266.36 to $266.93. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1475253,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855923,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":2439,"price":265.5896,"value":647773.0344,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F11","text":"The transaction was executed in multiple trades ranging from $265.235 to $266.19. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1476173,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855922,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":8798,"price":264.8501,"value":2330151.1798,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F10","text":"The transaction was executed in multiple trades ranging from $264.2 to $265.19. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1478612,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855921,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":2043,"price":263.7011,"value":538741.3473,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $263.19 to $264.1. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1487410,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855920,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":2380,"price":262.4448,"value":624618.624,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $262.08 to $263. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1489453,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855919,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":2962,"price":261.4075,"value":774289.015,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $261.07 to $262.04. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1491833,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855918,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":3128,"price":260.4867,"value":814802.3976,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $260.07 to $261.06. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1494795,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855917,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":1377,"price":259.8675,"value":357837.5475,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $259.07 to $260.06. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1497923,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855916,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":470,"price":258.3795,"value":121438.365,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $257.89 to $258.765. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1499300,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855915,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":483,"price":257.3131,"value":124282.2273,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier in accordance with the terms of the Rule 10b5-1 trading plan, including upon completion of the sale of all of the shares of the Company's common stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $256.81 to $257.75. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1499770,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":867452,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Restricted Stock Units","published_at":"2026-03-03T23:30:23.000Z","date":"2026-02-27","kind":"grant","planned":false,"acquired":true,"shares":18140,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F16","text":"Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date."},{"field":"shares","element":"transactionShares","label":"F17","text":"The number of RSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming the Reporting Person's continued service to the Company on all applicable vesting dates."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F18","text":"The RSUs vest in four equal annual installments with the first installment vesting on February 27, 2027."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F18","text":"The RSUs vest in four equal annual installments with the first installment vesting on February 27, 2027."}],"balance_after":18140,"derivative":{"underlying":"Common Stock","underlying_shares":18140},"source":{"system":"sec-edgar","filing":"0001298709-26-000002","document":"wk-form4_1772580619.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":17,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000002/wk-form4_1772580619.xml","form_type":"4"}},{"id":867451,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-03-03T23:30:23.000Z","date":"2026-02-27","kind":"grant","planned":false,"acquired":true,"shares":45249,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F15","text":"The stock options vests in four equal annual installments beginning on February 27, 2027."}],"balance_after":45249,"derivative":{"exercise_price":275.64,"expiration_date":"2036-02-26","underlying":"Common Stock","underlying_shares":45249},"source":{"system":"sec-edgar","filing":"0001298709-26-000002","document":"wk-form4_1772580619.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":16,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000002/wk-form4_1772580619.xml","form_type":"4"}},{"id":867450,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Restricted Stock Units","published_at":"2026-03-03T23:30:23.000Z","date":"2026-02-27","kind":"exercise","planned":false,"acquired":false,"shares":5725,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F6","text":"22,900 restricted stock units (\"RSUs\") were granted on February 28, 2025. 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Krishnan, the spouse of the Reporting Person."}],"balance_after":1413911,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":18,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979074,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":2627,"price":220.5179,"value":579300.5233,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F12","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F19","text":"The transaction was executed in multiple trades ranging from $220.21 to $221.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1424372,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":17,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979073,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":5419,"price":219.6757,"value":1190422.6183,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F12","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F18","text":"The transaction was executed in multiple trades ranging from $219.21 to $220.20. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1426999,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":16,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979072,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":3593,"price":218.8268,"value":786244.6924000001,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F12","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F17","text":"The transaction was executed in multiple trades ranging from $218.21 to $219.20. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1432418,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":15,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979071,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":1400,"price":216.9668,"value":303753.52,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F12","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F16","text":"The transaction was executed in multiple trades ranging from $216.60 to $217.53. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1436011,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":14,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979070,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":600,"price":215.4933,"value":129295.98,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F12","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F15","text":"The transaction was executed in multiple trades ranging from $215.34 to $215.80. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1437411,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":13,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979069,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":700,"price":214.2503,"value":149975.21,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F12","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F13","text":"The transaction was executed in multiple trades ranging from $213.87 to $214.68. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F14","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1438011,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979068,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-05","kind":"gift","planned":true,"acquired":false,"shares":5000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F10","text":"Represents a bona fide gift of Krystal Biotech, Inc.'s Common Stock to a charitable donor-advised fund."}],"balance_after":1478056,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979067,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":700,"price":222.1986,"value":155539.02,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $222.14 to $222.30. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1483056,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979066,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":10505,"price":221.7774,"value":2329771.587,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $221.14 to $222.11. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1483756,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979065,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":2625,"price":220.3408,"value":578394.6,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $220.14 to $221.11. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1494261,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979064,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":5693,"price":219.5533,"value":1249916.9369,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $219.14 to $220.13. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1496886,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979063,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":2577,"price":218.7186,"value":563637.8322,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $218.11 to $219.07. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1502579,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979062,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":1600,"price":217.0448,"value":347271.68,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $216.73 to $217.63. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1505156,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979061,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":344,"price":215.4814,"value":74125.6016,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $214.99 to $215.80. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1506756,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":979060,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-12-05T23:53:44.000Z","date":"2025-12-04","kind":"sale","planned":true,"acquired":false,"shares":956,"price":214.2797,"value":204851.3932,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transaction was executed in multiple trades ranging from $213.93 to $214.67. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1507100,"source":{"system":"sec-edgar","filing":"0001298709-25-000013","document":"wk-form4_1764978821.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000013/wk-form4_1764978821.xml","form_type":"4"}},{"id":1086565,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-07-16T22:41:30.000Z","date":"2025-07-16","kind":"sale","planned":true,"acquired":false,"shares":1529,"price":150,"value":229350.0,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in one trade."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Directly beneficially owned by Suma M. 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Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in one trade."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Directly beneficially owned by Suma M. 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Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $150.21 to $151.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Directly beneficially owned by Suma M. 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Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in one trade."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Directly beneficially owned by Suma M. 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Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $150.00 to $150.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Directly beneficially owned by Suma M. 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The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in one trade."}],"balance_after":1508056,"source":{"system":"sec-edgar","filing":"0001298709-25-000009","document":"wk-form4_1752705685.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000009/wk-form4_1752705685.xml","form_type":"4"}},{"id":1086559,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-07-16T22:41:30.000Z","date":"2025-07-15","kind":"sale","planned":true,"acquired":false,"shares":900,"price":151.79,"value":136611.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in one trade."}],"balance_after":1509445,"source":{"system":"sec-edgar","filing":"0001298709-25-000009","document":"wk-form4_1752705685.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000009/wk-form4_1752705685.xml","form_type":"4"}},{"id":1086558,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-07-16T22:41:30.000Z","date":"2025-07-15","kind":"sale","planned":true,"acquired":false,"shares":2184,"price":150.6817,"value":329088.8328,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $150.21 to $151.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1510345,"source":{"system":"sec-edgar","filing":"0001298709-25-000009","document":"wk-form4_1752705685.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000009/wk-form4_1752705685.xml","form_type":"4"}},{"id":1086557,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-07-16T22:41:30.000Z","date":"2025-07-14","kind":"sale","planned":true,"acquired":false,"shares":13400,"price":150.2996,"value":2014014.64,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transaction was executed in multiple trades ranging from $150.00 to $150.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1512529,"source":{"system":"sec-edgar","filing":"0001298709-25-000009","document":"wk-form4_1752705685.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000009/wk-form4_1752705685.xml","form_type":"4"}},{"id":1088606,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-07-11T21:44:09.000Z","date":"2025-07-10","kind":"sale","planned":true,"acquired":false,"shares":300,"price":151.3867,"value":45416.01,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in three trades of 100 shares each at $151.350, $151.40, and $151.41, respectively. The price reported above reflects the average sale price."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1456711,"source":{"system":"sec-edgar","filing":"0001298709-25-000007","document":"wk-form4_1752270242.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000007/wk-form4_1752270242.xml","form_type":"4"}},{"id":1088605,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-07-11T21:44:09.000Z","date":"2025-07-10","kind":"sale","planned":true,"acquired":false,"shares":6500,"price":150.2252,"value":976463.8,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $150.00 to $150.8500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Directly beneficially owned by Suma M. 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Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $150.1200 to $150.1600. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Directly beneficially owned by Suma M. 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The price reported above reflects the average sale price."}],"balance_after":1525929,"source":{"system":"sec-edgar","filing":"0001298709-25-000007","document":"wk-form4_1752270242.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000007/wk-form4_1752270242.xml","form_type":"4"}},{"id":1088602,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-07-11T21:44:09.000Z","date":"2025-07-10","kind":"sale","planned":true,"acquired":false,"shares":6627,"price":150.2184,"value":995497.3368,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 ."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $150.00 to $150.8500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1526229,"source":{"system":"sec-edgar","filing":"0001298709-25-000007","document":"wk-form4_1752270242.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000007/wk-form4_1752270242.xml","form_type":"4"}},{"id":1088601,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-07-11T21:44:09.000Z","date":"2025-07-09","kind":"sale","planned":true,"acquired":false,"shares":200,"price":150.07,"value":30014.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 ."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transaction was executed in two trades of 100 shares each at $150 and $150.14, respectively. The price reported above reflects the average sale price."}],"balance_after":1532856,"source":{"system":"sec-edgar","filing":"0001298709-25-000007","document":"wk-form4_1752270242.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000007/wk-form4_1752270242.xml","form_type":"4"}},{"id":1207821,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-03-13T22:04:23.000Z","date":"2025-03-13","kind":"sale","planned":true,"acquired":false,"shares":1331,"price":179.5466,"value":238976.5246,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F8","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share."},{"field":"price","element":"transactionPricePerShare","label":"F14","text":"The transaction was executed in multiple trades ranging from $179.33 to $179.70. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1463711,"source":{"system":"sec-edgar","filing":"0001298709-25-000004","document":"wk-form4_1741903456.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000004/wk-form4_1741903456.xml","form_type":"4"}},{"id":1207820,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-03-13T22:04:23.000Z","date":"2025-03-13","kind":"sale","planned":true,"acquired":false,"shares":6514,"price":178.7558,"value":1164415.2812,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F8","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share."},{"field":"price","element":"transactionPricePerShare","label":"F13","text":"The transaction was executed in multiple trades ranging from $178.31 to $179.26. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1465042,"source":{"system":"sec-edgar","filing":"0001298709-25-000004","document":"wk-form4_1741903456.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000004/wk-form4_1741903456.xml","form_type":"4"}},{"id":1207819,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-03-13T22:04:23.000Z","date":"2025-03-13","kind":"sale","planned":true,"acquired":false,"shares":10937,"price":177.6563,"value":1943026.9531,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F8","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share."},{"field":"price","element":"transactionPricePerShare","label":"F12","text":"The transaction was executed in multiple trades ranging from $177.30 to $178.28. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1471556,"source":{"system":"sec-edgar","filing":"0001298709-25-000004","document":"wk-form4_1741903456.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000004/wk-form4_1741903456.xml","form_type":"4"}},{"id":1207818,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-03-13T22:04:23.000Z","date":"2025-03-13","kind":"sale","planned":true,"acquired":false,"shares":4579,"price":176.8779,"value":809923.9041,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F8","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share."},{"field":"price","element":"transactionPricePerShare","label":"F11","text":"The transaction was executed in multiple trades ranging from $176.30 to $177.29. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1482493,"source":{"system":"sec-edgar","filing":"0001298709-25-000004","document":"wk-form4_1741903456.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000004/wk-form4_1741903456.xml","form_type":"4"}},{"id":1207817,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-03-13T22:04:23.000Z","date":"2025-03-13","kind":"sale","planned":true,"acquired":false,"shares":1639,"price":175.9724,"value":288418.7636,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F8","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share."},{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $175.30 to $176.28. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F10","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1487072,"source":{"system":"sec-edgar","filing":"0001298709-25-000004","document":"wk-form4_1741903456.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000004/wk-form4_1741903456.xml","form_type":"4"}},{"id":1207816,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-03-13T22:04:23.000Z","date":"2025-03-13","kind":"sale","planned":true,"acquired":false,"shares":1256,"price":179.5735,"value":225544.316,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $179.29 to $179.74. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1533056,"source":{"system":"sec-edgar","filing":"0001298709-25-000004","document":"wk-form4_1741903456.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000004/wk-form4_1741903456.xml","form_type":"4"}},{"id":1207815,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-03-13T22:04:23.000Z","date":"2025-03-13","kind":"sale","planned":true,"acquired":false,"shares":6769,"price":178.7674,"value":1210076.5306,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $178.29 to $179.27. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1534312,"source":{"system":"sec-edgar","filing":"0001298709-25-000004","document":"wk-form4_1741903456.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000004/wk-form4_1741903456.xml","form_type":"4"}},{"id":1207814,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-03-13T22:04:23.000Z","date":"2025-03-13","kind":"sale","planned":true,"acquired":false,"shares":10931,"price":177.6243,"value":1941611.2233,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $177.28 to $178.25. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1541081,"source":{"system":"sec-edgar","filing":"0001298709-25-000004","document":"wk-form4_1741903456.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000004/wk-form4_1741903456.xml","form_type":"4"}},{"id":1207813,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-03-13T22:04:23.000Z","date":"2025-03-13","kind":"sale","planned":true,"acquired":false,"shares":4944,"price":176.8048,"value":874122.9312,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $176.28 to $177.25. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1552012,"source":{"system":"sec-edgar","filing":"0001298709-25-000004","document":"wk-form4_1741903456.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000004/wk-form4_1741903456.xml","form_type":"4"}},{"id":1207812,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-03-13T22:04:23.000Z","date":"2025-03-13","kind":"sale","planned":true,"acquired":false,"shares":1100,"price":175.8256,"value":193408.16,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transaction was executed in multiple trades ranging from $175.23 to $176.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1556956,"source":{"system":"sec-edgar","filing":"0001298709-25-000004","document":"wk-form4_1741903456.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000004/wk-form4_1741903456.xml","form_type":"4"}},{"id":1238600,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Restricted Stock Units","published_at":"2025-02-28T23:58:12.000Z","date":"2025-02-28","kind":"grant","planned":false,"acquired":true,"shares":22900,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F19","text":"Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date."},{"field":"shares","element":"transactionShares","label":"F20","text":"The number of RSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming the Reporting Person's continued service to the Company on all applicable vesting dates."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F21","text":"The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2026."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F21","text":"The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2026."}],"balance_after":22900,"derivative":{"underlying":"Common Stock","underlying_shares":22900},"source":{"system":"sec-edgar","filing":"0001298709-25-000002","document":"wk-form4_1740787086.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":19,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000002/wk-form4_1740787086.xml","form_type":"4"}},{"id":1238599,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-02-28T23:58:12.000Z","date":"2025-02-28","kind":"grant","planned":false,"acquired":true,"shares":39300,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F18","text":"The option vests in four equal annual installments beginning on February 28, 2026."}],"balance_after":39300,"derivative":{"exercise_price":179.25,"expiration_date":"2035-02-28","underlying":"Common Stock","underlying_shares":39300},"source":{"system":"sec-edgar","filing":"0001298709-25-000002","document":"wk-form4_1740787086.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":18,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000002/wk-form4_1740787086.xml","form_type":"4"}},{"id":1238598,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Performance Stock Units","published_at":"2025-02-28T23:58:12.000Z","date":"2025-02-28","kind":"exercise","planned":false,"acquired":false,"shares":26250,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F8","text":"52,500 performance stock units (\"PSUs\") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"52,500 performance stock units (\"PSUs\") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F8","text":"52,500 performance stock units (\"PSUs\") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025."}],"balance_after":26250,"derivative":{"underlying":"Common Stock","underlying_shares":26250},"source":{"system":"sec-edgar","filing":"0001298709-25-000002","document":"wk-form4_1740787086.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":17,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000002/wk-form4_1740787086.xml","form_type":"4"}},{"id":1238597,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Restricted Stock Units","published_at":"2025-02-28T23:58:12.000Z","date":"2025-02-28","kind":"exercise","planned":false,"acquired":false,"shares":8750,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F6","text":"35,000 restricted stock units (\"RSUs\") were granted on February 29, 2024. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"35,000 restricted stock units (\"RSUs\") were granted on February 29, 2024. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"35,000 restricted stock units (\"RSUs\") were granted on February 29, 2024. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025."}],"balance_after":26250,"derivative":{"underlying":"Common Stock","underlying_shares":8750},"source":{"system":"sec-edgar","filing":"0001298709-25-000002","document":"wk-form4_1740787086.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":16,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000002/wk-form4_1740787086.xml","form_type":"4"}},{"id":1238596,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Performance Stock Units","published_at":"2025-02-28T23:58:12.000Z","date":"2025-02-28","kind":"exercise","planned":false,"acquired":false,"shares":12500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F3","text":"25,000 performance stock units (\"PSUs\") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the other 12,500 PSUs vested on February 28, 2025."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"25,000 performance stock units (\"PSUs\") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the other 12,500 PSUs vested on February 28, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"25,000 performance stock units (\"PSUs\") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the other 12,500 PSUs vested on February 28, 2025."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":12500},"source":{"system":"sec-edgar","filing":"0001298709-25-000002","document":"wk-form4_1740787086.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":15,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000002/wk-form4_1740787086.xml","form_type":"4"}},{"id":1238595,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-02-28T23:58:12.000Z","date":"2025-02-26","kind":"tax_withholding","planned":false,"acquired":false,"shares":3286,"price":176.39,"value":579617.54,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F11","text":"These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan."},{"field":"shares","element":"transactionShares","label":"F16","text":"Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 7,100 shares of restricted stock on February 26, 2025. 28,400 RSAs were granted on February 26, 2021, to the Reporting Person's spouse, Suma M. Krishnan. Each RSA represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's spouse continued service to the Company on each applicable vesting date. The RSAs vested in four equal annual installments beginning on February 26, 2022."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The closing price on February 26, 2025 of the Company's common stock on the Nasdaq Global Select Market."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F12","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1488711,"source":{"system":"sec-edgar","filing":"0001298709-25-000002","document":"wk-form4_1740787086.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000002/wk-form4_1740787086.xml","form_type":"4"}},{"id":1238594,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-02-28T23:58:12.000Z","date":"2025-02-28","kind":"tax_withholding","planned":false,"acquired":false,"shares":10414,"price":179.25,"value":1866709.5,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F11","text":"These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan."},{"field":"shares","element":"transactionShares","label":"F15","text":"Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 22,500 PSUs on February 28, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F12","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1491997,"source":{"system":"sec-edgar","filing":"0001298709-25-000002","document":"wk-form4_1740787086.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000002/wk-form4_1740787086.xml","form_type":"4"}},{"id":1238593,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-02-28T23:58:12.000Z","date":"2025-02-28","kind":"exercise","planned":false,"acquired":true,"shares":22500,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F11","text":"These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan."},{"field":"shares","element":"transactionShares","label":"F14","text":"45,000 PSUs were granted on February 29, 2024, to the Reporting Person's spouse, Suma M. Krishnan. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's spouse continued service to the Company on each applicable vesting date following such achievement. All of the performance criteria were achieved and one-half of the PSUs granted, or 22,500 PSUs, vested on February 28, 2025."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F12","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1502411,"source":{"system":"sec-edgar","filing":"0001298709-25-000002","document":"wk-form4_1740787086.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000002/wk-form4_1740787086.xml","form_type":"4"}},{"id":1238592,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-02-28T23:58:12.000Z","date":"2025-02-28","kind":"tax_withholding","planned":false,"acquired":false,"shares":3471,"price":179.25,"value":622176.75,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F11","text":"These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan."},{"field":"shares","element":"transactionShares","label":"F13","text":"Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 7,500 PSUs on February 28, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F12","text":"Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person."}],"balance_after":1479911,"source":{"system":"sec-edgar","filing":"0001298709-25-000002","document":"wk-form4_1740787086.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870925000002/wk-form4_1740787086.xml","form_type":"4"}}],"next_cursor":"2025-02-28T23:58:12.000000Z,1238592"}