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This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"shares","element":"transactionShares","label":"F2","text":"The original Form 4 inadvertently overstated the number of shares sold, weighted average price and the number of shares beneficially owned following the reported transactions. This amendment correctly states the number of shares sold, weighted average price and the number of shares beneficially owned following the reported transactions."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The original Form 4 inadvertently overstated the number of shares sold, weighted average price and the number of shares beneficially owned following the reported transactions. This amendment correctly states the number of shares sold, weighted average price and the number of shares beneficially owned following the reported transactions."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.56 to $3.57 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F2","text":"The original Form 4 inadvertently overstated the number of shares sold, weighted average price and the number of shares beneficially owned following the reported transactions. 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This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.41 to $3.525 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":15782,"source":{"system":"sec-edgar","filing":"0002079922-26-000006","document":"form4-10062026_041011.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2079922/000207992226000006/form4-10062026_041011.xml","form_type":"4"}},{"id":4636259,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":29665,"kind":"person","name":"Skynner Michael","position":1,"cik":"0001776582","reported_name":"Skynner Michael","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Ordinary Shares","published_at":"2026-10-06T20:45:14.000Z","date":"2026-10-05","kind":"sale","planned":false,"acquired":false,"shares":503,"price":3.57,"value":1795.71,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting and settlement of the RSUs. This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.56 to $3.57 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":154726,"source":{"system":"sec-edgar","filing":"0001776582-26-000010","document":"form4-10062026_041009.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1776582/000177658226000010/form4-10062026_041009.xml","form_type":"4"}},{"id":4636258,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":29665,"kind":"person","name":"Skynner Michael","position":1,"cik":"0001776582","reported_name":"Skynner Michael","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Ordinary Shares","published_at":"2026-10-06T20:45:14.000Z","date":"2026-10-02","kind":"sale","planned":false,"acquired":false,"shares":1942,"price":3.47,"value":6738.74,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting and settlement of the RSUs. This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.41 to $3.525 inclusive. 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This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.56 to $3.57 inclusive. 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This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.41 to $3.525 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":92803,"source":{"system":"sec-edgar","filing":"0002015378-26-000010","document":"form4-10062026_041007.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2015378/000201537826000010/form4-10062026_041007.xml","form_type":"4"}},{"id":4636254,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":29664,"kind":"person","name":"Perry Jennifer Scott","position":1,"cik":"0002119908","reported_name":"Perry Jennifer Scott","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Operating Officer"}}],"security":"Ordinary Shares","published_at":"2026-10-06T20:45:09.000Z","date":"2026-10-05","kind":"sale","planned":true,"acquired":false,"shares":326,"price":3.78,"value":1232.28,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F4","text":"This transaction was made pursuant to a Rule 10b5-1 trading plan adopted on March 27, 2025."}],"balance_after":89552,"source":{"system":"sec-edgar","filing":"0002119908-26-000011","document":"form4-10062026_041004.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/2119908/000211990826000011/form4-10062026_041004.xml","form_type":"4"}},{"id":4636253,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":29664,"kind":"person","name":"Perry Jennifer Scott","position":1,"cik":"0002119908","reported_name":"Perry Jennifer Scott","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Operating Officer"}}],"security":"Ordinary Shares","published_at":"2026-10-06T20:45:09.000Z","date":"2026-10-05","kind":"sale","planned":true,"acquired":false,"shares":80,"price":3.56,"value":284.8,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting and settlement of the RSUs. This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.56 to $3.57 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":89878,"source":{"system":"sec-edgar","filing":"0002119908-26-000011","document":"form4-10062026_041004.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2119908/000211990826000011/form4-10062026_041004.xml","form_type":"4"}},{"id":4636252,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":29664,"kind":"person","name":"Perry Jennifer Scott","position":1,"cik":"0002119908","reported_name":"Perry Jennifer Scott","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Operating Officer"}}],"security":"Ordinary Shares","published_at":"2026-10-06T20:45:09.000Z","date":"2026-10-02","kind":"sale","planned":true,"acquired":false,"shares":1094,"price":3.47,"value":3796.18,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting and settlement of the RSUs. This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.41 to $3.525 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote."}],"balance_after":89958,"source":{"system":"sec-edgar","filing":"0002119908-26-000011","document":"form4-10062026_041004.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2119908/000211990826000011/form4-10062026_041004.xml","form_type":"4"}},{"id":4636256,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":31703,"kind":"person","name":"Lee Kevin","position":1,"cik":"0001776938","reported_name":"Lee Kevin","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF EXECUTIVE OFFICER"}}],"security":"Ordinary Shares","published_at":"2026-10-06T20:45:06.000Z","date":"2026-10-05","kind":"sale","planned":false,"acquired":false,"shares":1638,"price":3.57,"value":5847.66,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting and settlement of the RSUs. This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.56 to $3.57 inclusive. 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This sale is mandated by the Reporting Person's award agreement that requires the satisfaction of minimum statutory tax withholding obligations to be funded by a \"sell to cover\" transaction and does not represent a discretionary sale by the Reporting Person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.41 to $3.525 inclusive. 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The RSUs shall vest in four equal installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"Each RSU represents a contingent right to receive one ordinary share."}],"balance_after":196427,"source":{"system":"sec-edgar","filing":"0001777021-26-000002","document":"form4-01062026_080109.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1761612/000177702126000002/form4-01062026_080109.xml","form_type":"4"}},{"id":945703,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":39558,"kind":"person","name":"Hoppenot Herve","position":1,"cik":"0001596492","reported_name":"Hoppenot Herve","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2026-01-07T01:00:19.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":6065,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"This option shall vest in four equal installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026."}],"balance_after":6065,"derivative":{"exercise_price":7.08,"expiration_date":"2036-01-02","underlying":"Ordinary Shares","underlying_shares":6065},"source":{"system":"sec-edgar","filing":"0001596492-26-000002","document":"form4-01062026_080107.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1596492/000159649226000002/form4-01062026_080107.xml","form_type":"4"}},{"id":945702,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":39558,"kind":"person","name":"Hoppenot Herve","position":1,"cik":"0001596492","reported_name":"Hoppenot Herve","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Ordinary Shares","published_at":"2026-01-07T01:00:19.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":3032,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents a restricted share unit (\"RSU\") award. 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Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan. The Share Options have a strike price of $7.08 and vest into ADS or Ordinary shares at the Issuer's option in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"Includes 38,000 Share Options granted by the Issuer to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan. The Share Options have a strike price of $7.08 and vest into ADS or Ordinary shares at the Issuer's option in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise."},{"field":"derivative.underlying","element":"underlyingSecurityTitle","label":"F2","text":"ADS each represent 1 Ordinary Share."},{"field":"derivative.underlying","element":"underlyingSecurityTitle","label":"F10","text":"Includes 38,000 Share Options granted by the Issuer to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan. The Share Options have a strike price of $7.08 and vest into ADS or Ordinary shares at the Issuer's option in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Baker Bros. Advisors LP (\"the Adviser\") serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Pursuant to the policies of the Adviser, Felix J. Baker does not have any right to any of the Issuer's securities issued as compensation for his service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs and non-qualified share options exercisable into ADS or Ordinary Shares of the Issuer (\"Share Options\") received as a result of his service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs, Share Options, and ADS or Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest) issued as compensation for such Board service."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"The Adviser has voting and dispositive power over the Share Options, RSUs and any ADS or Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"After giving effect to the transaction reported herein and as a result of their ownership interest in (i) Baker Brothers Life Sciences Capital, L.P. and (ii) Life Sciences, Julian C. Baker and Felix J. Baker may be deemed to have an indirect pecuniary interest in the securities reported in column 5 of Table I and in column 9 of Table II directly held by or held for the benefit of Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to their interest in Life Sciences and Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"The acquisitions of the RSUs and Share Options reported on this form represent a single grant to Felix J. Baker of 19,000 RSUs on Table I and 38,000 Share Options on Table II. These grants, totaling 19,000 RSUs and 38,000 Share Options for Felix J. Baker, are reported for each of the Funds as each has an indirect pecuniary interest in such securities."}],"balance_after":38000,"derivative":{"exercise_price":7.08,"expiration_date":"2036-01-02","underlying":"American Depositary Shares","underlying_shares":38000},"source":{"system":"sec-edgar","filing":"0001193125-26-004828","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1087940/000119312526004828/ownership.xml","form_type":"4"}},{"id":948183,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":24760,"kind":"person","name":"BAKER BROS. ADVISORS LP","position":1,"cik":"0001263508","reported_name":"BAKER BROS. ADVISORS LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24762,"kind":"person","name":"667, L.P.","position":2,"cik":"0001551139","reported_name":"667, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24761,"kind":"person","name":"Baker Bros. Advisors (GP) LLC","position":3,"cik":"0001580575","reported_name":"Baker Bros. Advisors (GP) LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24763,"kind":"person","name":"Baker Brothers Life Sciences LP","position":4,"cik":"0001363364","reported_name":"Baker Brothers Life Sciences LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24764,"kind":"person","name":"BAKER FELIX","position":5,"cik":"0001087940","reported_name":"BAKER FELIX","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24765,"kind":"person","name":"BAKER JULIAN","position":6,"cik":"0001087939","reported_name":"BAKER JULIAN","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2026-01-06T22:41:23.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":38000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F10","text":"Includes 38,000 Share Options granted by the Issuer to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan. The Share Options have a strike price of $7.08 and vest into ADS or Ordinary shares at the Issuer's option in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"Includes 38,000 Share Options granted by the Issuer to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan. The Share Options have a strike price of $7.08 and vest into ADS or Ordinary shares at the Issuer's option in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise."},{"field":"derivative.underlying","element":"underlyingSecurityTitle","label":"F2","text":"ADS each represent 1 Ordinary Share."},{"field":"derivative.underlying","element":"underlyingSecurityTitle","label":"F10","text":"Includes 38,000 Share Options granted by the Issuer to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan. The Share Options have a strike price of $7.08 and vest into ADS or Ordinary shares at the Issuer's option in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"After giving effect to the transactions reported herein and as a result of their ownership interest in (i) Baker Biotech Capital, L.P. and (ii) 667, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the securities reported in column 5 of Table I and in column 9 of Table II directly held by or held for the benefit of 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to their interest in 667 and Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Baker Bros. Advisors LP (\"the Adviser\") serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Pursuant to the policies of the Adviser, Felix J. Baker does not have any right to any of the Issuer's securities issued as compensation for his service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs and non-qualified share options exercisable into ADS or Ordinary Shares of the Issuer (\"Share Options\") received as a result of his service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs, Share Options, and ADS or Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest) issued as compensation for such Board service."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"The Adviser has voting and dispositive power over the Share Options, RSUs and any ADS or Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F11","text":"The acquisitions of the RSUs and Share Options reported on this form represent a single grant to Felix J. Baker of 19,000 RSUs on Table I and 38,000 Share Options on Table II. These grants, totaling 19,000 RSUs and 38,000 Share Options for Felix J. Baker, are reported for each of the Funds as each has an indirect pecuniary interest in such securities."}],"balance_after":38000,"derivative":{"exercise_price":7.08,"expiration_date":"2036-01-02","underlying":"American Depositary Shares","underlying_shares":38000},"source":{"system":"sec-edgar","filing":"0001193125-26-004828","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1087940/000119312526004828/ownership.xml","form_type":"4"}},{"id":948182,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":24760,"kind":"person","name":"BAKER BROS. ADVISORS LP","position":1,"cik":"0001263508","reported_name":"BAKER BROS. ADVISORS LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24762,"kind":"person","name":"667, L.P.","position":2,"cik":"0001551139","reported_name":"667, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24761,"kind":"person","name":"Baker Bros. Advisors (GP) LLC","position":3,"cik":"0001580575","reported_name":"Baker Bros. Advisors (GP) LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24763,"kind":"person","name":"Baker Brothers Life Sciences LP","position":4,"cik":"0001363364","reported_name":"Baker Brothers Life Sciences LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24764,"kind":"person","name":"BAKER FELIX","position":5,"cik":"0001087940","reported_name":"BAKER FELIX","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24765,"kind":"person","name":"BAKER JULIAN","position":6,"cik":"0001087939","reported_name":"BAKER JULIAN","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-01-06T22:41:23.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":19000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Includes 19,000 restricted share units (each an \"RSU\") payable in American Depositary Shares (\"ADS\") or Ordinary Shares (\"Ordinary Shares\") at the option of Bicycle Therapeutics plc (the \"Issuer\") granted by the Issuer to Felix J. Baker, a managing member of Baker Bros. Advisors (GP) LLC (the \"Adviser GP\") on January 2, 2026 pursuant to the Issuer's 2020 Equity Incentive Plan (the \"2020 Plan\"). The RSUs vest in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, subject to Felix J. Baker's continuous service on the board of directors of the Issuer (the \"Board\") through such vesting dates. Felix J. Baker serves on the Board as a representative of 667, L.P. (\"667\") and Baker Brothers Life Sciences, L.P. (\"Life Sciences\", and together with 667, the \"Funds\"). Each RSU represents a contingent right to receive one ADS or Ordinary Share."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"ADS each represent 1 Ordinary Share."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Baker Bros. Advisors LP (\"the Adviser\") serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Includes beneficial ownership of 16,400 ADS issuable upon the vesting of RSUs payable in ADS or Ordinary Shares at the Issuer's option previously issued to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan of which the Funds may be deemed to own a portion. 8,400 of the RSUs previously granted are fully vested and the remaining 8,000 vest in two equal annual installments beginning on April 18, 2026, subject to Felix J. Baker's continuous service on the Board through the vesting date. Felix J. Baker serves on the Board as a representative of the Funds and their affiliates and control persons. Each RSU represents a contingent right to receive one Ordinary Share of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Pursuant to the policies of the Adviser, Felix J. Baker does not have any right to any of the Issuer's securities issued as compensation for his service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs and non-qualified share options exercisable into ADS or Ordinary Shares of the Issuer (\"Share Options\") received as a result of his service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs, Share Options, and ADS or Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest) issued as compensation for such Board service."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"The Adviser has voting and dispositive power over the Share Options, RSUs and any ADS or Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"After giving effect to the transaction reported herein and as a result of their ownership interest in (i) Baker Brothers Life Sciences Capital, L.P. and (ii) Life Sciences, Julian C. Baker and Felix J. Baker may be deemed to have an indirect pecuniary interest in the securities reported in column 5 of Table I and in column 9 of Table II directly held by or held for the benefit of Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to their interest in Life Sciences and Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences."}],"balance_after":10018674,"source":{"system":"sec-edgar","filing":"0001193125-26-004828","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1087940/000119312526004828/ownership.xml","form_type":"4"}},{"id":948181,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":24760,"kind":"person","name":"BAKER BROS. ADVISORS LP","position":1,"cik":"0001263508","reported_name":"BAKER BROS. ADVISORS LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24762,"kind":"person","name":"667, L.P.","position":2,"cik":"0001551139","reported_name":"667, L.P.","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24761,"kind":"person","name":"Baker Bros. Advisors (GP) LLC","position":3,"cik":"0001580575","reported_name":"Baker Bros. Advisors (GP) LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24763,"kind":"person","name":"Baker Brothers Life Sciences LP","position":4,"cik":"0001363364","reported_name":"Baker Brothers Life Sciences LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24764,"kind":"person","name":"BAKER FELIX","position":5,"cik":"0001087940","reported_name":"BAKER FELIX","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":24765,"kind":"person","name":"BAKER JULIAN","position":6,"cik":"0001087939","reported_name":"BAKER JULIAN","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-01-06T22:41:23.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":19000,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Includes 19,000 restricted share units (each an \"RSU\") payable in American Depositary Shares (\"ADS\") or Ordinary Shares (\"Ordinary Shares\") at the option of Bicycle Therapeutics plc (the \"Issuer\") granted by the Issuer to Felix J. Baker, a managing member of Baker Bros. Advisors (GP) LLC (the \"Adviser GP\") on January 2, 2026 pursuant to the Issuer's 2020 Equity Incentive Plan (the \"2020 Plan\"). The RSUs vest in four equal quarterly installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026, subject to Felix J. Baker's continuous service on the board of directors of the Issuer (the \"Board\") through such vesting dates. Felix J. Baker serves on the Board as a representative of 667, L.P. (\"667\") and Baker Brothers Life Sciences, L.P. (\"Life Sciences\", and together with 667, the \"Funds\"). Each RSU represents a contingent right to receive one ADS or Ordinary Share."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"ADS each represent 1 Ordinary Share."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"After giving effect to the transactions reported herein and as a result of their ownership interest in (i) Baker Biotech Capital, L.P. and (ii) 667, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the securities reported in column 5 of Table I and in column 9 of Table II directly held by or held for the benefit of 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to their interest in 667 and Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F4","text":"Baker Bros. Advisors LP (\"the Adviser\") serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F5","text":"Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F6","text":"Includes beneficial ownership of 16,400 ADS issuable upon the vesting of RSUs payable in ADS or Ordinary Shares at the Issuer's option previously issued to Felix J. Baker, in his capacity as a director of the Issuer pursuant to the 2020 Plan of which the Funds may be deemed to own a portion. 8,400 of the RSUs previously granted are fully vested and the remaining 8,000 vest in two equal annual installments beginning on April 18, 2026, subject to Felix J. Baker's continuous service on the Board through the vesting date. Felix J. Baker serves on the Board as a representative of the Funds and their affiliates and control persons. Each RSU represents a contingent right to receive one Ordinary Share of the Issuer."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F7","text":"Pursuant to the policies of the Adviser, Felix J. Baker does not have any right to any of the Issuer's securities issued as compensation for his service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs and non-qualified share options exercisable into ADS or Ordinary Shares of the Issuer (\"Share Options\") received as a result of his service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the ADS or Ordinary Shares received upon vesting of RSUs, Share Options, and ADS or Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest) issued as compensation for such Board service."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"The Adviser has voting and dispositive power over the Share Options, RSUs and any ADS or Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs."}],"balance_after":937483,"source":{"system":"sec-edgar","filing":"0001193125-26-004828","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1087940/000119312526004828/ownership.xml","form_type":"4"}},{"id":946890,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":70020,"kind":"person","name":"Bourque Janice","position":1,"cik":"0001783330","reported_name":"Bourque Janice","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (right to buy)","published_at":"2026-01-06T20:00:16.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":19000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"This option shall vest in four equal installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026."}],"balance_after":19000,"derivative":{"exercise_price":7.08,"expiration_date":"2036-01-02","underlying":"Ordinary Shares","underlying_shares":19000},"source":{"system":"sec-edgar","filing":"0001783330-26-000002","document":"form4-01062026_080105.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1783330/000178333026000002/form4-01062026_080105.xml","form_type":"4"}},{"id":946889,"issuer":{"id":5993,"kind":"organization","name":"BICYCLE THERAPEUTICS PLC","symbol":"BCYC"},"owners":[{"id":70020,"kind":"person","name":"Bourque Janice","position":1,"cik":"0001783330","reported_name":"Bourque Janice","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Ordinary Shares","published_at":"2026-01-06T20:00:16.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":9500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"Represents a restricted share unit (\"RSU\") award. 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