{"transactions":[{"id":687917,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":100000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":4797166,"derivative":{"exercise_price":16,"underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":687916,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":60000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":4897166,"derivative":{"exercise_price":16.35,"underlying":"Ordinary Shares","underlying_shares":180000},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":687915,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":120000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":4957166,"derivative":{"exercise_price":16,"underlying":"Ordinary Shares","underlying_shares":360000},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":687914,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":605174,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":5077166,"derivative":{"exercise_price":16,"underlying":"Ordinary Shares","underlying_shares":1815522},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":687913,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":470820,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":5682340,"derivative":{"exercise_price":16.09,"underlying":"Ordinary Shares","underlying_shares":1412460},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":687912,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":382000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":6153160,"derivative":{"exercise_price":16,"underlying":"Ordinary Shares","underlying_shares":1146000},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":687911,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":800000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":6535160,"derivative":{"exercise_price":16,"underlying":"Ordinary Shares","underlying_shares":2400000},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":687910,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":3500,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":7335160,"derivative":{"exercise_price":16.35,"underlying":"Ordinary Shares","underlying_shares":10500},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":687909,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":50000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":7338660,"derivative":{"exercise_price":16.09,"underlying":"Ordinary Shares","underlying_shares":150000},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":687908,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":100000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":7388660,"derivative":{"exercise_price":15.58,"underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":687907,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-08-13T14:07:24.000Z","date":"2026-08-10","kind":"sale","planned":false,"acquired":true,"shares":2792826,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\"), Blake Holdings Limited (\"BHL\"), Ora Ventures Limited (\"OVL\"), Ora Capital Limited (\"OCL), Sarossa Plc (\"SAR\"), Pinkeys Limited (\"PKL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":7488660,"derivative":{"exercise_price":16,"underlying":"Ordinary Shares","underlying_shares":8378478},"source":{"system":"sec-edgar","filing":"0001104659-26-095574","document":"tm2623118-2_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926095574/tm2623118-2_4seq1.xml","form_type":"4"}},{"id":713593,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-07-07T13:09:40.000Z","date":"2026-07-06","kind":"sale","planned":false,"acquired":true,"shares":865112,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":10281486,"derivative":{"exercise_price":10.53,"underlying":"Ordinary Shares","underlying_shares":2595336},"source":{"system":"sec-edgar","filing":"0001104659-26-080997","document":"tm2619820-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926080997/tm2619820-1_4seq1.xml","form_type":"4"}},{"id":713592,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-07-07T13:09:40.000Z","date":"2026-07-02","kind":"sale","planned":false,"acquired":true,"shares":50082,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11146598,"derivative":{"exercise_price":10.47,"underlying":"Ordinary Shares","underlying_shares":150246},"source":{"system":"sec-edgar","filing":"0001104659-26-080997","document":"tm2619820-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926080997/tm2619820-1_4seq1.xml","form_type":"4"}},{"id":713591,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-07-07T13:09:40.000Z","date":"2026-07-01","kind":"sale","planned":false,"acquired":true,"shares":50000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11196680,"derivative":{"exercise_price":10.62,"underlying":"Ordinary Shares","underlying_shares":150000},"source":{"system":"sec-edgar","filing":"0001104659-26-080997","document":"tm2619820-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926080997/tm2619820-1_4seq1.xml","form_type":"4"}},{"id":713590,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-07-07T13:09:40.000Z","date":"2026-07-01","kind":"sale","planned":false,"acquired":true,"shares":79180,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11246680,"derivative":{"exercise_price":10.62,"underlying":"Ordinary Shares","underlying_shares":237540},"source":{"system":"sec-edgar","filing":"0001104659-26-080997","document":"tm2619820-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926080997/tm2619820-1_4seq1.xml","form_type":"4"}},{"id":713589,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-07-07T13:09:40.000Z","date":"2026-06-30","kind":"sale","planned":false,"acquired":true,"shares":169928,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11325860,"derivative":{"exercise_price":10.76,"underlying":"Ordinary Shares","underlying_shares":509784},"source":{"system":"sec-edgar","filing":"0001104659-26-080997","document":"tm2619820-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926080997/tm2619820-1_4seq1.xml","form_type":"4"}},{"id":713588,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-07-07T13:09:40.000Z","date":"2026-06-29","kind":"sale","planned":false,"acquired":true,"shares":330072,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Cream Capital Limited (\"CCL\") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11495788,"derivative":{"exercise_price":10.69,"underlying":"Ordinary Shares","underlying_shares":990216},"source":{"system":"sec-edgar","filing":"0001104659-26-080997","document":"tm2619820-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926080997/tm2619820-1_4seq1.xml","form_type":"4"}},{"id":905102,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-02-13T11:02:01.000Z","date":"2025-10-27","kind":"purchase","planned":false,"acquired":true,"shares":2000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Ora Capital Limited (\"OCL\") and purchased by Mr. Griffiths personally, essentially internal transfers with no change in total beneficial holding. Mr Griffiths is a director and the controlling shareholder of OCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11825861,"derivative":{"exercise_price":7.75,"underlying":"Ordinary Shares","underlying_shares":6000},"source":{"system":"sec-edgar","filing":"0001104659-26-014603","document":"tm266179-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926014603/tm266179-1_4seq1.xml","form_type":"4"}},{"id":905101,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-02-13T11:02:01.000Z","date":"2025-10-27","kind":"sale","planned":false,"acquired":true,"shares":2000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Ora Capital Limited (\"OCL\") and purchased by Mr. Griffiths personally, essentially internal transfers with no change in total beneficial holding. Mr Griffiths is a director and the controlling shareholder of OCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11819861,"derivative":{"exercise_price":7.75,"underlying":"Ordinary Shares","underlying_shares":6000},"source":{"system":"sec-edgar","filing":"0001104659-26-014603","document":"tm266179-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926014603/tm266179-1_4seq1.xml","form_type":"4"}},{"id":905100,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-02-13T11:02:01.000Z","date":"2025-08-03","kind":"purchase","planned":false,"acquired":true,"shares":20000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Ora Capital Limited (\"OCL\") and purchased by Mr. Griffiths personally, essentially internal transfers with no change in total beneficial holding. Mr Griffiths is a director and the controlling shareholder of OCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11825861,"derivative":{"exercise_price":5.45,"underlying":"Ordinary Shares","underlying_shares":60000},"source":{"system":"sec-edgar","filing":"0001104659-26-014603","document":"tm266179-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926014603/tm266179-1_4seq1.xml","form_type":"4"}},{"id":905099,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2026-02-13T11:02:01.000Z","date":"2025-08-03","kind":"sale","planned":false,"acquired":true,"shares":20000,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities were sold by Ora Capital Limited (\"OCL\") and purchased by Mr. Griffiths personally, essentially internal transfers with no change in total beneficial holding. Mr Griffiths is a director and the controlling shareholder of OCL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11805861,"derivative":{"exercise_price":5.45,"underlying":"Ordinary Shares","underlying_shares":60000},"source":{"system":"sec-edgar","filing":"0001104659-26-014603","document":"tm266179-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465926014603/tm266179-1_4seq1.xml","form_type":"4"}},{"id":946630,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":69998,"kind":"person","name":"MCINERNEY TIMOTHY","position":1,"cik":"0001226020","reported_name":"MCINERNEY TIMOTHY","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2026-01-06T21:15:19.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":90000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in equal monthly installments over a one-year period measured from one month following January 2, 2026, subject to the Reporting Person's continuous service as of each applicable vesting date."}],"balance_after":90000,"derivative":{"exercise_price":2.05,"expiration_date":"2036-01-02","underlying":"Ordinary Shares","underlying_shares":90000},"source":{"system":"sec-edgar","filing":"0001226020-26-000002","document":"form4-01062026_040107.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000122602026000002/form4-01062026_040107.xml","form_type":"4"}},{"id":946629,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":44739,"kind":"person","name":"Romano Steven J.","position":1,"cik":"0001639860","reported_name":"Romano Steven J.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP and Chief R&D Officer"}}],"security":"Employee Share Option (Right to Buy)","published_at":"2026-01-06T21:15:13.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":300000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2027 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date."}],"balance_after":300000,"derivative":{"exercise_price":2.05,"expiration_date":"2036-01-02","underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001639860-26-000002","document":"form4-01062026_040105.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000163986026000002/form4-01062026_040105.xml","form_type":"4"}},{"id":946628,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":69997,"kind":"person","name":"HELLUMS RHONDA LYNETTE","position":1,"cik":"0001766456","reported_name":"HELLUMS RHONDA LYNETTE","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Financial Officer"}}],"security":"Employee Share Option (Right to Buy)","published_at":"2026-01-06T21:15:09.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":375000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2027 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date."}],"balance_after":375000,"derivative":{"exercise_price":2.05,"expiration_date":"2036-01-02","underlying":"Ordinary Shares","underlying_shares":375000},"source":{"system":"sec-edgar","filing":"0001766456-26-000002","document":"form4-01062026_040103.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000176645626000002/form4-01062026_040103.xml","form_type":"4"}},{"id":946627,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":69996,"kind":"person","name":"Lemus David","position":1,"cik":"0001717972","reported_name":"Lemus David","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2026-01-06T21:15:06.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":90000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in equal monthly installments over a one-year period measured from one month following January 2, 2026, subject to the Reporting Person's continuous service as of each applicable vesting date."}],"balance_after":90000,"derivative":{"exercise_price":2.05,"expiration_date":"2036-01-02","underlying":"Ordinary Shares","underlying_shares":90000},"source":{"system":"sec-edgar","filing":"0001717972-26-000003","document":"form4-01062026_040101.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000171797226000003/form4-01062026_040101.xml","form_type":"4"}},{"id":947374,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":70072,"kind":"person","name":"Ede-Golightly James","position":1,"cik":"0002048873","reported_name":"Ede-Golightly James","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2026-01-06T16:15:24.000Z","date":"2026-01-02","kind":"grant","planned":false,"acquired":true,"shares":90000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in equal monthly installments over a one-year period measured from one month following January 2, 2026, subject to the Reporting Person's continuous service as of each applicable vesting date."}],"balance_after":90000,"derivative":{"exercise_price":2.05,"expiration_date":"2036-01-02","underlying":"Ordinary Shares","underlying_shares":90000},"source":{"system":"sec-edgar","filing":"0002048873-26-000002","document":"form4-01062026_040108.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2048873/000204887326000002/form4-01062026_040108.xml","form_type":"4"}},{"id":960884,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":70966,"kind":"person","name":"Ross Iain","position":1,"cik":"0001307218","reported_name":"Ross Iain","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Interim PEO"}}],"security":"Employee Share Option (Right to Buy)","published_at":"2025-12-22T23:04:27.000Z","date":"2025-12-18","kind":"grant","planned":false,"acquired":true,"shares":900000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in equal monthly installments over a one-year period measured from one month following December 18, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date."}],"balance_after":900000,"derivative":{"exercise_price":2.08,"expiration_date":"2035-12-18","underlying":"Ordinary Shares","underlying_shares":900000},"source":{"system":"sec-edgar","filing":"0001307218-25-000003","document":"form4-12222025_111224.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000130721825000003/form4-12222025_111224.xml","form_type":"4"}},{"id":961244,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":70072,"kind":"person","name":"Ede-Golightly James","position":1,"cik":"0002048873","reported_name":"Ede-Golightly James","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2025-12-22T18:03:23.000Z","date":"2025-12-22","kind":"grant","planned":false,"acquired":true,"shares":90000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in equal monthly installments over a one-year period measured from one month following December 22, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date."}],"balance_after":90000,"derivative":{"exercise_price":2.15,"expiration_date":"2035-12-22","underlying":"Ordinary Shares","underlying_shares":90000},"source":{"system":"sec-edgar","filing":"0002048873-25-000005","document":"form4-12222025_111219.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2048873/000204887325000005/form4-12222025_111219.xml","form_type":"4"}},{"id":1076209,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-08-04T12:03:08.000Z","date":"2025-08-01","kind":"purchase","planned":false,"acquired":true,"shares":4034,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11825861,"derivative":{"exercise_price":6.14,"underlying":"Ordinary Shares","underlying_shares":12102},"source":{"system":"sec-edgar","filing":"0001104659-25-073386","document":"tm2522470-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925073386/tm2522470-1_4seq1.xml","form_type":"4"}},{"id":1076208,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-08-04T12:03:08.000Z","date":"2025-07-31","kind":"purchase","planned":false,"acquired":true,"shares":14342,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11821827,"derivative":{"exercise_price":6.18,"underlying":"Ordinary Shares","underlying_shares":43026},"source":{"system":"sec-edgar","filing":"0001104659-25-073386","document":"tm2522470-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925073386/tm2522470-1_4seq1.xml","form_type":"4"}},{"id":1078366,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-07-31T12:43:13.000Z","date":"2025-07-30","kind":"purchase","planned":false,"acquired":true,"shares":8923,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11807485,"derivative":{"exercise_price":6.14,"underlying":"Ordinary Shares","underlying_shares":26769},"source":{"system":"sec-edgar","filing":"0001104659-25-072499","document":"tm2522205-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925072499/tm2522205-1_4seq1.xml","form_type":"4"}},{"id":1078365,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-07-31T12:43:13.000Z","date":"2025-07-29","kind":"purchase","planned":false,"acquired":true,"shares":14559,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11798562,"derivative":{"exercise_price":6.2,"underlying":"Ordinary Shares","underlying_shares":43667},"source":{"system":"sec-edgar","filing":"0001104659-25-072499","document":"tm2522205-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925072499/tm2522205-1_4seq1.xml","form_type":"4"}},{"id":1082761,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-07-23T18:22:48.000Z","date":"2025-07-22","kind":"purchase","planned":false,"acquired":true,"shares":2910,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11784003,"derivative":{"exercise_price":6.09,"underlying":"Ordinary Shares","underlying_shares":8730},"source":{"system":"sec-edgar","filing":"0001104659-25-069944","document":"tm2521554-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925069944/tm2521554-1_4seq1.xml","form_type":"4"}},{"id":1082760,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-07-23T18:22:48.000Z","date":"2025-07-21","kind":"purchase","planned":false,"acquired":true,"shares":22435,"ownership":{"direct":false,"nature":"See footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11781093,"derivative":{"exercise_price":6.04,"underlying":"Ordinary Shares","underlying_shares":67305},"source":{"system":"sec-edgar","filing":"0001104659-25-069944","document":"tm2521554-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925069944/tm2521554-1_4seq1.xml","form_type":"4"}},{"id":1086474,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-07-16T18:58:36.000Z","date":"2025-07-15","kind":"purchase","planned":false,"acquired":true,"shares":43293,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":11758658,"derivative":{"exercise_price":6.4,"underlying":"Ordinary Shares","underlying_shares":129879},"source":{"system":"sec-edgar","filing":"0001104659-25-068309","document":"tm2521080-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925068309/tm2521080-1_4seq1.xml","form_type":"4"}},{"id":1086473,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-07-16T18:58:36.000Z","date":"2025-07-11","kind":"purchase","planned":false,"acquired":true,"shares":28000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11715365,"derivative":{"exercise_price":6.43,"underlying":"Ordinary Shares","underlying_shares":84000},"source":{"system":"sec-edgar","filing":"0001104659-25-068309","document":"tm2521080-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925068309/tm2521080-1_4seq1.xml","form_type":"4"}},{"id":1089286,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-07-10T12:36:47.000Z","date":"2025-07-09","kind":"purchase","planned":false,"acquired":true,"shares":30133,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11687365,"derivative":{"exercise_price":6,"underlying":"Ordinary Shares","underlying_shares":90399},"source":{"system":"sec-edgar","filing":"0001104659-25-066857","document":"tm2520411-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925066857/tm2520411-1_4seq1.xml","form_type":"4"}},{"id":1089285,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-07-10T12:36:47.000Z","date":"2025-07-08","kind":"purchase","planned":false,"acquired":true,"shares":24387,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11657232,"derivative":{"exercise_price":5.94,"underlying":"Ordinary Shares","underlying_shares":73161},"source":{"system":"sec-edgar","filing":"0001104659-25-066857","document":"tm2520411-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925066857/tm2520411-1_4seq1.xml","form_type":"4"}},{"id":1089284,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-07-10T12:36:47.000Z","date":"2025-07-07","kind":"purchase","planned":false,"acquired":true,"shares":7937,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11632845,"derivative":{"exercise_price":5.65,"underlying":"Ordinary Shares","underlying_shares":23811},"source":{"system":"sec-edgar","filing":"0001104659-25-066857","document":"tm2520411-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925066857/tm2520411-1_4seq1.xml","form_type":"4"}},{"id":1099226,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-06-30T16:31:34.000Z","date":"2025-06-27","kind":"purchase","planned":false,"acquired":true,"shares":24000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11624908,"derivative":{"exercise_price":5.82,"underlying":"Ordinary Shares","underlying_shares":72000},"source":{"system":"sec-edgar","filing":"0001104659-25-063969","document":"tm2519448-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925063969/tm2519448-1_4seq1.xml","form_type":"4"}},{"id":1099225,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-06-30T16:31:34.000Z","date":"2025-06-26","kind":"purchase","planned":false,"acquired":true,"shares":20735,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11600908,"derivative":{"exercise_price":5.67,"underlying":"Ordinary Shares","underlying_shares":62205},"source":{"system":"sec-edgar","filing":"0001104659-25-063969","document":"tm2519448-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925063969/tm2519448-1_4seq1.xml","form_type":"4"}},{"id":1099224,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-06-30T16:31:34.000Z","date":"2025-06-26","kind":"purchase","planned":false,"acquired":true,"shares":65739,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11580173,"derivative":{"exercise_price":5.91,"underlying":"Ordinary Shares","underlying_shares":197217},"source":{"system":"sec-edgar","filing":"0001104659-25-063969","document":"tm2519448-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925063969/tm2519448-1_4seq1.xml","form_type":"4"}},{"id":1101679,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-06-25T12:59:53.000Z","date":"2025-06-24","kind":"purchase","planned":false,"acquired":true,"shares":26624,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11514434,"derivative":{"exercise_price":6.12,"underlying":"Ordinary Shares","underlying_shares":79872},"source":{"system":"sec-edgar","filing":"0001104659-25-062407","document":"tm2518943-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925062407/tm2518943-1_4seq1.xml","form_type":"4"}},{"id":1101678,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-06-25T12:59:53.000Z","date":"2025-06-23","kind":"purchase","planned":false,"acquired":true,"shares":35005,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11487810,"derivative":{"exercise_price":5.88,"underlying":"Ordinary Shares","underlying_shares":105015},"source":{"system":"sec-edgar","filing":"0001104659-25-062407","document":"tm2518943-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925062407/tm2518943-1_4seq1.xml","form_type":"4"}},{"id":1101677,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-06-25T12:59:53.000Z","date":"2025-06-22","kind":"purchase","planned":false,"acquired":true,"shares":20977,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11452805,"derivative":{"exercise_price":5.84,"underlying":"Ordinary Shares","underlying_shares":62931},"source":{"system":"sec-edgar","filing":"0001104659-25-062407","document":"tm2518943-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925062407/tm2518943-1_4seq1.xml","form_type":"4"}},{"id":1104955,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-06-20T10:46:02.000Z","date":"2025-06-18","kind":"purchase","planned":false,"acquired":true,"shares":39049,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11431828,"derivative":{"exercise_price":5.69,"underlying":"Ordinary Shares","underlying_shares":117147},"source":{"system":"sec-edgar","filing":"0001104659-25-060862","document":"tm2518525-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925060862/tm2518525-1_4seq1.xml","form_type":"4"}},{"id":1104954,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-06-20T10:46:02.000Z","date":"2025-06-17","kind":"purchase","planned":false,"acquired":true,"shares":31399,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11392779,"derivative":{"exercise_price":5.29,"underlying":"Ordinary Shares","underlying_shares":94197},"source":{"system":"sec-edgar","filing":"0001104659-25-060862","document":"tm2518525-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925060862/tm2518525-1_4seq1.xml","form_type":"4"}},{"id":1111554,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-06-13T12:06:49.000Z","date":"2025-06-12","kind":"purchase","planned":false,"acquired":true,"shares":39305,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11361380,"derivative":{"exercise_price":5.15,"underlying":"Ordinary Shares","underlying_shares":117915},"source":{"system":"sec-edgar","filing":"0001104659-25-059168","document":"tm2517968-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925059168/tm2517968-1_4seq1.xml","form_type":"4"}},{"id":1130507,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-29T15:21:29.000Z","date":"2025-05-28","kind":"purchase","planned":false,"acquired":true,"shares":9169,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11322075,"derivative":{"exercise_price":5.11,"underlying":"Ordinary Shares","underlying_shares":27507},"source":{"system":"sec-edgar","filing":"0001104659-25-054045","document":"tm2516482-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925054045/tm2516482-1_4seq1.xml","form_type":"4"}},{"id":1130506,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-29T15:21:29.000Z","date":"2025-05-27","kind":"purchase","planned":false,"acquired":true,"shares":50000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11312906,"derivative":{"exercise_price":5.13,"underlying":"Ordinary Shares","underlying_shares":150000},"source":{"system":"sec-edgar","filing":"0001104659-25-054045","document":"tm2516482-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925054045/tm2516482-1_4seq1.xml","form_type":"4"}},{"id":1130505,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-29T15:21:29.000Z","date":"2025-05-26","kind":"purchase","planned":false,"acquired":true,"shares":26669,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11262906,"derivative":{"exercise_price":4.91,"underlying":"Ordinary Shares","underlying_shares":80007},"source":{"system":"sec-edgar","filing":"0001104659-25-054045","document":"tm2516482-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925054045/tm2516482-1_4seq1.xml","form_type":"4"}},{"id":1133334,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-27T12:35:18.000Z","date":"2025-05-23","kind":"purchase","planned":false,"acquired":true,"shares":17187,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11236237,"derivative":{"exercise_price":4.92,"underlying":"Ordinary Shares","underlying_shares":51561},"source":{"system":"sec-edgar","filing":"0001104659-25-052749","document":"tm2516192-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925052749/tm2516192-1_4seq1.xml","form_type":"4"}},{"id":1133333,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-27T12:35:18.000Z","date":"2025-05-22","kind":"purchase","planned":false,"acquired":true,"shares":19174,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11219050,"derivative":{"exercise_price":5.04,"underlying":"Ordinary Shares","underlying_shares":57522},"source":{"system":"sec-edgar","filing":"0001104659-25-052749","document":"tm2516192-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925052749/tm2516192-1_4seq1.xml","form_type":"4"}},{"id":1138940,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-21T10:49:38.000Z","date":"2025-05-20","kind":"purchase","planned":false,"acquired":true,"shares":16000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11199876,"derivative":{"exercise_price":4.07,"underlying":"Ordinary Shares","underlying_shares":48000},"source":{"system":"sec-edgar","filing":"0001104659-25-051284","document":"tm2515795-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925051284/tm2515795-1_4seq1.xml","form_type":"4"}},{"id":1138939,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-21T10:49:38.000Z","date":"2025-05-19","kind":"purchase","planned":false,"acquired":true,"shares":26000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11183876,"derivative":{"exercise_price":4.07,"underlying":"Ordinary Shares","underlying_shares":78000},"source":{"system":"sec-edgar","filing":"0001104659-25-051284","document":"tm2515795-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925051284/tm2515795-1_4seq1.xml","form_type":"4"}},{"id":1138938,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-21T10:49:38.000Z","date":"2025-05-18","kind":"purchase","planned":false,"acquired":true,"shares":37023,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11157876,"derivative":{"exercise_price":4.01,"underlying":"Ordinary Shares","underlying_shares":111069},"source":{"system":"sec-edgar","filing":"0001104659-25-051284","document":"tm2515795-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925051284/tm2515795-1_4seq1.xml","form_type":"4"}},{"id":1140385,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":69998,"kind":"person","name":"MCINERNEY TIMOTHY","position":1,"cik":"0001226020","reported_name":"MCINERNEY TIMOTHY","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2025-05-20T20:14:11.000Z","date":"2025-05-05","kind":"grant","planned":false,"acquired":true,"shares":48000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in equal monthly installments over a three-year period measured from one month following May 5, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date."}],"balance_after":48000,"derivative":{"exercise_price":1.3,"expiration_date":"2035-05-05","underlying":"Ordinary Shares","underlying_shares":48000},"source":{"system":"sec-edgar","filing":"0001415889-25-013796","document":"form4-05202025_080507.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000141588925013796/form4-05202025_080507.xml","form_type":"4"}},{"id":1147298,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-15T20:51:57.000Z","date":"2025-05-14","kind":"purchase","planned":false,"acquired":true,"shares":55766,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11120853,"derivative":{"exercise_price":4.07,"underlying":"Ordinary Shares","underlying_shares":167298},"source":{"system":"sec-edgar","filing":"0001104659-25-049572","document":"tm2515252-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925049572/tm2515252-1_4seq1.xml","form_type":"4"}},{"id":1147297,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-15T20:51:57.000Z","date":"2025-05-13","kind":"purchase","planned":false,"acquired":true,"shares":94234,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":11065087,"derivative":{"exercise_price":4.01,"underlying":"Ordinary Shares","underlying_shares":282702},"source":{"system":"sec-edgar","filing":"0001104659-25-049572","document":"tm2515252-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925049572/tm2515252-1_4seq1.xml","form_type":"4"}},{"id":1155031,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-08T11:08:00.000Z","date":"2025-05-07","kind":"purchase","planned":false,"acquired":true,"shares":50000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10970853,"derivative":{"exercise_price":3.81,"underlying":"Ordinary Shares","underlying_shares":150000},"source":{"system":"sec-edgar","filing":"0001104659-25-045874","document":"tm2514463-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925045874/tm2514463-1_4seq1.xml","form_type":"4"}},{"id":1155030,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-08T11:08:00.000Z","date":"2025-05-06","kind":"purchase","planned":false,"acquired":true,"shares":100000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10920850,"derivative":{"exercise_price":3.96,"underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001104659-25-045874","document":"tm2514463-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925045874/tm2514463-1_4seq1.xml","form_type":"4"}},{"id":1155029,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-08T11:08:00.000Z","date":"2025-05-05","kind":"purchase","planned":false,"acquired":true,"shares":100000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10820853,"derivative":{"exercise_price":3.94,"underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001104659-25-045874","document":"tm2514463-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925045874/tm2514463-1_4seq1.xml","form_type":"4"}},{"id":1161119,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-02T14:28:34.000Z","date":"2025-05-01","kind":"purchase","planned":false,"acquired":true,"shares":75266,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10720853,"derivative":{"exercise_price":3.97,"underlying":"Ordinary Shares","underlying_shares":225798},"source":{"system":"sec-edgar","filing":"0001104659-25-043878","document":"tm2513902-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925043878/tm2513902-1_4seq1.xml","form_type":"4"}},{"id":1161118,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-05-02T14:28:34.000Z","date":"2025-04-30","kind":"purchase","planned":false,"acquired":true,"shares":34309,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10645587,"derivative":{"exercise_price":3.66,"underlying":"Ordinary Shares","underlying_shares":102927},"source":{"system":"sec-edgar","filing":"0001104659-25-043878","document":"tm2513902-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925043878/tm2513902-1_4seq1.xml","form_type":"4"}},{"id":1163339,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-30T11:13:20.000Z","date":"2025-04-29","kind":"purchase","planned":false,"acquired":true,"shares":54768,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10611278,"derivative":{"exercise_price":3.49,"underlying":"Ordinary Shares","underlying_shares":164304},"source":{"system":"sec-edgar","filing":"0001104659-25-041787","document":"tm2513649-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925041787/tm2513649-1_4seq1.xml","form_type":"4"}},{"id":1163338,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-30T11:13:20.000Z","date":"2025-04-28","kind":"purchase","planned":false,"acquired":true,"shares":95211,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10556510,"derivative":{"exercise_price":3.43,"underlying":"Ordinary Shares","underlying_shares":285633},"source":{"system":"sec-edgar","filing":"0001104659-25-041787","document":"tm2513649-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925041787/tm2513649-1_4seq1.xml","form_type":"4"}},{"id":1164855,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-28T10:50:03.000Z","date":"2025-04-25","kind":"purchase","planned":false,"acquired":true,"shares":59568,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10461299,"derivative":{"exercise_price":3.54,"underlying":"Ordinary Shares","underlying_shares":178704},"source":{"system":"sec-edgar","filing":"0001104659-25-039744","document":"tm2513337-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925039744/tm2513337-1_4seq1.xml","form_type":"4"}},{"id":1164854,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-28T10:50:03.000Z","date":"2025-04-24","kind":"purchase","planned":false,"acquired":true,"shares":90432,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10401731,"derivative":{"exercise_price":3.42,"underlying":"Ordinary Shares","underlying_shares":271296},"source":{"system":"sec-edgar","filing":"0001104659-25-039744","document":"tm2513337-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925039744/tm2513337-1_4seq1.xml","form_type":"4"}},{"id":1166382,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-24T11:16:25.000Z","date":"2025-04-23","kind":"purchase","planned":false,"acquired":true,"shares":50000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10311299,"derivative":{"exercise_price":3.18,"underlying":"Ordinary Shares","underlying_shares":150000},"source":{"system":"sec-edgar","filing":"0001104659-25-038340","document":"tm2513097-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925038340/tm2513097-1_4seq1.xml","form_type":"4"}},{"id":1166381,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-24T11:16:25.000Z","date":"2025-04-22","kind":"purchase","planned":false,"acquired":true,"shares":50000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10261299,"derivative":{"exercise_price":3.1,"underlying":"Ordinary Shares","underlying_shares":150000},"source":{"system":"sec-edgar","filing":"0001104659-25-038340","document":"tm2513097-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925038340/tm2513097-1_4seq1.xml","form_type":"4"}},{"id":1167711,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-22T14:35:32.000Z","date":"2025-04-21","kind":"purchase","planned":false,"acquired":true,"shares":100000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10211299,"derivative":{"exercise_price":3.12,"underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001104659-25-037215","document":"tm2512870-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925037215/tm2512870-1_4seq1.xml","form_type":"4"}},{"id":1167710,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-22T14:35:32.000Z","date":"2025-04-17","kind":"purchase","planned":false,"acquired":true,"shares":50000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10111299,"derivative":{"exercise_price":3.14,"underlying":"Ordinary Shares","underlying_shares":150000},"source":{"system":"sec-edgar","filing":"0001104659-25-037215","document":"tm2512870-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925037215/tm2512870-1_4seq1.xml","form_type":"4"}},{"id":1171769,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-15T18:17:20.000Z","date":"2025-04-15","kind":"purchase","planned":false,"acquired":true,"shares":27918,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10061299,"derivative":{"exercise_price":2.78,"underlying":"Ordinary Shares","underlying_shares":83754},"source":{"system":"sec-edgar","filing":"0001104659-25-035039","document":"tm2512383-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925035039/tm2512383-1_4seq1.xml","form_type":"4"}},{"id":1171768,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-15T18:17:20.000Z","date":"2025-04-14","kind":"purchase","planned":false,"acquired":true,"shares":50000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":10033381,"derivative":{"exercise_price":2.65,"underlying":"Ordinary Shares","underlying_shares":150000},"source":{"system":"sec-edgar","filing":"0001104659-25-035039","document":"tm2512383-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925035039/tm2512383-1_4seq1.xml","form_type":"4"}},{"id":1171767,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-15T18:17:20.000Z","date":"2025-04-14","kind":"purchase","planned":false,"acquired":true,"shares":40409,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":9983381,"derivative":{"exercise_price":2.71,"underlying":"Ordinary Shares","underlying_shares":121227},"source":{"system":"sec-edgar","filing":"0001104659-25-035039","document":"tm2512383-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925035039/tm2512383-1_4seq1.xml","form_type":"4"}},{"id":1171766,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-15T18:17:20.000Z","date":"2025-04-11","kind":"purchase","planned":false,"acquired":true,"shares":56480,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":9942972,"derivative":{"exercise_price":2.33,"underlying":"Ordinary Shares","underlying_shares":169440},"source":{"system":"sec-edgar","filing":"0001104659-25-035039","document":"tm2512383-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925035039/tm2512383-1_4seq1.xml","form_type":"4"}},{"id":1171765,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-15T18:17:20.000Z","date":"2025-04-10","kind":"purchase","planned":false,"acquired":true,"shares":25193,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":9886492,"derivative":{"exercise_price":2.14,"underlying":"Ordinary Shares","underlying_shares":75579},"source":{"system":"sec-edgar","filing":"0001104659-25-035039","document":"tm2512383-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925035039/tm2512383-1_4seq1.xml","form_type":"4"}},{"id":1186374,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-04-01T11:50:55.000Z","date":"2025-03-31","kind":"purchase","planned":false,"acquired":true,"shares":100000,"ownership":{"direct":false,"nature":"By Cream Capital Limited"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities transactions listed were made by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":9861299,"derivative":{"exercise_price":2.83,"underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001104659-25-030241","document":"tm2511054-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925030241/tm2511054-1_4seq1.xml","form_type":"4"}},{"id":1187836,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-03-31T14:47:52.000Z","date":"2025-03-31","kind":"purchase","planned":false,"acquired":true,"shares":100000,"ownership":{"direct":false,"nature":"By Cream Capital Limited"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities transactions listed were made by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":9761299,"derivative":{"exercise_price":3.46,"underlying":"Ordinary Shares","underlying_shares":300000},"source":{"system":"sec-edgar","filing":"0001104659-25-029715","document":"tm2510904-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925029715/tm2510904-1_4seq1.xml","form_type":"4"}},{"id":1187835,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-03-31T14:47:52.000Z","date":"2025-03-28","kind":"purchase","planned":false,"acquired":true,"shares":50000,"ownership":{"direct":false,"nature":"By Cream Capital Limited"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities transactions listed were made by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":9661299,"derivative":{"exercise_price":3.58,"underlying":"Ordinary Shares","underlying_shares":150000},"source":{"system":"sec-edgar","filing":"0001104659-25-029715","document":"tm2510904-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925029715/tm2510904-1_4seq1.xml","form_type":"4"}},{"id":1187834,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-03-31T14:47:52.000Z","date":"2025-03-27","kind":"purchase","planned":false,"acquired":true,"shares":50000,"ownership":{"direct":false,"nature":"By Cream Capital Limited"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities transactions listed were made by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":9611299,"derivative":{"exercise_price":3.32,"underlying":"Ordinary Shares","underlying_shares":150000},"source":{"system":"sec-edgar","filing":"0001104659-25-029715","document":"tm2510904-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925029715/tm2510904-1_4seq1.xml","form_type":"4"}},{"id":1219474,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-03-06T16:03:13.000Z","date":"2025-03-05","kind":"purchase","planned":false,"acquired":true,"shares":22632,"ownership":{"direct":false,"nature":"By Cream Capital Limited"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":9561299,"derivative":{"exercise_price":4.5,"underlying":"Ordinary Shares","underlying_shares":67896},"source":{"system":"sec-edgar","filing":"0001104659-25-021245","document":"tm258471-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925021245/tm258471-1_4seq1.xml","form_type":"4"}},{"id":1246000,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-02-25T15:59:52.000Z","date":"2025-02-18","kind":"purchase","planned":false,"acquired":true,"shares":60000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":9538667,"derivative":{"exercise_price":4.85,"underlying":"Ordinary Shares","underlying_shares":180000},"source":{"system":"sec-edgar","filing":"0001104659-25-016802","document":"tm257556-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925016802/tm257556-1_4seq1.xml","form_type":"4"}},{"id":1245999,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-02-25T15:59:52.000Z","date":"2025-02-13","kind":"purchase","planned":false,"acquired":true,"shares":60000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":9478667,"derivative":{"exercise_price":4.17,"underlying":"Ordinary Shares","underlying_shares":180000},"source":{"system":"sec-edgar","filing":"0001104659-25-016802","document":"tm257556-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925016802/tm257556-1_4seq1.xml","form_type":"4"}},{"id":1245998,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-02-25T15:59:52.000Z","date":"2025-02-13","kind":"purchase","planned":false,"acquired":true,"shares":92774,"ownership":{"direct":false,"nature":"By Cream Capital Limited"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":9418667,"derivative":{"exercise_price":4.29,"underlying":"Ordinary Shares","underlying_shares":278322},"source":{"system":"sec-edgar","filing":"0001104659-25-016802","document":"tm257556-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925016802/tm257556-1_4seq1.xml","form_type":"4"}},{"id":1245997,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-02-25T15:59:52.000Z","date":"2025-01-23","kind":"purchase","planned":false,"acquired":true,"shares":12226,"ownership":{"direct":false,"nature":"By Cream Capital Limited"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":9325893,"derivative":{"exercise_price":5.35,"underlying":"Ordinary Shares","underlying_shares":36678},"source":{"system":"sec-edgar","filing":"0001104659-25-016802","document":"tm257556-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925016802/tm257556-1_4seq1.xml","form_type":"4"}},{"id":1245996,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-02-25T15:59:52.000Z","date":"2025-01-21","kind":"purchase","planned":false,"acquired":true,"shares":20000,"ownership":{"direct":false,"nature":"By Cream Capital Limited"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":9313667,"derivative":{"exercise_price":5.48,"underlying":"Ordinary Shares","underlying_shares":60000},"source":{"system":"sec-edgar","filing":"0001104659-25-016802","document":"tm257556-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925016802/tm257556-1_4seq1.xml","form_type":"4"}},{"id":1245995,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-02-25T15:59:52.000Z","date":"2025-01-21","kind":"purchase","planned":false,"acquired":true,"shares":25000,"ownership":{"direct":false,"nature":"By Cream Capital Limited"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":9293667,"derivative":{"exercise_price":5.2,"underlying":"Ordinary Shares","underlying_shares":75000},"source":{"system":"sec-edgar","filing":"0001104659-25-016802","document":"tm257556-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925016802/tm257556-1_4seq1.xml","form_type":"4"}},{"id":1245994,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-02-25T15:59:52.000Z","date":"2025-01-17","kind":"purchase","planned":false,"acquired":true,"shares":150000,"ownership":{"direct":false,"nature":"By Cream Capital Limited"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Cream Capital Limited (\"Cream\"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein."}],"balance_after":9268667,"derivative":{"exercise_price":5.35,"underlying":"Ordinary Shares","underlying_shares":450000},"source":{"system":"sec-edgar","filing":"0001104659-25-016802","document":"tm257556-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925016802/tm257556-1_4seq1.xml","form_type":"4"}},{"id":1245993,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":23693,"kind":"person","name":"Griffiths Richard Ian","position":1,"cik":"0001846370","reported_name":"Griffiths Richard Ian","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"American Depositary Shares","published_at":"2025-02-25T15:59:52.000Z","date":"2025-01-08","kind":"purchase","planned":false,"acquired":true,"shares":30000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"Each American Depositary Share (\"ADS\") is immediately convertible into three ordinary shares for no consideration and has no expiration date."}],"balance_after":9118667,"derivative":{"exercise_price":6.48,"underlying":"Ordinary Shares","underlying_shares":90000},"source":{"system":"sec-edgar","filing":"0001104659-25-016802","document":"tm257556-1_4seq1.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000110465925016802/tm257556-1_4seq1.xml","form_type":"4"}},{"id":1310496,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":38747,"kind":"person","name":"Davidson Michael H.","position":1,"cik":"0001573785","reported_name":"Davidson Michael H.","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2025-01-06T21:15:20.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":48000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in equal monthly installments over a three-year period measured from one month following January 2, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date."}],"balance_after":48000,"derivative":{"exercise_price":2.4,"expiration_date":"2035-01-02","underlying":"Ordinary Shares","underlying_shares":48000},"source":{"system":"sec-edgar","filing":"0001415889-25-000749","document":"form4-01062025_040115.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000141588925000749/form4-01062025_040115.xml","form_type":"4"}},{"id":1310495,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":70966,"kind":"person","name":"Ross Iain","position":1,"cik":"0001307218","reported_name":"Ross Iain","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2025-01-06T21:15:18.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":90000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in equal monthly installments over a three-year period measured from one month following January 2, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date."}],"balance_after":90000,"derivative":{"exercise_price":2.4,"expiration_date":"2035-01-02","underlying":"Ordinary Shares","underlying_shares":90000},"source":{"system":"sec-edgar","filing":"0001415889-25-000747","document":"form4-01062025_040111.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000141588925000747/form4-01062025_040111.xml","form_type":"4"}},{"id":1310494,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":69996,"kind":"person","name":"Lemus David","position":1,"cik":"0001717972","reported_name":"Lemus David","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2025-01-06T21:15:13.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":48000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in equal monthly installments over a three-year period measured from one month following January 2, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date."}],"balance_after":48000,"derivative":{"exercise_price":2.4,"expiration_date":"2035-01-02","underlying":"Ordinary Shares","underlying_shares":48000},"source":{"system":"sec-edgar","filing":"0001415889-25-000746","document":"form4-01062025_040109.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000141588925000746/form4-01062025_040109.xml","form_type":"4"}},{"id":1310493,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":44739,"kind":"person","name":"Romano Steven J.","position":1,"cik":"0001639860","reported_name":"Romano Steven J.","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP and Chief R&D Officer"}}],"security":"Employee Share Option (Right to Buy)","published_at":"2025-01-06T21:15:12.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":285000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2026 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date."}],"balance_after":285000,"derivative":{"exercise_price":2.4,"expiration_date":"2035-01-02","underlying":"Ordinary Shares","underlying_shares":285000},"source":{"system":"sec-edgar","filing":"0001415889-25-000745","document":"form4-01062025_040106.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000141588925000745/form4-01062025_040106.xml","form_type":"4"}},{"id":1310492,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":69997,"kind":"person","name":"HELLUMS RHONDA LYNETTE","position":1,"cik":"0001766456","reported_name":"HELLUMS RHONDA LYNETTE","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Financial Officer"}}],"security":"Employee Share Option (Right to Buy)","published_at":"2025-01-06T21:15:08.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":375000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2026 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date."}],"balance_after":375000,"derivative":{"exercise_price":2.4,"expiration_date":"2035-01-02","underlying":"Ordinary Shares","underlying_shares":375000},"source":{"system":"sec-edgar","filing":"0001415889-25-000744","document":"form4-01062025_040104.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000141588925000744/form4-01062025_040104.xml","form_type":"4"}},{"id":1310491,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":84404,"kind":"person","name":"TOOMAN CRAIG A","position":1,"cik":"0001201050","reported_name":"TOOMAN CRAIG A","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CEO"}}],"security":"Employee Share Option (Right to Buy)","published_at":"2025-01-06T21:15:05.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":900000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2026 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date."}],"balance_after":900000,"derivative":{"exercise_price":2.4,"expiration_date":"2035-01-02","underlying":"Ordinary Shares","underlying_shares":900000},"source":{"system":"sec-edgar","filing":"0001415889-25-000743","document":"form4-01062025_040101.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1479615/000141588925000743/form4-01062025_040101.xml","form_type":"4"}},{"id":1311296,"issuer":{"id":5028,"kind":"organization","name":"Silence Therapeutics plc"},"owners":[{"id":70072,"kind":"person","name":"Ede-Golightly James","position":1,"cik":"0002048873","reported_name":"Ede-Golightly James","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Share Option (Right to Buy)","published_at":"2025-01-06T16:15:22.000Z","date":"2025-01-02","kind":"grant","planned":false,"acquired":true,"shares":48000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"This option shall vest in equal monthly installments over a three-year period measured from one month following January 2, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date."}],"balance_after":48000,"derivative":{"exercise_price":2.4,"expiration_date":"2035-01-02","underlying":"Ordinary Shares","underlying_shares":48000},"source":{"system":"sec-edgar","filing":"0001415889-25-000748","document":"form4-01062025_040113.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2048873/000141588925000748/form4-01062025_040113.xml","form_type":"4"}}]}