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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214966448,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996892,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":1,"price":1.2859,"value":1.2859,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214932875,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996890,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":428,"price":1.2847,"value":549.8516,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214436448,"source":{"system":"sec-edgar","filing":"0001193125-25-286448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000119312525286448/ownership.xml","form_type":"4"}},{"id":996882,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-11-18T22:18:12.000Z","date":"2025-11-18","kind":"purchase","planned":false,"acquired":true,"shares":410,"price":1.245,"value":510.45,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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These shares were purchased in multiple transactions at prices ranging from $1.415 to $1.4299, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  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Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214236448,"source":{"system":"sec-edgar","filing":"0000950170-25-110094","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025110094/ownership.xml","form_type":"4"}},{"id":1071763,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-08-08T20:56:12.000Z","date":"2025-08-08","kind":"purchase","planned":false,"acquired":true,"shares":675000,"price":1.32,"value":891000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":214001448,"source":{"system":"sec-edgar","filing":"0000950170-25-052925","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025052925/ownership.xml","form_type":"4"}},{"id":1176056,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-08T21:34:21.000Z","date":"2025-04-08","kind":"purchase","planned":false,"acquired":true,"shares":125000,"price":1.4772,"value":184650.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. 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The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213751448,"source":{"system":"sec-edgar","filing":"0000950170-25-048737","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025048737/ownership.xml","form_type":"4"}},{"id":1189196,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-28T21:22:09.000Z","date":"2025-03-28","kind":"purchase","planned":false,"acquired":true,"shares":150000,"price":1.6959,"value":254385.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.685 to $1.70, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213651448,"source":{"system":"sec-edgar","filing":"0000950170-25-046952","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025046952/ownership.xml","form_type":"4"}},{"id":1204859,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-17T21:27:48.000Z","date":"2025-03-17","kind":"purchase","planned":false,"acquired":true,"shares":200000,"price":1.7391,"value":347820.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.73 to $1.745, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213501448,"source":{"system":"sec-edgar","filing":"0000950170-25-040497","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025040497/ownership.xml","form_type":"4"}},{"id":1232261,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-04T23:16:02.000Z","date":"2025-03-04","kind":"purchase","planned":false,"acquired":true,"price":436500,"reported_value":250000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":217391},"source":{"system":"sec-edgar","filing":"0000950170-25-032615","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025032615/ownership.xml","form_type":"4"}},{"id":1237131,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-04T00:26:33.000Z","date":"2025-03-03","kind":"purchase","planned":false,"acquired":true,"price":1707125,"reported_value":1000000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":869565},"source":{"system":"sec-edgar","filing":"0000950170-25-031198","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025031198/ownership.xml","form_type":"4"}},{"id":1237130,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-04T00:26:33.000Z","date":"2025-03-03","kind":"purchase","planned":false,"acquired":true,"price":1703250,"reported_value":1000000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":869565},"source":{"system":"sec-edgar","filing":"0000950170-25-031198","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025031198/ownership.xml","form_type":"4"}},{"id":1239494,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2025-03-01T00:34:01.000Z","date":"2025-02-28","kind":"purchase","planned":false,"acquired":true,"price":1652750,"reported_value":1000000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":869565},"source":{"system":"sec-edgar","filing":"0000950170-25-030278","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025030278/ownership.xml","form_type":"4"}},{"id":1239493,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-01T00:34:01.000Z","date":"2025-02-28","kind":"purchase","planned":false,"acquired":true,"shares":67434,"price":1.71,"value":115312.14,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213301448,"source":{"system":"sec-edgar","filing":"0000950170-25-030278","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025030278/ownership.xml","form_type":"4"}},{"id":1293531,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-28T22:40:23.000Z","date":"2025-01-28","kind":"purchase","planned":false,"acquired":true,"shares":47537,"price":1.4738,"value":70060.0306,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.465 to $1.475, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213234014,"source":{"system":"sec-edgar","filing":"0000950170-25-009978","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025009978/ownership.xml","form_type":"4"}},{"id":1300928,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-17T22:06:34.000Z","date":"2025-01-17","kind":"purchase","planned":false,"acquired":true,"shares":150000,"price":1.4695,"value":220425.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.465 to $1.47, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213186477,"source":{"system":"sec-edgar","filing":"0000950170-25-006790","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025006790/ownership.xml","form_type":"4"}},{"id":1302919,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-15T22:18:44.000Z","date":"2025-01-15","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":1.4817,"value":740850.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.46 to $1.50, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":213036477,"source":{"system":"sec-edgar","filing":"0000950170-25-005908","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017025005908/ownership.xml","form_type":"4"}},{"id":1333083,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-13T22:04:40.000Z","date":"2024-12-13","kind":"purchase","planned":false,"acquired":true,"shares":125000,"price":1.595,"value":199375.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.585 to $1.605, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":212536477,"source":{"system":"sec-edgar","filing":"0000950170-24-136264","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024136264/ownership.xml","form_type":"4"}},{"id":1336362,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-12-11T22:21:28.000Z","date":"2024-12-11","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":1.5621,"value":781050.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.535 to $1.61, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":212411477,"source":{"system":"sec-edgar","filing":"0000950170-24-135471","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024135471/ownership.xml","form_type":"4"}},{"id":1348594,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-29T20:20:16.000Z","date":"2024-11-29","kind":"purchase","planned":false,"acquired":true,"shares":199072,"price":1.534,"value":305376.448,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.525 to $1.54, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211911477,"source":{"system":"sec-edgar","filing":"0000950170-24-131871","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024131871/ownership.xml","form_type":"4"}},{"id":1355037,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-22T22:17:09.000Z","date":"2024-11-22","kind":"purchase","planned":false,"acquired":true,"shares":100000,"price":1.59,"value":159000.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.585 to $1.59, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211712405,"source":{"system":"sec-edgar","filing":"0000950170-24-130292","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024130292/ownership.xml","form_type":"4"}},{"id":1357818,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-21T00:21:31.000Z","date":"2024-11-08","kind":"purchase","planned":false,"acquired":true,"shares":280183,"price":1.5045,"value":421535.3235,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.455 to $1.545, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211512405,"source":{"system":"sec-edgar","filing":"0000950170-24-129440","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024129440/ownership.xml","form_type":"4/A","original_submission_date":"2024-11-08"}},{"id":1365707,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-14T22:51:36.000Z","date":"2024-11-14","kind":"purchase","planned":false,"acquired":true,"shares":100000,"price":1.6198,"value":161980.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.615 to $1.6199, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211612405,"source":{"system":"sec-edgar","filing":"0000950170-24-127266","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024127266/ownership.xml","form_type":"4"}},{"id":1372035,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-11-08T22:40:44.000Z","date":"2024-11-08","kind":"purchase","planned":false,"acquired":true,"shares":280183,"price":1.5045,"value":421535.3235,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.455 to $1.545, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211512405,"source":{"system":"sec-edgar","filing":"0000950170-24-124261","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024124261/ownership.xml","form_type":"4"}},{"id":1398722,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2024-09-27T21:22:19.000Z","date":"2024-09-27","kind":"purchase","planned":false,"acquired":true,"price":2541737.5,"reported_value":1845000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a\nDelaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances\nand during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion\nprice of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a\nDelaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee. Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances\nand during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion\nprice of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":1604347},"source":{"system":"sec-edgar","filing":"0000950170-24-110098","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024110098/ownership.xml","form_type":"4"}},{"id":1398721,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2024-09-27T21:18:35.000Z","date":"2024-09-25","kind":"purchase","planned":false,"acquired":true,"price":1571050,"reported_value":1155000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee.  Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The 3.75% Convertible Senior Notes due 2029 (the \"Convertible Notes\") were issued on January 9, 2024 under, and are governed by, an indenture, dated as of January 9, 2024 (the \"Indenture\"), by and between the OPKO Health, Inc., a Delaware corporation (the \"Company\") and U.S. Bank Trust Company, National Association, as trustee.  Prior to September 15, 2028, holders of the Convertible Notes will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date, at a conversion price of $1.15, subject to adjustment as set forth in the Indenture. Interest accrues on the unpaid principal amount at a rate equal to 3.75% per annum and is payable semiannually in arrears on January 15 and July 15 of each year."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock","underlying_shares":1004347},"source":{"system":"sec-edgar","filing":"0000950170-24-110093","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024110093/ownership.xml","form_type":"4/A","original_submission_date":"2024-09-26"}},{"id":1399218,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"3.75% Convertible Notes due 2029","published_at":"2024-09-26T21:33:56.000Z","date":"2024-09-25","kind":"purchase","planned":false,"acquired":true,"price":1571050,"reported_value":1155000,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Prior to September 15, 2028, holders of the 3.75% Convertible Senior Notes due 2029 will have the right to convert such notes only in certain circumstances and during specified periods and thereafter, will be convertible at the option of the holder at any time prior to the close of business on the business day immediately preceding January 15, 2029, which is the maturity date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"derivative":{"exercise_price":1.15,"exercise_date":"2028-09-15","expiration_date":"2029-01-15","underlying":"Common Stock"},"source":{"system":"sec-edgar","filing":"0000950170-24-109683","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024109683/ownership.xml","form_type":"4"}},{"id":1448360,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}}],"security":"Common Stock","published_at":"2024-07-26T23:21:32.000Z","date":"2024-07-24","kind":"grant","planned":false,"acquired":true,"shares":500000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"Each restricted stock unit represents a contingent right to receive one share of OPKO common stock upon the vesting of the award. The\nrestricted stock units vest 50% on the second anniversary of the grant date, then 25% on each of the following two years."}],"balance_after":3568951,"source":{"system":"sec-edgar","filing":"0000950170-24-087042","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024087042/ownership.xml","form_type":"4"}},{"id":1448291,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":79126,"kind":"person","name":"HSIAO JANE PH D","position":1,"cik":"0001188834","reported_name":"HSIAO JANE PH D","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Vice Chairman & CTO"}}],"security":"Common Stock","published_at":"2024-07-26T23:18:18.000Z","date":"2024-07-24","kind":"grant","planned":false,"acquired":true,"shares":500000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"Each restricted stock unit represents a contingent right to receive one share of OPKO common stock upon the vesting of the award. The\nrestricted stock units vest 50% on the second anniversary of the grant date, then 25% on each of the following two years."}],"balance_after":28499880,"source":{"system":"sec-edgar","filing":"0000950170-24-087039","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/944809/000095017024087039/ownership.xml","form_type":"4"}},{"id":1448289,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":28376,"kind":"person","name":"Logal Adam","position":1,"cik":"0001356197","reported_name":"Logal Adam","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Sr. Vice President, CFO"}}],"security":"Common Stock","published_at":"2024-07-26T23:15:29.000Z","date":"2024-07-24","kind":"grant","planned":false,"acquired":true,"shares":437500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"Each restricted stock unit represents a contingent right to receive one share of OPKO common stock upon the vesting of the award. The\nrestricted stock units vest 50% on the second anniversary of the grant date, then 25% on each of the following two years."}],"balance_after":616662,"source":{"system":"sec-edgar","filing":"0000950170-24-087036","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/944809/000095017024087036/ownership.xml","form_type":"4"}},{"id":1448290,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25378,"kind":"person","name":"Rubin Steven D","position":1,"cik":"0001381874","reported_name":"Rubin Steven D","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Executive VP-Administration"}}],"security":"Common Stock","published_at":"2024-07-26T23:11:51.000Z","date":"2024-07-24","kind":"grant","planned":false,"acquired":true,"shares":437500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"Each restricted stock unit represents a contingent right to receive one share of OPKO common stock upon the vesting of the award. The\nrestricted stock units vest 50% on the second anniversary of the grant date, then 25% on each of the following two years."}],"balance_after":6625232,"source":{"system":"sec-edgar","filing":"0000950170-24-087034","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/944809/000095017024087034/ownership.xml","form_type":"4"}},{"id":1448288,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":14367,"kind":"person","name":"Zerhouni Elias A.","position":1,"cik":"0001478398","reported_name":"Zerhouni Elias A.","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Vice Chairman and President"}}],"security":"Common Stock","published_at":"2024-07-26T23:08:16.000Z","date":"2024-07-24","kind":"grant","planned":false,"acquired":true,"shares":500000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"Each restricted stock unit represents a contingent right to receive one share of OPKO common stock upon the vesting of the award. The\nrestricted stock units vest 50% on the second anniversary of the grant date, then 25% on each of the following two years."}],"balance_after":589600,"source":{"system":"sec-edgar","filing":"0000950170-24-087032","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/944809/000095017024087032/ownership.xml","form_type":"4"}},{"id":1448287,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":35576,"kind":"person","name":"Nabel Gary J.","position":1,"cik":"0001867450","reported_name":"Nabel Gary J.","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Innovation Officer"}}],"security":"Common Stock","published_at":"2024-07-26T23:05:39.000Z","date":"2024-07-24","kind":"grant","planned":false,"acquired":true,"shares":437500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"Each restricted stock unit represents a contingent right to receive one share of OPKO common stock upon the vesting of the award. The\nrestricted stock units vest 50% on the second anniversary of the grant date, then 25% on each of the following two years."}],"balance_after":700579,"source":{"system":"sec-edgar","filing":"0000950170-24-087030","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/944809/000095017024087030/ownership.xml","form_type":"4"}},{"id":1504439,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-05-24T00:04:15.000Z","date":"2024-05-23","kind":"purchase","planned":false,"acquired":true,"shares":770,"price":1.265,"value":974.05,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211232222,"source":{"system":"sec-edgar","filing":"0000950170-24-064248","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024064248/ownership.xml","form_type":"4"}},{"id":1504438,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-05-24T00:04:15.000Z","date":"2024-05-23","kind":"purchase","planned":false,"acquired":true,"shares":99230,"price":1.2694,"value":125962.562,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211231452,"source":{"system":"sec-edgar","filing":"0000950170-24-064248","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024064248/ownership.xml","form_type":"4"}},{"id":1512549,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-05-17T21:31:27.000Z","date":"2024-05-17","kind":"purchase","planned":false,"acquired":true,"shares":163997,"price":1.2878,"value":211195.3366,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.285 to $1.29, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":211132222,"source":{"system":"sec-edgar","filing":"0000950170-24-061910","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024061910/ownership.xml","form_type":"4"}},{"id":1573579,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-03-18T20:45:08.000Z","date":"2024-03-18","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":0.8742,"value":437100.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.8635 to $0.8788, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":210968225,"source":{"system":"sec-edgar","filing":"0000950170-24-032877","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024032877/ownership.xml","form_type":"4"}},{"id":1577352,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-03-14T21:00:41.000Z","date":"2024-03-14","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":0.8886,"value":444300.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.8862 to $0.89, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":210468225,"source":{"system":"sec-edgar","filing":"0000950170-24-031630","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024031630/ownership.xml","form_type":"4"}},{"id":1579476,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-03-13T20:44:17.000Z","date":"2024-03-13","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":0.9275,"value":463750.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9172 to $0.9383, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":209968225,"source":{"system":"sec-edgar","filing":"0000950170-24-030838","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024030838/ownership.xml","form_type":"4"}},{"id":1582401,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-03-12T21:27:29.000Z","date":"2024-03-12","kind":"purchase","planned":false,"acquired":true,"shares":600000,"price":0.9323,"value":559380.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9213 to $0.9398, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":209468225,"source":{"system":"sec-edgar","filing":"0000950170-24-030156","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024030156/ownership.xml","form_type":"4"}},{"id":1613439,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-02-28T22:31:35.000Z","date":"2024-02-28","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":0.9923,"value":496150.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9772 to $1.01, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":208868225,"source":{"system":"sec-edgar","filing":"0000950170-24-022306","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024022306/ownership.xml","form_type":"4"}},{"id":1630908,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-02-21T22:10:47.000Z","date":"2024-02-21","kind":"purchase","planned":false,"acquired":true,"shares":1000000,"price":0.9917,"value":991700.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9507 to $1.03, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":208368225,"source":{"system":"sec-edgar","filing":"0000950170-24-018079","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024018079/ownership.xml","form_type":"4"}},{"id":1655895,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-02-07T22:09:25.000Z","date":"2024-02-07","kind":"purchase","planned":false,"acquired":true,"shares":1500000,"price":0.9752,"value":1462800.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9399 to $1.01, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":207368225,"source":{"system":"sec-edgar","filing":"0000950170-24-012312","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024012312/ownership.xml","form_type":"4"}},{"id":1668494,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":80467,"kind":"person","name":"KRASNO RICHARD M","position":1,"cik":"0001215060","reported_name":"KRASNO RICHARD M","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2024-01-29T20:30:14.000Z","date":"2024-01-29","kind":"purchase","planned":false,"acquired":true,"shares":30000,"price":0.9946,"value":29838.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"Securities held by the Richard M. Krasno Trust, of which Richard M. Krasno, Ph.D. is the Trustee."}],"balance_after":103333,"source":{"system":"sec-edgar","filing":"0000950170-24-008273","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/944809/000095017024008273/ownership.xml","form_type":"4"}},{"id":1675802,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-01-19T21:54:00.000Z","date":"2024-01-19","kind":"purchase","planned":false,"acquired":true,"shares":500000,"price":0.9773,"value":488650.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.955 to $0.9985, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":205868225,"source":{"system":"sec-edgar","filing":"0000950170-24-005847","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024005847/ownership.xml","form_type":"4"}},{"id":1677075,"issuer":{"id":4891,"kind":"organization","name":"OPKO HEALTH, INC."},"owners":[{"id":25984,"kind":"person","name":"FROST PHILLIP MD ET AL","position":1,"cik":"0000898860","reported_name":"FROST PHILLIP MD ET AL","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"CEO & Chairman"}},{"id":72760,"kind":"organization","name":"Frost Gamma Investments Trust","position":2,"cik":"0001380896","reported_name":"Frost Gamma Investments Trust","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2024-01-18T22:06:22.000Z","date":"2024-01-18","kind":"purchase","planned":false,"acquired":true,"shares":400000,"price":0.9655,"value":386200.0,"ownership":{"direct":false,"nature":"See Footnote"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9555 to $0.99, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the \"Company\"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee.  Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust.  Dr. Frost is one of two limited partners of Frost Gamma L.P.  The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation.  Dr. Frost is also the sole shareholder of Frost-Nevada Corporation.  The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose."}],"balance_after":205368225,"source":{"system":"sec-edgar","filing":"0000950170-24-005448","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/898860/000095017024005448/ownership.xml","form_type":"4"}}],"next_cursor":"2024-01-18T22:06:22.000000Z,1677075"}