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The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.85 to $25.88, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price."}],"balance_after":23205,"source":{"system":"sec-edgar","filing":"0002127119-26-000006","document":"wk-form4_1791584905.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2127119/000212711926000006/wk-form4_1791584905.xml","form_type":"4"}},{"id":4638842,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":52824,"kind":"person","name":"Schayowitz Adam","position":1,"cik":"0002127119","reported_name":"Schayowitz Adam","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Head of R&D"}}],"security":"Common 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The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return (\"TSR\") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 38,000 PSUs (\"Target Number\") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"(Continued from footnote 1) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"Each performance restricted stock unit (\"PSU\") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return (\"TSR\") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 38,000 PSUs (\"Target Number\") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"(Continued from footnote 1) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"Each performance restricted stock unit (\"PSU\") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return (\"TSR\") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 38,000 PSUs (\"Target Number\") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"(Continued from footnote 1) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control)."}],"balance_after":76000,"derivative":{"underlying":"Common Stock","underlying_shares":76000},"source":{"system":"sec-edgar","filing":"0001193125-26-151265","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1937653/000119312526151265/ownership.xml","form_type":"4"}},{"id":810081,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":52824,"kind":"person","name":"Schayowitz Adam","position":1,"cik":"0002127119","reported_name":"Schayowitz Adam","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Restricted Stock Unit","published_at":"2026-04-10T20:10:04.000Z","date":"2026-04-09","kind":"grant","planned":false,"acquired":true,"shares":47000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F2","text":"Each restricted stock unit (\"RSU\")  represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"RSUs vest in four equal annual installments beginning on first anniversary of grant date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"RSUs vest in four equal annual installments beginning on first anniversary of grant date."}],"balance_after":47000,"derivative":{"underlying":"Common Stock","underlying_shares":47000},"source":{"system":"sec-edgar","filing":"0001193125-26-151265","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1937653/000119312526151265/ownership.xml","form_type":"4"}},{"id":810080,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":52824,"kind":"person","name":"Schayowitz Adam","position":1,"cik":"0002127119","reported_name":"Schayowitz Adam","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"See Remarks"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-04-10T20:10:04.000Z","date":"2026-04-09","kind":"grant","planned":false,"acquired":true,"shares":70000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date."}],"balance_after":70000,"derivative":{"exercise_price":27.35,"expiration_date":"2036-04-08","underlying":"Common Stock","underlying_shares":70000},"source":{"system":"sec-edgar","filing":"0001193125-26-151265","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1937653/000119312526151265/ownership.xml","form_type":"4"}},{"id":810518,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":52905,"kind":"person","name":"Platshon Scott","position":1,"cik":"0001816539","reported_name":"Platshon Scott","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, Chief Business Officer"}}],"security":"Performance Stock Unit","published_at":"2026-04-10T20:10:03.000Z","date":"2026-04-09","kind":"grant","planned":false,"acquired":true,"shares":76000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each performance restricted stock unit (\"PSU\") represents a contingent right to receive one share of common stock. 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Between 50% and 200% of the target number of 38,000 PSUs (\"Target Number\") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"(Continued from footnote 4) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"Each performance restricted stock unit (\"PSU\") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return (\"TSR\") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). 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The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return (\"TSR\") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 38,000 PSUs (\"Target Number\") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"(Continued from footnote 4) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control)."}],"balance_after":76000,"derivative":{"underlying":"Common 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The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals,"},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F9","text":"(Continued from footnote 8) except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F8","text":"Each performance restricted stock unit (\"PSU\") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return (\"TSR\") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). 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The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $22.49 to $23.05, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price."}],"balance_after":48497,"source":{"system":"sec-edgar","filing":"0001193125-26-010834","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1937653/000119312526010834/ownership.xml","form_type":"4"}},{"id":940626,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":69494,"kind":"person","name":"Moore Paul Andrew","position":1,"cik":"0001938192","reported_name":"Moore Paul Andrew","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Scientific Officer"}}],"security":"Common Stock","published_at":"2026-01-13T01:32:15.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":true,"shares":17666,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents shares of common stock issued upon vesting of one third of the restricted stock units (\"RSUs\") granted on January 10, 2025."}],"balance_after":58057,"source":{"system":"sec-edgar","filing":"0001193125-26-010834","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1937653/000119312526010834/ownership.xml","form_type":"4"}},{"id":940739,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":69500,"kind":"person","name":"Smith Jeffrey T L","position":1,"cik":"0001604800","reported_name":"Smith Jeffrey T L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP & Chief Medical Officer"}}],"security":"Restricted Stock Unit","published_at":"2026-01-12T21:00:11.000Z","date":"2026-01-12","kind":"exercise","planned":false,"acquired":false,"shares":17666,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The RSUs were granted on January 10, 2025 and vest in three equal annual installments beginning on the first anniversary of grant date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The RSUs were granted on January 10, 2025 and vest in three equal annual installments beginning on the first anniversary of grant date."}],"balance_after":35334,"derivative":{"underlying":"Common Stock","underlying_shares":17666},"source":{"system":"sec-edgar","filing":"0001193125-26-010865","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1604800/000119312526010865/ownership.xml","form_type":"4"}},{"id":940738,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":69500,"kind":"person","name":"Smith Jeffrey T L","position":1,"cik":"0001604800","reported_name":"Smith Jeffrey T L","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP & Chief Medical Officer"}}],"security":"Common Stock","published_at":"2026-01-12T21:00:11.000Z","date":"2026-01-12","kind":"sale","planned":false,"acquired":false,"shares":9310,"price":22.6735,"value":211090.285,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory \"sell to cover\" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $22.49 to $23.05, inclusive. 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The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return (\"TSR\") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 111,000 PSUs (\"Target Number\") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index. The PSUs will only vest at the end of the three-year performance period if the reporting person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals,"},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F9","text":"(Continued from footnote 8) except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control)."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"Each performance restricted stock unit (\"PSU\") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return (\"TSR\") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 111,000 PSUs (\"Target Number\") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index. The PSUs will only vest at the end of the three-year performance period if the reporting person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals,"},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F9","text":"(Continued from footnote 8) except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control)."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F8","text":"Each performance restricted stock unit (\"PSU\") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return (\"TSR\") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 111,000 PSUs (\"Target Number\") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index. The PSUs will only vest at the end of the three-year performance period if the reporting person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals,"},{"field":"derivative.expiration_date","element":"expirationDate","label":"F9","text":"(Continued from footnote 8) except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control)."}],"balance_after":222000,"derivative":{"underlying":"Common Stock","underlying_shares":222000},"source":{"system":"sec-edgar","filing":"0001193125-26-010790","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1567045/000119312526010790/ownership.xml","form_type":"4"}},{"id":940768,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks 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The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $24.715 to $25.84, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price."}],"balance_after":193266,"source":{"system":"sec-edgar","filing":"0001193125-26-003097","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1567045/000119312526003097/ownership.xml","form_type":"4"}},{"id":950208,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":69501,"kind":"person","name":"Galbraith Kenneth","position":1,"cik":"0001567045","reported_name":"Galbraith Kenneth","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chair & CEO"}}],"security":"Common Stock","published_at":"2026-01-05T20:20:03.000Z","date":"2026-01-05","kind":"exercise","planned":false,"acquired":true,"shares":66666,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"Represents shares of common stock issued upon vesting of one third of the RSUs granted on January 5, 2024."}],"balance_after":224952,"source":{"system":"sec-edgar","filing":"0001193125-26-003097","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1567045/000119312526003097/ownership.xml","form_type":"4"}},{"id":950207,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":69501,"kind":"person","name":"Galbraith Kenneth","position":1,"cik":"0001567045","reported_name":"Galbraith Kenneth","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chair & CEO"}}],"security":"Common Stock","published_at":"2026-01-05T20:20:03.000Z","date":"2026-01-05","kind":"sale","planned":false,"acquired":false,"shares":22657,"price":25.0969,"value":568620.4633,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory \"sell to cover\" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $24.715 to $25.84, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price."}],"balance_after":158286,"source":{"system":"sec-edgar","filing":"0001193125-26-003097","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1567045/000119312526003097/ownership.xml","form_type":"4"}},{"id":950206,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":69501,"kind":"person","name":"Galbraith Kenneth","position":1,"cik":"0001567045","reported_name":"Galbraith Kenneth","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chair & CEO"}}],"security":"Common Stock","published_at":"2026-01-05T20:20:03.000Z","date":"2026-01-05","kind":"exercise","planned":false,"acquired":true,"shares":47668,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents shares of common stock issued upon vesting of one third of the restricted stock units (\"RSUs\") granted on January 5, 2023."}],"balance_after":180943,"source":{"system":"sec-edgar","filing":"0001193125-26-003097","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1567045/000119312526003097/ownership.xml","form_type":"4"}},{"id":960661,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":69501,"kind":"person","name":"Galbraith Kenneth","position":1,"cik":"0001567045","reported_name":"Galbraith Kenneth","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chair & CEO"}}],"security":"Restricted Stock Unit","published_at":"2025-12-22T17:52:15.000Z","date":"2025-12-22","kind":"exercise","planned":false,"acquired":false,"shares":100000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The RSUS vested on December 22, 2025."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The RSUS vested on December 22, 2025."}],"balance_after":0,"derivative":{"exercise_date":"2025-12-22","expiration_date":"2025-12-22","underlying":"Common Stock","underlying_shares":100000},"source":{"system":"sec-edgar","filing":"0001193125-25-329028","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1567045/000119312525329028/ownership.xml","form_type":"4"}},{"id":960660,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":69501,"kind":"person","name":"Galbraith Kenneth","position":1,"cik":"0001567045","reported_name":"Galbraith Kenneth","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chair & CEO"}}],"security":"Common Stock","published_at":"2025-12-22T17:52:15.000Z","date":"2025-12-22","kind":"sale","planned":false,"acquired":false,"shares":47528,"price":27.0222,"value":1284311.1216,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory \"sell to cover\" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $26.83 to $27.16 inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price."}],"balance_after":133275,"source":{"system":"sec-edgar","filing":"0001193125-25-329028","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1567045/000119312525329028/ownership.xml","form_type":"4"}},{"id":960659,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":69501,"kind":"person","name":"Galbraith Kenneth","position":1,"cik":"0001567045","reported_name":"Galbraith Kenneth","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chair & CEO"}}],"security":"Common Stock","published_at":"2025-12-22T17:52:15.000Z","date":"2025-12-22","kind":"exercise","planned":false,"acquired":true,"shares":100000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents shares of common stock issued upon vesting of restricted stock units (\"RSUs\") granted on December 22, 2022."}],"balance_after":180803,"source":{"system":"sec-edgar","filing":"0001193125-25-329028","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1567045/000119312525329028/ownership.xml","form_type":"4"}},{"id":1069099,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":19139,"kind":"person","name":"Ciongoli Gregory Austin","position":1,"cik":"0002023732","reported_name":"Ciongoli Gregory Austin","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2025-08-13T00:30:06.000Z","date":"2025-08-11","kind":"grant","planned":false,"acquired":true,"shares":62000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"Stock options vest in 36 equal monthly installments starting one month after grant date of August 11, 2025."}],"balance_after":62000,"derivative":{"exercise_price":12.44,"expiration_date":"2035-08-10","underlying":"Common Stock","underlying_shares":62000},"source":{"system":"sec-edgar","filing":"0000950170-25-107544","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/2023732/000095017025107544/ownership.xml","form_type":"4"}},{"id":1069098,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":19139,"kind":"person","name":"Ciongoli Gregory Austin","position":1,"cik":"0002023732","reported_name":"Ciongoli Gregory Austin","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2025-08-13T00:30:06.000Z","date":"2025-08-12","kind":"grant","planned":false,"acquired":true,"shares":415000,"price":12.02,"value":4988300.0,"ownership":{"direct":true},"balance_after":488500,"source":{"system":"sec-edgar","filing":"0000950170-25-107544","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2023732/000095017025107544/ownership.xml","form_type":"4"}},{"id":1068602,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":43928,"kind":"person","name":"Landry Robert E","position":1,"cik":"0001585160","reported_name":"Landry Robert E","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2025-08-13T00:30:04.000Z","date":"2025-08-11","kind":"grant","planned":false,"acquired":true,"shares":62000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"Stock options vest in 36 equal monthly installments starting one month after grant date of August 11, 2025."}],"balance_after":62000,"derivative":{"exercise_price":12.44,"expiration_date":"2035-08-10","underlying":"Common Stock","underlying_shares":62000},"source":{"system":"sec-edgar","filing":"0000950170-25-107543","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1585160/000095017025107543/ownership.xml","form_type":"4"}},{"id":1100138,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrants (right to acquire)","published_at":"2025-06-27T17:50:21.000Z","date":"2025-06-26","kind":"other","planned":false,"acquired":false,"shares":5086521,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"See note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund exercised 4,818,462 of the pre-funded warrants reported in this transaction."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"The pre-funded warrants did not have an expiration date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":0,"derivative":{"exercise_price":0.0001,"exercise_date":"2023-12-26","underlying":"Common Stock","underlying_shares":5086521},"source":{"system":"sec-edgar","filing":"0000935836-25-000438","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000438/ownership.xml","form_type":"4"}},{"id":1100137,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-06-27T17:50:21.000Z","date":"2025-06-26","kind":"tax_withholding","planned":false,"acquired":false,"shares":41,"price":12.71,"value":521.11,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F4","text":"On June 26, 2025,the reporting persons exercised pre-funded warrants to purchase 5,086,521 shares of the Issuer's Common Stock for $0.0001 per share. The reporting persons paid the exercise price on a cashless basis, resulting in the Issuer withholding 41 of the warrant shares (including 38 warrant shares issuable to Qualified Fund) to pay the exercise price and issuing to the reporting persons the remaining 5,086,480 shares."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After the transactions reported herein, Qualified Fund held 21,582,563 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":22970388,"source":{"system":"sec-edgar","filing":"0000935836-25-000438","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000438/ownership.xml","form_type":"4"}},{"id":1100136,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-06-27T17:50:21.000Z","date":"2025-06-26","kind":"other","planned":false,"acquired":true,"shares":5086480,"price":0.0001,"value":508.648,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund acquired 4,818,424 shares of Common Stock in connection with the exercise of the pre-funded warrants."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After the transactions reported herein, Qualified Fund held 21,582,563 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":22970388,"source":{"system":"sec-edgar","filing":"0000935836-25-000438","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000438/ownership.xml","form_type":"4"}},{"id":1142553,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-19T18:35:05.000Z","date":"2025-05-19","kind":"purchase","planned":false,"acquired":true,"shares":5919,"price":11.7821,"value":69738.2499,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 5,550 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 16,764,139 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17883908,"source":{"system":"sec-edgar","filing":"0000935836-25-000389","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000389/ownership.xml","form_type":"4"}},{"id":1142552,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-05-19T18:35:05.000Z","date":"2025-05-15","kind":"purchase","planned":false,"acquired":true,"shares":49502,"price":11.4308,"value":565847.4616,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 46,405 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 16,758,589 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17877989,"source":{"system":"sec-edgar","filing":"0000935836-25-000389","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000389/ownership.xml","form_type":"4"}},{"id":1169069,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-18T15:17:11.000Z","date":"2025-04-17","kind":"purchase","planned":false,"acquired":true,"shares":54760,"price":11.5197,"value":630818.772,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased 51,344 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $11.5125 to $11.5214, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 16,712,184 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17828487,"source":{"system":"sec-edgar","filing":"0000935836-25-000292","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000292/ownership.xml","form_type":"4"}},{"id":1169068,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-18T15:17:11.000Z","date":"2025-04-16","kind":"purchase","planned":false,"acquired":true,"shares":73953,"price":11.1637,"value":825589.1061,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 69,339 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $10.9823 to $11.2339 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each seperate price within the ranges set forth in this footnote and footnote 6."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 16,660,840 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17773727,"source":{"system":"sec-edgar","filing":"0000935836-25-000292","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000292/ownership.xml","form_type":"4"}},{"id":1176576,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-07T18:34:11.000Z","date":"2025-04-04","kind":"purchase","planned":false,"acquired":true,"shares":196438,"price":11.1679,"value":2193799.9402,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased 184,181 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $10.9804 to $11.2921, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 16,591,501 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17699774,"source":{"system":"sec-edgar","filing":"0000935836-25-000266","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000266/ownership.xml","form_type":"4"}},{"id":1176575,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-07T18:34:11.000Z","date":"2025-04-03","kind":"purchase","planned":false,"acquired":true,"shares":120770,"price":11.8421,"value":1430170.417,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 113,233 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $11.8101 to $11.9123 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each seperate price within the ranges set forth in this footnote and footnote 6."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 16,407,320 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17503336,"source":{"system":"sec-edgar","filing":"0000935836-25-000266","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000266/ownership.xml","form_type":"4"}},{"id":1183241,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-02T19:02:09.000Z","date":"2025-04-02","kind":"purchase","planned":false,"acquired":true,"shares":74360,"price":11.848,"value":881017.28,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"Qualified Fund purchased 69,720 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 16,294,087 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17382566,"source":{"system":"sec-edgar","filing":"0000935836-25-000259","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000259/ownership.xml","form_type":"4"}},{"id":1183240,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-02T19:02:09.000Z","date":"2025-04-01","kind":"purchase","planned":false,"acquired":true,"shares":48658,"price":11.6044,"value":564646.8952,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 45,622 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 16,224,367 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17308206,"source":{"system":"sec-edgar","filing":"0000935836-25-000259","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000259/ownership.xml","form_type":"4"}},{"id":1183239,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-04-02T19:02:09.000Z","date":"2025-03-31","kind":"purchase","planned":false,"acquired":true,"shares":4397,"price":11.7485,"value":51658.1545,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 4,129 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 16,178,745 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17259548,"source":{"system":"sec-edgar","filing":"0000935836-25-000259","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000259/ownership.xml","form_type":"4"}},{"id":1189675,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-27T18:53:43.000Z","date":"2025-03-26","kind":"purchase","planned":false,"acquired":true,"shares":43848,"price":12.2436,"value":536857.3728,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 41,177 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.2293 to $12.3537, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F6","text":"After this transaction, Qualified Fund held 16,174,616 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17255151,"source":{"system":"sec-edgar","filing":"0000935836-25-000253","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000253/ownership.xml","form_type":"4"}},{"id":1189674,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-27T18:53:43.000Z","date":"2025-03-25","kind":"purchase","planned":false,"acquired":true,"shares":53501,"price":12.9054,"value":690451.8054,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 50,243 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 16,133,439 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17211303,"source":{"system":"sec-edgar","filing":"0000935836-25-000253","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000253/ownership.xml","form_type":"4"}},{"id":1193344,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-24T17:45:12.000Z","date":"2025-03-24","kind":"purchase","planned":false,"acquired":true,"shares":22689,"price":13.0833,"value":296846.9937,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F7","text":"Qualified Fund purchased 21,307 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F8","text":"After this transaction, Qualified Fund held 16,083,196 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17157802,"source":{"system":"sec-edgar","filing":"0000935836-25-000245","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000245/ownership.xml","form_type":"4"}},{"id":1193343,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-24T17:45:12.000Z","date":"2025-03-21","kind":"purchase","planned":false,"acquired":true,"shares":31033,"price":12.7773,"value":396517.9509,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 29,143 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.6895 to $12.9881 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote with the ranges set forth in this footnote."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F6","text":"After this transaction, Qualified Fund held 16,061,889 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17135113,"source":{"system":"sec-edgar","filing":"0000935836-25-000245","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000245/ownership.xml","form_type":"4"}},{"id":1193342,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-24T17:45:12.000Z","date":"2025-03-20","kind":"purchase","planned":false,"acquired":true,"shares":73476,"price":12.9278,"value":949883.0328,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 69,000 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 16,032,746 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17104080,"source":{"system":"sec-edgar","filing":"0000935836-25-000245","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000245/ownership.xml","form_type":"4"}},{"id":1196988,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-19T18:32:24.000Z","date":"2025-03-19","kind":"purchase","planned":false,"acquired":true,"shares":58306,"price":12.6442,"value":737232.7252,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F8","text":"Qualified Fund purchased 54,758 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.5029 to $12.7711, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F10","text":"After this transaction, Qualified Fund held 15,963,746 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":17030604,"source":{"system":"sec-edgar","filing":"0000935836-25-000239","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000239/ownership.xml","form_type":"4"}},{"id":1196987,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-19T18:32:24.000Z","date":"2025-03-18","kind":"purchase","planned":false,"acquired":true,"shares":113880,"price":12.6524,"value":1440855.312,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased 106,944 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.3214 to $12.7045, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 15,908,988 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":16972298,"source":{"system":"sec-edgar","filing":"0000935836-25-000239","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000239/ownership.xml","form_type":"4"}},{"id":1196986,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-19T18:32:24.000Z","date":"2025-03-17","kind":"purchase","planned":false,"acquired":true,"shares":56277,"price":12.2335,"value":688464.6795,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 52,849 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.1287 to $12.2678 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote with the ranges set forth in this footnote."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 15,802,044 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":16858418,"source":{"system":"sec-edgar","filing":"0000935836-25-000239","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000239/ownership.xml","form_type":"4"}},{"id":1207711,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-13T19:35:15.000Z","date":"2025-03-13","kind":"purchase","planned":false,"acquired":true,"shares":468356,"price":12.4846,"value":5847237.3176,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F8","text":"Qualified Fund purchased 439,831 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.26 to $12.55, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F10","text":"After this transaction, Qualified Fund held 15,749,195 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":16802141,"source":{"system":"sec-edgar","filing":"0000935836-25-000225","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000225/ownership.xml","form_type":"4"}},{"id":1207710,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-13T19:35:15.000Z","date":"2025-03-12","kind":"purchase","planned":false,"acquired":true,"shares":292934,"price":12.2479,"value":3587826.3386,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F5","text":"Qualified Fund purchased 275,095 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.0008 to $12.3728, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 15,309,364 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":16333785,"source":{"system":"sec-edgar","filing":"0000935836-25-000225","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000225/ownership.xml","form_type":"4"}},{"id":1207709,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":69542,"kind":"person","name":"NODELMAN OLEG","position":2,"cik":"0001454385","reported_name":"NODELMAN OLEG","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-03-13T19:35:15.000Z","date":"2025-03-11","kind":"purchase","planned":false,"acquired":true,"shares":320690,"price":11.4935,"value":3685850.515,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 301,160 of the shares purchased in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $11.115 to $11.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote with the ranges set forth in this footnote and footnote 6 and 9."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 15,034,269 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":16040851,"source":{"system":"sec-edgar","filing":"0000935836-25-000225","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1454385/000093583625000225/ownership.xml","form_type":"4"}},{"id":1298532,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-21T22:34:28.000Z","date":"2025-01-17","kind":"purchase","planned":false,"acquired":true,"shares":19748,"price":13.8747,"value":273997.5756,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 18,557 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 14,733,109 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15720161,"source":{"system":"sec-edgar","filing":"0000935836-25-000074","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000074/ownership.xml","form_type":"4"}},{"id":1298531,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-21T22:34:28.000Z","date":"2025-01-16","kind":"purchase","planned":false,"acquired":true,"shares":121681,"price":13.885,"value":1689540.685,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 114,344 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 14,714,552 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15700413,"source":{"system":"sec-edgar","filing":"0000935836-25-000074","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000074/ownership.xml","form_type":"4"}},{"id":1302315,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-15T23:12:17.000Z","date":"2025-01-15","kind":"purchase","planned":false,"acquired":true,"shares":39029,"price":14.0068,"value":546671.3972,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F6","text":"Qualified Fund purchased 36,676 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F7","text":"After this transaction, Qualified Fund held 14,600,208 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15578732,"source":{"system":"sec-edgar","filing":"0000935836-25-000067","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000067/ownership.xml","form_type":"4"}},{"id":1302314,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-15T23:12:17.000Z","date":"2025-01-14","kind":"purchase","planned":false,"acquired":true,"shares":54500,"price":13.5645,"value":739265.25,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F4","text":"Qualified Fund purchased 51,213 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F5","text":"After this transaction, Qualified Fund held 14,563,532 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15539703,"source":{"system":"sec-edgar","filing":"0000935836-25-000067","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000067/ownership.xml","form_type":"4"}},{"id":1302313,"issuer":{"id":4458,"kind":"organization","name":"Zymeworks Inc.","symbol":"ZYME"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-01-15T23:12:17.000Z","date":"2025-01-13","kind":"purchase","planned":false,"acquired":true,"shares":74125,"price":13.3946,"value":992874.725,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund purchased 69,655 of the shares purchased in this transaction."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F3","text":"After this transaction, Qualified Fund held 14,512,319 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"EcoR1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Funds\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":15485203,"source":{"system":"sec-edgar","filing":"0000935836-25-000067","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1587114/000093583625000067/ownership.xml","form_type":"4"}}],"next_cursor":"2025-01-15T23:12:17.000000Z,1302313"}