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The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1307256,"source":{"system":"sec-edgar","filing":"0001298711-26-000009","document":"wk-form4_1788563746.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000009/wk-form4_1788563746.xml","form_type":"4"}},{"id":5018,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-09-04T23:15:49.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":2320,"price":360.466,"value":836281.12,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1308498,"source":{"system":"sec-edgar","filing":"0001298711-26-000009","document":"wk-form4_1788563746.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000009/wk-form4_1788563746.xml","form_type":"4"}},{"id":5017,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-09-04T23:15:49.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3392,"price":359.3862,"value":1219037.9904,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1310818,"source":{"system":"sec-edgar","filing":"0001298711-26-000009","document":"wk-form4_1788563746.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000009/wk-form4_1788563746.xml","form_type":"4"}},{"id":5016,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-09-04T23:15:49.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3180,"price":358.4203,"value":1139776.554,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1314210,"source":{"system":"sec-edgar","filing":"0001298711-26-000009","document":"wk-form4_1788563746.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000009/wk-form4_1788563746.xml","form_type":"4"}},{"id":5015,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-09-04T23:15:49.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3962,"price":357.5742,"value":1416708.9804,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1317390,"source":{"system":"sec-edgar","filing":"0001298711-26-000009","document":"wk-form4_1788563746.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000009/wk-form4_1788563746.xml","form_type":"4"}},{"id":5014,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-09-04T23:15:49.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3267,"price":356.3679,"value":1164253.9293,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $355.98 to $356.96. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1321352,"source":{"system":"sec-edgar","filing":"0001298711-26-000009","document":"wk-form4_1788563746.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000009/wk-form4_1788563746.xml","form_type":"4"}},{"id":5013,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-09-04T23:15:49.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":2006,"price":355.5719,"value":713277.2314,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1324619,"source":{"system":"sec-edgar","filing":"0001298711-26-000009","document":"wk-form4_1788563746.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000009/wk-form4_1788563746.xml","form_type":"4"}},{"id":5012,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-09-04T23:15:49.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":520,"price":354.54,"value":184360.8,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Krish S. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by her spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1326625,"source":{"system":"sec-edgar","filing":"0001298711-26-000009","document":"wk-form4_1788563746.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000009/wk-form4_1788563746.xml","form_type":"4"}},{"id":5011,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":405,"price":366.5567,"value":148455.4635,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F15","text":"The transaction was executed in multiple trades ranging from $366.39 to $366.91. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1347543,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":13,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5010,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":847,"price":365.4163,"value":309507.6061,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F14","text":"The transaction was executed in multiple trades ranging from $365.07 to $366.03. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1347948,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":12,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5009,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":1358,"price":364.4794,"value":494963.0252,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F13","text":"The transaction was executed in multiple trades ranging from $364.07 to $365.05. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1348795,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5008,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":573,"price":363.3424,"value":208195.1952,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F12","text":"The transaction was executed in multiple trades ranging from $363.05 to $364.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1350153,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5007,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":2010,"price":362.6504,"value":728927.304,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F11","text":"The transaction was executed in multiple trades ranging from $362.02 to $363.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1350726,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5006,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":1214,"price":361.6091,"value":438993.4474,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F10","text":"The transaction was executed in multiple trades ranging from $361.02 to $362.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1352736,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5005,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":2266,"price":360.463,"value":816809.158,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1353950,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5004,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3357,"price":359.3861,"value":1206459.1377,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1356216,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5003,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3143,"price":358.4182,"value":1126508.4026,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1359573,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5002,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3981,"price":357.5738,"value":1423501.2978,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1362716,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5001,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":3297,"price":356.3687,"value":1174947.6039,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $355.98 to $356.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1366697,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":5000,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":2029,"price":355.5719,"value":721455.3851,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1369994,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":4999,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-09-04T23:14:09.000Z","date":"2026-09-04","kind":"sale","planned":true,"acquired":false,"shares":520,"price":354.54,"value":184360.8,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1372023,"source":{"system":"sec-edgar","filing":"0001298709-26-000011","document":"wk-form4_1788563646.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000011/wk-form4_1788563646.xml","form_type":"4"}},{"id":686961,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":23346,"kind":"person","name":"ROSSI DINO A","position":1,"cik":"0001209059","reported_name":"ROSSI DINO A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-08-14T22:22:39.000Z","date":"2026-08-14","kind":"sale","planned":false,"acquired":false,"shares":40,"price":333.23,"value":13329.2,"ownership":{"direct":true},"balance_after":50000,"source":{"system":"sec-edgar","filing":"0001209059-26-000006","document":"wk-form4_1786746156.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000120905926000006/wk-form4_1786746156.xml","form_type":"4"}},{"id":686960,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":23346,"kind":"person","name":"ROSSI DINO A","position":1,"cik":"0001209059","reported_name":"ROSSI DINO A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-08-14T22:22:39.000Z","date":"2026-08-14","kind":"sale","planned":false,"acquired":false,"shares":3095,"price":331.4333,"value":1025786.0635,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $331.02 to $331.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":50040,"source":{"system":"sec-edgar","filing":"0001209059-26-000006","document":"wk-form4_1786746156.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000120905926000006/wk-form4_1786746156.xml","form_type":"4"}},{"id":686959,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":23346,"kind":"person","name":"ROSSI DINO A","position":1,"cik":"0001209059","reported_name":"ROSSI DINO A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-08-14T22:22:39.000Z","date":"2026-08-14","kind":"sale","planned":false,"acquired":false,"shares":4896,"price":330.3558,"value":1617421.9968,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $330 to $330.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":53135,"source":{"system":"sec-edgar","filing":"0001209059-26-000006","document":"wk-form4_1786746156.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000120905926000006/wk-form4_1786746156.xml","form_type":"4"}},{"id":686958,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":23346,"kind":"person","name":"ROSSI DINO A","position":1,"cik":"0001209059","reported_name":"ROSSI DINO A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-08-14T22:22:39.000Z","date":"2026-08-14","kind":"sale","planned":false,"acquired":false,"shares":7428,"price":329.6015,"value":2448279.942,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $329.01 to $329.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":58031,"source":{"system":"sec-edgar","filing":"0001209059-26-000006","document":"wk-form4_1786746156.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000120905926000006/wk-form4_1786746156.xml","form_type":"4"}},{"id":686957,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":23346,"kind":"person","name":"ROSSI DINO A","position":1,"cik":"0001209059","reported_name":"ROSSI DINO A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-08-14T22:22:39.000Z","date":"2026-08-14","kind":"sale","planned":false,"acquired":false,"shares":1687,"price":328.5152,"value":554205.1424,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $328.01 to $328.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":65459,"source":{"system":"sec-edgar","filing":"0001209059-26-000006","document":"wk-form4_1786746156.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000120905926000006/wk-form4_1786746156.xml","form_type":"4"}},{"id":686956,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":23346,"kind":"person","name":"ROSSI DINO A","position":1,"cik":"0001209059","reported_name":"ROSSI DINO A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-08-14T22:22:39.000Z","date":"2026-08-14","kind":"sale","planned":false,"acquired":false,"shares":5226,"price":327.3939,"value":1710960.5214,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $327 to $327.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":67146,"source":{"system":"sec-edgar","filing":"0001209059-26-000006","document":"wk-form4_1786746156.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000120905926000006/wk-form4_1786746156.xml","form_type":"4"}},{"id":686955,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":23346,"kind":"person","name":"ROSSI DINO A","position":1,"cik":"0001209059","reported_name":"ROSSI DINO A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-08-14T22:22:39.000Z","date":"2026-08-14","kind":"sale","planned":false,"acquired":false,"shares":2287,"price":326.6028,"value":746940.6036,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $326.04 to $326.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":72372,"source":{"system":"sec-edgar","filing":"0001209059-26-000006","document":"wk-form4_1786746156.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000120905926000006/wk-form4_1786746156.xml","form_type":"4"}},{"id":686954,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":23346,"kind":"person","name":"ROSSI DINO A","position":1,"cik":"0001209059","reported_name":"ROSSI DINO A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-08-14T22:22:39.000Z","date":"2026-08-14","kind":"sale","planned":false,"acquired":false,"shares":341,"price":325.5985,"value":111029.0885,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transaction was executed in multiple trades ranging from $325 to $325.96. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":74659,"source":{"system":"sec-edgar","filing":"0001209059-26-000006","document":"wk-form4_1786746156.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000120905926000006/wk-form4_1786746156.xml","form_type":"4"}},{"id":686953,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":23346,"kind":"person","name":"ROSSI DINO A","position":1,"cik":"0001209059","reported_name":"ROSSI DINO A","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Common Stock","published_at":"2026-08-14T22:22:39.000Z","date":"2026-08-14","kind":"gift","planned":false,"acquired":false,"shares":3691,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents a bona fide gift of Krystal Biotech, Inc.'s Common Stock to a charitable donor-advised fund."}],"balance_after":75000,"source":{"system":"sec-edgar","filing":"0001209059-26-000006","document":"wk-form4_1786746156.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000120905926000006/wk-form4_1786746156.xml","form_type":"4"}},{"id":725518,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":35156,"kind":"person","name":"Thomas John Charles","position":1,"cik":"0002114900","reported_name":"Thomas John Charles","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, General Counsel"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-06-26T22:45:51.000Z","date":"2026-06-25","kind":"exercise","planned":true,"acquired":false,"shares":1000,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"The options vest ratably over a four-year period beginning on February 28, 2026."}],"balance_after":6500,"derivative":{"exercise_price":179.25,"expiration_date":"2035-02-27","underlying":"Common Stock","underlying_shares":1000},"source":{"system":"sec-edgar","filing":"0002114900-26-000009","document":"wk-form4_1782513949.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000211490026000009/wk-form4_1782513949.xml","form_type":"4"}},{"id":725517,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":35156,"kind":"person","name":"Thomas John Charles","position":1,"cik":"0002114900","reported_name":"Thomas John Charles","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, General Counsel"}}],"security":"Common Stock","published_at":"2026-06-26T22:45:51.000Z","date":"2026-06-25","kind":"sale","planned":true,"acquired":false,"shares":1000,"price":347.27,"value":347270.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The acquisition and sale of shares of the Company's common stock reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 23, 2026. All transactions contemplated by the plan have been completed, and the plan has terminated in accordance with its terms."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0002114900-26-000009","document":"wk-form4_1782513949.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000211490026000009/wk-form4_1782513949.xml","form_type":"4"}},{"id":725516,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":35156,"kind":"person","name":"Thomas John Charles","position":1,"cik":"0002114900","reported_name":"Thomas John Charles","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, General Counsel"}}],"security":"Common Stock","published_at":"2026-06-26T22:45:51.000Z","date":"2026-06-25","kind":"exercise","planned":true,"acquired":true,"shares":1000,"price":179.25,"value":179250.0,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The acquisition and sale of shares of the Company's common stock reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 23, 2026. 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The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1378155,"source":{"system":"sec-edgar","filing":"0001298711-26-000006","document":"wk-form4_1780699235.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000006/wk-form4_1780699235.xml","form_type":"4"}},{"id":748014,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-06-05T22:40:38.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":2039,"price":310.937,"value":634000.543,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F11","text":"The transaction was executed in multiple trades ranging from $310.44 to $311.41. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1378395,"source":{"system":"sec-edgar","filing":"0001298711-26-000006","document":"wk-form4_1780699235.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000006/wk-form4_1780699235.xml","form_type":"4"}},{"id":748013,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-06-05T22:40:38.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":2801,"price":309.9451,"value":868156.2251,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F10","text":"The transaction was executed in multiple trades ranging from $309.43 to $310.38. The price reported above reflects the weighted average sale price. 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The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1383235,"source":{"system":"sec-edgar","filing":"0001298711-26-000006","document":"wk-form4_1780699235.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000006/wk-form4_1780699235.xml","form_type":"4"}},{"id":748011,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-06-05T22:40:38.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":12729,"price":307.8066,"value":3918070.2114,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $307.38 to $308.37. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1387038,"source":{"system":"sec-edgar","filing":"0001298711-26-000006","document":"wk-form4_1780699235.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000006/wk-form4_1780699235.xml","form_type":"4"}},{"id":748010,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-06-05T22:40:38.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":1348,"price":307.0948,"value":413963.7904,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $306.38 to $307.37. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1399767,"source":{"system":"sec-edgar","filing":"0001298711-26-000006","document":"wk-form4_1780699235.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000006/wk-form4_1780699235.xml","form_type":"4"}},{"id":748009,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-06-05T22:40:38.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":480,"price":305.865,"value":146815.2,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $305.19 to $306.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1401115,"source":{"system":"sec-edgar","filing":"0001298711-26-000006","document":"wk-form4_1780699235.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000006/wk-form4_1780699235.xml","form_type":"4"}},{"id":748008,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-06-05T22:40:38.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":400,"price":304.8939,"value":121957.56,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $304.07 to $304.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1401595,"source":{"system":"sec-edgar","filing":"0001298711-26-000006","document":"wk-form4_1780699235.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000006/wk-form4_1780699235.xml","form_type":"4"}},{"id":748007,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-06-05T22:40:38.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":247,"price":303.1703,"value":74883.0641,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $303.05 to $303.77. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1401995,"source":{"system":"sec-edgar","filing":"0001298711-26-000006","document":"wk-form4_1780699235.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000006/wk-form4_1780699235.xml","form_type":"4"}},{"id":748006,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-06-05T22:40:38.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":593,"price":302.2508,"value":179234.7244,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $302.05 to $303.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1402242,"source":{"system":"sec-edgar","filing":"0001298711-26-000006","document":"wk-form4_1780699235.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000006/wk-form4_1780699235.xml","form_type":"4"}},{"id":748005,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-06-05T22:40:38.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":320,"price":300.75,"value":96240.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Krish S. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by her spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025, and will terminate on December 4, 2026, or earlier in accordance with the terms of the Rule 10b5-1 trading plan, including upon completion of the sale of all of the shares of the Company's common stock subject to the Rule 10b5-1 trading plan."}],"balance_after":1402835,"source":{"system":"sec-edgar","filing":"0001298711-26-000006","document":"wk-form4_1780699235.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000006/wk-form4_1780699235.xml","form_type":"4"}},{"id":748004,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":40,"price":312.23,"value":12489.2,"ownership":{"direct":true},"balance_after":1450253,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":11,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":748003,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":964,"price":311.358,"value":300149.112,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F11","text":"The transaction was executed in multiple trades ranging from $311.07 to $311.77. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1450293,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":748002,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":2652,"price":310.429,"value":823257.708,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F10","text":"The transaction was executed in multiple trades ranging from $310.06 to $311.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1451257,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":748001,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":2784,"price":309.4901,"value":861620.4384,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $309.04 to $310.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1453909,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":748000,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":4830,"price":308.4677,"value":1489898.991,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $308.03 to $309.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1456693,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747999,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":11461,"price":307.6776,"value":3526292.9736,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $307.03 to $308.02. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1461523,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747998,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":589,"price":306.3318,"value":180429.4302,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $306.00 to $306.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1472984,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747997,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":544,"price":304.8102,"value":165816.7488,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $304.07 to $304.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1473573,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747996,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":176,"price":303.1689,"value":53357.7264,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $303.05 to $303.82. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1474117,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747995,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":640,"price":302.2367,"value":193431.488,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $302.05 to $303.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1474293,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":747994,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-06-05T22:38:36.000Z","date":"2026-06-04","kind":"sale","planned":true,"acquired":false,"shares":320,"price":300.75,"value":96240.0,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025, and will terminate on December 4, 2026, or earlier in accordance with the terms of the Rule 10b5-1 trading plan, including upon completion of the sale of all of the shares of the Company's common stock subject to the Rule 10b5-1 trading plan."}],"balance_after":1474933,"source":{"system":"sec-edgar","filing":"0001298709-26-000009","document":"wk-form4_1780699113.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000009/wk-form4_1780699113.xml","form_type":"4"}},{"id":761860,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":35156,"kind":"person","name":"Thomas John Charles","position":1,"cik":"0002114900","reported_name":"Thomas John Charles","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"EVP, General Counsel"}}],"security":"Common Stock","published_at":"2026-05-27T21:17:56.000Z","date":"2026-05-26","kind":"sale","planned":true,"acquired":false,"shares":642,"price":302.03,"value":193903.26,"ownership":{"direct":true},"footnotes":[{"field":"shares","element":"transactionShares","label":"F1","text":"The sales reported in this Form 4 were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 23, 2026. The Rule 10b5-1 trading plan will terminate on December 31, 2026, or earlier in accordance with the terms of the Rule 10b5-1 trading plan, including upon completion of the sale of all of the shares of the Company's common stock subject to the Rule 10b5-1 trading plan."}],"balance_after":0,"source":{"system":"sec-edgar","filing":"0002114900-26-000006","document":"wk-form4_1779916673.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000211490026000006/wk-form4_1779916673.xml","form_type":"4"}},{"id":855934,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-06T23:23:09.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":1700,"price":266.4224,"value":452918.08,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F12","text":"The transaction was executed in multiple trades ranging from $266 to $266.93. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1403155,"source":{"system":"sec-edgar","filing":"0001298711-26-000004","document":"wk-form4_1772839386.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000004/wk-form4_1772839386.xml","form_type":"4"}},{"id":855933,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-06T23:23:09.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":6000,"price":265.1632,"value":1590979.2,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F11","text":"The transaction was executed in multiple trades ranging from $265 to $265.73. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1404855,"source":{"system":"sec-edgar","filing":"0001298711-26-000004","document":"wk-form4_1772839386.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000004/wk-form4_1772839386.xml","form_type":"4"}},{"id":855932,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-06T23:23:09.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":4852,"price":264.6371,"value":1284019.2092,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F10","text":"The transaction was executed in multiple trades ranging from $264 to $264.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1410855,"source":{"system":"sec-edgar","filing":"0001298711-26-000004","document":"wk-form4_1772839386.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000004/wk-form4_1772839386.xml","form_type":"4"}},{"id":855931,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-06T23:23:09.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":2248,"price":263.5831,"value":592534.8088,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $263 to $263.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1415707,"source":{"system":"sec-edgar","filing":"0001298711-26-000004","document":"wk-form4_1772839386.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000004/wk-form4_1772839386.xml","form_type":"4"}},{"id":855930,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-06T23:23:09.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":1938,"price":262.3479,"value":508430.2302,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $262 to $262.8. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1417955,"source":{"system":"sec-edgar","filing":"0001298711-26-000004","document":"wk-form4_1772839386.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000004/wk-form4_1772839386.xml","form_type":"4"}},{"id":855929,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-06T23:23:09.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":2931,"price":261.4119,"value":766198.2789,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $261 to $261.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1419893,"source":{"system":"sec-edgar","filing":"0001298711-26-000004","document":"wk-form4_1772839386.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000004/wk-form4_1772839386.xml","form_type":"4"}},{"id":855928,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-06T23:23:09.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":3667,"price":260.3661,"value":954762.4887,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $259.98 to $260.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1422824,"source":{"system":"sec-edgar","filing":"0001298711-26-000004","document":"wk-form4_1772839386.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000004/wk-form4_1772839386.xml","form_type":"4"}},{"id":855927,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-06T23:23:09.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":668,"price":259.6095,"value":173419.146,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $258.98 to $259.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1426491,"source":{"system":"sec-edgar","filing":"0001298711-26-000004","document":"wk-form4_1772839386.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000004/wk-form4_1772839386.xml","form_type":"4"}},{"id":855926,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-06T23:23:09.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":589,"price":258.5404,"value":152280.2956,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $257.93 to $258.92. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1427159,"source":{"system":"sec-edgar","filing":"0001298711-26-000004","document":"wk-form4_1772839386.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000004/wk-form4_1772839386.xml","form_type":"4"}},{"id":855925,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-06T23:23:09.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":407,"price":257.3186,"value":104728.6702,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Krish S. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by her spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sales reported in this Form 4 were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier in accordance with the terms of the Rule 10b5-1 trading plan, including upon completion of the sale of all of the shares of the Company's common stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $256.68 to $257.67. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1427748,"source":{"system":"sec-edgar","filing":"0001298711-26-000004","document":"wk-form4_1772839386.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000004/wk-form4_1772839386.xml","form_type":"4"}},{"id":855924,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":920,"price":266.555,"value":245230.6,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F12","text":"The transaction was executed in multiple trades ranging from $266.36 to $266.93. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1475253,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855923,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":2439,"price":265.5896,"value":647773.0344,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F11","text":"The transaction was executed in multiple trades ranging from $265.235 to $266.19. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1476173,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855922,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":8798,"price":264.8501,"value":2330151.1798,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F10","text":"The transaction was executed in multiple trades ranging from $264.2 to $265.19. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1478612,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855921,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":2043,"price":263.7011,"value":538741.3473,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F9","text":"The transaction was executed in multiple trades ranging from $263.19 to $264.1. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1487410,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855920,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":2380,"price":262.4448,"value":624618.624,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F8","text":"The transaction was executed in multiple trades ranging from $262.08 to $263. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1489453,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855919,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":2962,"price":261.4075,"value":774289.015,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The transaction was executed in multiple trades ranging from $261.07 to $262.04. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1491833,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855918,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":3128,"price":260.4867,"value":814802.3976,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The transaction was executed in multiple trades ranging from $260.07 to $261.06. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1494795,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855917,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":1377,"price":259.8675,"value":357837.5475,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The transaction was executed in multiple trades ranging from $259.07 to $260.06. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1497923,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855916,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":470,"price":258.3795,"value":121438.365,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F4","text":"The transaction was executed in multiple trades ranging from $257.89 to $258.765. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1499300,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":855915,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10295,"kind":"person","name":"Krishnan Krish S","position":1,"cik":"0001298709","reported_name":"Krishnan Krish S","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-03-06T23:22:14.000Z","date":"2026-03-04","kind":"sale","planned":true,"acquired":false,"shares":483,"price":257.3131,"value":124282.2273,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein."},{"field":"shares","element":"transactionShares","label":"F2","text":"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier in accordance with the terms of the Rule 10b5-1 trading plan, including upon completion of the sale of all of the shares of the Company's common stock subject to the Rule 10b5-1 trading plan."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The transaction was executed in multiple trades ranging from $256.81 to $257.75. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":1499770,"source":{"system":"sec-edgar","filing":"0001298709-26-000004","document":"wk-form4_1772839326.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129870926000004/wk-form4_1772839326.xml","form_type":"4"}},{"id":867467,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Performance Stock 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award."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F20","text":"If any applicable portion of the performance criteria have been achieved, the PSU award shall  cliff vest on February 27, 2029."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F21","text":"If some or all of the performance criteria are not achieved, the applicable portion of the PSU award will be forfeited."}],"balance_after":43536,"derivative":{"underlying":"Common Stock","underlying_shares":43536},"source":{"system":"sec-edgar","filing":"0001298711-26-000002","document":"wk-form4_1772580780.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":17,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000002/wk-form4_1772580780.xml","form_type":"4"}},{"id":867466,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan 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four equal annual installments with the first installment vesting on February 27, 2027."}],"balance_after":7256,"derivative":{"underlying":"Common Stock","underlying_shares":7256},"source":{"system":"sec-edgar","filing":"0001298711-26-000002","document":"wk-form4_1772580780.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":16,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000002/wk-form4_1772580780.xml","form_type":"4"}},{"id":867465,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Stock Option (Right to Buy)","published_at":"2026-03-03T23:33:07.000Z","date":"2026-02-27","kind":"grant","planned":false,"acquired":true,"shares":18100,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F15","text":"The stock options vest in four equal annual installments beginning on February 27, 2027."}],"balance_after":18100,"derivative":{"exercise_price":275.64,"expiration_date":"2036-02-26","underlying":"Common Stock","underlying_shares":18100},"source":{"system":"sec-edgar","filing":"0001298711-26-000002","document":"wk-form4_1772580780.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":15,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000002/wk-form4_1772580780.xml","form_type":"4"}},{"id":867464,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan 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Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 4,000 RSUs, vesting on February 27, 2026."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"16,000 restricted stock units (\"RSUs\") were granted on February 28, 2025. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 4,000 RSUs, vesting on February 27, 2026."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"16,000 restricted stock units (\"RSUs\") were granted on February 28, 2025. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 4,000 RSUs, vesting on February 27, 2026."}],"balance_after":12000,"derivative":{"underlying":"Common Stock","underlying_shares":4000},"source":{"system":"sec-edgar","filing":"0001298711-26-000002","document":"wk-form4_1772580780.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":14,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000002/wk-form4_1772580780.xml","form_type":"4"}},{"id":867463,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Performance Stock Units","published_at":"2026-03-03T23:33:07.000Z","date":"2026-02-27","kind":"exercise","planned":false,"acquired":false,"shares":22500,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"45,000 performance stock units (\"PSUs\") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and the remaining one-half of the PSUs granted, or 22,500 PSUs, vested on February 27, 2026."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"45,000 performance stock units (\"PSUs\") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and the remaining one-half of the PSUs granted, or 22,500 PSUs, vested on February 27, 2026."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F1","text":"45,000 performance stock units (\"PSUs\") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and the remaining one-half of the PSUs granted, or 22,500 PSUs, vested on February 27, 2026."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":22500},"source":{"system":"sec-edgar","filing":"0001298711-26-000002","document":"wk-form4_1772580780.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":13,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000002/wk-form4_1772580780.xml","form_type":"4"}},{"id":867462,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-03T23:33:07.000Z","date":"2026-02-27","kind":"tax_withholding","planned":false,"acquired":false,"shares":2605,"price":275.64,"value":718042.2,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F7","text":"These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan."},{"field":"shares","element":"transactionShares","label":"F13","text":"Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Krish S. Krishnan, upon the vesting of 5,725 RSUs on February 27, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The closing price on February 27, 2026 of the Company's common stock on the Nasdaq Global Select Market."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person."}],"balance_after":1500253,"source":{"system":"sec-edgar","filing":"0001298711-26-000002","document":"wk-form4_1772580780.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":10,"url":"https://www.sec.gov/Archives/edgar/data/1711279/000129871126000002/wk-form4_1772580780.xml","form_type":"4"}},{"id":867461,"issuer":{"id":3500,"kind":"organization","name":"Krystal Biotech, Inc.","symbol":"KRYS"},"owners":[{"id":10296,"kind":"person","name":"Krishnan Suma","position":1,"cik":"0001298711","reported_name":"Krishnan Suma","relationship":{"director":true,"officer":true,"ten_percent_owner":true,"other":false,"officer_title":"President, R&D"}}],"security":"Common Stock","published_at":"2026-03-03T23:33:07.000Z","date":"2026-02-27","kind":"exercise","planned":false,"acquired":true,"shares":5725,"price":0,"value":0.0,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F7","text":"These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan."},{"field":"shares","element":"transactionShares","label":"F12","text":"22,900 restricted stock units (\"RSUs\") were granted on February 28, 2025, to the Reporting Person's spouse, Krish S. Krishnan. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's spouse continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 5,725 RSUs, vesting on February 27, 2026."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"Directly beneficially owned by Krish S. 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