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The shares were sold in multiple transactions at prices ranging from $37.34 to $38.21. 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These shares were sold in multiple transactions at prices ranging from $51.00 to $51.10, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4)."},{"field":"ownership.direct","element":"directOrIndirectOwnership","label":"F3","text":"These shares are directly held by Third Rock Ventures V, L.P. (\"TRV V\"). The general partner of TRV V is Third Rock Ventures GP V, L.P. (\"TRV GP V\"). The general partner of TRV GP V is TRV GP V, LLC (\"TRV GP V LLC\"). 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These shares were sold in multiple transactions at prices ranging from $50.05 to $50.81, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2)."},{"field":"ownership.direct","element":"directOrIndirectOwnership","label":"F3","text":"These shares are directly held by Third Rock Ventures V, L.P. (\"TRV V\"). The general partner of TRV V is Third Rock Ventures GP V, L.P. (\"TRV GP V\"). The general partner of TRV GP V is TRV GP V, LLC (\"TRV GP V LLC\"). 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Issuer's Non-Employee Director Compensation Policy.  The shares subject to the option shall vest on the earlier of (i) June 17, 2026 or (ii) the Issuer's next annual meeting of stockholders, subject to Dr. Simson's continued service to the Issuer through such vesting date."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"RA Capital Management, L.P. (the \"Adviser\") is the investment manager for RA Capital Healthcare Fund, L.P. (the \"Fund\") and RA Capital Nexus Fund III, L.P. (the \"Nexus Fund III\"). The general partner of the Adviser is RA Capital Management GP, LLC (the \"Adviser GP\"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, the Nexus Fund III, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"Jake Simson is a Partner of the Adviser who serves on the Issuer's board of directors. Under Dr. Simson's arrangement with the Adviser, Dr. Simson holds the option for the benefit of the Fund and the Nexus Fund III. Dr. Simson is obligated to turn over to the Adviser any net cash or stock received upon exercise of\nthe option, which will offset advisory fees owed by the Fund and the Nexus Fund III to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock."}],"balance_after":16623,"derivative":{"exercise_price":10.24,"expiration_date":"2035-06-16","underlying":"Common Stock","underlying_shares":16623},"source":{"system":"sec-edgar","filing":"0001415889-25-017903","document":"form4-06202025_100616.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1315082/000141588925017903/form4-06202025_100616.xml","form_type":"4"}},{"id":1104737,"issuer":{"id":2452,"kind":"organization","name":"Septerna, Inc.","symbol":"SEPN"},"owners":[{"id":34427,"kind":"person","name":"Sharp Shalini","position":1,"cik":"0001377202","reported_name":"Sharp Shalini","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2025-06-20T22:44:30.000Z","date":"2025-06-17","kind":"grant","planned":false,"acquired":true,"shares":16623,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares underlying the stock option will vest in full upon the earlier of (i) June 17, 2026 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer through such vesting date."}],"balance_after":16623,"derivative":{"exercise_price":10.24,"expiration_date":"2035-06-16","underlying":"Common Stock","underlying_shares":16623},"source":{"system":"sec-edgar","filing":"0000950170-25-088622","document":"ownership.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1377202/000095017025088622/ownership.xml","form_type":"4"}}],"next_cursor":"2025-06-20T22:44:30.000000Z,1104737"}