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The reporting person undertakes to provide to Prothena Corp Public Ltd Co, any security holder of Prothena Corp Public Ltd Co, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1) and (2) to this Form 4."}],"balance_after":439000,"source":{"system":"sec-edgar","filing":"0001045463-26-000020","document":"primary_doc.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000104546326000020/primary_doc.xml","form_type":"4"}},{"id":4635861,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":2376,"kind":"person","name":"SCULLY WILLIAM P","position":1,"cik":"0001045463","reported_name":"SCULLY WILLIAM P","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares, par value $0.01 per share","published_at":"2026-10-06T17:53:53.000Z","date":"2026-10-02","kind":"purchase","planned":false,"acquired":true,"shares":100000,"price":8.5724,"value":857240.0,"ownership":{"direct":false,"nature":"By Spouse"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"The price reported in Column 4 is a weighted average price. 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These RSUs are being moved to Table II as of this Form 4."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit (\"RSU\") represents the contingent right to receive one share of the Issuer's Ordinary Shares upon vesting."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"These RSUs reported in Table II are fully vested as of July 28, 2026 (the one-year anniversary of the grant date). The remainder of the 25,000 RSUs reported in Table I (10,000 RSUs) are subject to vesting."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"These RSUs reported in Table II are fully vested as of July 28, 2026 (the one-year anniversary of the grant date). 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These RSUs are being moved to Table II as of this Form 4."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit (\"RSU\") represents the contingent right to receive one share of the Issuer's Ordinary Shares upon vesting."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"These RSUs reported in Table II are fully vested as of July 28, 2026 (the one-year anniversary of the grant date). The remainder of the 85,000 RSUs reported in Table I (34,000 RSUs) are subject to vesting."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"These RSUs reported in Table II are fully vested as of July 28, 2026 (the one-year anniversary of the grant date). 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These RSUs are being moved to Table II as of this Form 4."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit (\"RSU\") represents the contingent right to receive one share of the Issuer's Ordinary Shares upon vesting."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"These RSUs reported in Table II are fully vested as of July 28, 2026 (the one-year anniversary of the grant date). The remainder of the 130,000 RSUs reported in Table I (52,000 RSUs) are subject to vesting."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"These RSUs reported in Table II are fully vested as of July 28, 2026 (the one-year anniversary of the grant date). 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These RSUs are being moved to Table II as of this Form 4."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit (\"RSU\") represents the contingent right to receive one share of the Issuer's Ordinary Shares upon vesting."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"These RSUs reported in Table II are fully vested as of July 28, 2026 (the one-year anniversary of the grant date). The remainder of the 95,000 RSUs reported in Table I (38,000 RSUs) are subject to vesting."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"These RSUs reported in Table II are fully vested as of July 28, 2026 (the one-year anniversary of the grant date). 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These RSUs are being moved to Table II as of this Form 4."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"Each restricted stock unit (\"RSU\") represents the contingent right to receive one share of the Issuer's Ordinary Shares upon vesting."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F3","text":"These RSUs reported in Table II are fully vested as of July 28, 2026 (the one-year anniversary of the grant date). The remainder of the 140,000 RSUs reported in Table I (56,000 RSUs) are subject to vesting."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F3","text":"These RSUs reported in Table II are fully vested as of July 28, 2026 (the one-year anniversary of the grant date). The remainder of the 140,000 RSUs reported in Table I (56,000 RSUs) are subject to vesting."}],"balance_after":0,"derivative":{"underlying":"Ordinary Shares","underlying_shares":84000},"source":{"system":"sec-edgar","filing":"0000905148-26-003412","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000090514826003412/form4.xml","form_type":"4"}},{"id":700511,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":27703,"kind":"person","name":"Kinney Gene G.","position":1,"cik":"0001564380","reported_name":"Kinney Gene G.","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CEO"}}],"security":"Ordinary Shares, par value $0.01 per share","published_at":"2026-07-31T00:31:52.000Z","date":"2026-07-28","kind":"disposition_to_issuer","planned":false,"acquired":false,"shares":84000,"price":8.56,"value":719040.0,"ownership":{"direct":true},"balance_after":68793,"source":{"system":"sec-edgar","filing":"0000905148-26-003412","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000090514826003412/form4.xml","form_type":"4"}},{"id":700510,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":27703,"kind":"person","name":"Kinney Gene G.","position":1,"cik":"0001564380","reported_name":"Kinney Gene G.","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CEO"}}],"security":"Ordinary Shares, par value $0.01 per share","published_at":"2026-07-31T00:31:52.000Z","date":"2026-07-28","kind":"exercise","planned":false,"acquired":true,"shares":84000,"ownership":{"direct":true},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Each restricted stock unit (\"RSU\") represents the contingent right to receive one share of the Issuer's Ordinary Shares upon vesting."}],"balance_after":152793,"source":{"system":"sec-edgar","filing":"0000905148-26-003412","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000090514826003412/form4.xml","form_type":"4"}},{"id":700509,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":27702,"kind":"person","name":"Kingston Anne Evans","position":1,"cik":"0002127851","reported_name":"Kingston Anne Evans","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Strategy Officer"}}],"security":"Ordinary Shares, par value $0.01 per share","published_at":"2026-07-31T00:31:02.000Z","date":"2026-07-29","kind":"sale","planned":true,"acquired":false,"shares":7662,"price":8.4729,"value":64919.3598,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 30, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transaction was executed in multiple trades in prices ranging from $8.40 to $8.64, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in this footnote."}],"balance_after":55782,"source":{"system":"sec-edgar","filing":"0000905148-26-003410","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000090514826003410/form4.xml","form_type":"4"}},{"id":700508,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":27702,"kind":"person","name":"Kingston Anne Evans","position":1,"cik":"0002127851","reported_name":"Kingston Anne Evans","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Strategy Officer"}}],"security":"Ordinary Shares, par value $0.01 per share","published_at":"2026-07-31T00:31:02.000Z","date":"2026-07-28","kind":"tax_withholding","planned":true,"acquired":false,"shares":3498,"price":8.56,"value":29942.88,"ownership":{"direct":true},"balance_after":63444,"source":{"system":"sec-edgar","filing":"0000905148-26-003410","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000090514826003410/form4.xml","form_type":"4"}},{"id":700505,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":27701,"kind":"person","name":"Isaacs Michael John","position":1,"cik":"0002127815","reported_name":"Isaacs Michael John","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"General Counsel & Company Sec."}}],"security":"Ordinary Shares, par value $0.01 per share","published_at":"2026-07-31T00:30:22.000Z","date":"2026-07-29","kind":"sale","planned":true,"acquired":false,"shares":8386,"price":8.4731,"value":71055.4166,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"The transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 3, 2026."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The transaction was executed in multiple trades in prices ranging from $8.40 to $8.65, inclusive. The price reported in Column 4 above reflects the weighted average sale price. 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These shares were sold in multiple transactions at prices ranging from $7.4637 to $8.5939, inclusive."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F10","text":"After this transaction, Qualified Fund held 4,973,891 of the Issuer's Ordinary Shares."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"Ecor1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Fund\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. 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The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein."}],"balance_after":7288649,"source":{"system":"sec-edgar","filing":"0000935836-25-000309","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1559053/000093583625000309/ownership.xml","form_type":"4"}},{"id":1157126,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":48279,"kind":"organization","name":"EcoR1 Capital, LLC","position":1,"cik":"0001587114","reported_name":"EcoR1 Capital, LLC","relationship":{"director":false,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Ordinary Shares","published_at":"2025-05-06T23:06:05.000Z","date":"2025-05-02","kind":"sale","planned":false,"acquired":false,"shares":3317938,"price":8.3621,"value":27744929.3498,"ownership":{"direct":false,"nature":"See Note"},"footnotes":[{"field":"shares","element":"transactionShares","label":"F2","text":"Qualified Fund sold 3,097,619 of the shares sold in this transaction."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.2715 to $9.1789, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission upon request, full information regarding the number of shares sold at each seperate price within the ranges set forth in this footnote and footnotes 6 and 9."},{"field":"balance_after","element":"sharesOwnedFollowingTransaction","label":"F4","text":"After this transaction, Qualified Fund held 7,750,234 shares of the Issuer's Common Stock."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F1","text":"The reporting persons are EcoR1 Capital, LLC (\"Ecor1\"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (\"Qualified Fund\"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the \"Fund\"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. 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These shares were purchased in multiple transactions at prices ranging from $13.85 to $14.00, inclusive. The reporting person undertakes to provide to Prothena Corp Public Ltd Co, any security holder of Prothena Corp Public Ltd Co, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1), (2), and (3) to this Form 4."}],"balance_after":1297693,"source":{"system":"sec-edgar","filing":"0000950170-25-062317","document":"ownership.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1045463/000095017025062317/ownership.xml","form_type":"4"}},{"id":1161566,"issuer":{"id":2375,"kind":"organization","name":"PROTHENA CORP PUBLIC LTD CO","symbol":"PRTA"},"owners":[{"id":2376,"kind":"person","name":"SCULLY WILLIAM P","position":1,"cik":"0001045463","reported_name":"SCULLY WILLIAM 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