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The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":15851,"source":{"system":"sec-edgar","filing":"0002037968-26-000004","document":"form4-03062026_120318.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2037968/000203796826000004/form4-03062026_120318.xml","form_type":"4"}},{"id":859027,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52747,"kind":"person","name":"Renninger Robert","position":1,"cik":"0002037968","reported_name":"Renninger Robert","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF FINANCIAL OFFICER"}}],"security":"Common Stock","published_at":"2026-03-06T00:10:24.000Z","date":"2026-03-03","kind":"exercise","planned":false,"acquired":true,"shares":3900,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":16757,"source":{"system":"sec-edgar","filing":"0002037968-26-000004","document":"form4-03062026_120318.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2037968/000203796826000004/form4-03062026_120318.xml","form_type":"4"}},{"id":858793,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52727,"kind":"person","name":"Worthington Mark","position":1,"cik":"0001861464","reported_name":"Worthington Mark","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"GENERAL COUNSEL and CCO"}}],"security":"Restricted Stock Units","published_at":"2026-03-06T00:06:26.000Z","date":"2026-03-03","kind":"exercise","planned":false,"acquired":false,"shares":5726,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F3","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"On March 3, 2025, the reporting person was granted 5,726 RSUs (as adjusted for the 10-for-1 reverse stock split completed on September 17, 2025). 100% of the RSUs vested on the one (1) year anniversary of the grant date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"On March 3, 2025, the reporting person was granted 5,726 RSUs (as adjusted for the 10-for-1 reverse stock split completed on September 17, 2025). 100% of the RSUs vested on the one (1) year anniversary of the grant date."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":5726},"source":{"system":"sec-edgar","filing":"0001861464-26-000004","document":"form4-03062026_120320.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1861464/000186146426000004/form4-03062026_120320.xml","form_type":"4"}},{"id":858792,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52727,"kind":"person","name":"Worthington Mark","position":1,"cik":"0001861464","reported_name":"Worthington Mark","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"GENERAL COUNSEL and CCO"}}],"security":"Common Stock","published_at":"2026-03-06T00:06:26.000Z","date":"2026-03-04","kind":"sale","planned":false,"acquired":false,"shares":1328,"price":5.37,"value":7131.36,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the Issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person. No additional shares of common stock were sold by the reporting person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $5.03 to $5.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":18376,"source":{"system":"sec-edgar","filing":"0001861464-26-000004","document":"form4-03062026_120320.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1861464/000186146426000004/form4-03062026_120320.xml","form_type":"4"}},{"id":858791,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52727,"kind":"person","name":"Worthington Mark","position":1,"cik":"0001861464","reported_name":"Worthington Mark","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"GENERAL COUNSEL and CCO"}}],"security":"Common Stock","published_at":"2026-03-06T00:06:26.000Z","date":"2026-03-03","kind":"exercise","planned":false,"acquired":true,"shares":5726,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":19704,"source":{"system":"sec-edgar","filing":"0001861464-26-000004","document":"form4-03062026_120320.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1861464/000186146426000004/form4-03062026_120320.xml","form_type":"4"}},{"id":859622,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Restricted Stock Units","published_at":"2026-03-06T00:02:55.000Z","date":"2026-03-03","kind":"exercise","planned":false,"acquired":false,"shares":5856,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F3","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"On March 3, 2025, the reporting person was granted 5,856 RSUs (as adjusted for the 10-for-1 reverse stock split completed on September 17, 2025). 100% of the RSUs vested on the one (1) year anniversary of the grant date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"On March 3, 2025, the reporting person was granted 5,856 RSUs (as adjusted for the 10-for-1 reverse stock split completed on September 17, 2025). 100% of the RSUs vested on the one (1) year anniversary of the grant date."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":5856},"source":{"system":"sec-edgar","filing":"0001822499-26-000004","document":"form4-03062026_120346.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000182249926000004/form4-03062026_120346.xml","form_type":"4"}},{"id":859621,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Common Stock","published_at":"2026-03-06T00:02:55.000Z","date":"2026-03-04","kind":"sale","planned":false,"acquired":false,"shares":1359,"price":5.37,"value":7297.83,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the Issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person. No additional shares of common stock were sold by the reporting person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $5.03 to $5.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":25178,"source":{"system":"sec-edgar","filing":"0001822499-26-000004","document":"form4-03062026_120346.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000182249926000004/form4-03062026_120346.xml","form_type":"4"}},{"id":859620,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Common Stock","published_at":"2026-03-06T00:02:55.000Z","date":"2026-03-03","kind":"exercise","planned":false,"acquired":true,"shares":5856,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":26537,"source":{"system":"sec-edgar","filing":"0001822499-26-000004","document":"form4-03062026_120346.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000182249926000004/form4-03062026_120346.xml","form_type":"4"}},{"id":857805,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52680,"kind":"person","name":"San Martin Javier","position":1,"cik":"0001794629","reported_name":"San Martin Javier","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF MEDICAL OFFICER"}}],"security":"Restricted Stock Units","published_at":"2026-03-05T23:59:34.000Z","date":"2026-03-03","kind":"exercise","planned":false,"acquired":false,"shares":7418,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F3","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F4","text":"On March 3, 2025, the reporting person was granted 7,418 RSUs (as adjusted for the 10-for-1 reverse stock split completed on September 17, 2025). 100% of the RSUs vested on the one (1) year anniversary of the grant date."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"On March 3, 2025, the reporting person was granted 7,418 RSUs (as adjusted for the 10-for-1 reverse stock split completed on September 17, 2025). 100% of the RSUs vested on the one (1) year anniversary of the grant date."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":7418},"source":{"system":"sec-edgar","filing":"0001794629-26-000004","document":"form4-03052026_110324.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1620463/000179462926000004/form4-03052026_110324.xml","form_type":"4"}},{"id":857804,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52680,"kind":"person","name":"San Martin Javier","position":1,"cik":"0001794629","reported_name":"San Martin Javier","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF MEDICAL OFFICER"}}],"security":"Common Stock","published_at":"2026-03-05T23:59:34.000Z","date":"2026-03-04","kind":"sale","planned":false,"acquired":false,"shares":1720,"price":5.37,"value":9236.4,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the Issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person. No additional shares of common stock were sold by the reporting person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $5.03 to $5.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":15887,"source":{"system":"sec-edgar","filing":"0001794629-26-000004","document":"form4-03052026_110324.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1620463/000179462926000004/form4-03052026_110324.xml","form_type":"4"}},{"id":857803,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52680,"kind":"person","name":"San Martin Javier","position":1,"cik":"0001794629","reported_name":"San Martin Javier","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF MEDICAL OFFICER"}}],"security":"Common Stock","published_at":"2026-03-05T23:59:34.000Z","date":"2026-03-03","kind":"exercise","planned":false,"acquired":true,"shares":7418,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":17607,"source":{"system":"sec-edgar","filing":"0001794629-26-000004","document":"form4-03052026_110324.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1620463/000179462926000004/form4-03052026_110324.xml","form_type":"4"}},{"id":949940,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52680,"kind":"person","name":"San Martin Javier","position":1,"cik":"0001794629","reported_name":"San Martin Javier","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF MEDICAL OFFICER"}}],"security":"Restricted Stock Units","published_at":"2026-01-06T00:52:35.000Z","date":"2025-12-31","kind":"exercise","planned":false,"acquired":false,"shares":4667,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F4","text":"RSUs convert into common stock on a one-for-one basis."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"On October 1, 2024, the reporting person was granted 14,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"On October 1, 2024, the reporting person was granted 14,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":4667},"source":{"system":"sec-edgar","filing":"0001794629-26-000002","document":"form4-01062026_120132.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1620463/000179462926000002/form4-01062026_120132.xml","form_type":"4"}},{"id":949939,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52680,"kind":"person","name":"San Martin Javier","position":1,"cik":"0001794629","reported_name":"San Martin Javier","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF MEDICAL OFFICER"}}],"security":"Common Stock","published_at":"2026-01-06T00:52:35.000Z","date":"2026-01-02","kind":"sale","planned":false,"acquired":false,"shares":1644,"price":6.88,"value":11310.72,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person. No additional shares of common stock were sold by the reporting person and the shares of common stock received upon settlement of the RSUs are subject to a lock-up agreement with Cantor Fitzgerald & Co. entered into in connection with the Issuer's private placement in December 2025."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $6.60 to $7.56, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":10189,"source":{"system":"sec-edgar","filing":"0001794629-26-000002","document":"form4-01062026_120132.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1620463/000179462926000002/form4-01062026_120132.xml","form_type":"4"}},{"id":949938,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52680,"kind":"person","name":"San Martin Javier","position":1,"cik":"0001794629","reported_name":"San Martin Javier","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF MEDICAL OFFICER"}}],"security":"Common Stock","published_at":"2026-01-06T00:52:35.000Z","date":"2025-12-31","kind":"exercise","planned":false,"acquired":true,"shares":4667,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"The reported number of shares in this Form 4 has been adjusted to reflect the impact of the Issuer's 10-for-1 reverse stock split completed on September 17, 2025 (the \"Reverse Stock Split\")."}],"balance_after":11833,"source":{"system":"sec-edgar","filing":"0001794629-26-000002","document":"form4-01062026_120132.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1620463/000179462926000002/form4-01062026_120132.xml","form_type":"4"}},{"id":950009,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52683,"kind":"person","name":"Litton Mark James","position":1,"cik":"0001604834","reported_name":"Litton Mark James","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CEO"}}],"security":"Restricted Stock Units","published_at":"2026-01-06T00:51:49.000Z","date":"2025-12-31","kind":"exercise","planned":false,"acquired":false,"shares":10834,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F7","text":"RSUs convert into common stock on a one-for-one basis."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F8","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F9","text":"On October 1, 2024, the reporting person was granted 32,500 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F9","text":"On October 1, 2024, the reporting person was granted 32,500 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":10834},"source":{"system":"sec-edgar","filing":"0001604834-26-000002","document":"form4-01062026_120146.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1604834/000160483426000002/form4-01062026_120146.xml","form_type":"4"}},{"id":950008,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52683,"kind":"person","name":"Litton Mark James","position":1,"cik":"0001604834","reported_name":"Litton Mark James","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-01-06T00:51:49.000Z","date":"2026-01-02","kind":"sale","planned":false,"acquired":false,"shares":2586,"price":6.88,"value":17791.68,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person. No additional shares of common stock were sold by the reporting person and the shares of common stock received upon settlement of the RSUs are subject to a lock-up agreement with Cantor Fitzgerald & Co. entered into in connection with the Issuer's private placement in December 2025."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $6.60 to $7.56, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":40828,"source":{"system":"sec-edgar","filing":"0001604834-26-000002","document":"form4-01062026_120146.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1604834/000160483426000002/form4-01062026_120146.xml","form_type":"4"}},{"id":950007,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52683,"kind":"person","name":"Litton Mark James","position":1,"cik":"0001604834","reported_name":"Litton Mark James","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2026-01-06T00:51:49.000Z","date":"2025-12-31","kind":"exercise","planned":false,"acquired":true,"shares":10834,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"The reported number of shares in this Form 4 has been adjusted to reflect the impact of the Issuer's 10-for-1 reverse stock split completed on September 17, 2025 (the \"Reverse Stock Split\")."}],"balance_after":43414,"source":{"system":"sec-edgar","filing":"0001604834-26-000002","document":"form4-01062026_120146.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1604834/000160483426000002/form4-01062026_120146.xml","form_type":"4"}},{"id":952310,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52747,"kind":"person","name":"Renninger Robert","position":1,"cik":"0002037968","reported_name":"Renninger Robert","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Financial Officer"}}],"security":"Restricted Stock Units","published_at":"2026-01-06T00:50:54.000Z","date":"2025-12-31","kind":"exercise","planned":false,"acquired":false,"shares":1236,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F7","text":"RSUs convert into common stock on a one-for-one basis."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F8","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F9","text":"On October 1, 2024, the reporting person was granted 3,707 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F9","text":"On October 1, 2024, the reporting person was granted 3,707 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":1236},"source":{"system":"sec-edgar","filing":"0002037968-26-000002","document":"form4-01062026_120150.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/2037968/000203796826000002/form4-01062026_120150.xml","form_type":"4"}},{"id":952309,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52747,"kind":"person","name":"Renninger Robert","position":1,"cik":"0002037968","reported_name":"Renninger Robert","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Financial Officer"}}],"security":"Common Stock","published_at":"2026-01-06T00:50:54.000Z","date":"2026-01-02","kind":"sale","planned":false,"acquired":false,"shares":297,"price":6.88,"value":2043.36,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F5","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person. No additional shares of common stock were sold by the reporting person and the shares of common stock received upon settlement of the RSUs are subject to a lock-up agreement with Cantor Fitzgerald & Co. entered into in connection with the Issuer's private placement in December 2025."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $6.60 to $7.56, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":12857,"source":{"system":"sec-edgar","filing":"0002037968-26-000002","document":"form4-01062026_120150.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/2037968/000203796826000002/form4-01062026_120150.xml","form_type":"4"}},{"id":952308,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52747,"kind":"person","name":"Renninger Robert","position":1,"cik":"0002037968","reported_name":"Renninger Robert","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Financial Officer"}}],"security":"Common Stock","published_at":"2026-01-06T00:50:54.000Z","date":"2025-12-31","kind":"exercise","planned":false,"acquired":true,"shares":1236,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":13154,"source":{"system":"sec-edgar","filing":"0002037968-26-000002","document":"form4-01062026_120150.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/2037968/000203796826000002/form4-01062026_120150.xml","form_type":"4"}},{"id":952307,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52747,"kind":"person","name":"Renninger Robert","position":1,"cik":"0002037968","reported_name":"Renninger Robert","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Financial Officer"}}],"security":"Common Stock","published_at":"2026-01-06T00:50:54.000Z","date":"2025-11-18","kind":"grant","planned":false,"acquired":true,"shares":1000,"price":2.31,"value":2310.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"The reporting person is voluntarily reporting the acquisition of shares of the issuer's common stock pursuant to the Athira Pharma, Inc. 2020 Employee Stock Purchase Plan (\"ESPP\"), for the ESPP Purchase Period (as defined in the ESPP) of May 19, 2025 through November 18, 2025. This transaction is also exempt under Rule 16b-3(c)."},{"field":"security","element":"securityTitle","label":"F2","text":"The reported number of shares in this Form 4 has been adjusted to reflect the impact of the Issuer's 10-for-1 reverse stock split completed on September 17, 2025 (the \"Reverse Stock Split\")."},{"field":"date","element":"transactionDate","label":"F3","text":"The Purchase Period ended November 18, 2025 and is the Purchase Period comprising the Offering Period (as defined in the ESPP) that began May 19, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"In accordance with the ESPP, these shares were purchased based on 85% of the closing price on November 18, 2025."}],"balance_after":11918,"source":{"system":"sec-edgar","filing":"0002037968-26-000002","document":"form4-01062026_120150.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2037968/000203796826000002/form4-01062026_120150.xml","form_type":"4"}},{"id":953355,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Restricted Stock Units","published_at":"2026-01-06T00:50:13.000Z","date":"2025-12-31","kind":"exercise","planned":false,"acquired":false,"shares":3667,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F7","text":"RSUs convert into common stock on a one-for-one basis."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F8","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F9","text":"On October 1, 2024, the reporting person was granted 11,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F9","text":"On October 1, 2024, the reporting person was granted 11,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":3667},"source":{"system":"sec-edgar","filing":"0001822499-26-000002","document":"form4-01062026_120110.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000182249926000002/form4-01062026_120110.xml","form_type":"4"}},{"id":953354,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Common Stock","published_at":"2026-01-06T00:50:13.000Z","date":"2026-01-02","kind":"sale","planned":false,"acquired":false,"shares":876,"price":6.88,"value":6026.88,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F5","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person. No additional shares of common stock were sold by the reporting person and the shares of common stock received upon settlement of the RSUs are subject to a lock-up agreement with Cantor Fitzgerald & Co. entered into in connection with the Issuer's private placement in December 2025."},{"field":"price","element":"transactionPricePerShare","label":"F6","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $6.60 to $7.56, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":20681,"source":{"system":"sec-edgar","filing":"0001822499-26-000002","document":"form4-01062026_120110.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000182249926000002/form4-01062026_120110.xml","form_type":"4"}},{"id":953353,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Common Stock","published_at":"2026-01-06T00:50:13.000Z","date":"2025-12-31","kind":"exercise","planned":false,"acquired":true,"shares":3667,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":21557,"source":{"system":"sec-edgar","filing":"0001822499-26-000002","document":"form4-01062026_120110.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000182249926000002/form4-01062026_120110.xml","form_type":"4"}},{"id":953352,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Common Stock","published_at":"2026-01-06T00:50:13.000Z","date":"2025-11-18","kind":"grant","planned":false,"acquired":true,"shares":1000,"price":2.31,"value":2310.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"The reporting person is voluntarily reporting the acquisition of shares of the issuer's common stock pursuant to the Athira Pharma, Inc. 2020 Employee Stock Purchase Plan (\"ESPP\"), for the ESPP Purchase Period (as defined in the ESPP) of May 19, 2025 through November 18, 2025. This transaction is also exempt under Rule 16b-3(c)."},{"field":"security","element":"securityTitle","label":"F2","text":"The reported number of shares in this Form 4 has been adjusted to reflect the impact of the Issuer's 10-for-1 reverse stock split completed on September 17, 2025 (the \"Reverse Stock Split\")."},{"field":"date","element":"transactionDate","label":"F3","text":"The Purchase Period ended November 18, 2025 and is the Purchase Period comprising the Offering Period (as defined in the ESPP) that began May 19, 2025."},{"field":"price","element":"transactionPricePerShare","label":"F4","text":"In accordance with the ESPP, these shares were purchased based on 85% of the closing price on November 18, 2025."}],"balance_after":17890,"source":{"system":"sec-edgar","filing":"0001822499-26-000002","document":"form4-01062026_120110.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000182249926000002/form4-01062026_120110.xml","form_type":"4"}},{"id":951867,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52727,"kind":"person","name":"Worthington Mark","position":1,"cik":"0001861464","reported_name":"Worthington Mark","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"General Counsel and CCO"}}],"security":"Restricted Stock Units","published_at":"2026-01-06T00:49:24.000Z","date":"2025-12-31","kind":"exercise","planned":false,"acquired":false,"shares":3667,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F4","text":"RSUs convert into common stock on a one-for-one basis."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F5","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"On October 1, 2024, the reporting person was granted 11,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"On October 1, 2024, the reporting person was granted 11,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."}],"balance_after":0,"derivative":{"underlying":"Common Stock","underlying_shares":3667},"source":{"system":"sec-edgar","filing":"0001861464-26-000002","document":"form4-01062026_120121.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1861464/000186146426000002/form4-01062026_120121.xml","form_type":"4"}},{"id":951866,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52727,"kind":"person","name":"Worthington Mark","position":1,"cik":"0001861464","reported_name":"Worthington Mark","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"General Counsel and CCO"}}],"security":"Common Stock","published_at":"2026-01-06T00:49:24.000Z","date":"2026-01-02","kind":"sale","planned":false,"acquired":false,"shares":876,"price":6.88,"value":6026.88,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F2","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person. No additional shares of common stock were sold by the reporting person and the shares of Common Stock received upon settlement of the RSUs are subject to a lock-up agreement with Cantor Fitzgerald & Co. entered into in connection with the Issuer's private placement in December 2025."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $6.60 to $7.56, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":13978,"source":{"system":"sec-edgar","filing":"0001861464-26-000002","document":"form4-01062026_120121.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1861464/000186146426000002/form4-01062026_120121.xml","form_type":"4"}},{"id":951865,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52727,"kind":"person","name":"Worthington Mark","position":1,"cik":"0001861464","reported_name":"Worthington Mark","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"General Counsel and CCO"}}],"security":"Common Stock","published_at":"2026-01-06T00:49:24.000Z","date":"2025-12-31","kind":"exercise","planned":false,"acquired":true,"shares":3667,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"The reported number of shares in this Form 4 has been adjusted to reflect the impact of the Issuer's 10-for-1 reverse stock split completed on September 17, 2025 (the \"Reverse Stock Split\")."}],"balance_after":14854,"source":{"system":"sec-edgar","filing":"0001861464-26-000002","document":"form4-01062026_120121.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1861464/000186146426000002/form4-01062026_120121.xml","form_type":"4"}},{"id":958468,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52747,"kind":"person","name":"Renninger Robert","position":1,"cik":"0002037968","reported_name":"Renninger Robert","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"Chief Financial Officer"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-29T21:19:08.000Z","date":"2025-12-24","kind":"grant","planned":false,"acquired":true,"shares":34358,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The exercise price is equal to the closing price per share of Common Stock as reported on the Nasdaq Global Market on the date of grant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"On September 24, 2025, the reporting person was granted an option to purchase 34,358 shares of common stock. The option was scheduled to vest only upon satisfaction of both a milestone requirement (the \"Milestone Requirement\") and a service-based requirement (the \"Service-Based Requirement\"). The Milestone Requirement was satisfied on December 23, 2025. The Service-Based Requirement will be satisfied as to 50% of the total number of shares granted under the option on December 23, 2026 and as to 1/36th of the remaining 50% on the 23rd day of each month thereafter, subject to the optionee continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan) through the applicable vesting dates."}],"balance_after":34358,"derivative":{"exercise_price":4.07,"expiration_date":"2035-09-23","underlying":"Common Stock","underlying_shares":34358},"source":{"system":"sec-edgar","filing":"0002037968-25-000003","document":"form4-12292025_091202.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2037968/000203796825000003/form4-12292025_091202.xml","form_type":"4"}},{"id":957900,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52683,"kind":"person","name":"Litton Mark James","position":1,"cik":"0001604834","reported_name":"Litton Mark James","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CEO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-29T21:17:39.000Z","date":"2025-12-24","kind":"grant","planned":false,"acquired":true,"shares":133526,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The exercise price is equal to the closing price per share of Common Stock as reported on the Nasdaq Global Market on the date of grant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"On September 25, 2025, the reporting person was granted an option to purchase 133,526 shares of common stock. The option was scheduled to vest only upon satisfaction of both a milestone requirement (the \"Milestone Requirement\") and a service-based requirement (the \"Service-Based Requirement\"). The Milestone Requirement was satisfied on December 23, 2025. The Service-Based Requirement will be satisfied as to 50% of the total number of shares granted under the option on December 23, 2026 and as to 1/36th of the remaining 50% on the 23rd day of each month thereafter, subject to the optionee continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan) through the applicable vesting dates."}],"balance_after":133526,"derivative":{"exercise_price":3.81,"expiration_date":"2035-09-24","underlying":"Common Stock","underlying_shares":133526},"source":{"system":"sec-edgar","filing":"0001604834-25-000004","document":"form4-12292025_091231.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1604834/000160483425000004/form4-12292025_091231.xml","form_type":"4"}},{"id":958922,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-29T21:15:51.000Z","date":"2025-12-24","kind":"grant","planned":false,"acquired":true,"shares":35138,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The exercise price is equal to the closing price per share of Common Stock as reported on the Nasdaq Global Market on the date of grant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"On September 24, 2025, the reporting person was granted an option to purchase 35,138 shares of common stock. The option was scheduled to vest only upon satisfaction of both a milestone requirement (the \"Milestone Requirement\") and a service-based requirement (the \"Service-Based Requirement\"). The Milestone Requirement was satisfied on December 23, 2025. The Service-Based Requirement will be satisfied as to 50% of the total number of shares granted under the option on December 23, 2026 and as to 1/36th of the remaining 50% on the 23rd day of each month thereafter, subject to the optionee continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan) through the applicable vesting dates."}],"balance_after":35138,"derivative":{"exercise_price":4.07,"expiration_date":"2035-09-23","underlying":"Common Stock","underlying_shares":35138},"source":{"system":"sec-edgar","filing":"0001822499-25-000005","document":"form4-12292025_091245.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000182249925000005/form4-12292025_091245.xml","form_type":"4"}},{"id":957892,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52680,"kind":"person","name":"San Martin Javier","position":1,"cik":"0001794629","reported_name":"San Martin Javier","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF MEDICAL OFFICER"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-29T21:14:11.000Z","date":"2025-12-24","kind":"grant","planned":false,"acquired":true,"shares":44508,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The exercise price is equal to the closing price per share of Common Stock as reported on the Nasdaq Global Market on the date of grant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"On September 24, 2025, the reporting person was granted an option to purchase 44,508 shares of common stock. The option was scheduled to vest only upon satisfaction of both a milestone requirement (the \"Milestone Requirement\") and a service-based requirement (the \"Service-Based Requirement\"). The Milestone Requirement was satisfied on December 23, 2025. The Service-Based Requirement will be satisfied as to 50% of the total number of shares granted under the option on December 23, 2026 and as to 1/36th of the remaining 50% on the 23rd day of each month thereafter, subject to the optionee continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan) through the applicable vesting dates."}],"balance_after":44508,"derivative":{"exercise_price":4.07,"expiration_date":"2035-09-23","underlying":"Common Stock","underlying_shares":44508},"source":{"system":"sec-edgar","filing":"0001794629-25-000003","document":"form4-12292025_091206.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1620463/000179462925000003/form4-12292025_091206.xml","form_type":"4"}},{"id":958316,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52727,"kind":"person","name":"Worthington Mark","position":1,"cik":"0001861464","reported_name":"Worthington Mark","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"General Counsel and CCO"}}],"security":"Stock Option (Right to Buy)","published_at":"2025-12-29T21:12:07.000Z","date":"2025-12-24","kind":"grant","planned":false,"acquired":true,"shares":34358,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F1","text":"The exercise price is equal to the closing price per share of Common Stock as reported on the Nasdaq Global Market on the date of grant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F2","text":"On September 24, 2025, the reporting person was granted an option to purchase 34,358 shares of common stock. The option was scheduled to vest only upon satisfaction of both a milestone requirement (the \"Milestone Requirement\") and a service-based requirement (the \"Service-Based Requirement\"). The Milestone Requirement was satisfied on December 23, 2025. The Service-Based Requirement will be satisfied as to 50% of the total number of shares granted under the option on December 23, 2026 and as to 1/36th of the remaining 50% on the 23rd day of each month thereafter, subject to the optionee continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan) through the applicable vesting dates."}],"balance_after":34358,"derivative":{"exercise_price":4.07,"expiration_date":"2035-09-23","underlying":"Common Stock","underlying_shares":34358},"source":{"system":"sec-edgar","filing":"0001861464-25-000003","document":"form4-12292025_091201.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1861464/000186146425000003/form4-12292025_091201.xml","form_type":"4"}},{"id":959955,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":5502402,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F7","text":"The securities were issued to Sermonix Pharmaceuticals, Inc. (\"Sermonix\") in exchange for the grant of certain licenses and rights by Sermonix to the Issuer. The Pre-Funded Warrants will become exercisable upon receipt by the Issuer of stockholder approval such that the Pre-Funded Warrants can be exercised at any time without restriction or additional stockholder approval. The Pre-Funded Warrants do not expire."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F7","text":"The securities were issued to Sermonix Pharmaceuticals, Inc. (\"Sermonix\") in exchange for the grant of certain licenses and rights by Sermonix to the Issuer. The Pre-Funded Warrants will become exercisable upon receipt by the Issuer of stockholder approval such that the Pre-Funded Warrants can be exercised at any time without restriction or additional stockholder approval. The Pre-Funded Warrants do not expire."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F11","text":"The terms of the Pre-Funded Warrants provide that such warrants may not be exercised if, after such exercise, Sermonix, together with its Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 4.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Sermonix Beneficial Ownership Limitation\"). As of the date hereof, the Sermonix Beneficial Ownership Limitation does not permit Sermonix to exercise any of its Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F7","text":"The securities were issued to Sermonix Pharmaceuticals, Inc. (\"Sermonix\") in exchange for the grant of certain licenses and rights by Sermonix to the Issuer. The Pre-Funded Warrants will become exercisable upon receipt by the Issuer of stockholder approval such that the Pre-Funded Warrants can be exercised at any time without restriction or additional stockholder approval. The Pre-Funded Warrants do not expire."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F8","text":"The securities are directly held by Sermonix. An affiliate of the Advisor currently holds approximately 29% of the outstanding capital stock of Sermonix (excluding securities convertible into shares of Sermonix capital stock). Pursuant to General Instruction 4.b.(iv) of Form 4, the Reporting Persons with this filing have reported the entire amount of Sermonix's interest in the securities, rather than the Reporting Person's proportionate interest in the securities held by Sermonix."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":5502402,"derivative":{"exercise_price":0.001,"underlying":"Common Stock","underlying_shares":5502402},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":9,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959954,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series B Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":1181101,"price":6.35,"value":7499991.35,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying Series A Warrant and Series B Warrant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"The Series B Warrants will be exercisable after the later of (1) June 30, 2026 and (2) the date of the completion of the public readout of topline results of the Issuer's ELAINE-3 trial. (the \"Series B Expiration Date\") and expire on the earlier of (1) the 30th day following the Series B Expiration Date and (2) December 23, 2030."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"The Series B Warrants will be exercisable after the later of (1) June 30, 2026 and (2) the date of the completion of the public readout of topline results of the Issuer's ELAINE-3 trial. (the \"Series B Expiration Date\") and expire on the earlier of (1) the 30th day following the Series B Expiration Date and (2) December 23, 2030."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Xontogeny Venture Fund II, LP (\"PXV II\"). Perceptive Venture Advisors, LLC (the \"Venture Advisor\") serves as the investment manager of PXV II and is controlled by the Advisor, and Perceptive Xontogeny Venture II GP, LLC (\"PXV GP\") is the general partner of PXV II. Mr. Edelman is the managing member of PXV GP and the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1181101,"derivative":{"exercise_price":7.62,"underlying":"Common Stock","underlying_shares":1181101},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":8,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959953,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series A Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":1279526,"price":6.35,"value":8124990.1,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying Series A Warrant and Series B Warrant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The Series A Warrants will be exercisable after the earlier of (1) the latest of (a) June 30, 2026, (b) the date on which the Issuer announces the enrollment of the 500th subject or the last subject, whichever is earlier, in its ELAINE-3 trial, and (c) the date on which the U.S. Food and Drug Administration approves or issues a complete response letter to Eli Lilly & Co.'s marketing application for imlunestrant in combination with abemaciclib in breast cancer, and (2) October 31, 2026 (the \"Series A Expiration Date\") and expire on the earlier of (1) the 30th day following the Series A Expiration Date and (2) December 23, 2030."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The Series A Warrants will be exercisable after the earlier of (1) the latest of (a) June 30, 2026, (b) the date on which the Issuer announces the enrollment of the 500th subject or the last subject, whichever is earlier, in its ELAINE-3 trial, and (c) the date on which the U.S. Food and Drug Administration approves or issues a complete response letter to Eli Lilly & Co.'s marketing application for imlunestrant in combination with abemaciclib in breast cancer, and (2) October 31, 2026 (the \"Series A Expiration Date\") and expire on the earlier of (1) the 30th day following the Series A Expiration Date and (2) December 23, 2030."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Xontogeny Venture Fund II, LP (\"PXV II\"). Perceptive Venture Advisors, LLC (the \"Venture Advisor\") serves as the investment manager of PXV II and is controlled by the Advisor, and Perceptive Xontogeny Venture II GP, LLC (\"PXV GP\") is the general partner of PXV II. Mr. Edelman is the managing member of PXV GP and the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1279526,"derivative":{"exercise_price":6.35,"underlying":"Common Stock","underlying_shares":1279526},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":7,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959952,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":457645,"price":6.349,"value":2905588.105,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"The Pre-Funded Warrants do not expire."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Xontogeny Venture Fund II, LP (\"PXV II\"). Perceptive Venture Advisors, LLC (the \"Venture Advisor\") serves as the investment manager of PXV II and is controlled by the Advisor, and Perceptive Xontogeny Venture II GP, LLC (\"PXV GP\") is the general partner of PXV II. Mr. Edelman is the managing member of PXV GP and the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":457645,"derivative":{"exercise_price":0.001,"exercise_date":"2025-12-23","underlying":"Common Stock","underlying_shares":457645},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959951,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series B Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":3543307,"price":6.35,"value":22499999.45,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying Series A Warrant and Series B Warrant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F6","text":"The Series B Warrants will be exercisable after the later of (1) June 30, 2026 and (2) the date of the completion of the public readout of topline results of the Issuer's ELAINE-3 trial. (the \"Series B Expiration Date\") and expire on the earlier of (1) the 30th day following the Series B Expiration Date and (2) December 23, 2030."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F6","text":"The Series B Warrants will be exercisable after the later of (1) June 30, 2026 and (2) the date of the completion of the public readout of topline results of the Issuer's ELAINE-3 trial. (the \"Series B Expiration Date\") and expire on the earlier of (1) the 30th day following the Series B Expiration Date and (2) December 23, 2030."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":3543307,"derivative":{"exercise_price":7.62,"underlying":"Common Stock","underlying_shares":3543307},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":5,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959950,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Series A Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":3838583,"price":6.35,"value":24375002.05,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying Series A Warrant and Series B Warrant."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"The Series A Warrants will be exercisable after the earlier of (1) the latest of (a) June 30, 2026, (b) the date on which the Issuer announces the enrollment of the 500th subject or the last subject, whichever is earlier, in its ELAINE-3 trial, and (c) the date on which the U.S. Food and Drug Administration approves or issues a complete response letter to Eli Lilly & Co.'s marketing application for imlunestrant in combination with abemaciclib in breast cancer, and (2) October 31, 2026 (the \"Series A Expiration Date\") and expire on the earlier of (1) the 30th day following the Series A Expiration Date and (2) December 23, 2030."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"The Series A Warrants will be exercisable after the earlier of (1) the latest of (a) June 30, 2026, (b) the date on which the Issuer announces the enrollment of the 500th subject or the last subject, whichever is earlier, in its ELAINE-3 trial, and (c) the date on which the U.S. Food and Drug Administration approves or issues a complete response letter to Eli Lilly & Co.'s marketing application for imlunestrant in combination with abemaciclib in breast cancer, and (2) October 31, 2026 (the \"Series A Expiration Date\") and expire on the earlier of (1) the 30th day following the Series A Expiration Date and (2) December 23, 2030."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":3838583,"derivative":{"exercise_price":6.35,"underlying":"Common Stock","underlying_shares":3838583},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959949,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Pre-Funded Warrant (right to buy)","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":1372935,"price":6.349,"value":8716764.315,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F10","text":"The terms of the Pre-Funded Warrants, Series A Warrants and Series B Warrants provide that such warrants may not be exercised if, after such exercise, the Reporting Persons, together with their Attribution Parties (as defined in the warrants) would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock then issued and outstanding after giving effect to such exercise (the \"Beneficial Ownership Limitation\"). As of the date hereof, the Beneficial Ownership Limitation does not permit the Master Fund or PXV II to exercise any of their Warrants."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F4","text":"The Pre-Funded Warrants do not expire."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1372935,"derivative":{"exercise_price":0.001,"exercise_date":"2025-12-23","underlying":"Common Stock","underlying_shares":1372935},"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959948,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":329756,"price":6.35,"value":2093950.6,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying Series A Warrant and Series B Warrant."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F3","text":"The securities are directly held by Perceptive Xontogeny Venture Fund II, LP (\"PXV II\"). Perceptive Venture Advisors, LLC (the \"Venture Advisor\") serves as the investment manager of PXV II and is controlled by the Advisor, and Perceptive Xontogeny Venture II GP, LLC (\"PXV GP\") is the general partner of PXV II. Mr. Edelman is the managing member of PXV GP and the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":329756,"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":959947,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":19219,"kind":"person","name":"PERCEPTIVE ADVISORS LLC","position":1,"cik":"0001224962","reported_name":"PERCEPTIVE ADVISORS LLC","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19221,"kind":"person","name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","position":2,"cik":"0001249675","reported_name":"PERCEPTIVE LIFE SCIENCES MASTER FUND LTD","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":19220,"kind":"person","name":"EDELMAN JOSEPH","position":3,"cik":"0001164426","reported_name":"EDELMAN JOSEPH","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}},{"id":70910,"kind":"person","name":"Perceptive Xontogeny Venture Fund II, LP","position":4,"cik":"0001851820","reported_name":"Perceptive Xontogeny Venture Fund II, LP","relationship":{"director":true,"officer":false,"ten_percent_owner":true,"other":false}}],"security":"Common Stock","published_at":"2025-12-23T22:12:03.000Z","date":"2025-12-23","kind":"grant","planned":false,"acquired":true,"shares":989270,"price":6.35,"value":6281864.5,"ownership":{"direct":false,"nature":"See Footnotes"},"footnotes":[{"field":"price","element":"transactionPricePerShare","label":"F1","text":"Represents the combined purchase price for each share of Common Stock and accompanying Series A Warrant and Series B Warrant."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F2","text":"The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the \"Master Fund\"). Perceptive Advisors LLC (the \"Advisor\") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor."},{"field":"ownership.nature","element":"natureOfOwnership","label":"F9","text":"Each of Mr. Edelman, the Advisor, the Master Fund and PXV II disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of such securities for purposes of Section 16 or for any other purposes."}],"balance_after":1529566,"source":{"system":"sec-edgar","filing":"0001012975-25-000979","document":"form4.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1164426/000101297525000979/form4.xml","form_type":"4"}},{"id":1096511,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Restricted Stock Units","published_at":"2025-07-02T20:35:30.000Z","date":"2025-06-30","kind":"exercise","planned":false,"acquired":false,"shares":36666,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F6","text":"RSUs convert into common stock on a one-for-one basis."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F7","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"On October 1, 2024, the reporting person was granted 110,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F8","text":"On October 1, 2024, the reporting person was granted 110,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."}],"balance_after":36667,"derivative":{"underlying":"Common Stock","underlying_shares":36666},"source":{"system":"sec-edgar","filing":"0001415889-25-019070","document":"form4-07022025_080725.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":4,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000141588925019070/form4-07022025_080725.xml","form_type":"4"}},{"id":1096510,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Common Stock","published_at":"2025-07-02T20:35:30.000Z","date":"2025-07-01","kind":"sale","planned":false,"acquired":false,"shares":8526,"price":0.2935,"value":2502.381,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F4","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person."},{"field":"price","element":"transactionPricePerShare","label":"F5","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $0.2854 to $0.3031, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":168901,"source":{"system":"sec-edgar","filing":"0001415889-25-019070","document":"form4-07022025_080725.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000141588925019070/form4-07022025_080725.xml","form_type":"4"}},{"id":1096509,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Common Stock","published_at":"2025-07-02T20:35:30.000Z","date":"2025-06-30","kind":"exercise","planned":false,"acquired":true,"shares":36666,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":177427,"source":{"system":"sec-edgar","filing":"0001415889-25-019070","document":"form4-07022025_080725.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000141588925019070/form4-07022025_080725.xml","form_type":"4"}},{"id":1096508,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52780,"kind":"person","name":"CHURCH KEVIN","position":1,"cik":"0001822499","reported_name":"CHURCH KEVIN","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF SCIENTIFIC OFFICER"}}],"security":"Common Stock","published_at":"2025-07-02T20:35:30.000Z","date":"2025-05-19","kind":"grant","planned":false,"acquired":true,"shares":10000,"price":0.2312,"value":2312.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F1","text":"The reporting person is voluntarily reporting the acquisition of shares of the issuer's common stock pursuant to the Athira Pharma, Inc. 2020 Employee Stock Purchase Plan (\"ESPP\"),for the ESPP Purchase Period (as defined in the ESPP) of November 18, 2024 through May 19, 2025. This transaction is exempt under Rule 16b-3(c)."},{"field":"date","element":"transactionDate","label":"F2","text":"The Purchase Period ended March 19, 2025 and is the Purchase Period comprising the Offering Period (as defined in the ESPP) that began November 18, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"In accordance with the ESPP, these shares were purchased based on 85% of the closing price on May 19, 2025."}],"balance_after":140761,"source":{"system":"sec-edgar","filing":"0001415889-25-019070","document":"form4-07022025_080725.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1822499/000141588925019070/form4-07022025_080725.xml","form_type":"4"}},{"id":1094233,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52683,"kind":"person","name":"Litton Mark James","position":1,"cik":"0001604834","reported_name":"Litton Mark James","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CEO"}}],"security":"Restricted Stock Units","published_at":"2025-07-02T20:34:41.000Z","date":"2025-06-30","kind":"exercise","planned":false,"acquired":false,"shares":108334,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F6","text":"RSUs convert into common stock on a one-for-one basis."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F7","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"On October 1, 2024, the reporting person was granted 325,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F8","text":"On October 1, 2024, the reporting person was granted 325,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."}],"balance_after":108333,"derivative":{"underlying":"Common Stock","underlying_shares":108334},"source":{"system":"sec-edgar","filing":"0001415889-25-019069","document":"form4-07022025_080737.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":6,"url":"https://www.sec.gov/Archives/edgar/data/1604834/000141588925019069/form4-07022025_080737.xml","form_type":"4"}},{"id":1094232,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52683,"kind":"person","name":"Litton Mark James","position":1,"cik":"0001604834","reported_name":"Litton Mark James","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-07-02T20:34:41.000Z","date":"2025-07-01","kind":"sale","planned":false,"acquired":false,"shares":25123,"price":0.2935,"value":7373.6005,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $0.2854 to $0.3031, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":325802,"source":{"system":"sec-edgar","filing":"0001415889-25-019069","document":"form4-07022025_080737.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1604834/000141588925019069/form4-07022025_080737.xml","form_type":"4"}},{"id":1094231,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52683,"kind":"person","name":"Litton Mark James","position":1,"cik":"0001604834","reported_name":"Litton Mark James","relationship":{"director":true,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"President and CEO"}}],"security":"Common Stock","published_at":"2025-07-02T20:34:41.000Z","date":"2025-06-30","kind":"exercise","planned":false,"acquired":true,"shares":108334,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":350925,"source":{"system":"sec-edgar","filing":"0001415889-25-019069","document":"form4-07022025_080737.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1604834/000141588925019069/form4-07022025_080737.xml","form_type":"4"}},{"id":1094204,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52680,"kind":"person","name":"San Martin Javier","position":1,"cik":"0001794629","reported_name":"San Martin Javier","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF MEDICAL OFFICER"}}],"security":"Restricted Stock Units","published_at":"2025-07-02T20:33:46.000Z","date":"2025-06-30","kind":"exercise","planned":false,"acquired":false,"shares":46666,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"RSUs convert into common stock on a one-for-one basis."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"On October 1, 2024, the reporting person was granted 140,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"On October 1, 2024, the reporting person was granted 140,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's 2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."}],"balance_after":46667,"derivative":{"underlying":"Common Stock","underlying_shares":46666},"source":{"system":"sec-edgar","filing":"0001415889-25-019068","document":"form4-07022025_080743.xml","document_sequence":1,"table":"derivative","row_type":"transaction","position":3,"url":"https://www.sec.gov/Archives/edgar/data/1620463/000141588925019068/form4-07022025_080743.xml","form_type":"4"}},{"id":1094203,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52680,"kind":"person","name":"San Martin Javier","position":1,"cik":"0001794629","reported_name":"San Martin Javier","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF MEDICAL OFFICER"}}],"security":"Common Stock","published_at":"2025-07-02T20:33:46.000Z","date":"2025-07-01","kind":"sale","planned":false,"acquired":false,"shares":10842,"price":0.2935,"value":3182.127,"ownership":{"direct":true},"footnotes":[{"field":"kind","element":"transactionCoding","label":"F1","text":"Represents shares of common stock sold to cover tax withholding and remittance obligations in connection with the vesting of restricted stock units (\"RSU\") pursuant to mandatory \"sell to cover\" policies maintained by the issuer and provisions contained in the reporting person's applicable RSU agreement, and does not represent a discretionary sale by the reporting person."},{"field":"price","element":"transactionPricePerShare","label":"F2","text":"The \"Amount\" and \"Price\" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $0.2854 to $0.3031, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":71665,"source":{"system":"sec-edgar","filing":"0001415889-25-019068","document":"form4-07022025_080743.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1620463/000141588925019068/form4-07022025_080743.xml","form_type":"4"}},{"id":1094202,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52680,"kind":"person","name":"San Martin Javier","position":1,"cik":"0001794629","reported_name":"San Martin Javier","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"CHIEF MEDICAL OFFICER"}}],"security":"Common Stock","published_at":"2025-07-02T20:33:46.000Z","date":"2025-06-30","kind":"exercise","planned":false,"acquired":true,"shares":46666,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":82507,"source":{"system":"sec-edgar","filing":"0001415889-25-019068","document":"form4-07022025_080743.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1620463/000141588925019068/form4-07022025_080743.xml","form_type":"4"}},{"id":1095489,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52727,"kind":"person","name":"Worthington Mark","position":1,"cik":"0001861464","reported_name":"Worthington Mark","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"General Counsel and CCO"}}],"security":"Restricted Stock Units","published_at":"2025-07-02T20:33:04.000Z","date":"2025-06-30","kind":"exercise","planned":false,"acquired":false,"shares":36666,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F3","text":"RSUs convert into common stock on a one-for-one basis."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F4","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F5","text":"On October 1, 2024, the reporting person was granted 110,000 RSUs. One-third (1/3rd) of the RSUs vest on each of December 31, 2024, June 30, 2025 and December 31, 2025, subject to the reporting person continuing to be a Service Provider (as defined in the Issuer's\n2020 Equity Incentive Plan (the \"Plan\")) through the applicable vesting dates."},{"field":"derivative.expiration_date","element":"expirationDate","label":"F5","text":"On October 1, 2024, the reporting person was granted 110,000 RSUs. 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These shares were sold in multiple transactions at prices ranging from $0.2854 to $0.3031, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein."}],"balance_after":111875,"source":{"system":"sec-edgar","filing":"0001415889-25-019066","document":"form4-07022025_080700.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":2,"url":"https://www.sec.gov/Archives/edgar/data/1861464/000141588925019066/form4-07022025_080700.xml","form_type":"4"}},{"id":1095487,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52727,"kind":"person","name":"Worthington Mark","position":1,"cik":"0001861464","reported_name":"Worthington Mark","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"General Counsel and CCO"}}],"security":"Common Stock","published_at":"2025-07-02T20:33:04.000Z","date":"2025-06-30","kind":"exercise","planned":false,"acquired":true,"shares":36666,"price":0,"value":0.0,"ownership":{"direct":true},"balance_after":120401,"source":{"system":"sec-edgar","filing":"0001415889-25-019066","document":"form4-07022025_080700.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/1861464/000141588925019066/form4-07022025_080700.xml","form_type":"4"}},{"id":1095795,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52747,"kind":"person","name":"Renninger Robert","position":1,"cik":"0002037968","reported_name":"Renninger Robert","relationship":{"director":false,"officer":true,"ten_percent_owner":false,"other":false,"officer_title":"SVP, Finance and Accounting"}}],"security":"Restricted Stock Units","published_at":"2025-07-02T20:32:09.000Z","date":"2025-06-30","kind":"exercise","planned":false,"acquired":false,"shares":12359,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"security","element":"securityTitle","label":"F6","text":"RSUs convert into common stock on a one-for-one basis."},{"field":"derivative.exercise_price","element":"conversionOrExercisePrice","label":"F7","text":"Each RSU represents a contingent right to receive one (1) share of Issuer's common stock."},{"field":"derivative.exercise_date","element":"exerciseDate","label":"F8","text":"On October 1, 2024, the reporting person was granted 37,077 RSUs. 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This transaction is exempt under Rule 16b-3(c)."},{"field":"date","element":"transactionDate","label":"F2","text":"The Purchase Period ended March 19, 2025 and is the Purchase Period comprising the Offering Period (as defined in the ESPP) that began November 18, 2024."},{"field":"price","element":"transactionPricePerShare","label":"F3","text":"In accordance with the ESPP, these shares were purchased based on 85% of the closing price on May 19, 2025."}],"balance_after":99724,"source":{"system":"sec-edgar","filing":"0001415889-25-019064","document":"form4-07022025_080705.xml","document_sequence":1,"table":"nonDerivative","row_type":"transaction","position":1,"url":"https://www.sec.gov/Archives/edgar/data/2037968/000141588925019064/form4-07022025_080705.xml","form_type":"4"}},{"id":1124516,"issuer":{"id":1487,"kind":"organization","name":"LeonaBio, Inc.","symbol":"LONA"},"owners":[{"id":52700,"kind":"person","name":"FLUKE JOHN M JR","position":1,"cik":"0001191906","reported_name":"FLUKE JOHN M JR","relationship":{"director":true,"officer":false,"ten_percent_owner":false,"other":false}}],"security":"Stock Option (Right to Buy)","published_at":"2025-06-03T21:37:07.000Z","date":"2025-05-30","kind":"grant","planned":false,"acquired":true,"shares":20900,"price":0,"value":0.0,"ownership":{"direct":true},"footnotes":[{"field":"derivative.exercise_date","element":"exerciseDate","label":"F1","text":"The shares subject to the option will vest on the earlier of (i) May 30, 2026, or (ii) the day immediately before the date of the next annual meeting of the Issuer's stockholders that occurs after May 30, 2025. 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